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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation显示文摘 | Hui CK Lie A Au WY Leung YH Ma SY Cheung WW Zhang HY Chim CS Kwong YL Liang R Lau GK | 2006 | 中国生物学文摘2006，20，5： | 10 |
| 3 | The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?显示文摘当跟随主要人的 cytomegalovirus (HCMV ) 感染的主人免疫者反应在停止病毒复制和传播通常是有效的时,病毒从来没被主人并且象所有 herpesviruses 一样清除,永久坚持。至少部分地,这坚持被知道被 HCMV 的能力便于在感染是实质上沉默的与的 myeloid 在房间建立潜伏,重要地新病毒生产的全部的缺乏。然而,尽管病毒的抄写计划很在潜伏期间被压制,很多病毒的基因在蛋白质水平在潜伏的感染期间被表示,这些中的许多被显示了在潜伏的房间和它的环境上有深刻效果。有趣地,许多也在 lysin 的感染期间这些联系潜伏的基因被表示。因此,一样的有势力主人免疫者回答为什么在 lysin 的感染期间产生了到这些病毒的基因产品,没在潜伏期间被认出,从而允许隐而不见地的感染的房间的清理,是远非清楚的。从潜伏的复活也是调停 HCMV 的疾病的一个主要原因,特别地在损害的免疫者和免疫者天真,并且也是可能的是在被建议了与象动脉粥样硬化和一些瘤形成那样的长期的疾病被联系的长期的无临床症状的 HCMV 感染的病毒的主要来源。因而,理解潜伏并且隐而不见地的感染的房间为什么看起来是 immunoprivileged,为 HCMV 的致病的理解是关键的并且可以帮助设计策略消除潜伏的病毒水库,至少在某些临床的背景。 | Mark R Wills Emma Poole Betty Lau Ben Krishna John H Sinclair | 2015 | Cellular & Molecular Immunology2015，12，2： | 6 |
| 4 | Global Nanoteehnology Research Literature Overview显示文摘 | Kostoff R N Koytcheff R G Lau C G Y | 2007 | Current Science2007，，11： | 1 |
| 5 | Strategy in emerging economies 显示文摘 | Hoskisson R E Eden L Lau C M Wright M | 2000 | Academy of Management Journal2000，43，3： | 1 |
| 6 | Daytime urban heat island effect in high-rise and high-density residential developments in Hong Kong显示文摘 | Giridharan R Ganesan S Lau S S Y | 2004 | Energy and Building2004，36，6： | 1 |
| 7 | Emerging Web Graphics Standards and Technologies 显示文摘 | Lau R W H Li F Kunii T L | 2003 | IEEE Computer Graphics and Applications2003，，1： | 1 |
| 8 | Effect of Milk Fat on the Stability of Vitamin A in Ultra-High Temperature Milk 显示文摘 | LAU B L T KAKUDA Y ARNOTT D R | 1986 | J Dairy Sci1986，69，： | 1 |
| 9 | Combined effects of HDL cholesterol,triglyceride,and total cholesterol concentrations on 18-year risk of atherosclerotic disease显示文摘 | LAUS A BENFANTE R | 1995 | Circulation1995，92，6： | 1 |
| 10 | DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues显示文摘 | Moll U Lau R Sypes MA | 1999 | Oncogene1999，18，20： | 1 |
| 11 | EASL International Consensus Conference on Hepatitis B 显示文摘 | De Franehis R Hadengue A Lau G | 2003 | J Hepatol2003，39，： | 1 |
| 12 | Sound alters visual motion pereeption显示文摘 | Sekuler R Sekuler A B Lau T | 1997 | Nature1997，385，6614： | 1 |
| 13 | Determi- nation of the energy equivalent of a water solution calorim- eter with a standard substance显示文摘 | Mnotgomery R L Melaugh R A Lau C C | 1997 | J Chem Thermodynam- ics1997，9，： | 1 |
| 14 | Effects of feeding fat-coated butyrate on mueosal morphology and function in the small intestine of the pig显示文摘 | LAUS R GUNTHNER D LETZGU H | 2007 | J of Animal Physiology and Animal Nutrition2007，91，78： | 1 |
| 15 | Breastmilk cultures and infection in extremely premature infants 显示文摘 | Schanler R J Fraley J K Lau C | 2011 | J Perinatol2011，31，5： | 1 |
| 16 | A comparative study on catalyst deactivation of nickel and cobalt incorporated MCM-41 catalysts modified by platinum in methane reforming with carbon dioxide 显示文摘 | LIU D P CHEO W N E LIM Y W Y BORGN A LAU R YANG Y H | 2010 | Catalysis Today2010，154，34： | 1 |
| 17 | The relationship between air- ways inflammation and asthma severity显示文摘 | Louis R Lau LC Bron AO | 2000 | Am J Respir Crit Care Med2000，161，1： | 1 |
| 18 | Molecular characterization of fluoroquinolone resistance in Mycobacterium tuberculosis: functional analysis of gyrA mutation at position 74 显示文摘 | Lau R W Ho P L Kao R Y | 2011 | Antimicrob Agents Chemother2011，55，2： | 1 |
| 19 | The impact of product modularity on new product performance: Mediation by product innovativeness显示文摘 | Lau A W Yam R M Tang E | 2011 | Journal of Product Inno- vation Management2011，28，2： | 1 |
| 20 | Red and processed meat and colorectal cancer incidence: meta - analysis of pro- spective studies 显示文摘 | Chan DS Lau R Aune D | 2011 | PLoS One2011，6，20： | 1 |
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