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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | The role of squamous cell carcinoma antigen in the management of laryngeal and hypopharyngeal cancer显示文摘 | Lara P C Cuyas J M | 1995 | Cancer1995，76，5： | 1 |
| 3 | Involvement of the S-layer proteins Hpi and S1pA in the maintenance of cell integrity in Deinococcns radiodnrans Rl显示文摘 | Rotlifnss H Lara J C Sclnnid A K | 2006 | Microbiology2006，152，9： | 1 |
| 4 | Channel estintation using implicit training 显示文摘 | Orozvo- Lugo A G Lara M M M McLernon D C | 2004 | IEEE Transactions on Signal Processing2004，52，1： | 1 |
| 5 | 显示文摘 | Lara Wilfredo C Schweitzer Jeremy | 1998 | Journal of Long-Term Effects of Medical Implants1998，8，1： | 1 |
| 6 | Mamey sapote cultivars in Florida显示文摘 | Campbell C W S P Lara | 1982 | Processdings of the Florida State Horticultural Society1982，95，： | 1 |
| 7 | 显示文摘 | Lara Wilfredo C Jeremy S Lewis Rodney P | 1998 | Journal of Long-Term Effects of Medical Implants1998，8，1： | 1 |
| 8 | Channel Estimation Using Implicit Training 显示文摘 | Orozco-Lugo A G Lara M M McLemon D C | 2004 | IEEE Trans on Signal Processing2004，52，1： | 1 |
| 9 | Ex-ploratory study of Mycoplasma suis (Eperythrozoonsui'O on four commercial pig farms in southern Brazil显示文摘 | Guimaraes A M S Biondo A W^ Lara A C | 2007 | Vet Record2007，160，2： | 1 |
| 10 | Age-related changes in basal substrate oxidation and visceral adiposity and their association with metabolic syndrome显示文摘 | Siervo M Lara J Celis-Morales C | 2015 | Eur J Nutr2015，80，4： | 1 |
| 11 | Channel estimation using implicit training显示文摘 | OROZCO-LUGO A G LARA M M MCLERNON D C | 2004 | IEEE Trans Signal Processing2004，52，1： | 1 |
| 12 | The cesarean delivery scar pouch: clinical implications and diagnostic correlation between transvaginal sonography and hysteroscopy 显示文摘 | Fabres C Aviles G De La lara C | 2003 | JUltrasound Med2003，22，： | 1 |
| 13 | Memantine and constraint-induced aphasia therapy in chronic poststroke aphasia 显示文摘 | BERTHIER ML GREEN C LARA JP | 2009 | Ann Neurol2009，65，5： | 1 |
| 14 | Association of human polyomavirus JCV with colon cancer:evidence for interaction of viral T-antigen and beta catenin 显示文摘 | Enam S Del Valle L Lara C | 2002 | Cancer Res2002，62，23： | 1 |
| 15 | STin2 variant and family history of suicide as significant predictors of suicide completion in major depression显示文摘 | LOPEZ DE LARA C DUMAIS A ROULEAU G | 2006 | Biol Psychiatry2006，59，2： | 1 |
| 16 | A simple method for real-time DSP-based neutron-chopper speed and phase control显示文摘 | ROSE C R LARA P D NELSON R O | 2001 | Proceedings of the Particle Accelera- tor Conference2001，，： | 1 |
| 17 | Extracellular invertase is an essential component of cytokinnin-mediated delay of senescence显示文摘 | LARA M E B GARCIA M C G FATIMA T | 2004 | The Plant Ce112004，16，： | 1 |
| 18 | Energy and Electrode Consumption Anal- ysis of Electrocoagulation for the Remove of Arsenic from Underground Water显示文摘 | J F MARTINEZ- VILLAFANE C MONTERO- OCAMPO A M GARCIA- LARA | 2009 | Journal of Hazardous Materials2009，，： | 1 |
| 19 | Ethnic differences between Maori, Pacific Island and European New Zealand women in prevalence and attitudes to urinary incontinence显示文摘 | Lara C Nacey J | 1994 | NZ Med J1994，107，： | 1 |
| 20 | Genetic polymorphisms at the k-casein locus in Pantaneiro cattle 显示文摘 | Lara M A C Gama LT Bufarah G | 2002 | Arch Zoo Tec2002，51，193： | 1 |
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