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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | 延胡索酸水合酶缺陷型肾细胞癌32例临床病理和分子分析显示文摘延胡索酸水合酶缺陷型肾细胞癌属于罕见的、新近发现的与遗传性平滑肌瘤病和肾细胞癌综合征相关的肿瘤实体。延胡索酸水合酶缺陷型肾细胞癌可表现出多种临床和病理学表现,但通常表现为局部进展和转移性疾病,预后较差。作者通过延胡索酸水合酶免疫组化和(或)延胡索酸水合酶突变分析确定32例延胡索酸水合酶缺陷型肾细胞癌,并对其临床和病理特征进行回顾性分析。 | Lau H D Chan E Fan A C 魏建国(摘译) 方三高(审校) | 2020 | 临床与实验病理学杂志2020，36，3： | 19 |
| 3 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 4 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 5 | Influence of impact velocity and chest compression on experimental pulmonary injury severity in rabbits显示文摘 | Lau V K Viano D C | 1981 | J Trauma1981，21，12： | 2 |
| 6 | Internal stability of granular filters显示文摘 | Kenney T C Lau D | 1985 | Canadian Geotechnical Journal1985，22，2： | 2 |
| 7 | Sphenoid sinus mucocole presenting with isolated oculomotor nerve palsy显示文摘 | Sethic D S Lau dpc Chan C | 1997 | J Laryngol Otol1997，111，： | 1 |
| 8 | Effect of Milk Fat on the Stability of Vitamin A in Ultra-High Temperature Milk 显示文摘 | LAU B L T KAKUDA Y ARNOTT D R | 1986 | J Dairy Sci1986，69，： | 1 |
| 9 | Gravitational Constraints on the Internal Structure of Ganymede显示文摘 | LAU E L SJOGREN W L, | 1996 | Nature1996，384，6609： | 1 |
| 10 | Effects of feeding fat-coated butyrate on mueosal morphology and function in the small intestine of the pig显示文摘 | LAUS R GUNTHNER D LETZGU H | 2007 | J of Animal Physiology and Animal Nutrition2007，91，78： | 1 |
| 11 | A comparative study on catalyst deactivation of nickel and cobalt incorporated MCM-41 catalysts modified by platinum in methane reforming with carbon dioxide 显示文摘 | LIU D P CHEO W N E LIM Y W Y BORGN A LAU R YANG Y H | 2010 | Catalysis Today2010，154，34： | 1 |
| 12 | Red and processed meat and colorectal cancer incidence: meta - analysis of pro- spective studies 显示文摘 | Chan DS Lau R Aune D | 2011 | PLoS One2011，6，20： | 1 |
| 13 | Corporate Entrepreneurship as Resource Capital Configuration in Emerging Mar- ket Firms 显示文摘 | YIU D W LAU C M | 2008 | Entrepreneurship Theory and Prac- tice2008，32，1： | 1 |
| 14 | A novel assay for cobalt-al- bumin binding and its potential as a marker for myocardial ischemia-a preliminary report显示文摘 | Bar-Or D Lau E Winkler JV | 2000 | Journal of Emergency Medicine2000，19，4： | 1 |
| 15 | Twice-Weekly paclitaxel and weekly carboplatin with concurrent thoracic radiation followed by carboplatin/paclitaxel consolidation for stage Ⅲ non-small-cell lung cancer: a California Cancer Consortium phase Ⅱ trial显示文摘 | Lau D Leigh B Gandara D | 2001 | J Clin Oncol2001，19，： | 1 |
| 16 | Effectiveness of using carbon nanotubes as nanoreinforcements for advanced composite structures显示文摘 | LAU KT HUI D | 2002 | Carbon2002，40，： | 1 |
| 17 | lInterleukin-10 treatment reduces fibrosis inpatients with chronic hepatitis C:A pilottrail of interferon nonresponders显示文摘 | Nelson D R Lauwers G Y Lau J Y | 2000 | Gas-troenterology2000，118，4： | 1 |
| 18 | A novel assay for cobalt-albumin Binding and its potential as a marker for myocardial ischemia a pre-Liminary report显示文摘 | Bar-Or D Lau E Winkler JV | 2000 | J Emcrg Med2000，19，4： | 1 |
| 19 | Clusterin plays an important role in hepatocellular carcinoma metastasis 显示文摘 | Lau SH Sham JS Xie D | 2006 | Oncogene2006，25，8： | 1 |
| 20 | Adjuvant treatment of stage I B NSCLC: the problem of stage subset heterogeneity显示文摘 | Calhoun R Jablons D Lau D | 2008 | Oncology ( Williston Park )2008，22，5： | 1 |
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