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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Crossed products by endomorphisms and reduction of relations in relative Cuntz-Pimsner algebras显示文摘 | Kwasniewski B K Lebedev A V | 2013 | J Func Anal2013，264，： | 1 |
| 3 | Equilibrium flow structures and scaling of implosion trajectories in wire array Z pinches 显示文摘 | Chittenden J P Lebedev S V Oliver B V | 2004 | PhysPlasmas2004，11，： | 1 |
| 4 | Epitaxial growth of AlN and GaN on Si(111)by plasmaassisted molecular beam epitaxy显示文摘 | Schenk H P D Kipshidze G D Lebedev V B | 1999 | J Cryst Grow1999，，： | 1 |
| 5 | Synthesis and N-alkylation of 2-alkyl- and 2-arylimidazole-4,5-dicarbox- ylic acid esters 显示文摘 | Lebedev A V Lebedeva A B Sheludyakov V D | 2007 | Russ J Gen Chem2007，77，5： | 1 |
| 6 | Self-organization of sulfonated polystyrene ionomers in low-polarity solvents显示文摘 | LEBEDEV V T MEL' NIKOV A B VINOGRADOVA L V | 2010 | Polymer Science Series C2010，52，1： | 1 |
| 7 | Increase in the degree of catastrophic optical degradation of InGaAs/AIGaAs (977 nm) laser diodes after sulfidization in solutions based on isopropyl alcohol 显示文摘 | BESSOLOV V LEBEDEV M TSARENKO B | 1995 | Tech Phys Lett1995，，7： | 1 |
| 8 | Thermal sta- bility of submicrocrystalline copper and Cu : ZrO2 composite 显示文摘 | Lebedev A B Pulnev S A Kopylov V I | 1996 | Scripta Mater1996，35，9： | 1 |
| 9 | 显示文摘 | Pyda M Boller A Grebowicz J Chuah H H Lebedev B V Wunderlich B | 1998 | J Polym Sci Part B:Polym Phys1998，36，： | 1 |
| 10 | Identification and localization of differences between Escherichia coli and Salmonella typhimurlum genomes by suppressive subtractive hybridization显示文摘 | Bogush M L Velikodvorskaya T V Lebedev Y B | 1999 | Mol Gen Genet1999，262，45： | 1 |
| 11 | Synthesis and N-alkylation of 2-alkyl and 2-arylimidazole-4,5-dicarbox- ylic acid esters 显示文摘 | Lebedev A V Lebedeva A B Sheludyakov V D | 2007 | Russ J Gen Chem2007，77，5： | 1 |
| 12 | Laser- triggered vacuum switch显示文摘 | Bulygin V S Lebedev V B Pryanikova G A | 1975 | Soviet Physics-Technical Physics1975，20，4： | 1 |
| 13 | Identification of differences between Escherichia coli and Salmonella typhimurium genomes by suppressive subtractive hybridization显示文摘 | BOGUSH M L VELIKODVORSKAYA T V LEBEDEV Y B | 1999 | Mol Gen Genet1999，62，3： | 1 |
| 14 | Synthesis and N-alkylation of 2-alkyl- and 2-arylimidazole-4,5-dicarbox- ylic acid esters 显示文摘 | Lebedev A V Lebedeva A B Sheludyakov V D | 2007 | Russ J Gen Chem2007，77，5： | 1 |
| 15 | Thermodynamics of alternating ethylene-butadiene copolymer in the 0 ~ 333 Kregion显示文摘 | Lebedev B V Smirnova N N Vasilev V G | 1990 | Vysokomol Soedin Set A1990，32，： | 1 |
| 16 | Thermodynamics of DL-lactide, polylactide and polymerization of DL-lactide in the range of 0-430K显示文摘 | Kulagina T G Lebedev B V Kiparisova Ye G Lyudvig Ye B and Barskaya L G | 1982 | Plym Sci USSR1982，24，： | 1 |
| 17 | Texture transfomaations upon anpealing of aluminum foils: I smmg texture components显示文摘 | Titorov D B Volkov V A Lebedev V P | 2006 | Physics of Metals and Metallography2006，102，1： | 1 |
| 18 | Appli-cation of K008 camera in diagnostics of shock and deto-nation waves 显示文摘 | Lebedev V B Feldman G G Karpov M A | 2007 | Measurement Techniques2007，50，5： | 1 |
| 19 | De-velopment of reactor models of a diffiision combustionchamber for comparative analysis of detailed and reducedkinetic schemes of combustion of hydrocarbon fuels 显示文摘 | Zakharov V M Kozlov V E Lebedev A B | 2009 | Combustion Explosion and Shock Waves2009，45，2： | 1 |
| 20 | Mechanism of radioresistance of the hematopoietic system after treatment with diethylstilbestrol显示文摘 | LEBEDEV V G MOROZ B B VOROTNIKOVA T V | 1994 | Radiats Biol Radioecol1994，34，45： | 1 |
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