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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury显示文摘It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, P<0.01, P<0.05 and P<0.01 respectively). The hepatocyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-treated counterparts, but they were not different from carboxy-PTIO treated animals (P>0.05). CONCLUSION:NO2--derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo. | Department of General Surgery ( Lu P, Wang CY and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 3 | A background-thinning-based approach for separating and recognizing connected handwritten digit strings显示文摘 | Lu Z Chi Z Shi P | 1999 | Pattern Recognition1999，32，6： | 2 |
| 4 | Role of the crystallite phase of TiO2 in heterogeneous photocatalysis for phenol oxidation in water显示文摘 | Ding Z Lu G Q Greenfield P F | 2000 | J Phys Chem B2000，104，19： | 1 |
| 5 | Influence of processing conditions on the luminescence of YVO4: Eu3 + nanoparticles 显示文摘 | ZHANG H P LU M K XIU Z L | 2006 | Mater Sci Eng: B2006，130，： | 1 |
| 6 | Effect of mechanical activation on physical-chemical properties and structure of cassava starch显示文摘 | HUANG Z Q LU J P LI X H | 2007 | Carbohydrate Polymers2007，68，1： | 1 |
| 7 | Thermal evolution of the Archaean basement rocks from the eastern part of the North China Craton and its International Geology Review, bearing on tectonic setting 显示文摘 | Zhao G C Wilde S A Cawood P A Lu L Z | 1998 | 40: 706-7211998，40，： | 1 |
| 8 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon显示文摘 | Fang C Yi Z Liu F Lan S Wang J Lu H Yang P Yuan Z | 2006 | Proteomics2006，6，2： | 1 |
| 9 | A Comparison Study on the Electronic Structure of the Thermoelectric Materials CoSb3 and LaFe3 CoSb12 显示文摘 | Lu P X Shen Z G Hu X | 2010 | Physica B2010，405，： | 1 |
| 10 | On sliding friction and wear of PEEK and its composites显示文摘 | Lu Z P Friedrich K | 1995 | Wear1995，，： | 1 |
| 11 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 12 | Inorganic nanoparticles as carriers for efficient cellular delivery 显示文摘 | XU Z P ZENG Q H LU G Q | 2006 | Chem Eng Sci2006，61，3： | 1 |
| 13 | Model of plasmid-bearing, plasmid-free competition in the Chemostat with nutrient recycling and an inhibitor显示文摘 | Lu Z Q Hadeler K P | 1998 | Mathematical Biosciences1998，148，： | 1 |
| 14 | Activated anti-tumor immu- nity in cancer patients after high intensity focused ultrasound ablation显示文摘 | Wu F Wang Z B Lu P | 2004 | Ultrasound Med Biol2004，30，9： | 1 |
| 15 | Ligustilide prevents cognitive impairment and attenuates neurotoxicity in D-galactose induced aging mice brain显示文摘 | Li J J Zhu Q Lu Y P Zhao P Feng Z B Qian Z M | 2015 | Brain Res2015，1595，： | 1 |
| 16 | Molecular cell biology of male meiotic chromosomes and isolation of male meiocytes in Arabidopsis thaliana显示文摘 | WANG Y CHENG Z LU P | 2014 | Methods in Molecular Biology2014，1110，： | 1 |
| 17 | Localized audio watermarking technique robust against time-scale modification 显示文摘 | Li W Xue X Y Lu P Z | 2006 | IEEE Transactions on Multimedia2006，8，1： | 1 |
| 18 | Structure and photophysical properties of europium complexes of succinamic acid and 1, 10-phenanthroline 显示文摘 | Zheng X J Jin L P Wang Z M Yan C H Lu S Z Li Q | 2003 | Polyhedron2003，22，2： | 1 |
| 19 | Large-eddy simulations (LES) of temperature fluctuations in a mixing tee with/without a porous medium 显示文摘 | LU T JING P X GAO Z J ZHANG Y W | 2007 | Int J of Heat and Mass Transfer2007，53，2122： | 1 |
| 20 | Dependence of Properties of N-Al Codoped p-Type ZnO Thin Films on Hrowth Temperature显示文摘 | Lu J G Zhu L P Ye Z Z | 2005 | Applied Surface Science2005，245，： | 1 |
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