|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition显示文摘Astronauts are under high stress for a long time because of the microgravity condition,which leads to anxiety,affects their learning and memory abilities,and seriously impairs the health of astronauts.Aromatherapy can improve the physical and mental health of astronauts in a way that moisturizes them softly and silently.However,the strong volatility of fragrances and inconvenience of aroma treatment greatly limit their application in the field of spaceflight.In this study,reactive mesoporous silica nanoparticles were prepared to encapsulate and slowly release limonene.The limonene loaded nanoparticles were named limonene@mesoporous silica nanoparticles-cyanuric chloride(LE@MSNs-CYC).LE@MSNs-CYC were then applied to wallpaper to improve the convenience of aromatherapy.LE@MSNs-CYC could chemically react with the wallpaper,thus firmly adsorbed on the wallpaper.In the following,the mice were treated with hindlimb unloading(HU)to simulate a microgravity environment.The results showed that 28-day HU led to an increase in the level of anxiety and declines in learning,memory,and physical health in mice.LE@MSNs-CYC showed significant relief effects on anxiety,learning,memory,and physical health of HU treated mice.Subsequently,the molecular mechanisms were explored by hypothalamic-pituitary-adrenal axis related hormones,immune-related cytokines,learning,and memory-related neurotransmitters and proteins. | Zhiguo Lu Jianze Wang Lina Qu Guanghan Kan Tianlu Zhang Jie Shen Yan Li Jun Yang Yunwei Niu Zuobing Xiao Yinghui Li Xin Zhang | 2020 | Bioactive Materials2020，5，4： | 5 |
| 2 | Optical properties and chemical composition of PM_(2.5) in Shanghai in the spring of 2012显示文摘The semi-diurnal mean aerosol mass concentration, chemical composition, and optical properties of PM2.5were investigated in Shanghai during the spring of 2012. Slight pollution was observed during the study period. The average PM2.5 concentration was 64.11 土 22.83(xg/m3. The mean coefficients of extinction,scattering, and absorption at 532 nm were 125.9 士 78.5,91.1 士 56.3,and 34.9 士 23.6 Mm-1, respectively. A relatively low mean single scattering albedo at 532 nm(0.73 士 0.04) and low level of elemental carbon(EC,2.67 士 1.96 |xg/m3) suggested that the light absorption was enhanced due to the internal mixing of the EC.Sulfate contributed the most to aerosol light scattering in Shanghai. The chemical composition of PM2.5was dominated by particulate organic matter, sulfate, nitrate, ammonium, and EC. Anthropogenic sources made a significant contribution to the emission and loading of the particulate pollutants. A relatively good correlation between the aerosol chemical composition and the cloud condensation nuclei(CCN) activation indicated that aerosol chemistry is an important factor that influences the saturated hygroscopicity and growth of the aerosol. | Guanghan Huang Tiantao Cheng Renjian Zhang Jun Tao Chunpeng Leng Yunwei Zhang Shuping Zha Deqin Zhang Xiang Li Chunyang Xu | 2014 | Particuology2014，12，2： | 4 |
| 3 | The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention显示文摘Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances bone strength,whereas mechanical unloading leads to bone loss. Increasing evidence has demonstrated that long noncoding RNAs(lnc RNAs) play key roles in diverse biological, physiological and pathological contexts. However, the roles of lnc RNAs in mechanotransduction and their relationships with bone formation remain unknown. In this study, we screened mechanosensing lnc RNAs in osteoblasts and identified Neat1, the most clearly decreased lnc RNA under simulated microgravity. Of note, not only Neat1 expression but also the specific paraspeckle structure formed by Neat1 was sensitive to different mechanical stimulations, which were closely associated with osteoblast function. Paraspeckles exhibited small punctate aggregates under simulated microgravity and elongated prolate or larger irregular structures under mechanical loading. Neat1 knockout mice displayed disrupted bone formation, impaired bone structure and strength, and reduced bone mass. Neat1 deficiency in osteoblasts reduced the response of osteoblasts to mechanical stimulation. In vivo, Neat1 knockout in mice weakened the bone phenotypes in response to mechanical loading and hindlimb unloading stimulation. Mechanistically, paraspeckles promoted nuclear retention of E3 ubiquitin ligase Smurf1 m RNA and downregulation of their translation, thus inhibiting ubiquitination-mediated degradation of the osteoblast master transcription factor Runx2, a Smurf1 target. Our study revealed that Neat1 plays an essential role in osteoblast function under mechanical stimulation, which provides a paradigm for the function of the lnc RNA-assembled structure in response to mechanical stimulation and offers a therapeutic strategy for long-term spaceflight-or bedrest-induced bone loss and age-related osteoporosis. | Caizhi Liu Xingcheng Gao Yuheng Li Weijia Sun Youjia Xu Yingjun Tan Ruikai Du Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Yinlong Zhao Yinbo Wang Xinxin Yuan Junjie Pan Guodong Yuan Youyou Li Wenjuan Xing Guanghan Kan Yanqing Wang Qi Li Xuan Han Jianwei Li Shukuan Ling Yingxian Li | 2022 | Bone Research2022，10，2： | 3 |
| 4 | The circFASN/miR-33a pathway participates in tacrolimusinduced dysregulation of hepatic triglyceride homeostasis显示文摘Dyslipidemia exhibits a high incidence after liver transplantation,in which tacrolimus,a widely used immunosuppressant,plays a fundamental role.MicroRNAs and related circRNAs represent a class of noncoding RNAs that have been recognized as important regulators of genes associated with lipid metabolism.However,their transcriptional activities and functional mechanisms in tacrolimus-related dyslipidemia remain unclear.In this study,we observed that tacrolimus could induce triglyceride accumulation in hepatocytes by stimulating sterol response element-binding proteins(SREBPs)and miR-33a.Our in silico and experimental analyses identified miR-33a as a direct target of circFASN.Tacrolimus could downregulate circFASN and result in elevated miR-33a in vivo and in vitro.Overexpression of circFASN or silencing of miR-33a decreased the promoting effects of tacrolimus on triglyceride accumulation.Clinically,the incidence of dyslipidemia in liver transplant recipients with elevated serum miR-33a after liver transplantation was higher than that in patients without elevated serum miR-33a(46.3%vs.18.8%p=0.012,n=73).Our results showed that the circFASN/miR-33a regulatory system plays a distinct role in tacrolimus-induced disruption of lipid homeostasis.MiR-33a is likely a risk factor for tacrolimus-related dyslipidemia,providing a potential therapeutic target to combat tacrolimus-induced dyslipidemia after liver transplantation. | Chenzhi Zhang Kangchen Chen Rongli Wei Guanghan Fan Xuechun Cai Li Xu Beini Cen Jianguo Wang Haiyang Xie Shusen Zheng Xiao Xu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 5 | Advantage of dual wavelength light-emitting diodes with dip-shaped quantum wells显示文摘Dual-wavelength light-emitting diodes (DW-LEDs) with dip-shaped quantum wells have been studied by numerical simulation.The emission spectra,light output power,carrier concentration in the quantum wells and internal quantum efficiency are investigated.The simulation results indicate that the DW-LEDs with dip-shaped quantum wells perform better than conventional LEDs with rectangular quantum wells in terms of light output power,leakage current and efficiency droop.These improvements in the electrical and optical characteristics are mainly attributed to the alleviation of the electrostatic field in the dip-shaped quantum wells. | XU YiQin FAN GuangHan ZHOU DeTao LI Xin LU TaiPing ZHAO Fang ZHANG YunYan ZHENG ShuWen GONG ChangChun | 2012 | Chinese Science Bulletin2012，57，20： | 2 |
| 6 | Insights into summertime haze pollution events over Shanghai based on online water-soluble ionic composition of aerosols显示文摘 | Huanhuan Du Lingdong Kong Tiantao Cheng Jianmin Chen Jianfei Du Ling Li Xiangao Xia Chunpeng Leng Guanghan Huang | 2011 | Atmospheric Environment2011，，29： | 2 |
| 7 | Multi-mode energy management strategy for hydraulic hub-motor auxiliary system based on improved global optimization algorithm显示文摘Heavy commercial vehicles equipped with a hydraulic hub-motor auxiliary system(HHMAS)often operate under complex road conditions.Selecting appropriate operating mode and realizing reasonable energy management to match unpredictable road conditions are the keys to the driving performance and fuel economy of HHMAS.Therefore,a multi-mode energy management strategy(MM-EMS)based on improved global optimization algorithm is proposed in this study for HHMAS.First,an improved dynamic programming(DP)algorithm for HHMAS is developed.This improved DP algorithm considers the effect of SOC and vehicle speed,thereby preventing the calculation results from falling into local optimization.This algorithm also reduces the dimension of the control variable data grid,and the calculation time is reduced by 35%without affecting the accuracy.Second,a MM-EMS with hierarchical control is proposed.This strategy extracts the optimal control rules from the results of the improved DP algorithm.Then it divides the system’s operating region into two types,namely,single-mode working region and mixedmode working region.In the single-mode working region,mode switching is realized through fixed thresholds.In the mixedmode working region,a linear quadratic regulator(LQR)is adopted to determine a target mode and realize SOC tracking control.Finally,the designed MM-EMS is verified separately in offline simulation and hardware-in-the-loop(HIL)under actual vehicle test cycles.Simulation results show that the results between HIL and offline simulation are largely coincidence.Besides,in comparison with the engine optimal control strategy,the designed MM-EMS can achieve an approximate optimal control,with oil savings of 3.96%. | ZENG XiaoHua WU ZiQiao WANG Yue SONG DaFeng LI GuangHan | 2020 | Science China(Technological Sciences)2020，63，10： | 1 |
| 8 | Ideal einstein, conformally flat and semi-symmetric immersions显示文摘 | Guanghan Li | 2002 | Israel Journal of Mathematics2002，，1： | 1 |
| 9 | Closed Geodesics and Volume Growth of Open Manifolds with Sectional Curvature Bounded from Below显示文摘In this paper,the relationship between the existence of closed geodesies and the volume growth of complete noncompact Riemannian manifolds is studied.First the authors prove a diffeomorphic result of such an n-manifold with nonnegative sectional curvature,which improves Marenich-Toponogov's theorem.As an application,a rigidity theorem is obtained for nonnegatively curved open manifold which contains a closed geodesic.Next the authors prove a theorem about the nonexistence of closed geodesies for Riemannian manifolds with sectional curvature bounded from below by a negative constant. | Yi SHI Guanghan LI Chuanxi WU | 2014 | Chinese Annals of Mathematics,Series B2014，35，1： | 1 |
| 10 | Determination of trace tin in foods by single- sweep polarography 显示文摘 | Li Qiong Lu Guanghan Wu Heng | 1999 | Food Chemistry1999，64，： | 1 |
| 11 | Optical properties and chemical composition of PM 2.5 in Shanghai in the spring of 2012显示文摘 | Guanghan Huang Tiantao Cheng Renjian Zhang Jun Tao Chunpeng Leng Yunwei Zhang Shuping Zha Deqin Zhang Xiang Li Chunyang Xu | 2013 | Particuology2013，，： | 1 |
| 12 | Structural and superconducting properties of LaFeAs_(1-x)Sb_xO_(1-y)F_y显示文摘We report the antimony(Sb) doping effect in a prototype system of iron-based superconductors LaFeAsO1-yFy(y=0,0.1,0.15).X-ray powder diffraction indicates that the lattice parameters increase with Sb content within the doping limit.Rietveld structural refinements show that,with the partial substitution of Sb for As,the thickness of the Fe2As2 layers increases significantly,whereas that of the La2O2 layers shrinks simultaneously.So a negative chemical pressure is indeed 'applied' to the superconducting-active Fe2As2 layers,in contrast to the effect of positive chemical pressure by the phosphorus doping.Electrical resistance and magnetic susceptibility measurements indicate that,while the Sb doping hardly influences the SDW anomaly in LaFeAsO,it recovers SDW order for the optimally-doped sample of y=0.1.In the meantime,the superconducting transition temperature can be raised up to 30 K in LaFeAs1-xSbxO1-yFy with x=0.1 and y=0.15.The Sb doping effects are discussed in term of both J1-J2 model and Fermi Surface(FS) nesting scenario. | WANG Cao,MA ZhiFeng,JIANG Shuai,LI YuKe,XU ZhuAn & CAO GuangHan* Department of Physics,Zhejiang University,Hangzhou 310027,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，7： | 1 |
| 13 | Giant positive magnetoresistance in non-magnetic bismuth nanopartiles显示文摘 | Wang Junwei Cao Guanghan Li Yadong | 2003 | Mater Res Bull2003，38，： | 1 |
| 14 | Superconductivity in ThMo_2Si_2C with Mo_2C square net显示文摘We report the superconductivity of a new quaternary compound ThMo_(2)Si_(2)C, synthesized with the arc-melting technique. The compound crystallizes in a tetragonal CeCr_(2)Si_(2)C-type structure with cell parameters of a = 4.2296A and c = 5.3571 A. An interlayer Si–Si covalent bonding is suggested by the atomic distance. The electrical resistivity and magnetic susceptibility measurements indicate a Pauli-paramagnetic metal with dominant electron-electron scattering in the normal-state. Bulk superconductivity at 2.2 K is demonstrated with a dimensionless specific-heat jump of △C/γnT = 0.98. The superconducting parameters of the critical magnetic fields, coherence length, penetration depth, and superconducting energy gap are given. | ZiChen Liu BaiZhuo Li YuSen Xiao QingChen Duan YanWei Cui YuXue Mei Qian Tao ShuLi Wei ShuGang Tan Qiang Jing Qing Lu YuPing Sun YunYan Liu ShengGui Fu Hao Jiang Zhi Ren ZhuAn Xu Cao Wang GuangHan Cao | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，7： | 1 |
| 15 | Flow instability of buoyant-Marangoni convection in the LEC GaAs melt显示文摘Flow transitions and instabilities have significant effects on the quality of the crystals. The flow and heat transfer in the LEC GaAs melt are numerically studied by a time-dependent and three-dimensional turbulent flow model. The effects of the change of the buoyancy and Marangoni force on the flow state are analyzed by changing the temperature difference between the crystal and the crucible walls. The results show that the flow will transform from axisymmetric steady flow to non-axisymmetric oscillatory flow when the temperature difference exceeds the critical value, and that the mechanism of the transition is attributed to the Marangoni instability. The critical temperature differences for the flow transitions corresponding to different melt depth H are numerically predicted. Several important characteristics of the non-axisymmetric buoyant-Marangoni convection are numerically observed and compared with that of the non-axisymmetric mixed convection coupled with crystal rotation. | CHEN ShuXian1 & LI MingWei2,3 1 Aviation Engineering Institute, Civil Aviation Flight University of China, Guanghan 618307, China 2 Institute of Power Engineering of Chongqing University, Chongqing 400030, China 3 Research Center of Biological Function Information and Instruments of Chongqing University by Sec-ond-Term National 985 Project, Chongqing University, Chongqing 400030, China | 2008 | Science China(Technological Sciences)2008，51，4： | 1 |
| 16 | HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation显示文摘Bone marrow mesenchymal stem cell(BMSC)osteogenic differentiation and osteoblast function play critical roles in bone formation,which is a highly regulated process.Long noncoding RNAs(lncRNAs)perform diverse functions in a variety of biological processes,including BMSC osteogenic differentiation.Although several studies have reported that HOX transcript antisense RNA(HOTAIR)is involved in BMSC osteogenic differentiation,its effect on bone formation in vivo remains unclear.Here,by constructing transgenic mice with BMSC(Prx1-HOTAIR)-and osteoblast(Bglap-HOTAIR)-specific overexpression of HOTAIR,we found that Prx1-HOTAIR and Bglap-HOTAIR transgenic mice show different bone phenotypes in vivo.Specifically,Prx1-HOTAIR mice showed delayed bone formation,while Bglap-HOTAIR mice showed increased bone formation.HOTAIR inhibits BMSC osteogenic differentiation but promotes osteoblast function in vitro.Furthermore,we identified that HOTAIR is mainly located in the nucleus of BMSCs and in the cytoplasm of osteoblasts.HOTAIR displays a nucleocytoplasmic translocation pattern during BMSC osteogenic differentiation.We first identified that the RNA-binding protein human antigen R(HuR)is responsible for HOTAIR nucleocytoplasmic translocation.HOTAIR is essential for osteoblast function,and cytoplasmic HOTAIR binds to miR-214 and acts as a ceRNA to increase Atf4 protein levels and osteoblast function.BglapHOTAIR mice,but not Prx1-HOTAIR mice,showed alleviation of bone loss induced by unloading.This study reveals the importance of temporal and spatial regulation of HOTAIR in BMSC osteogenic differentiation and bone formation,which provides new insights into precise regulation as a target for bone loss. | Yuheng Li Weijia Sun Jianwei Li Ruikai Du Wenjuan Xing Xinxin Yuan Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Junjie Pan Youyou Li Qi Li Guanghan Kan Xuan Han Shukuan Ling Xiqing Sun Yingxian Li | 2023 | Bone Research2023，11，4： | 0 |
| 17 | Dynamic Investigations on the Wear Behavior of a 3D Revolute Joint Considering Time-Varying Contact Stiffness: Simulation and Experiment显示文摘The existence of the relative radial and axial movements of a revolute joint’s journal and bearing is widely known.The three-dimensional(3D)revolute joint model considers relative radial and axial clearances;therefore,the freedoms of motion and contact scenarios are more realistic than those of the two-dimensional model.This paper proposes a wear model that integrates the modeling of a 3D revolute clearance joint and the contact force and wear depth calculations.Time-varying contact stiffness is first considered in the contact force model.Also,a cycle-update wear depth calculation strategy is presented.A digital image correlation(DIC)non-contact measurement and a cylindricity test are conducted.The measurement results are compared with the numerical simulation,and the proposed model’s correctness and the wear depth calculation strategy are verified.The results show that the wear amount distribution on the bearing’s inner surface is uneven in the axial and radial directions due to the journal’s stochastic oscillations.The maximum wear depth locates where at the bearing’s edges the motion direction of the follower shifts.These find-ings help to seek the revolute joints’wear-prone parts and enhance their durability and reliability through improved design. | Li Zhang Yining Fang Guanghan Bai Junyong Tao | 2023 | Chinese Journal of Mechanical Engineering2023，36，6： | 0 |
| 18 | High Quality Zinc Sulfide Epitaxial Layers Grown by Metalorganic Chemical Vapour Deposition显示文摘ZnS films were successfully grown by metalorganic chemical vapour deposition (MOCVD) at atmospheric pressure on (100)GaAs substrates.The deposition was carried out at substrate temperature between 280~550℃ with optimisation of reactor de-sign and growth conditions,the gas phase prereaction is effectively restrained.These epilayers exhibit high crystallographic quali-ty and reveal a mirror surface morphology,the peak halfwidths of X-ray diffraction patterns from their (400) faces are within0.06~0.09°.The epilayers grown on (111) GaAs,(110) Al2O3 and (100) Si are proved single crystalline feature as well.The op-tical and electrical characteristics of ZnS epilayers are measured by photoluminescence,cathodeluminescence,and Van der Pauwmethod.The results indicate that there are not a large number of deep centers that could be detected both at 77K and at roomtemperature,a broad CL peak around 2.897eV and 2.672eV are observed only under very strong excitation,their origin has notbeen examined.All epilayers present high resistivities up to 1013Ω·cm. | Fan, Guanghan Liao, Qiwei Fan, Xiwu Zhang, Zhishun Li, Mei Zhang, Jiying | 1989 | Rare Metals1989，9，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员