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| 1 | 采用计量型扫描力显微镜校准微纳米标准样板显示文摘为了建立质量保证体系,微米和纳米样板至今仍被广泛地应用于校准微纳米尺度的测量仪器中.介绍了应用由德国联邦物理研究所开发研究的、测量范围为25 mm×25 mm×5 mm的计量型扫描力显微镜(M-LRSFM)的校准方法.上述计量型扫描力显微镜配置有三个零拍的激光干涉仪,可分别测量沿x、y、z三条轴线方向的位移,因而其测量值可直接溯源于“米”定义.此种M-LRSFM能够校准横向的微纳尺度的结构尺寸,诸如阶梯高度、一维和二维光栅、镀层厚度、线宽、微纳尺度的表面粗糙度等.作为实例,介绍了一种横向样板的校准程序及获得的校准结果.研究表明这种方法适合于校验扫描电子显微镜(SEM)的放大倍率. | 戴高良 KOENDERS Ludger DANZEBRINK Ulrich WILKENING Günter 周健雄 陈振宇 | 2006 | 纳米技术与精密工程2006，4，1： | 8 |
| 2 | 动态^(18)F-FDG PET定量分析用于骨病变鉴别诊断显示文摘目的 评价18F 脱氧葡萄糖 (FDG)PET在骨骼病变中的诊断价值。方法 研究对象为40例原发性骨骼病变患者。所有患者在注射示踪剂后立即开始动态PET采集 ,持续 6 0min。对动态PET图像进行半定量分析 ,分别计算平均和最大标准摄取值 (SUVaver和SUVmax) ,病灶SUV/肌肉SUV比值 (T/M) ,病灶 6 0minSUV/ 30minSUV比值 (SUVaver 60 /3 0min和SUVmax 60 /3 0min)等。采用Patlak作图分析法对动态图像数据进行拟合计算 ,得出摄入常数 (Ki) ,计算FDG代谢率 (MRFDG)。根据接受器工作特性曲线 (ROC)确定各定量指标的诊断阈值 ,并比较其鉴别良恶性病变的灵敏度和特异性。结果 经病理检查证实恶性病变 2 1例 ,良性病变 19例。恶性病变的MRFDG和SUV值高于良性病变 ,但各种指标的数值分布均存在交叉重叠。SUVaver与MRFDG呈正相关 (r=0 6 7)。以SUV值≥ 1 8作为阈值时 ,鉴别良恶性病变的灵敏度和特异性分别为 85 0 %和 82 4% ,以MRFDG(1 1)为阈值时的灵敏度 (82 4% )与SUV相近 ,而特异性 (92 9% )较高。同时采用SUV(1 8)和SUVaver 60 /3 0min(1 1)作为鉴别标准时 ,较之单独采用SUV特异性可改善为 93 3% ,灵敏度略有降低 (81 3% )。结论 骨骼良恶性病变之间存在葡萄糖代谢率差异。单用静态FDGPET获取SUV值不能很好鉴? | 吴华 Antonia Dimitrakopoulou-Strauss Thomas O-Heichel Burkhard Lehner Ludger Bernd Volker Ewerbeck Cyrill Burger Ludwig G Strauss | 2002 | 中华核医学杂志2002，22，2： | 3 |
| 3 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 4 | Microarray analysis of gene expression in metastatic gastric cancer cells after incubation with the methylation inhibitor 5-aza-2′-deoxycytidine显示文摘 | Jie Chen Christoph R?cken Ludger Klein-Hitpass Tobias G?tze Andreas Leodolter Peter Malfertheiner Matthias P.A. Ebert | 2004 | Clinical & Experimental Metastasis2004，，5： | 1 |
| 5 | Estrogenic and antiestrogenic regulation of MMP-2 and MMP-13 mRNA in RUCA-I endometrial tumor cells in vitro and in vivo显示文摘 | Ludger Tüshaus Anne-Christine Hopert Elisabeth Strunck Christine Schubert Winfried Wünsche Günter Vollmer | 2003 | Cancer Letters2003，，： | 1 |
| 6 | Differential sorption behaviour of aromatic hydrocarbons on charcoals prepared at different temperatures from grass and wood显示文摘 | Ludger C Bornemann G W | 2007 | Chemosphere2007，67，5： | 1 |
| 7 | Microarray analysis of gene expression in metastatic gastric cancer cells after incubation with the methylation inhibitor 5-aza-2′-deoxycytidine显示文摘 | Jie Chen Christoph R?cken Ludger Klein-Hitpass Tobias G?tze Andreas Leodolter Peter Malfertheiner Matthias P.A. Ebert | 2004 | Clinical & Experimental Metastasis2004，，5： | 1 |
| 8 | A Simple Method to Extract Essential Oils from Tissue Samples by Using Microwave Radiation显示文摘 | Nélida E. Gómez Ludger Witte | 2001 | Journal of Chemical Ecology2001，，11： | 1 |
| 9 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 1 |
| 10 | WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis显示文摘 | K?nigshoff Melanie Kramer Monika Balsara Nisha Wilhelm Jochen Amarie Oana Veronica Jahn Andreas Rose Frank Fink Ludger Seeger Werner Schaefer Liliana Günther Andreas Eickelberg Oliver | 2009 | Journal of Clinical Investigation2009，，4： | 1 |
| 11 | Extracorporeal Shock Wave Therapy for the Treatment of Chronic Calcifying Tendonitis of the Rotator Cuff显示文摘 | Ludger G Stefan W Michael H | 2003 | The Journal of the American Medical Association2003，290，19： | 1 |
| 12 | Surgery of Colorectal Cancer: Surgical Morbidity and Five- and Ten-Year Results in 2400 Patients—Monoinstitutional Experience显示文摘 | Ludger Staib M.D. Karl Heinz Link M.D. Annette Blatz Hans Günther Beger M.D | 2002 | World Journal of Surgery2002，，1： | 1 |
| 13 | Biochar,hydrochar and uncarbonized feedstock application to permanent grassland--Effects on greenhouse gas emissions and plant growth显示文摘 | SONJA S CHRISTOPH M LUDGER G | 2014 | Agriculture Ecosystems&Environment2014，191，： | 1 |
| 14 | Was Weber wrong? A human capital theory of protestant economic history 显示文摘 | Becker G Sascha O Ludger W | 2009 | Quarterly Journal of Economics2009，124，2： | 1 |
| 15 | Patient-centered developments in colon-and rectal cancer with a multidisciplinary international team:From translational research to national guidelines显示文摘Rarely,scientific developments centered around the patient as a whole arepublished.Our multidisciplinary group,headed by gastrointestinal surgeons,applied this research philosophy considering the most important aspects of thediseases“colon-and rectal cancer”in the long-term developments.Good expertcooperation/knowledge at the Comprehensive Cancer Center Ulm(CCCU)wereapplied in several phase III trials for multimodal treatments of primary tumors(MMT)and metastatic diseases(involving nearly 2000 patients and 64 centers),fortreatment individualization of MMT and of metastatic disease,for psychooncology/quality of life involving the patients’wishes,and for disease prevention.Most of the targets initially were heavily rejected/discussed in thescientific communities,but now have become standards in treatments andnational guidelines or are topics in modern translational research protocolsinvolving molecular biology for e.g.,“patient centered individualized treatment”.In this context we also describe the paths we had to tread in order to realize ournew goals,which at the end were highly beneficial for the patients from manypoints of view.This description is also important for students and youngresearchers who,with an actual view on our recent developments,might want toknow how medical progress was achieved. | Karl-Heinrich Link Marko Kornmann Ludger Staib Ernst-Dietrich Kreuser Wilhelm Gaus Erwin Röttinger Peter Suhr Catharina Maulbecker-Armstrong Peter Danenberg Kathleen Danenberg Miriam Schatz Silvia Sander Zhen-Ling Ji Jiang-Tao Li Shu-You Peng Reinhard Bittner Hans Günther Beger Benno Traub | 2021 | World Journal of Gastrointestinal Surgery2021，13，12： | 0 |
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