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| 1 | Longitudinal dynamics and energy analysis for heavy haul trains显示文摘Whole trip longitudinal dynamics and energy analysis of heavy haul trains are required by operators and manufacturers to enable optimisation of train controls and rolling stock components. A new technology named train dynamics and energy analyser/train simulator(TDEAS)has been developed by the State Key Laboratory of Traction Power in China to perform detailed whole trip longitudinal train dynamics and energy analyses. Facilitated by a controller user interface and a graphic user interface, the TDEAS can also be used as a train driving simulator. This paper elaborates the modelling of three primary parts in the TDEAS, namely wagon connection systems, air brake systems and train energy components. TDEAS uses advanced wedge-spring draft gear models that can simulate a wider spectrum of friction draft gear behaviour. An effective and efficient air brake model that can simulate air brake systems in various train configurations has been integrated. In addition, TDEAS simulates the train energy on the basis of a detailed longitudinal train dynamics simulation, which enables a further perspective of the train energy composition and the overall energy consumption.To demonstrate the validity of the TDEAS, a case study was carried out on a 120-km-long Chinese railway. The results show that the employment of electric locomotives with regenerative braking could bring considerable energy benefits. Nearly 40 % of the locomotive energy usage could be collected from the dynamic brake system. Most of tractive energy was dissipated by propulsion resistance that accounted for 42.48 % of the total energy. Only a small amount of tractive energy was dissipated by curving resistance, air brake and draft gear systems. | Qing Wu Shihui Luo Colin Cole | 2014 | Journal of Modern Transportation2014，22，3： | 7 |
| 2 | Ablative fractional CO_(2)laser surgery improving sleep quality,pain and pruritus in adult hypertrophic scar patients:a prospective cohort study显示文摘Background:Poor sleep quality is associated with a decrease in quality of life in patients with major burn scars,combined with pruritus and pain.Few interventions have been reported to improve the sleep quality of patients with scars.In the current prospective cohort study,we investigated the efficacy of CO_(2)-ablative fractional laser(AFL)surgery vs conventional surgery in post-burn patients with hypertrophic scars with sleep quality as the primary study outcome.Methods:In total 68 consecutive patients undergoing scar surgical treatment were recruited,including a CO_(2)-AFL surgery cohort(n=35)and a conventional surgery cohort(n=33).A subgroup from the AFL cohort was selected.Sleep quality,pain and pruritus were evaluated.Multiple linear regression analyses were performed to reveal the effect of CO_(2)-AFL surgery.Results:The CO_(2)-AFL surgery cohort had significantly lower Pittsburgh sleep quality index(PSQI)global scores than the conventional surgery cohort after the last surgical treatment.In the subgroup of patients receiving hardware sleep monitoring,CO_(2)-AFL markedly increased deep sleep time,deep sleep efficiency and reduced initial sleep latency.Compared to the conventional surgery cohort,the CO_(2)-AFL cohort presented significantly lower pain and pruritus scores.Correlation analysis showed pain and pruritus were significantly associated with PSQI scores,and there were also significant correlations between pain and pruritus scores.Multiple linear regression analysis showed that surgery method was negatively linearly correlated with visual analog scale(VAS)pain score,brief pain inventory(BPI)total,VAS pruritus score,5-D itch scale total,four-item itch questionnaire(FIIQ)total and PSQI total.Conclusions:CO_(2)-AFL surgery significantly improved sleep quality and reduced pain and pruritus of hypertrophic scar patients.The alleviation of sleep disorder was associated with improvement of deep sleep quality including deep sleep time and deep sleep deficiency.Trial registration:The Chinese Clinical Trial Registry(ChiCTR200035268)approved retrospectively registration on 5 Aug 2020. | Kaiyang Lv Huazhen Liu Haiting Xu Caixia Wang Shihui Zhu Xiaozhen Lou Pengfei Luo Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 4 |
| 3 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 4 | Experimental investigation on vibration characteristics of the medium-low-speed maglev vehicle-turnout coupled system显示文摘The steel turnout is one of the key components in the medium–low-speed maglev line system.However,the vehicle under active control is prone to vehicle–turnout coupled vibration,and thus,it is necessary to identify the vibration characteristics of this coupled system through field tests.To this end,dynamic performance tests were conducted on a vehicle–turnout coupled system in a medium–low-speed maglev test line.Firstly,the dynamic response data of the coupled system under various operating conditions were obtained.Then,the natural vibration characteristics of the turnout were analysed using the free attenuation method and the finite element method,indicating a good agreement between the simulation results and the measured results;the acceleration response characteristics of the coupled system were analysed in detail,and the ride quality of the vehicle was assessed by Sperling index.Finally,the frequency distribution characteristics of the coupled system were discussed.All these test results could provide references for model validation and optimized design of medium–low-speed maglev transport systems. | Miao Li Dinggang Gao Tie Li Shihui Luo Weihua Ma Xiaohao Chen | 2022 | Railway Engineering Science2022，30，2： | 3 |
| 5 | Stabilizing Mechanism and Running Behavior of Couplers on Heavy Haul Trains显示文摘Published studies in regard to coupler systems have been mainly focused on the manufacturing process or coupler strength issues. With the ever increasing of tonnage and length of heavy haul trains, lateral in-train forces generated by longitudinal in-train forces and coupler rotations have become a more and more significant safety issue for heavy haul train operations. Derailments caused by excessive lateral in-train forces are frequently reported. This article studies two typical coupler systems used on heavy haul locomotives. Their structures and stabilizing mechanism are analyzed before the corresponding models are developed. Coupler systems models are featured by two distinct stabilizing mechanism models and draft gear models with hysteresis considered. A model set which consists of four locomotives and three coupler systems is developed to study the rotational behavior of different coupler systems and their implications for locomotive dynamics. Simulated results indicate that when the locomotives are equipped with the type B coupler system, locomotives can meet the dynamics standard on tangent tracks; while the dynamics performance on curved tracks is very poor. The maximum longitudinal in-train force for locomotives equipped with the type B coupler system is 2000 kN. Simulations revealed a distinct trend for the type A coupler system. Locomotive dynamics are poorer for the type A case when locomotives are running on tangent tracks, while the dynamics are better for the type A case when locomotives are running on curved tracks. Theoretical studies and simulations carried out in this article suggest that a combination of the two types of stabilizing mechanism can result in a good design which can significantly decrease the relevant derailments. | XU Ziqiang WU Qing LUO Shihui MA Weihua DONG Xiaoqing | 2014 | Chinese Journal of Mechanical Engineering2014，27，6： | 2 |
| 6 | Whole genome engineering by synthesis显示文摘Whole genome engineering is now feasible with the aid of genome editing and synthesis tools. Synthesizing a genome from scratch allows modifications of the genomic structure and function to an extent that was hitherto not possible, which will finally lead to new insights into the basic principles of life and enable valuable applications. With several recent genome synthesis projects as examples, the technical details to synthesize a genome and applications of synthetic genome are addressed in this perspective. A series of ongoing or future synthetic genomics projects, including the different genomes to be synthesized in GPwrite, synthetic minimal genome, massively recoded genome, chimeric genome and synthetic genome with expanded genetic alphabet, are also discussed here with a special focus on theoretical and technical impediments in the design and synthesis process. Synthetic genomics will become a commonplace to engineer pathways and genomes according to arbitrary sets of design principles with the development of high-efficient, low-cost genome synthesis and assembly technologies. | Zhouqing Luo Qing Yang Binan Geng Shuangying Jiang Shihui Yang Xiaozheng Li Yizhi Cai Junbiao Dai | 2018 | Science China(Life Sciences)2018，61，12： | 2 |
| 7 | Assessment of the curving performance of heavy haul trains under braking conditions显示文摘To study the curving performance of trains,ID and 3D dynamic models of trains were built using numerical methods.The ID model was composed of 210 simple wagons,each allowed only longitudinal motion;whereas the 3D model included three complicated wagons for which longitudinal,lateral,and vertical degrees of freedom were considered.Combined with the calculated results from the ID model under braking conditions,the behavior of draft gears and brake shoes were added to the3 D model.The assessment of the curving performance of trains was focused on making comparisons between idling and braking conditions.The results indicated the following:when a train brakes on a curved track,the wheel-rail lateral force and derailment factor are greater than under idling conditions.Because the yawing movement of the wheelset is limited by brake shoes,the zone of wheel contact along the wheel tread is wider than under idling conditions.Furthermore,as the curvature becomes tighter,the traction ratio shows a nonlinear increasing trend,whether under idling or braking conditions.By increasing the brake shoe pressure,train steering becomes more difficult. | Liangliang Yang Yu Kang Shihui Luo Maohai Fu | 2015 | Journal of Modern Transportation2015，23，3： | 2 |
| 8 | Asbestos related diseases from environmental exposure to crocidolite in Dayao显示文摘 | LUO Suqiong LIU Xueze MU Shihui | 2003 | Occup Environ Med2003，60，1： | 1 |
| 9 | Coupler dynamic performance analysis of heavy haul locomotives显示文摘 | MA Weihua LUO Shihui SONG Rongrong | | 0，，3： | 1 |
| 10 | The ability of NT-proBNP to detect chronic heart failure and predict all-cause mortality is higher in elderly Chinese coronary artery disease patients with chronic kidney disease显示文摘 | Shihui Fu Ying Ye Yongyi Bai Tiehui Xiao Liang Wang Bing Zhu Yuan Liu Shuangyan Yi Leiming Luo | 2013 | 2013 (defa)2013，，： | 1 |
| 11 | Analysis ofwheel set longitudinal vibration and the correlateddynamic performance显示文摘 | MA Weihua LUO Shihui SONG Rongrong | 2011 | Applied Mechanics andMaterials2011，5254，： | 1 |
| 12 | Influence of track irregularity on wheelset longitudinal vibration and the correlation performance 显示文摘 | MA Weihua LUO Shihui | 2006 | Journal of Southwest Jiaotong University2006，14，3： | 1 |
| 13 | Coupler Dy- namic Performance Analysis of Heavy Haul Locomotives 显示文摘 | MA Weihua LUO Shihui SONG Rongrong | 2012 | Vehicle System Dynamics2012，50，9： | 1 |
| 14 | Coupler Jack- knifing and Derailments of Locomotives on Tangent Track 显示文摘 | WU Qing LUO Shihui XU Ziqiang | 2013 | Vehicle System Dynamics2013，51，11： | 1 |
| 15 | Asbestos related diseases from environmental exposure to crocidolite in Dayao 显示文摘 | LUO Suqiong LIU Xueze MU Shihui et at | 2003 | Occup Environ Med2003，60，1： | 1 |
| 16 | Abnormal Vertical Dynamic Performance of Subway Vehicles显示文摘A serious wheel out-of-round phenomenon exists in a certain subway vehicle in China.More seriously,the vertical vibration of car body of this subway vehicle will go beyond the restriction of the standard criterion when the wheel out-of-round exceeds 0.2 mm in radial direction.And the wheel out-of-round problem could not be solved by polishing the rail or re-profiling wheels.Aimed at this problem,a further analysis is conducted on the structure and the suspension systems of the subway vehicle.It is thought that the additional stiffness function of the traction bar,caused by the short length and the bigger connection stiffness of the traction bar,leads to the problem that the subway vehicle is sensitive to the vertical impact.By taking into account the stiffness of the traction bar,dynamic simulation models of the subway vehicle are set up to study the influence of the additional stiffness function of the traction bar on the vertical dynamic performance of the subway vehicle through the simulation method.The response of the subway vehicle to vertical impact of a triangle pitch is also simulated.Simulation results indicate that the connection between the car body and the bogie will become rigid and the damping function of the secondary suspension will be decreased due to the additional stiffness of the traction bar in braking condition or running on curve track.Then the vertical response of the car body to vertical impact will be strengthened and the vertical ride index decreased.The vertical dynamic performance of the subway vehicle will be improved through the method of decreasing the connection stiffness of the traction bar,which has been validated by the simulation results.This method of improvement can effectively solve the problem of abnormal dynamic performance of this subway vehicle,and provide a foundation for a new theory about the traction bar system design. | MA Weihua LUO Shihui SONG Rongrong | 2010 | Chinese Journal of Mechanical Engineering2010，23，2： | 0 |
| 17 | Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation显示文摘With the emergence of DNA nanotechnology in the 1980s, self-assembled DNA nanostructures have attracted considerable attention worldwide due to their inherent biocompatibility, unsurpassed programmability, and versatile functions. Especially promising nanostructures are tetrahedral framework nucleic acids(t FNAs), first proposed by Turberfield with the use of a one-step annealing approach. Benefiting from their various merits, such as simple synthesis, high reproducibility, structural stability, cellular internalization, tissue permeability, and editable functionality, t FNAs have been widely applied in the biomedical field as threedimensional DNA nanomaterials. Surprisingly, t FNAs exhibit positive effects on cellular biological behaviors and tissue regeneration,which may be used to treat inflammatory and degenerative diseases. According to their intended application and carrying capacity,t FNAs could carry functional nucleic acids or therapeutic molecules through extended sequences, sticky-end hybridization,intercalation, and encapsulation based on the Watson and Crick principle. Additionally, dynamic t FNAs also have potential applications in controlled and targeted therapies. This review summarized the latest progress in pure/modified/dynamic t FNAs and demonstrated their regenerative medicine applications. These applications include promoting the regeneration of the bone,cartilage, nerve, skin, vasculature, or muscle and treating diseases such as bone defects, neurological disorders, joint-related inflammatory diseases, periodontitis, and immune diseases. | Yunfeng Lin Qian Li Lihua Wang Quanyi Guo Shuyun Liu Shihui Zhu Yu Sun Yujiang Fan Yong Sun Haihang Li Xudong Tian Delun Luo Sirong Shi | 2022 | International Journal of Oral Science2022，14，4： | 0 |
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