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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
| 3 | Platelet glycoprotein IIIA PIA1/A2 polymorphism in young patients with ST elevation myocardial infarction and idiopathic ischemic stroke显示文摘 | Blanca Elsa Rivera-García Juan Carlos Esparza-García Jose Luis Aceves-Chimal Alfredo Lea?os-Miranda Abraham Majluf-Cruz Irma Isordia-Salas | 2013 | Molecular and Cellular Biochemistry (-)2013，，1： | 1 |
| 4 | Comparison of genomic DNA extraction techniques from whole blood samples: a time, cost and quality evaluation study 显示文摘 | Chaeon-Cortes D Haupt L M Lea R A | 2012 | Mol Biol Rep2012，39，5： | 1 |
| 5 | Routing and Time-Slot Assignment in Photonic Circuit Switching Networks显示文摘 | Yu W W Wong A K Lea C T | 2002 | IEEE GIOBECOM2002，，： | 1 |
| 6 | Antioxidant enzyme response to cadmium in radish tissues显示文摘 | VITORIA A P LEA P J AZEVEDO R A | 2001 | Phytochemistry2001，57，： | 1 |
| 7 | Two cytosolic glutamine synthetase isoforms of maize are specifically involved in the control of grain production 显示文摘 | Martin A Lee J Kichey T Gerentes D Zivy M Tatout C Dubois F Balliau T Valot B Davanture M Laforgue T T Quillere I Coque M Gallais A Moro M B G Bethencourt L Habash D Z Lea P J Charcosset A Perez P Murigneux A Sakakibara H Edwards K J Hirel B | 2006 | The Plant Cell2006，18，11： | 1 |
| 8 | Control of luteinizing hormone and prolactin secretion in birds显示文摘 | Sharp P J Dawson A Lea R W | 1998 | Comparative Biochemistry and Physiology Part C:Pharmacology Toxicology and Endocrinology1998，119，3： | 1 |
| 9 | Inhibition of photosynthesis in barley with decreased levels of chloroplastic glutamine synthetase activity显示文摘 | Blackwell R D Murray A J S Lea P J | 1987 | J Exp Bot1987，38，： | 1 |
| 10 | Effect of costimulation and the microenvironment on antigen presentation by leukemic cells显示文摘 | BUGGINS A G LEA N GAKEN J | 1999 | Blood1999，94，： | 1 |
| 11 | Registration and inmbilization in robot assisted surgery显示文摘 | Lea JT Watkins D Mills A | 1995 | J Image Guid Surg1995，1，2： | 1 |
| 12 | ERCC1 Expression Analysisto Guide Therapy in Non-Small Cell Lung Cancer显示文摘 | Allingham-Hawkins D Lea A Levine S | 2010 | PLoS Curr2010，2，： | 1 |
| 13 | Caring research and concepts:A selected review of the literature显示文摘 | Lea A Watson R | | Journal of Clinical Nursing0，5，2： | 1 |
| 14 | Heterodyne Optical Phase-locking of Extended-cavity Semiconductor Lasers at 9 GHz 显示文摘 | SANTARELLI G CLAIRON A LEA S N | 1994 | Opt Commun1994，1114，46： | 1 |
| 15 | Soybean proteinase-inhibitors affect intestinal trypsin activities and amino-acid digestibilities in rainbow-trout (Oncorhyachus-mykiss )显示文摘 | Krogdahl A Lea T B OUi J L | 1994 | Comp Biochem Physiol A1994，107，： | 1 |
| 16 | Satisfaction guaranteed? What clients on methadone and buprenorphine think about their treatment显示文摘 | Madden A Lea T Bath N | 2008 | Drug Alcohol Rev2008，27，6： | 1 |
| 17 | Seasonal prediction of hurricane activity reaching the coast of the United States 显示文摘 | SAUNDERS M A LEA A S | 2005 | Nature2005，434，： | 1 |
| 18 | Nano-silver induces dose- response effects on the nematode Caenorhabditis elegans 显示文摘 | Lea EJ Keld A J Anders J | 2012 | Ecotoxicol Environ Saf2012，0，1： | 1 |
| 19 | Comparison of ge- nomic DNA extraction techniques from whole blood samples: a time, cost and quality evaluation study 显示文摘 | Chacon - cortes D Haupt L M Lea R A | 2012 | Mol Biol Rep2012，39，5： | 1 |
| 20 | Properties of linear waterfloods 显示文摘 | Rapoport L A Leas W J | 1953 | Petroleum Transactions AIME1953，198，： | 1 |
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