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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Effect of acute and chronic arecoline treatment on cerebralmetabolism and blood flow in the conscious rat显示文摘 | MAIESE K HOLLOWAY H H LARSON D M | 1994 | Brain Res1994，641，1： | 1 |
| 4 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 5 | Absence of association of genetic linkage between the angiotensin converting-enzyme gene and left ventricular mass显示文摘 | Lindpaintner K Lee M Larson MG | 1996 | N Engl J Med1996，334，： | 1 |
| 6 | Rapid com- munication: restriction fragment length polymorphisms at the porcine transporter associated with antigen processing 1 (TAP1) locus显示文摘 | Vaske D A Ruohonen M K Larson R ~ | 1994 | JAnim Sci1994，72，1： | 1 |
| 7 | Minimally invasive plating of high-energy metaphyseal distal tibia fractuxe8显示文摘 | Collinge C Kuper M Larson K | 2007 | J Orthop Trauma2007，21，6： | 1 |
| 8 | Association of blood pressure with fibrinolytic potential in the Framingham offspring population显示文摘 | Poli K A Tofler G H Larson M G | 2000 | Circulation2000，25，： | 1 |
| 9 | Global plate velocities from Global Positioning System 显示文摘 | Larson M K Freymueller J | 1997 | Journal of Geophysical Research1997，102，5： | 1 |
| 10 | Collocation versus differential inclusion in direct optimization 显示文摘 | Conway B A Larson K M | 1998 | Journal of Guidance Control and Dynamics1998，21，5： | 1 |
| 11 | Precipitation and segregation in a2+ titanium aluminides 显示文摘 | Larson D J Miller M K | 1998 | Materials Science and Engineering1998，250，： | 1 |
| 12 | Reli- ability and validity of the 12 - minute distance walk in pa- tients with chronic obstructive pulmonary disease显示文摘 | LARSON J L COVEY M K VITALO C A | 1996 | Nurs Res1996，45，4： | 1 |
| 13 | Tungsten segregation in a2+Y titanium aluminides 显示文摘 | Larson D J Liu C T Miller M K | 1997 | Intermetallics1997，5，7： | 1 |
| 14 | Absence of association of genetic linkage between the angiotensin-converting-enzymegene and left ventricular mass显示文摘 | Lindpainmer K Lee M larson MG | 1996 | N Engl J Med1996，334，16： | 1 |
| 15 | Impact of glucose intolerance and insulin resistance on cardiac structure and function显示文摘 | KUTTER M K BENJAMIN E J LARSON | 2003 | Circulation2003，107，3： | 1 |
| 16 | Absolute calibration of a geodetic time transfer system显示文摘 | Plumb J Larson K M White J | 2005 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2005，52，11： | 1 |
| 17 | Comparative measurement efficiency and sensitivity of five health status instruments for arthritis research显示文摘 | Liang M H Larson M G Cullen K E | 1987 | Arthritis Rheum1987，28，5： | 1 |
| 18 | Coalition Structure generation with worst case guarantees显示文摘 | Sandholm T W Larson K Andersson M Shehory O Tohme F | 1999 | Artificial Intelligence1999，111，12： | 1 |
| 19 | Scaling in the Safety of Next Generation Reactors 显示文摘 | Banerjee S Ortiz M Q Larson T K | 1998 | Nuclear Engineering and Design1998，186，： | 1 |
| 20 | Subjective fatigue,influencing variables,and consequences in chronic obstructive pulmonary disease显示文摘 | KAPELLA M C LARSON J L PATEL M K | 2006 | Nurs Res2006，55，1： | 1 |
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