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| 1 | Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study显示文摘Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost was obtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness(ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalization were itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD=6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urban patients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancer patients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACI was associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among the population in China. Preferential policies of medical insurance should be designed to tackle with this burden and further reduce the health care inequalities. | Zhixun Yang Hongmei Zeng Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，4： | 22 |
| 2 | The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital.based multi.center study显示文摘Background: Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. However, subgroup survival data from a large study sample are limited in China.To estimate the survival differences among patients with different stages and various subtypes of breast cancer, we conducted a hospital-based multi-center study on breast cancer in Beijing, China.Methods: All resident patients diagnosed with primary, invasive breast cancer between January 1,2006 and December 31,2010 from four selected hospitals in Beijing were included and followed up until December 31,2015. Hospitalbased data of stage at diagnosis, hormone receptor status, and selected clinical characteristics, including body mass index(BMI), menopausal status, histological grade, and histological type, were collected from the medical records of the study subjects. Overall survival(OS) and cancer-specific survival(CSS) were estimated. Cox proportional hazards models were employed to evaluate the associations of stage at diagnosis and molecular subtype with patient survival.Results: The 5-year OS and CSS rates for all patients were 89.4% and 90.3%. Survival varied by stage and molecular subtype. The 5-year OS rates for patients with stage I, Ⅱ, Ⅲ, and IV diseases were 96.5%, 91.6%, 74.8%, and 40.7%,respectively, and the corresponding estimates of 5-year CSS rates were 97.1%, 92.6%, 75.6%, and 42.7%, respectively.The 5-year OS rates for patients with luminal A, luminal B, HER2, and triple-negative subtypes of breast cancer were92.6%, 88.4%, 83.6%, and 82.9%, respectively, and the corresponding estimates of 5-year CSS rates were 93.2%, 89.1 %,85.4%, and 83.5%, respectively. Multivariate analysis showed that stage at diagnosis and molecular subtype were important prognostic factors for breast cancer.Conclusions: Survival of breast cancer patients varied significantly by stage and molecular subtype. Cancer screening is encouraged for the early detection and early diagnosis of breast cancer. More advanced therapies and health care policies are needed on HER2 and triple-negative subtypes. | Tingting Zuo Hongmei Zeng Huichao Li Shuo Liu Lei Yang Changfa Xia Rongshou Zheng Fei Ma Lifang Liu Ning Wang Lixue Xuan Wanqing Chen | 2017 | Chinese Journal of Cancer2017，36，11： | 18 |
| 3 | Evaluation of the reliability of twin variant analysis in Mg alloys by in situ EBSD technique显示文摘Electron backscatter diffraction(EBSD)is an orientation mapping technique,which has been widely used to study texture evolution and twinning behavior.This work aims to study the variant of{10¯12}twins during tensile deformation of AZ31 Mg alloys.An in-situ tensile stage was used,and coupled with EBSD technique,the variants of twins can be analyzed without releasing the tensile stress.Based on the EBSD maps,the first and second smallest misorientation angles(M_(1)and M 2)between each active twin and respective potential variants were calculated,and the distribution of M_(1)values with tensile strain was obtained.The results indicated that{10¯12}twins were deviated from their ideal orientations with strain increased.The criteria of M_(1)<4°and M 2−M_(1)>2°were suggested to be applied to select the data points for reliable variant identification.Moreover,it confirmed that the deviation of twin relationship was ascribed to the profuse basal glide in matrices and/or twins. | Feiya Liu Changfa Guo Renlong Xin Guilin Wu Qing Liu | 2019 | Journal of Magnesium and Alloys2019，7，2： | 2 |
| 4 | CALTPP:A general program to calculate thermophysical properties显示文摘A program CALTPP(CALculation of ThermoPhysical Properties)is developed in order to provide various thermophysical properties such as diffusion coefficient,interfacial energy,thermal conductivity,viscosity and molar volume mainly as function of temperature and composition.These thermophysical properties are very important inputs for microstructure simulations and mechanical property predictions.The general structure of CALTPP is briefly described,and the CALPHAD-type models for the description of these thermophysical properties are presented.The CALTPP program contains the input module,calculation and/or optimization modules and output module.A few case studies including(a)the calculation of diffusion coefficient and optimization of atomic mobility,(b)the calculation of solid/liquid,coherent solid/solid and liquid/liquid interfacial energies,(c)the calculation of thermal conductivity,(d)the calculation of viscosity,and(e)the establishment of molar volume database in binary and ternary alloys are demonstrated to show the features of CALTPP.It is expected that CALTPP will be an effective contribution in both scientific research and education. | Yuling Liu Cong Zhang Changfa Du Yong Du Zhoushun Zheng Shuhong Liu Lei Huang Shiyi Wen Youliang Jin Huaqing Zhang Fan Zhang George Kaptay | 2020 | Journal of Materials Science & Technology2020，42，7： | 2 |
| 5 | Response of microbial biomass and bacterial community composition to fertilization in a salt marsh in China显示文摘The effects of nitrogen(N) addition on microbial biomass, bacterial abundance, and community composition in sediment colonized by Suaeda heteroptera were examined by chloroform fumigation extraction method, real-time quantitative polymerase chain reaction, and denaturing gradient gel electrophoresis(DGGE) in a salt marsh located in Shuangtai Estuary, China. The sediment samples were collected from plots treated with different amounts of a single N fertilizer(urea supplied at 0.1, 0.2, 0.4 and 0.8 g/kg(nitrogen content in sediment) and different forms of N fertilizers(urea,(NH_4)_2SO_4, and NH_4NO_3, each supplied at 0.2 g/kg(calculated by nitrogen).The fertilizers were applied 1–4 times during the plant-growing season in May, July, August, and September of 2013. Untreated plots were included as a control. The results showed that both the amount and form of N positively influenced microbial biomass carbon, microbial biomass nitrogen, and bacterial abundance. The DGGE profiles revealed that the bacterial community composition was also affected by the amount and form of N.Thus, our findings indicate that short-term N amendment increases microbial biomass and bacterial abundance,and alters the structure of bacterial community. | MA Yuexin TAO Wei LIU Changfa LIU Jiao YANG Zhiping LI Jin LIU Jichen | 2017 | Acta Oceanologica Sinica2017，36，6： | 2 |
| 6 | Structure design and performance study on braid-reinforced cellulose acetate hollow fiber membranes显示文摘 | Fan Zuwei Xiao Changfa Liu Hailiang | 2015 | Journal of Membrane Science2015，486，： | 1 |
| 7 | 显示文摘 | Cui Aihua Liu Zhen Xiao Changfa | 2010 | J MemSci2010，360，12： | 1 |
| 8 | Investigations on the structures and performances of a polypiperazine amide/polysulfone composite membrane显示文摘 | ZHANG Yufeng XIAO Changfa LIU Enhua | 2006 | Desalination2006，191，13： | 1 |
| 9 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 10 | THE CONSTRUCTION OF THE EAST ASIA MERIDINA CHAIN OF GEOMAGNETIC OBSERVATORIES显示文摘In Order to study the Global Characteristics of Solar-terrestrial System in the 22th Solar Cycle, our Institute has built up a few geomagnetic observatories recently years at Mohe, Beijing (Ming Toms), Sanya (Hainan Insland) in the torritorg of China. These stations together with some old stations close to 120° E meridian and form the East Asia Meridian Chain of Geomagnetic Observatories. In the meantime we were set up also a observatory of the Chinese Great Wall Station in Antarctica. According to theather character of different area we designed and built the house with different structural style.The magnetic recording house is the under ground in Mohe, the semi-under ground in Beijing, the ground in sanya of China.The recording and the absolute houses are all built on stilts in the Chinese Great Wall Station of Antarctica. All buildins are made of non magnetic materials, Such as limestone, sun-dried mud brick, wood, copper and Aluminum etc.Therefore there are not affects of the magnetic materiat | Liu Changfa, Wang Juyi, Zhang Weixi, Dou Shaopu, Zhang PingInstitute of Geophysics, Chinese Academy of Sciences | 1990 | 天文研究与技术1990，，4： | 1 |
| 11 | Fabrication and characterization of novel foaming polyurethane hollow fiber membrane显示文摘Foam-like materials had attracted great interest as promising absorbent. In this study, thermoplastic polyurethane(TPU) block sponge was synthesized. Polyester(PET) braid tubular reinforced polyurethane(PU) spongy hollow fiber membrane was prepared by a concentric circular spinning method. The method was woven from an outer coated water-blown PU separation layer and inner PET braid tubular. We have developed a simple and useful preparation technique for the PU spongy hollow fiber membrane. For the first time, the PU spongy hollow fiber membrane was prepared using a coating and controlled foaming technique. The influence of toluene isocyanate index on the physical properties, morphology, and structure of flexible PU sponge was discussed in terms of water contact angle(CA), pure water flux(PWF), Fourier Transform Infrared Analysis(FTIR),pressure-responsive property, and pull-out strength. The morphologies of the membranes were investigated by scanning electron microscopy. We have characterized the foams from an intuitive point of view and demonstrated that the dimensional morphology of the membrane was closely related to isocyanate index. The result showed that the surface cell size of the PU sponge hollow fiber membrane gradually decreased with an increase of the isocyanate index. Due to the elasticity of PU at room temperature, the pressure responsive characteristic of the membrane was prepared. When isocyanate index was 1.05, the interface bonding strength of PU spongy hollow fiber membranes reached as high as 0.37 MPa, porosity and PWF were 71.5% and 415.5 L·m^-2·h^-1,respectively. | Yanjie Wu Changfa Xiao Hailiang Liu Qinglin Huang | 2019 | Chinese Journal of Chemical Engineering2019，27，4： | 1 |
| 12 | Optimization ofpolyurethane-based hollow fiber membranes morphology andperformance by post-treatment methods显示文摘 | Liu Meitian Xiao Changfa Hu Xiaoyu | 2011 | Desalination2011，275，123： | 1 |
| 13 | Effect of take-upspeed on polyvinylidene fluoride hollow fiber membrane in athermally induced phase separation process 显示文摘 | Li Xianfeng Liu Huiyu Xiao Changfa ef al | 2013 | Joumal ofApplied Polymer Science2013，128，2： | 1 |
| 14 | Optimization of polyurethane-based hollow fiber membranes morphology and perfotmance by post-treatment methods显示文摘 | LIU Meitian XIAO Changfa HU Xiaoyu | 2011 | Desalination2011，275，123： | 1 |
| 15 | Six novel single-nucleotide polymorphisms in SPAG11 gene and their association with sperm quality traits in Chinese Holstein bulls显示文摘 | Xinyan Liu Zhihua Ju Lingling Wang Yan Zhang Jingmin Huang Qiuling Li Jianbin Li Jifeng Zhong Liguo An Changfa Wang | 2011 | Animal Reproduction Science2011，，1： | 1 |
| 16 | Microvoid formation of acrylic copolymer/cellulose acetate blend fibers显示文摘 | Xiao Changfa Liu Zhaofeng | 1990 | Journal of Applied Polymer Science1990，41，： | 1 |
| 17 | Effect of micro- sized SiQ2-particle on the performance of PVDF blend membranes via TIPS 显示文摘 | Aihua Cui Zhen Liu Changfa Xiao | 2010 | Journal of Membrane Science2010，360，12： | 1 |
| 18 | DM Code Key Point Detection Algorithm Based on CenterNet显示文摘Data Matrix(DM)codes have been widely used in industrial production.The reading of DM code usually includes positioning and decoding.Accurate positioning is a prerequisite for successful decoding.Traditional image processing methods have poor adaptability to pollution and complex backgrounds.Although deep learning-based methods can automatically extract features,the bounding boxes cannot entirely fit the contour of the code.Further image processing methods are required for precise positioning,which will reduce efficiency.Because of the above problems,a CenterNet-based DM code key point detection network is proposed,which can directly obtain the four key points of the DM code.Compared with the existing methods,the degree of fitness is higher,which is conducive to direct decoding.To further improve the positioning accuracy,an enhanced loss function is designed,including DM code key point heatmap loss,standard DM code projection loss,and polygon Intersection-over-Union(IoU)loss,which is beneficial for the network to learn the spatial geometric characteristics of DM code.The experiment is carried out on the self-made DM code key point detection dataset,including pollution,complex background,small objects,etc.,which uses the Average Precision(AP)of the common object detection metric as the evaluation metric.AP reaches 95.80%,and Frames Per Second(FPS)gets 88.12 on the test set of the proposed dataset,which can achieve real-time performance in practical applications. | Wei Wang Xinyao Tang Kai Zhou Chunhui Zhao Changfa Liu | 2023 | Computers, Materials & Continua2023，77，11： | 0 |
| 19 | Animal models for COVID-19:advances,gaps and perspectives显示文摘COVID-19,caused by SARS-CoV-2,is the most consequential pandemic of this century.Since the outbreak in late 2019,animal models have been playing crucial roles in aiding the rapid development of vaccines/drugs for prevention and therapy,as well as understanding the pathogenesis of SARS-CoV-2 infection and immune responses of hosts.However,the current animal models have some deficits and there is an urgent need for novel models to evaluate the virulence of variants of concerns(VOC),antibodydependent enhancement(ADE),and various comorbidities of COVID-19.This review summarizes the clinical features of COVID-19 in different populations,and the characteristics of the major animal models of SARS-CoV-2,including those naturally susceptible animals,such as non-human primates,Syrian hamster,ferret,minks,poultry,livestock,and mouse models sensitized by genetically modified,AAV/adenoviral transduced,mouse-adapted strain of SARS-CoV-2,and by engraftment of human tissues or cells.Since understanding the host receptors and proteases is essential for designing advanced genetically modified animal models,successful studies on receptors and proteases are also reviewed.Several improved alternatives for future mouse models are proposed,including the reselection of alternative receptor genes or multiple gene combinations,the use of transgenic or knock-in method,and different strains for establishing the next generation of genetically modified mice. | Changfa Fan Yong Wu Xiong Rui Yuansong Yang Chen Ling Susu Liu Shunan Liu Youchun Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 20 | CHARACTERISTICS OF Sq VARIATION OF GEOMAGNETIC FIELD AT THE GREAT WALL STATION, ANTARCTICA IN WINTER显示文摘In this paper the characteristics of Sq variation of geomagnetic field in the region of the Chinese Great Wall Station (CGWS), Antarctica, in winter are analyzed from geomagnetic data obtained at the Geomagnetic Observatory of CGWS. The result enables us to reveal the following aspects: (1) The pattern of Sq variation at CGWS in early (Apr.) and Late winter (Sep.) is similar to that at Beijing Geomagnetic Observatory (BJO) at the middle latitude in the Northern Hemisphere. It may be controlled by the midlatitudinal ionospheric dynamo current. Amplitude of Sq variation is very small, and the harmonics in 8 hours or shorter periods in midwinter (June and July) is predominant because of the decreased effect of solar ultraviolet radiation and the dominant geomagnetic disturbance at high latitudes. (2) The vectors of Sq-equivalent current in the daytime are about five times more than that in the night. The direction of the vectors is clockwise in the daytime (08-15h) and counterclockwise in the night in | Liu Changfa, Zhang Ping Jiao Chengmin Institute of Geophysics, Academia Sinica, Beijing 100101 | 1991 | Chinese Journal of Polar Science1991，2，1： | 0 |
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