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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Antioxidant supplementation may improve renal transplant function: a preliminary report 显示文摘 | Loong C C Chang Y H Wu T H | 2004 | Transplant Proc2004，36，8： | 1 |
| 3 | Clinical significance of microscopic tumor venous invasion in patients with resectable hepatocellular carcinoma显示文摘 | Tsai T J Chau G Y Lui W Y Tsay S H King K L Loong C C | 2000 | Surgery2000，127，： | 1 |
| 4 | Epigenetic inactivationof the miR-124-1 in haematological malignancies显示文摘 | WONG K Y SO C C LOONG F | 2011 | PLoS One2011，6，19： | 1 |
| 5 | Multiplex genotyping of novel tetranucleotide microsatellites from a marine foodfish species crimson red snapper( Lutjanus erythropterus) 显示文摘 | Loong C L Zhu Z Y Yue G H | 2006 | Molecular Ecology Notes2006，，6： | 1 |
| 6 | Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells显示文摘 | Hsieh H G Loong C C Lin C Y | 2002 | Cytokine2002，19，： | 1 |
| 7 | Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection显示文摘 | Loong C C Hsieh H G Lui W Y | 2002 | Pathol2002，19，7： | 1 |
| 8 | Performance Analysis of Intelligent Robust Facility Layout Design显示文摘Design of a robust production facility layout with minimum handling cost(MHC) presents an appropriate approach to tackle facility layout problems in a dynamic volatile environment, in which product demands randomly change in each planning period. The objective of the design is to find the robust facility layout with minimum total material handling cost over the entire multiperiod planning horizon. This paper proposes a new mathematical model for designing robust machine layout in the stochastic dynamic environment of manufacturing systems using quadratic assignment problem(QAP) formulation. In this investigation, product demands are assumed to be normally distributed random variables with known expected value, variance, and covariance that randomly change from period to period. The proposed model was verified and validated using randomly generated numerical data and benchmark examples. The effect of dependent product demands and varying interest rate on the total cost function of the proposed model has also been investigated. Sensitivity analysis on the proposed model has been performed. Dynamic programming and simulated annealing optimization algorithms were used in solving the modeled example problems. | G MOSLEMIPOUR T S LEE Y T LOONG | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 1 |
| 9 | Novel procedure for the synthesis of 1,3,4 - oxadiazoles from 1,2 - diacylhydrazines using polymer supported Burgess reagent under microwave conditions 显示文摘 | BRAIN C T PAUL J M LOONG Y | 1999 | Tetrahedron Lett1999，40，16： | 1 |
| 10 | The freshwater Amazonian stingray,Potamotrygon motoro,up-regulates glutamine synthetase activity and protein abundance,and accumulates glutamine when exposed to brackish(15 per thousand)water显示文摘 | Ip Y K Loong A M Ching B | 2009 | The Journal of Experimental Biology2009，212，23： | 1 |
| 11 | Epigenetic inactivation of the miR-34a in hematological malignancies显示文摘 | Chim CS Wong KY Qi Y Loong F Lam WL Wong LG | 2010 | Carcinogenesis2010，31，4： | 1 |
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