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| 1 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 2 | Protective effects of human iPS derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat 显示文摘 | Carr AJ Vugel AA Hikita ST Lawrence JM Gias C Chen LL | 2009 | PLoS One2009，4，12： | 1 |
| 3 | Factors influencing condom use among Af- rican American women: implications for risk reduction inter- ventions显示文摘 | St Lawrence J S Eldridge G D Reitman D Little C E Shelby M C Brasfield T L | 1998 | Am J Community Psychol1998，26，： | 1 |
| 4 | Adjunctive Thrombectomy for Acute Myocardial Infarction: A Bayesian Meta-Analysis显示文摘 | Fran?ois-Pierre Mongeon Patrick Bélisle Lawrence Joseph Mark J. Eisenberg Stéphane Rinfret | 2010 | Circulation: Cardiovascular Interventions2010，，1： | 1 |
| 5 | The social organiza-tion of commercial sex work in Moscow,Russia显示文摘 | Aral SO Lawrence ST Tikhonova L | 2003 | Sexually Transmitted Diseases2003，31，1： | 1 |
| 6 | Spatial localization combin-ing projection presaturation with a two-dimensional excitation pulse显示文摘 | St Lawrence K Lee TY Henkelman M | 1998 | Magn Reson Med1998，40，6： | 1 |
| 7 | Effect of restricted water exchange on cerebral blood flow values calculated with arterial spin tagging:a theoretical investigation显示文摘 | St Lawrence KS Frank JA McLaughlin AC | | 0，，： | 1 |
| 8 | Measuring the effects of indomethacin on changes in cerebral oxidative metabolism and cerebral blood flow during sensorimotor activation显示文摘 | Ye FQ Lewis BK | 2003 | Magn Reson Med2003，50，1： | 1 |
| 9 | HIV risk behavior reduction following intervention with key opinion leaders of population: an experimental analysis 显示文摘 | Kelly JA St Lawrence JS Diaz YE | 1991 | Am J Public Health1991，81，2： | 1 |
| 10 | Epidemiology and impact of scar- fing after bum injury:a systematic review of the literature显示文摘 | Lawrence JW Mason ST Schomer K | 2012 | J Burn Care Res2012，33，1： | 1 |
| 11 | Quantification issues in arterial spin labeling perfusion magnetic resonance imaging显示文摘 | Wu WC St Lawrence KS Licht D J | 2010 | Top Magn Reson Imaging2010，21，2： | 1 |
| 12 | When perfusion meets diffusion: in vivo measurement of water permeability in human brain显示文摘 | Wang JJ Fernindez-Seara MA Wang SM St Lawrence KS | 2007 | J Cereb Blood Flow Metab2007，27，4： | 1 |
| 13 | Protective effects of human iPS-derived retinal pigment epi-thelium cell transplantation in the retinal dystrophic rat 显示文摘 | Carr AJ Vugler AA Hikita ST Lawrence JM Gias C ’ Chen LL etal | 2009 | PLoS 0^2009，4，12： | 1 |
| 14 | Protective effects of human iPS-derived retinal pigment epi- thelium cell transplantation in the retinal dystrophic rat 显示文摘 | Cart AJ Vugler AA Hikita ST Lawrence JM Gias C Chen LL | 2009 | PLoS One2009，4，5： | 1 |
| 15 | The Metabolic Syndrome and Cardiovascular Risk显示文摘 | Salvatore Mottillo Kristian B. Filion Jacques Genest Lawrence Joseph Louise Pilote Paul Poirier Stéphane Rinfret Ernesto L. Schiffrin Mark J. Eisenberg | 2010 | Journal of the American College of Cardiology2010，，14： | 1 |
| 16 | Theoretical derivation显示文摘 | St Lawrence KS Lee TY An adiabatic approximation to the tissue homogeneity model for water exchange in the brain : I | 1998 | J Cereb Blood Flow Metab1998，18，12： | 1 |
| 17 | Effects of the apparent transverse relaxation time on cerebral blood flow measurements obtained by arterial spin labeling显示文摘 | St Lawrence K S Wang J | 2005 | Magn Reson Med2005，53，2： | 1 |
| 18 | The Metabolic Syndrome and Cardiovascular Risk显示文摘 | Salvatore Mottillo Kristian B. Filion Jacques Genest Lawrence Joseph Louise Pilote Paul Poirier Stéphane Rinfret Ernesto L. Schiffrin Mark J. Eisenberg | 2010 | Journal of the American College of Cardiology2010，，14： | 1 |
| 19 | Evaluation and treatment of pre- mature ejaculation : a critical review 显示文摘 | St Lawrence JS Madakasira S | 1992 | Int J Psychiatr Med1992，22，1： | 1 |
| 20 | 优化检测制程设计加速改善65nm芯片的良率显示文摘描述一种广泛应用于探索制程设计方面的系统性及随机性故障的短流程测试芯片与先进的检测工具平台相结合的综合方法,以对在65nm技术节点上的关键性缺陷进行特征化描述和监控,借此加速基于缺陷的良率学习。通过独特的快速电性测试方案、快速分析软件以及优化的检测效果,可缩短快速制程开发的学习周期。通过将在一个领先的300mm晶片厂得到的CV检测设置知识经验成功运用于制造过程,优化了产品的关键缺陷(DOI)检测。 | Sang Chong Eric Rying Alexa Perry Stephen Lam Mary Ann St Lawrence | 2008 | 电子工业专用设备2008，37，3： | 0 |
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