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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | 中年成人平均动脉压的体位改变与动脉硬度的关系:Framingham心脏研究显示文摘Torjesen A, Cooper LL, Rong J, Larson MG, Hamburg NM, Levy D, Benjamin EJ, Vasan RS, Mitchell GF. Relations of arterial stiffness with postural change in mean arterial pressure in middle-aged adults:the Framingham heart study. Hyperten- sion,2017,69(4) :685-690.站立位血压稳定调节受损可导致不良结果,包括跌倒、晕厥和定向障碍。平均动脉压(meanarterialpressure,MAP)通常在站立位时增加,然而,站立位MAP增加不足或减少可能导致脑灌注减少。已有研究报道,在动脉硬度增加的老年人中存在体位性低血压,年轻至中年人MAP的体位性改变与动脉硬度的相关性尚未阐明。该研究分析了Framingham心脏研究第3代队列中的受试者3205人(女性1693人,占53%)的直立性血压反应和全面血液动力学数据。 | Torjesen A Cooper LL Rong J Larson MG Hamburg NM Levy D Benjamin EJ Vasan RS Mitchell GF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，3： | 5 |
| 3 | Photocatalytic oxidation of ethanol:isotopic labeling and transient reaction显示文摘 | Mugli D S Larson S A Falconer J L | 1996 | J Phys Chem1996，100，15： | 3 |
| 4 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 5 | The effect of removing the true dental follicle on premolar eruption in the dog 显示文摘 | LARSON E K CAHILL D R GORSKI J P | 1994 | Arch Oral Biol1994，39，4： | 1 |
| 6 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 7 | Kinetics and heat transfer of CdZnTe Bridgman growth without wall contact 显示文摘 | ZHANG H LARSON JR D J WANG C L | 2003 | Journal of Crystal Growth2003，250，12： | 1 |
| 8 | Two-photon luminescence imaging of cancer ceils using molecularly targeted gold nanorods显示文摘 | Durr N J Larson T Smith D K | 2007 | Nano Lett2007，7，4： | 1 |
| 9 | Precipitation and segregation in a2+ titanium aluminides 显示文摘 | Larson D J Miller M K | 1998 | Materials Science and Engineering1998，250，： | 1 |
| 10 | Particulate air pollution and hospital emergency visits for asthma in Seattle显示文摘 | Schwartz J Slater D Larson TV | 1993 | Am Rev Respir Dis1993，145，： | 1 |
| 11 | Revised form of Jackson-Hunt theory: application to directional solidification of MnBi/Bi eutectics 显示文摘 | Zheng L L Larson Jr D J Zhang H | 2000 | J Cryst Growth2000，209，1： | 1 |
| 12 | Tungsten segregation in a2+Y titanium aluminides 显示文摘 | Larson D J Liu C T Miller M K | 1997 | Intermetallics1997，5，7： | 1 |
| 13 | Traumatic intracranial aneurysms显示文摘 | Larson P S Reisner A Morassutti D J | | 0，，01： | 1 |
| 14 | Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European LeukemiaNet显示文摘 | Dhner H Estey EH Amadori S Appelbaum FR Büchner T Burnett AK Dombret H Fenaux P Grimwade D Larson RA Lo-Coco F Naoe T Niederwieser D Ossenkoppele GJ Sanz MA Sierra J Tallman MS Lwenberg B Bloomfield CD | 2010 | {H}Blood2010，，03： | 1 |
| 15 | Relationships between spa- tial environmental heterogeneity and plant species diversity on a limestone pavement 显示文摘 | LUNDHOLM J T LARSON D W | 2003 | Ecography2003，26，6： | 1 |
| 16 | Two-photon lumi- nescence imaging of cancer cells using molecularly targeted gold nanorods 显示文摘 | DURR N J LARSON T SMITH D K | 2007 | Nano Letters2007，7，4： | 1 |
| 17 | Chromatin structure in globozoospermia:a case report显示文摘 | LARSON K L BRANNIAN J D SINGH N P | 2001 | J Androl2001，22，3： | 1 |
| 18 | Structural determinants of allosteric ligand activation in RXR heterodimers 显示文摘 | Shulman AI Larson C Mangelsdorf D J | 2004 | Cell2004，116，： | 1 |
| 19 | Three dimensional atom probe investigation of vanadium nitride precipitates and the role of oxygen and boron in rapidly solidified 316 stainless steel 显示文摘 | Kelly T F Larson D J Miller M K | 1999 | Materials Science and Engineering1999，270，： | 1 |
| 20 | Revised Form of Jackson-Hunt Theory:Application to Solidification of MnBi/Bi Eutectics显示文摘 | L L Zheng D J Larson H Zhang | 2009 | Crystal Growth2009，209，1： | 1 |
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