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| 1 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 2 | CONTROL OF VEHICLE PLATOONS FOR HIGHWAY SAFETY AND EFFICIENT UTILITY:CONSENSUS WITH COMMUNICATIONS AND VEHICLE DYNAMICS显示文摘Platoon formation of highway vehicles is a critical foundation for autonomous or semiautonomous vehicle control for enhanced safety,improved highway utility,increased fuel economy,and reduced emission toward intelligent transportation systems.Platoon control encounters great challenges from vehicle control,communications,team coordination,and uncertainties.This paper introduces a new method for coordinated control of platoons by using integrated network consensus decisions and vehicle control.To achieve suitable coordination of the team vehicles based on terrain and environmental conditions,the emerging technology of network consensus control is modified to a weighted and constrained consensus-seeking framework.Algorithms are introduced and their convergence properties are established.The methodology employs neighborhood information through on-board sensors and V2 V or V2 I communications,but achieves global coordination of the entire platoon.The ability of the methods in terms of robustness,disturbance rejection,noise attenuation,and cyber-physical interaction is analyzed and demonstrated with simulated case studies. | WANG Le Yi SYED Ali YIN Gang George PANDYA Abhilash ZHANG Hongwei | 2014 | Journal of Systems Science & Complexity2014，27，4： | 5 |
| 3 | Internal nutrient efficiencies of irrigated lowland rice in tropical and subtropical Asia显示文摘 | C Witt A Dobermann S Abdulrachman H.C Gines Wang Guanghuo R Nagarajan S Satawatananont Tran Thuc Son Pham Sy Tan Le Van Tiem G.C Simbahan D.C Olk | 1999 | Field Crops Research1999，，2： | 2 |
| 4 | Ethanol-induced teratogenesis:free radical damage as a possible mechanism显示文摘 | Kotch LE Chen SY Sulik KK | 1995 | Teratology1995，52，3： | 1 |
| 5 | Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth显示文摘 | Wang X Tang S Le SY | 2008 | PLoS One2008，3，7： | 1 |
| 6 | Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth显示文摘 | Wang X Tang S Le SY | 2008 | PLoS One2008，3，： | 1 |
| 7 | Aberrantexpressionofoncogeni- eandtumor-suppressivemicro RNA sineervicalcaneerisrequired forcancercellgrowth显示文摘 | Wang X Tang S Le SY | 2008 | PLoS One2008，3，7： | 1 |
| 8 | Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth 显示文摘 | Wang X Tang S Le SY | 2008 | PLoS ONE2008，3，7： | 1 |
| 9 | The HIV-1 rev trans activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA显示文摘 | Hauber J Le SY | 1989 | Nature1989，338，6212： | 1 |
| 10 | Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth显示文摘 | WANG X TANG S LE SY | | 0，，07： | 1 |
| 11 | Association of cyclooxygenase-2 expression withHP-eagA infection in gastric cancer显示文摘 | Wang LE Du SY | 2003 | World-J-Gastroenterol2003，9，2： | 1 |
| 12 | Aberrant expression of onco- genic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth 显示文摘 | Wang X Tang S Le SY | 2008 | PLoS One2008，3，7： | 1 |
| 13 | JNK regulation of oncogenesis显示文摘 | Heasley LE Han SY | 2006 | Mol Cells2006，21，2： | 1 |
| 14 | Alcohol self- administration acutely stimulates the hypothalamie -pituitary -adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state显示文摘 | Richardson HN Lee SY ODell LE | 2008 | Eur J Neurosei2008，28，8： | 1 |
| 15 | HIV-1 encoded candidate micro-RNAs and their cellular targets显示文摘 | Bennasser Y Le SY Yeung ML | 2004 | Retrovirology2004，1，1： | 1 |
| 16 | Aberrant expression of oneogenie and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth 显示文摘 | Wang X Tang S Le SY | 2008 | PLoS One2008，3，7： | 1 |
| 17 | Aberrant expression of oncogenic and tumor-suppressive miRNAs in cervical cancer is required for cancer cell growth显示文摘 | Wang X Tang S Le SY | | 0，，07： | 1 |
| 18 | Aberrant expression of on- cogenie and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth显示文摘 | Wang X Tang S Le SY | 2008 | PLoS One2008，3，7： | 1 |
| 19 | Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT(1 A) receptors 显示文摘 | Wang LE Cui XY Cui SY | 2010 | Phytomedicine2010，17，6： | 1 |
| 20 | JNK regulation of oncogenesis显示文摘 | Heasley LE Han SY | 2006 | Mol Cells2006，21，2： | 1 |
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