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| 1 | 甲状腺乳头状癌诊断与鉴别的可靠标记物显示文摘目的寻找更好的标记物,用于甲状腺乳头状癌的诊断与鉴别。方法以甲状腺乳头状癌(PTC)为研究组,以甲状腺滤泡状腺瘤(FA)和良性乳头状病变(BPL)作对照组。经自制组织芯片和免疫组化技术,对Twist、Galectin-3、HBME-1、p14ARF和TPO进行标记,并与CK19对比实验。结果6种指标阳性表达率依次为:PTC组100.0%、95.6%、80.0%、28.9%、15.6%和78.0%;FA组0.0、11.1%、6.7%、75.6%、88.9%和0.0;BPL组7.0%、7.5%、2.5%、77.5%、100.0%和0.0。PTC组与FA和BPL组比较差异均有显著性(P<0.05)。6种指标的灵敏度、特异度、准确度分别为100.0%、95.6%、80.0%、71.1%、84.4%、78.0;96.4%、90.1%、95.3%、76.5%、94.1%、100.0%和97.7%、92.3%、90.0%、74.6%、90.8%、91.9%。结论在PTC中6种指标阳性表达率最高的为Twist,其次为Galectin-3,因此临床病理工作中标记Twist和Galectin-3鉴别PTC与FA或BPL有实用意义。Twist的灵敏度和准确度最高,CK19特异度最高。因此该2种指标联合使用对于PTC的鉴别诊断最可靠。 | 何春年 Lili H Jin Q CH 陈士超 赵焕芬 翟金萍 | 2007 | 临床与实验病理学杂志2007，23，6： | 14 |
| 2 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 3 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 4 | A nutrition education curriculumfor health education:its effect on students’knowledge,attitudesand behavior显示文摘 | CarolB Lily H Barbara S | 1984 | J Sch Health1984，54，10： | 1 |
| 5 | Comparison of Temperature Conditions in Direct Liquefaction of Selected Low-rank Coals显示文摘 | Huang Lili Schobert H H | 2005 | Energy & Fuels2005，19，1： | 1 |
| 6 | NetQuest: a flexible frame- work for large-scale network measurement显示文摘 | Song H H Qiu Lili Zhang Yin | 2009 | IEEE/ACM Transactions on Networking2009，17，1： | 1 |
| 7 | Asleep-awake-asleep technique in children during strabismus surgery under sufentanil balanced anesthesia显示文摘 | Lili X Zhiyong H Jianjun S | | 0，，12： | 1 |
| 8 | L-Arginine hy- drochloride increases the solubility of folded and unfolded re combinant plasminogen activator rPA显示文摘 | TISCHER A LILIE H RUDOLPH R et 01 | 2010 | Protein Science2010，19，： | 1 |
| 9 | A preliminary study of the effects of ulinastatin on early postoperative cognition function in patients undergoing abdominal surgery显示文摘 | Lili X Zhiyong H Jianjun S | 2013 | Neurosci Lett2013，29，541： | 1 |
| 10 | In vitro folding of inclusion body proteins 显示文摘 | Rudolph R Lili H | 1996 | FASEB J1996，10，1： | 1 |
| 11 | Activation of the redoxregulated molecular chaperone Hsp33-A two-step mechanism 显示文摘 | Graumann J Lilie H Tang X L | 2001 | Structure2001，9，5： | 1 |
| 12 | In vitro folding of inclusion body proteins 显示文摘 | Rudolph R Lilie H | 1996 | FASEB J1996，10，1： | 1 |
| 13 | In vitro folding of inclusion body proteins显示文摘 | RUDOLPH R Lilie H | 1996 | FasebJ1996，10，： | 1 |
| 14 | Folding of a synthetic parallel beta-roll protein 显示文摘 | Lilie H Haehnel W Rudolph R | 2000 | FEBS Lett2000，470，2： | 1 |
| 15 | A Modification to the NOAH LSM to Simulate Heat Mitigation Strategies in the New York City Metropolitan Area显示文摘 | Lynn Barry H Carlson Toby N Rosenzweig Cynthia Goldberg Richard Druyan Leonard Cox Jennifer Gaffin Stuart Parshall Lily Civerolo Kevin | 2009 | Journal of Applied Meteorology and Climatology2009，，2： | 1 |
| 16 | Coupling of antibodies via protein Z on modified polyoma virus-like particles 显示文摘 | Gleiter S Lilie H | 2001 | Protein Science2001，10，2： | 1 |
| 17 | Lipid changes on hormone therapy and coronary heart disease events in the Heart and Estrogen/progestin Replacement Study (HERS)显示文摘 | Michael G Shlipak Lily A Chaput Eric Vittinghoff Feng Lin Vera Bittner Robert H Knopp Stephen B Hulley | 2003 | American Heart Journal2003，，5： | 1 |
| 18 | In vitro folding of inclusion body proteins显示文摘 | Rudolph R Lilie H | 1996 | FASEB1996，10，： | 1 |
| 19 | In vitro folding of inclusion body proteins显示文摘 | Rudolph R Lilie H | 1996 | FASEB1996，10，1： | 1 |
| 20 | Prolyl isomerases catalyze antibody folding in vitro 显示文摘 | Lilie H Lang K Rudolph R | 1993 | Protein Sci1993，2，9： | 1 |
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