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| 1 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 2 | Land use effects on soil organic matter properties of chromic luvisols in semi-arid northern Tanzania: carbon, nitrogen, lignin and carbohydrates显示文摘 | D Solomon J Lehmann W Zech | 2000 | Agriculture Ecosystems and Environment2000，，3： | 2 |
| 3 | Biologically and chemically optimised composites of carbonated apatite and polyglycolide as bone substitution materials显示文摘 | Linhart W Peters F Lehmann W | 2001 | J Biomed Mater Res2001，54，： | 1 |
| 4 | Ameliorating physical and chemical properties of highly weathered soils in the tropics with eharcoal-a review 显示文摘 | Glaser B Lehmann J Zech W | 2002 | Biol Fert Soils2002，35，： | 1 |
| 5 | Myeorrhizal responses to bioehar in soil-concepts and mechanisms显示文摘 | Warnock D D Lehmann J Kuyper T W | 2007 | Plant and soil2007，300，12： | 1 |
| 6 | Antisense-media- ted inhibition of ICAM-1 expression: a therapeutic strategy a- gainst inflammation of human periodontal tissue 显示文摘 | Nedbal W Tomakidi P Lehmann MJ | 2002 | Antisense Nucleic Aci~f Drug Dev2002，12，2： | 1 |
| 7 | Long term effects of manure, charcoal and mineral fertilization on crop production and fertility on a highly weathered Central Amazonian upland soil显示文摘 | Steiner C Teixeira W G Lehmann J | 2007 | Plant and Soil2007，291，： | 1 |
| 8 | Idiopathic(unexplained)pulmonary embolism is associated with an impaired prognosis compared to other entities of pulmonary embolism显示文摘 | LEHMANN R LUXEMBOURG B MIESBACH W | 2010 | Blood Coagul Fibrinolysis2010，21，： | 1 |
| 9 | Next generation distal locking for intramedullary nails using an electromag- netic X-ray-radiation-free real-time navigation system 显示文摘 | Hoffmann M Schroder M Lehmann W | 2012 | J Trauma Acute Care Surg2012，73，： | 1 |
| 10 | Safety aspects for LHe cryostats and LHe transport containers显示文摘 | Lehmann W Zahn G | 1978 | Advances in cryogenic engineering1978，23，： | 1 |
| 11 | Long term effects of ma- nure, charcoal and mineral fertilization on crop production and fertility on a highly weathered central Amazonian upland soil 显示文摘 | Steiner C Teixeira W G Lehmann J | 2007 | Plant and Soil2007，291，： | 1 |
| 12 | Long term effects of manure, charcoal and mineral fertilization on crop production and fertility on a highly weathered Central Amazonian upland soil 显示文摘 | Steincr C Teixeira W G Lehmann J | 2007 | Plant and Soil2007，291，： | 1 |
| 13 | Customer satisfaction,market share,and profitability显示文摘 | Anderson E W Fornell C Lehmann D R | 1993 | Journal of Marketing1993，56，3： | 1 |
| 14 | Pervaporation separation of water/alcohol mixtures using composite membranes based on polyelectrolyte muhilayer assemblies 显示文摘 | Meier - Haack J Lenk W Lehmann D | 2001 | J Membr Sci2001，184，： | 1 |
| 15 | Ameliorating Physical and Chemical Properties of Highly Weathered Soils in the Tropics With Charcoal: A Review 显示文摘 | GLASER B LEHMANN J ZECH W | 2002 | Biology and Fertility of Soils2002，35，4： | 1 |
| 16 | Cus tomer satisfaction, market share, and profitability: find ings from Sweden显示文摘 | ANDERSON E W FORNELL C LEHMANN D R | 1994 | Journal of Marketing1994，58，3： | 1 |
| 17 | Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing显示文摘 | Lehmann W Edgar CM Wang K | | 0，，02： | 1 |
| 18 | JIP60, a methyl jasmonate-induced ribosome-inactivating protein involved in plant stress reactions显示文摘 | Reinbothe S C Reinbothe J Lehmann W | 1994 | Proc Natl Acad Sci USA1994，6，： | 1 |
| 19 | Ameliorating physical and chemical properties of highly weathered soils in the tropics with charcoal a review显示文摘 | GLASER B LEHMANN J ZECH W | 2002 | Biology and Fertility of Soils2002，35，： | 1 |
| 20 | Human parvovirus B19 infection and antiphospholipid antibodies显示文摘 | yon Landenberg P Lehmann H W Modrow S | | Autoimmunity Reviews0，，： | 1 |
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