|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Presence of extensive intraductal component in patients undergoing breast conservative surgery predicts presence of residual disease in subsequent completion mastectomy显示文摘背景本地复发在经历胸保守人士外科的病人之中仍然是一个严重问题。这研究瞄准了在这回顾的研究基于的胸保守人士 surgery.Methods 以后为剩余疾病识别风险因素收到了胸保守人士外科和随后的结束乳房切除术的有侵略乳癌的病人。所有病人在起始的操作有清楚的切除术边缘。我们在结束乳房切除术和下列风险因素期间分析了在剩余疾病的存在之间的协会:广泛的 intraductal 部件(EIC ) 的 T 阶段,年轻年龄,和存在,靠近的边缘, lymphovascular 浸透(LVP ) ,雌激素受体的确实,孕酮受体,和 c-erbB-2.Results 剩余疾病在 21 被遇到(45.7%) 46 个病人;EIC 在 28 个病人(60.9%) 是在场的,谁 17 有的剩余疾病。EIC 的存在在结束乳房切除术(P=0.011 ) 期间与剩余疾病的更高的风险在胸保存外科期间被联系。另外的变量不是为剩余疾病的存在的统计上重要的风险因素。在结束乳房切除术为有有 EIC 的存在是的 not.Conclusions 的剩余疾病和那些的病人是类似的以后,没有本地复发在我们的队,和没有疾病的幸存和全面幸存被记录为在在胸保守人士外科以后的病人的剩余疾病的一个重要风险因素。我们的调查结果可以在起始的胸保守人士外科期间与 EIC 在病人建议结束乳房切除术的显示的价值减少随后的本地失败的风险。 | Christopher C. E Yiu Wings T. Y. Loo C. K. Lam Louis W. C. Chow | 2009 | Chinese Medical Journal2009，，8： | 4 |
| 2 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 3 | Cubic AgPb, SbTez+,, : bulk thermoelectric materials with high figure of merit 显示文摘 | Hsu K F Loo S Guo F Chen W Dyck J S Uher C Hogan T Polychroniadis E K Kanatzidis M G | 2004 | Science2004，303，： | 1 |
| 4 | Airway inflammation and IgE production induced by dust mite allergen-specific memory/effector Th2cell line can be effectively attenuated by IL-35显示文摘 | HUANG C H LOO E X KUO I C | 2011 | J Immunol2011，187，： | 1 |
| 5 | Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation显示文摘 | Onno J de Boer Floris Hirsch Allard C van der Wal Chris M van der Loos Pranab K Das Anton E Becker | 1997 | Atherosclerosis1997，，2： | 1 |
| 6 | Water-borne resins for industrial coating显示文摘 | Loos F | 1998 | Surface Coating International1998，，3： | 1 |
| 7 | Activation of ribu- lose - 1, 5 - bisphosphate carboxyiase/oxygenase (Rubisco) involves Rubisco activase Trpl6 显示文摘 | VAN DE LOO F J SALVUCCI M E | 1996 | Bio- chemistry1996，35，25： | 1 |
| 8 | Con- sumers' willingness to pay for organic chicken breast: evi- dence from choice experiment显示文摘 | VAN LOO E J CAPUTO V NAYGA J R M | 2011 | Food Quality and Prefer- ence2011，22，7： | 1 |
| 9 | Human metabolic phenotype diversity and its association with diet and blood pressure显示文摘 | Holmes E Loo R L Stamler J | 2008 | Nature2008，453，7193： | 1 |
| 10 | Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4 显示文摘 | Lubberts E Joosten LA van de Loo FA | 2000 | Arthritis Rheum2000，43，6： | 1 |
| 11 | Interleukin-17 acts independently of TNF-alpha under arthritic conditions显示文摘 | Koenders M I Lubberts E van de Loo F A | 2006 | J Immunol2006，176，10： | 1 |
| 12 | Interleukin-17acts independently of TNF-alpha under arthritic conditions显示文摘 | Koenders MI Lubberts E van de Loo FA | 2006 | J Immunol2006，176，10： | 1 |
| 13 | A Perspective of Goethitic Ore Sintering Fundamentals 显示文摘 | LOO C E | 2005 | ISIJ International2005，45，： | 1 |
| 14 | Concomitantinhibition of HSP90,its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-Ⅱ cells显示文摘 | Zhang L Pang E Loo RR | 2011 | Proteomics2011，11，24： | 1 |
| 15 | Consumer attitudes, knowledge, and consumption of organic yogurt显示文摘 | VAN LOO E J DIEM M N H PIENIAK Z | 2013 | Journal of Dairy Science2013，96，4： | 1 |
| 16 | Islolated ventricular non- compaction of the myocardium in adults显示文摘 | Jenni R Oechslin E vander Loo B | 2007 | Heart2007，93，1： | 1 |
| 17 | Mechanical properties of natural and synthetic mineral phases in sinters having varying reduction degradation indices显示文摘 | Loo C E Wan K T Howes V R | 1998 | Irounaking and Steelmaking1998，25，6： | 1 |
| 18 | Limitations to photosynthesis in Coffea canephora as a result of nitrogen and water availability显示文摘 | DaMatta F M Loos R A Silva E A | 2002 | Journal of Plant Physiology2002，159，9： | 1 |
| 19 | A Perspective of Goethitic Ore Sintering Fundamen- tals 显示文摘 | Loo C E | 2005 | ISIJ Int2005，45，4： | 1 |
| 20 | Classic biphasic pulmonary blastoma:a case report and review of the literature显示文摘 | Van Loo S Boeykens E Stappaerts I | 2011 | Lung Cancer2011，73，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员