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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Crossed products by endomorphisms and reduction of relations in relative Cuntz-Pimsner algebras显示文摘 | Kwasniewski B K Lebedev A V | 2013 | J Func Anal2013，264，： | 1 |
| 3 | Synthesis and N-alkylation of 2-alkyl- and 2-arylimidazole-4,5-dicarbox- ylic acid esters 显示文摘 | Lebedev A V Lebedeva A B Sheludyakov V D | 2007 | Russ J Gen Chem2007，77，5： | 1 |
| 4 | Self-organization of sulfonated polystyrene ionomers in low-polarity solvents显示文摘 | LEBEDEV V T MEL' NIKOV A B VINOGRADOVA L V | 2010 | Polymer Science Series C2010，52，1： | 1 |
| 5 | Thermal sta- bility of submicrocrystalline copper and Cu : ZrO2 composite 显示文摘 | Lebedev A B Pulnev S A Kopylov V I | 1996 | Scripta Mater1996，35，9： | 1 |
| 6 | 显示文摘 | Pyda M Boller A Grebowicz J Chuah H H Lebedev B V Wunderlich B | 1998 | J Polym Sci Part B:Polym Phys1998，36，： | 1 |
| 7 | Synthesis and N-alkylation of 2-alkyl and 2-arylimidazole-4,5-dicarbox- ylic acid esters 显示文摘 | Lebedev A V Lebedeva A B Sheludyakov V D | 2007 | Russ J Gen Chem2007，77，5： | 1 |
| 8 | Laser- triggered vacuum switch显示文摘 | Bulygin V S Lebedev V B Pryanikova G A | 1975 | Soviet Physics-Technical Physics1975，20，4： | 1 |
| 9 | Synthesis and N-alkylation of 2-alkyl- and 2-arylimidazole-4,5-dicarbox- ylic acid esters 显示文摘 | Lebedev A V Lebedeva A B Sheludyakov V D | 2007 | Russ J Gen Chem2007，77，5： | 1 |
| 10 | Structural flexibility of the macruphge dengue virus receptor CLEC5A implications fro ligand binding and signaling 显示文摘 | Watson A A Lebedev An A Hall B A | 2011 | J Biol Chem2011，286，24： | 1 |
| 11 | Texture transfomaations upon anpealing of aluminum foils: I smmg texture components显示文摘 | Titorov D B Volkov V A Lebedev V P | 2006 | Physics of Metals and Metallography2006，102，1： | 1 |
| 12 | Appli-cation of K008 camera in diagnostics of shock and deto-nation waves 显示文摘 | Lebedev V B Feldman G G Karpov M A | 2007 | Measurement Techniques2007，50，5： | 1 |
| 13 | De-velopment of reactor models of a diffiision combustionchamber for comparative analysis of detailed and reducedkinetic schemes of combustion of hydrocarbon fuels 显示文摘 | Zakharov V M Kozlov V E Lebedev A B | 2009 | Combustion Explosion and Shock Waves2009，45，2： | 1 |
| 14 | N,N-Nitration of amides, VI : Mechanism of the nitrol- ysis of N, N-dialkylamides of carboxylic acids by ni- tronium tetratluoroborate in acetonitrile 显示文摘 | Andreev S A Lebedev B A Tselinskii I V | 1980 | Zh Org Khim1980，16，： | 1 |
| 15 | Laser-triggered vacuum switch 显示文摘 | Bulyin V S Lebedev V B Prianikova G A | 1976 | Soviet Physics- Technical Physics1976，20，4： | 1 |
| 16 | Modeling study of gas turbine combustor emission显示文摘 | Lebedev A B Secundov A N Starik A M | 2009 | Proceedings of the Combustion Institute2009，32，： | 1 |
| 17 | Syn-thesis and N-alkylation of 2-alkyland 2-aiylimidazole-4,5-dicarboxylic acid esters显示文摘 | Lebedev A V Lebedeva A B Sheludyakov V D | 2007 | Russ J Gen Chem2007，77，5： | 1 |
| 18 | Modeling study of gas turbine combustor emission显示文摘 | Lebedev A B Secundov A N Starik A M | 2009 | Proceedings of the Combustion Institute2009，32，： | 1 |
| 19 | Effects of glucagon-like peptide 1 analogs in combination with insulin on myocardial infarct size in rats with type 2 diabetes mellitus显示文摘AIM To evaluate the effects of glucagon-like peptide-1 analogs(GLP-1 a) combined with insulin on myocardial ischemiareperfusion injury in diabetic rats.METHODS Type 2 diabetes mellitus(T2 DM) was induced in maleWistar rats with streptozotocin(65 mg/kg) and verified using an oral glucose tolerance test. After anesthesia, the left coronary artery was occluded for 40 min followed by 80 min reperfusion. Blood glucose level was measured during surgery. Rats were randomized into six groups as follows:(1) control rats;(2) insulin(0.1 U/kg) treated rats prior to ischemia;(3) insulin(0.1 U/kg) treated rats at reperfusion;(4) GLP-1 a(140 mg/kg) treated rats prior to ischemia;(5) GLP-1 a(140 mg/kg) treated rats at reperfusion; and(6) rats treated with GLP-1 a(140 mg/kg) prior to ischemia plus insulin(0.1 U/kg) at reperfusion. Myocardial area at risk and infarct size was measured planimetrically using Evans blue and triphenyltetrazolium chloride staining, respectively.RESULTS There was no significant difference in the myocardial area at risk among groups. Insulin treatment before ischemia resulted in a significant increase in infarct size(34.7% ± 3.4% vs 18.6% ± 3.1% in the control rats, P < 0.05). Post-ischemic administration of insulin or GLP-1 a had no effect on infarct size. However, pre-ischemic administration of GLP-1 a reduced infarct size to 12% ± 2.2%(P < 0.05). The maximal infarct size reduction was observed in the group treated with GLP-1 a prior to ischemia and insulin at reperfusion(8% ± 1.6%, P < 0.05 vs the control and GLP-1 a alone treated groups).CONCLUSION GLP-1 a pre-administration results in myocardial infarct size reduction in rats with T2 DM. These effects are maximal in rats treated with GLP-1 a pre-ischemia plus insulin at reperfusion. | Vladislav A Zykov Taisiia P Tuchina Denis A Lebedev Irina B Krylova Alina Y Babenko Elvira V Kuleshova Elena N Grineva Alekber A Bayramov Michael M Galagudza | 2018 | World Journal of Diabetes2018，9，9： | 1 |
| 20 | Voltage- controlled uniaxial magnetic anisotropy in soft magne- tostrictive ferromagnetic thin films显示文摘 | Lebedev O A Viala B Delamare J Cugat O | 2011 | Magnetics IEEE Transactions on2011，47，40： | 1 |
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