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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Osteoporosis screening in postmenopausal women 50 to 64 years old: comparison of US Preventive Services Task Force strategy and two traditional strategies in the Women's Health Initiative 显示文摘 | Crandall C J Larson J Gourlay ML | 2014 | J Bone Miner Res2014，29，7： | 1 |
| 4 | Kinetics and heat transfer of CdZnTe Bridgman growth without wall contact 显示文摘 | ZHANG H LARSON JR D J WANG C L | 2003 | Journal of Crystal Growth2003，250，12： | 1 |
| 5 | Reli- ability and validity of the 12 - minute distance walk in pa- tients with chronic obstructive pulmonary disease显示文摘 | LARSON J L COVEY M K VITALO C A | 1996 | Nurs Res1996，45，4： | 1 |
| 6 | Asymmetric frontal brain activity, cortisol, and behavior associated with fearful temperament in rhesus monkeys显示文摘 | Kalin N H Larson C Shelton S E Davidson R J | 1998 | Behavioral Neuroscience1998，112，2： | 1 |
| 7 | Tungsten segregation in a2+Y titanium aluminides 显示文摘 | Larson D J Liu C T Miller M K | 1997 | Intermetallics1997，5，7： | 1 |
| 8 | Nephrectomy induced chronic renal insufficiency is associated with increased risk of cardiovascular death and death from any cause in patients with localized cT1b renal masses显示文摘 | WEIGHT C J LARSON B T FERGANY A F | 2010 | J Urol2010，183，4： | 1 |
| 9 | Towards multidimensional radiotherapy (MD -CRT) :biological imaging and biological conformality 显示文摘 | LING C C HUMM J LARSON S | 2000 | Int J Radiat Oncol Biol Phys2000，47，3： | 1 |
| 10 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 11 | Magnetic lineations in the Pacific Jurassic quiet zone 显示文摘 | Cande S C Larson R L LaBrecque J L | 1978 | Earth and Planetary Science Letters1978，41，： | 1 |
| 12 | The ankle-brachial index in the elderly and risk of stroke,coronary disease and death显示文摘 | Murabito J M Evans J C Larson M G | 2003 | Arch Intern Med2003，163，： | 1 |
| 13 | Subjective fatigue,influencing variables,and consequences in chronic obstructive pulmonary disease显示文摘 | KAPELLA M C LARSON J L PATEL M K | 2006 | Nurs Res2006，55，1： | 1 |
| 14 | Structural determinants of allosteric ligand activation in RXR heterodimers 显示文摘 | Shulman AI Larson C Mangelsdorf D J | 2004 | Cell2004，116，： | 1 |
| 15 | Heritability of heart rate variability: the Framingham Heart Study显示文摘 | LARSON M G O′DONNELL C J | 1999 | Circulation1999，99，17： | 1 |
| 16 | Sperm chromatin structure assay parameters as predictors of failed pregnancy following assisted reproductive techniques 显示文摘 | Larson KL DeJonge C J Barnes AM | 2000 | Hum Reprod2000，15，8： | 1 |
| 17 | Ne- phrectomy induced chronic renal insufficiency is associ- ated with increased risk of cardiovascular death and death from any cause in patients with localized cTlb re- nal masses显示文摘 | Weight C J Larson B T Fergany A F | 2010 | J Urol2010，183，4： | 1 |
| 18 | Dysfunction in the neural circuitry of emotion regulation-a possible prelude to violence显示文摘 | Davidson R J Putnam K M Larson C L | | 0，，5479： | 1 |
| 19 | Towards multidimensional radiotherapy(MD-CRT):biological imaging and biological conformality显示文摘 | Ling C C Humm J Larson S | 2000 | Int J Radiat Oncol Biol Phys2000，47，3： | 1 |
| 20 | Cross-classi-fication of JNC VI blood pressure stages and risk groups in the Framingham Heart study显示文摘 | Loyd-Jones D M Evans J C Larson M G | 1999 | Arch Intern Med1999，159，18： | 1 |
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