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| 1 | Effect of anti-fibrosis compound on collagen expression of hepatic cells in experimental liver fibrosis of rats显示文摘INTRODUCTIONLiver fibrosis is mainly characterized by theexcessive synthesis and decreased degradation ofextracellular matrix(ECM),especially the synthesisand deposition of collagen.Almost all kinds of cellsin the liver have participated in the production ofcollagen.The most important ones are hepaticstellate cells(HSC)and hepatocytes.We | Wang LT Zhang B Chen JJ | 2000 | World Journal of Gastroenterology2000，6，6： | 31 |
| 2 | Effect of Helicobacter pylori infection on gastric epithelial cell proliferation显示文摘INTRODUCTION Helicobacter pylori(H.pylori)infection is one ofthe main pathogens of chronic gastritis and duodenalulcer(DU),and it may be considered as a riskfactor in the incidence of gastric cancer.H.pylori infection may lead to the anomaly of gastricepithelial cell proliferation which is closely relatedto the development of gastric cancer.Vacuolatingcytotoxin(VacA)is an important virulence andvacA subtype determines the toxic activity.According to its signal sequence,it can be groupedinto type sla,slb,slc and s2.Strains harboringvacAsla are more closely related with digestivediseases and may be the strains with high toxicity.The effect of H.pylori infection on | Gao H Wang JY Shen XZ Liu JJ | 2000 | World Journal of Gastroenterology2000，6，3： | 14 |
| 3 | Doxycycline-regulated co-expression of GDNF and TH in PC12 cells.显示文摘 | Wang JJ Zhang T Niu DB Wang K Li KR Xue B Wang XM | 2006 | 中国生物学文摘2006，20，10： | 11 |
| 4 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011，30，1： | 8 |
| 5 | Black and green tea consumption and the risk of coronary artery disease, a meta-analysis显示文摘 | Wang ZM Zhou, B Wang, YS Gong, QY Wang, QM Yan, JJ Gao, W Wang, LS | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 5 |
| 6 | A comparison between intravenous and peritoneal route on liver targeted uptake and expression of plasmid delivered by Glyco-poly-L-lysine显示文摘AIM To compare the effects of intravenous routeand peritoneal route on liver targeted uptake andexpression of plasmid delivered by galactose-terminal glyco-poly-L-lysine(G-PLL).METHODS The plasmid pTM/MMP-1 which couldbe expressed in eukaryotic cells was bound to G-PLL,and was then transferred into Wistar rats byintravenous and intraperitoneal injection.Theexpression and distribution of the plasmid wereobserved at different time periods by in situhybridization and immunohistochemistry.RESULTS The plasmid could be expressedsignificantly within 24 h after being transferred invivo by both intravenous and intraperitonealroutes.One week later the expression began todecrease,and could still be observed three weekslater.Although both the intravenous andintraperitoneal route could target-specificallydeliver the plasmid to the liver,the effect of theformer was better as compared to that of the latter.CONCLUSION Intravenous route is better for livertargeted uptake and expression of G-PLL-boundplasmids than the peritoneal route. | Yang CQ Wang JY Fang GT Liu JJ Guo JS | 2000 | World Journal of Gastroenterology2000，6，4： | 4 |
| 7 | Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver显示文摘AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat liver.METHODS After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by intravenousroute.At different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and immunohistochemistry.RESULTS The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three weeks.Both liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the liver.CONCLUSION G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver. | Yang, CQ Wang, JY He, BM Liu, JJ Guo, JS | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 8 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 9 | Dexame-thasone has a central antiemetic mechanism in decerebrated cats 显示文摘 | Ho CM Ho ST Wang JJ | 2004 | Anesth Analg2004，99，3： | 1 |
| 10 | Risk factors and significance of finding asymptomatic retinal emboli 显示文摘 | Mitchell P Wang JJ Smith W | 2000 | Clin Experiment Ophthalmol2000，28，： | 1 |
| 11 | The effect of aligned core-shel nanofibres delivering NGF on the promotion of sciatic nerve regeneration显示文摘 | Wang CY Liu JJ Fan CY | | 0，，1： | 1 |
| 12 | Electricity production coupled to ammonium in a microbial fuel cell显示文摘 | He Z Kan JJ Wang YB | | 0，，09： | 1 |
| 13 | Detection of lymph node metastasis in cervic',d and uterine cancers by diffusion-weighted magnetic Tsonance imaging at 3T显示文摘 | Lin G Ho KC Wang JJ | 2008 | J Magn Reson Imaging2008，28，： | 1 |
| 14 | Effects of atorvastatin on pathological changes in brain tissue and plasma MMP-9 in rats with intracerebral hemorrhage 显示文摘 | Cui JJ Wang D Gao F | 2012 | Cell Biochem Biophys2012，62，1： | 1 |
| 15 | Pigment epithelium-derived factor(PEDF) is an endogenous antiinflammatory factor 显示文摘 | Zhang SX Wang JJ Gao G Shao C Mott R Ma JX | 2006 | FASEB J2006，20，2： | 1 |
| 16 | Astaxanthin induces mitochondria-mediated apoptosis in rat hepatocellular carcinoma CBRH-7919 cells显示文摘 | Song XD Zhang JJ Wang MR | 2011 | Biob Pharm Bu112011，34，： | 1 |
| 17 | Methotrexate treatment for ectopic pregnancy at the KK Women's and Children' s Hospital,Singapore 显示文摘 | Thia EW Loi K Wang JJ | 2009 | Singapore Med J2009，50，11： | 1 |
| 18 | Albendazole-soybean oil e- mulsion for the treatment of human cystic echinococcosis: evalu ation of bioavailability and bioequivalence显示文摘 | Wang MJ Xiao SH Chai JJ ct al | 2002 | Acta Trop2002，83，2： | 1 |
| 19 | Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy显示文摘 | Zhang SX Wang JJ Gao G | 2006 | Mol Endocrinol2006，37，1： | 1 |
| 20 | Phenolic compounds from the rhizo- mes of Gastrodia elata 显示文摘 | Lin H Wang KJ Chen JJ | 2007 | Asian Nat Prod Res2007，9，35： | 1 |
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