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	题名	作者	年代	出处	被引量
1	肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells.	Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone	2010	中华神经外科疾病研究杂志2010，9，1：	16
2	Differentiation of neuroblastoma enbances Bcl-2 expression and induces alterations of apoptosis and drug resistance显示文摘	Lasorella A Lavarone A Istacl MA	1995	Cancer Res1995，55，20：	1
3	Single and combined deactivating effect of alkali metals and HCl on commercial SCR catalysts显示文摘	L Lisi G Lasorella S Malloggi G Russo	2004	Applied Catalysis B Environmental2004，，4：	1
4	Id2 is a retinoblastoma pretein target and mediates signalling by Myc oncoproteins显示文摘	Noseda M Beyna M	2000	Nature2000，407，：	1
5	Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth 显示文摘	Lasorella A Stegmuller J Guardavaccaro D	2006	Nature2006，442，7101：	1
6	Id2 is a retinoblastoma protein target and mediates signaling by Myc oncoproteins 显示文摘	Lasorella A Noseda M Beyna M	2000	Nature2000，407，：	1
7	The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system 显示文摘	Lasorella A Iavarone A	2006	Proc Natl Aead Sci USA2006，103，13：	1
8	ID proteins as targets in cancer and tools in neurobiology 显示文摘	Iavarone I Lasorella A	2006	Trends Mol Med2006，12，12：	1
9	Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins 显示文摘	Noseda M Beyna M	2000	Nature2000，407，6804：	1
10	Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins 显示文摘	Iavarone A Israel MA	1996	Mol Cell Biol1996，16，6：	1
11	ID proteins at the cross-road of development and cancer显示文摘	Lasorella A Uo T Iavarone A	2001	Oncogene2001，20，58：	1
12	Diagnostic imaging of primitive neuroectodermal tumour of the chest wall (Askin tumour) 显示文摘	Sallustio G Pirronti T Lasorella A	1998	Pediatr Radiol1998，28，：	1
13	The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein显示文摘	Iavarone A Garg P Lasorella A	1994	Genes Dev1994，8，11：	1
14	Id proteins at the cross-road of development and cancer显示文摘	Lasorella A Iavarone A	2001	Oncogene2001，20，58：	1
15	Single and combined deactiva- ting effect of alkali metals and HCI on commercial SCR catalysts 显示文摘	Lisi L Lasorella G Malloggi S	2004	Applied Catalysis B : Environmental2004，50，4：	1
16	Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins 显示文摘	Lasorella A Noseda M Beyna M	2000	Nature2000，407，6804：	1
17	Diagnostic imaging of primitive neuroectodermal tumor of the chest wall (Askin tumor)显示文摘	Pirronti T Lasorella A	1998	Pediatr Radiol1998，28，：	1
18	Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutantmice 显示文摘	Lasorella A Rothschild G Yokota Y	2005	Mol Cell Biol2005，25，：	1
19	Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins显示文摘	Lasorella A Iavarone A Israel M A	1996	Mol Cell Biol1996，16，6：	1
20	ht2 specifically alters regulation of the cell cycle by tumor suppressor proteins 显示文摘	1 LASORELLA A IAVARONE A ISRAEL M A	1996	Mol Cell Bio11996，16，6：	1

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