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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Interaction between duct fires and ventilation flow-An experimental study显示文摘 | Lee C K Chaiken R F Singer J M | 1979 | Combust Sci Technol1979，20，： | 2 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | The Continuous Challenge of Citrus Tristeza Virus Control显示文摘 | M Bar-Joseph R Marcus R F Lee | 1989 | Annual Review of Phytopathology1989，，： | 2 |
| 5 | Chronic pancreatitis显示文摘 | Joan M Braganza Stephen H Lee Rory F McCloy Michael J McMahon | 2011 | The Lancet . 2011 (9772)2011，，： | 2 |
| 6 | Traits of Citrus trisyeza virus important for mild strain cross protection of citrus:the Florida approach 显示文摘 | Lee R F Brlansky R H Gamsey S M | 1987 | Phytophylactica1987，，19： | 2 |
| 7 | Next generation/dynamic spectrum access/cognitive radio wireless networks:A survey 显示文摘 | AKYILDIZ I F LEE W Y VURAN M C | 2006 | Comput Netw2006，50，13： | 1 |
| 8 | Role of GGF/Neuregulin Signaling in Interactions between Migrating Neurons and Radial Glia in the Developing Cerebral Cortex显示文摘 | Anton E S Marehionni M A Lee K F | 1997 | Development1997，124，18： | 1 |
| 9 | Characterization of selected volatile organic compounds, polycyclie aromatic hydrocarbons and earbonyl compounds at a roadside monitoring station 显示文摘 | HO K F LEE S C GLORIA M Y | 2002 | Atmos Environ2002，36，1： | 1 |
| 10 | A prospective randomized controlled trial on ureteral stenting after ureteroscopic holmium laser lithotripsy显示文摘 | CHEUNG M C LEE F LEUNG Y L | 2003 | J Urol2003，169，4： | 1 |
| 11 | A GIS based back - propagation neural network model and its cross - application and validation for landslide susceptibility analyses显示文摘 | Pradhan B Lee S Buchroithner M F | 2010 | Computers Environment and Urban Systems2010，34，3： | 1 |
| 12 | Interactive fuzzy goal programming for multi-objective transportation problems显示文摘 | El-Wahed W F Lee S M | 2006 | Omega2006，34，： | 1 |
| 13 | Application of neural networks in vibrational signature analysis显示文摘 | ELKORDY M F CHANG K C LEE G C | 1998 | Journal of Engineering Mechanics1998，120，2： | 1 |
| 14 | Structural color in porous, superhydrophilic, and self-cleaning SiO2/TiOz Bragg stacks 显示文摘 | Wu Z Lee D Rubner M F | 2007 | Small2007，3，8： | 1 |
| 15 | Sedimentary 24-n-cholestanes,molecular fossils diagnostic of marine algae显示文摘 | MOLDOWAN J M FAGO F J LEE C J | 1990 | Science1990，247，： | 1 |
| 16 | Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride显示文摘 | Lee C Y Peng W H Cheng H Y Chen F N Lai M T | 2006 | The American Journal of Chinese Medicine2006，34，3： | 1 |
| 17 | Virtual Community Informatics: A Review and Research Agenda显示文摘 | Lee F S L Vogel D Limayem M | 2003 | Journal of Information Technology and Applica- tion2003，5，1： | 1 |
| 18 | Attenuating organic contaminant mobility by soil modification显示文摘 | Boyd S A Lee J F Mortland M M | 1988 | Nature1988，333，26： | 1 |
| 19 | Prospective comparison of diagnostic peritoneal lavage,computer tomographic scanning,and ultrasonography for the diagnosis of blunt abdominal trauma显示文摘 | Liu M Lee C H Peng F K | 1993 | J Trauma1993，35，2： | 1 |
| 20 | Agenetic framework for floral patterning显示文摘 | Parcy F Nilsson O Busch M A Lee I Weigel D | 1998 | Nature1998，395，： | 1 |
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