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| 1 | Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis显示文摘恶意的阴囊的细菌房间肿瘤(TGCT ) 与 70% 增加的发生最后是在白种人男性(20-40 年) 的最经常的癌症 20 年,可能由于联合行动(epi ) 基因并且(微) 环境因素。TGCT 作为他们的普通先锋在 situ (CIS ) 有癌,这被期望,从在它的成熟过程堵住的一个胚胎的细菌房间发源。然而, TGCT 的全面痊愈率是超过 90% 人幸存 TGCT 能介绍全身的癌症治疗的长期的副作用。相反,没有这些长期的副作用,为 CIS 诊断并且对待的人仅仅继续生活。因此, CIS 的早察觉有大健康好处,它将要求一个增进知识的屏蔽方法。这评论描述了病原学和早察觉的 TGCT 和为 TGCT 在风险屏蔽人的未来潜力的早致病。为屏蔽,明确的风险侧面基于基因、环境的风险因素被需要。自从 2009 ,宽协会学习的几个染色体( GWAS )被出版了,在有重要协会在或在基因 KITLG , SPRY4 , BAK1 , DMRT1 , TERT , ATF7IP , HPGDS , MAD1L1 , RFWD3 , TEX14 ,和 PPM1E 附近的单个核苷酸的多型性( SNP )上报导,可能与 TGCT 开发有关。出生前, perinatal,和出生后的环境因素也影响 CIS 的发作。noninvasive 为 CIS 的早察觉方法将在一个临床的背景,在精液的特定的 miRNA 察觉为似乎很有希望是高度有益的。进一步的研究被需要发展基于基因环境相互作用,明确的 TGCT 风险侧面为 CIS 与 noninvasive 察觉方法结合了。 | Jenny E Elzinga-Tinke Gert R Dohle Leendert HJ Looijenga | 2015 | Asian Journal of Andrology2015，17，3： | 4 |
| 2 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 3 | A critical review of the methods for cleavage of fusion proteins with thrombin and factor Xa显示文摘 | Jenny R J Mann K G Lundblad R L | 2003 | Protein Expr Purif2003，31，1： | 1 |
| 4 | Measurementof reactive oxygen intermediate production in haemocytes ofthe penaeid shrimp, Penaeus vannamei 显示文摘 | MARCELO M RICARDO C JENNY R | 2000 | Aquaculture2000，191，： | 1 |
| 5 | A simple intervention to improve hospital antibiotic prescribing 显示文摘 | Michael S Jenny R Michael S | 2003 | MJA2003，178，： | 1 |
| 6 | Unconventional shallow biogenic gas systems 显示文摘 | George W S Jennie L R | 2002 | AAPG Bulletin2002，86，11： | 1 |
| 7 | Kuz a conserved metalloprotease disintegrin protein with two roles in Drosopgila neurogenesis 显示文摘 | Jenny R | 1996 | Science1996，273，： | 1 |
| 8 | Proteomice: capacity versus utility 显示文摘 | Jenny L Marc R Ben R | 2000 | Electrophoresis2000，21，6： | 1 |
| 9 | Echocardiography and pathoanatomical characteristics of isolated left ventricular non-compaction:a step towards classification as a distinct cardiomyopathy显示文摘 | Jenni R Oechslin E Schneider J | 2001 | Heart2001，86，： | 1 |
| 10 | Cardiac abnormalities in Mc Leod syndrome显示文摘 | Oechslin E Kaup D Jenni R | 2009 | Int J Cardial2009，132，： | 1 |
| 11 | Islolated ventricular non- compaction of the myocardium in adults显示文摘 | Jenni R Oechslin E vander Loo B | 2007 | Heart2007，93，1： | 1 |
| 12 | Echocardiographic and pathoanatomical characteristcs of isolated left ventricular noncom- paction:a step towards classifiication as a distinct cardiomyopathy 显示文摘 | Jenni R Oechslin E Schneider J | 2001 | Heart2001，86，6： | 1 |
| 13 | Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction:a step towards classification as a distinct cardiomyopathy显示文摘 | Jenni R Oechslin E Schneider J | 2001 | Heart2001，86，6： | 1 |
| 14 | Echocardiographic and pathoanatomical characteristics of isolated left ventrlcular noncompaction: a step towards classification as a distinct cardiomyopathy 显示文摘 | Jenni R Oechslin E Schneider J | 2001 | Heart2001，86，： | 1 |
| 15 | Echocardiographic and pathoanatomical characteristicsof isolated left ventricular non-compaction:a step to-wards classification as a distinct cardiomyopathy显示文摘 | JENNI R OECHSLIN E SCHNEIDER J | 2001 | Heart2001，86，： | 1 |
| 16 | A critical review ofthe methods for cleavage of fusion proteins with thrombinand factor Xa显示文摘 | Jenny R J Mann K G Lundblad R L | 2003 | Protein Expr Purif2003，31，1： | 1 |
| 17 | An intrapericardial bronchogenic cyst显示文摘 | Kobza R Oechslin E Jenni R | 2003 | Interact Cardiovasc Thorac Surg2003，2，2： | 1 |
| 18 | Pulmonary exposure to 1-3-β-glucan alters adaptive immune responses in rats显示文摘 | Young SH Jenny R James MA | 2006 | Inhalation Toxicology2006，18，： | 1 |
| 19 | Echocardiographic and pathoanatomical characteristics of isolated left ventricular noncompaction:a step towards a classification as a distinct cardiomyopathy显示文摘 | Jenni R Oechslin E Schneider J | 2001 | Heart2001，86，6： | 1 |
| 20 | Isolated venuicular noncompaction is associated with coronary microcirculatory dysfunction显示文摘 | Jenni R Wyss CA Oechslin EN | 2002 | J Am Coll Cardiol2002，39，： | 1 |
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