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| 1 | Exposure to endocrine disrupting chemicals perturbs lipid metabolism and circadian rhythms显示文摘A growing body of evidence indicates that exposure to environmental chemicals can contribute to the etiology of obesity by inappropriately stimulating adipogenesis as well as perturbing lipid metabolism and energy balance. One potential mechanism by which chemical exposure can influence lipid metabolism is through disturbance of circadian rhythms, endogenously-driven cycles of roughly 24 hr in length that coordinate biochemical, physiological, and behavioral processes in all organisms. Here we show for the first time that exposure to endocrine disrupting compounds(EDCs), including the pesticide tributyltin, two commercial flame retardants, and a UV-filter chemical found in sunscreens,can perturb both circadian clocks and lipid metabolism in vertebrates. Exposure of developing zebrafish to EDCs affects core clock activity and leads to a remarkable increase in lipid accumulation that is reminiscent of the effects observed for longdaysin, a known disruptor of circadian rhythms. Our data reveal a novel obesogenic mechanism of action for environmental chemicals, an observation which warrants further research. Because circadian clocks regulate a wide variety of physiological processes, identification of environmental chemicals capable of perturbing these systems may provide important insights into the development of environmentally-induced metabolic disease. | Renate Kopp Irene Ozáez Martínez Jessica Legradi Juliette Legler | 2017 | Journal of Environmental Sciences2017，29，12： | 4 |
| 2 | Intracerebroventricular administration of ct-melanocyte stimulating hormone in- creases phosphorylation of CREB in TRH-and CRH-pro- ducing neurons of the hypothalamic paraventricular nu- cleus 显示文摘 | Sarkar S Legradi G Lechan R M | 2002 | Brain Research2002，945，1： | 1 |
| 3 | Calcium-sensing receptor in the rat hippocampus: a developmental study显示文摘 | Chattopadhyay N Legradi G Bai M | 1997 | Brain Res Dev Brain Res1997，100，1： | 1 |
| 4 | Thermal Charaterisation of a Direction Dependent Flow Sensor显示文摘 | Furjes P Legradi G Ducso C | 2004 | Sensors and Actuators A2004，115，： | 1 |
| 5 | Leptin prevents fasting - in- duced suppression of prothyrotropin - releasing hormone messenger ri- bonucleic acid in neurons of the hypothalamic paraventricular nucleus 显示文摘 | Legradi G Emerson CH Ahima RS | 1997 | Endocrinology1997，138，： | 1 |
| 6 | Neurovascular pulsatile compression and neurosurgical decompression of the rostral ventrolateral medulla in medically resistant hypertensive patients显示文摘 | Legrady P Voros E Bajcsi D | | 0，，： | 1 |
| 7 | Behavioral effects of local microinfusion of pittlitary adenylate cyclase activating polypeptide(PACAP)into the paraventricular nucleus of the hypothalamus (PVN)显示文摘 | Non-holm S D Mahasweta Das Gabor Legradi | 2005 | Regulatory Peptides2005，128，： | 1 |
| 8 | Leptin prevents fastinginduced suppression of prothyrotropin - releasing hormone messenger rihonucleic acid in neurons of the hypothalamic paraventricular nucleus 显示文摘 | Legradi G Emerson CH Ahima RS | 1997 | Endocrinology1997，138，6： | 1 |
| 9 | Glucagon like peptide-1(7-36)amide(GLP-1)nerve terminals densely innervate corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus显示文摘 | Sarkar S Fekete C Legradi G | 2003 | Brain Res2003，985，2： | 1 |
| 10 | Zebrafish embryos as models for embryotoxic and teratological effects of chemicals显示文摘 | Yang L Ho NY Alshut R Legradi J Weiss C Reischl M | 2009 | Reprod Toxicol2009，28，2： | 1 |
| 11 | Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism显示文摘 | Ellisa Parker-Athill Deyan Luo Antoinette Bailey Brian Giunta Jun Tian R. Douglas Shytle Tanya Murphy Gabor Legradi Jun Tan | 2009 | Journal of Neuroimmunology2009，，1： | 1 |
| 12 | Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus显示文摘 | Legradi G Emerson CH Ahima RS | 1997 | Endocrinology1997，138，6： | 1 |
| 13 | Glucocorticoids inhibit stress-induced phosphorylation of CREB in corticotropin-releasing hormone neurons of the hypothalarnic paraventricular nucleus 显示文摘 | Legradi G Holzer D Kapcala L P | 1997 | Neuroendocrinology1997，66，2： | 1 |
| 14 | A Randomized Trial on the Effect of Decreased Dietary Sodium Intake on Blood Pressure in Adolescents显示文摘 | Richard Cooper Linda Van Horn Kiang Liu Maurizio Trevisan Seraphim Nanas Hirotsugu Ueshima Emmanuel Larbi Chiu-Sheng Yu Christopher Sempos Dan LeGrady Jeremiah Stamler | 1984 | Journal of Hypertension1984，，4： | 1 |
| 15 | Behavioral effects of local microinfusion of pituitary adenylate cyclase activating polypeptide ( PACAP )into the paraventricular nucleus of the hypothalamus ( PVN ) 显示文摘 | Norrholm S D Das M Legradi G | 2005 | Regul Pept2005，128，1： | 1 |
| 16 | Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger vibonucleic acid in neurons of the hypothalamic paraventricular nucleus显示文摘 | Legradi G Emerson GH Ahima RS | 2003 | Edocrinology2003，138，： | 1 |
| 17 | 显示文摘 | Legradi G Emerson CH Ahima RS | 1997 | Endocrinology1997，138，： | 1 |
| 18 | 显示文摘 | Legradi G Emerson CH Ahima RS et al | 1998 | Neuroendocrinology1998，68，： | 1 |
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