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| 1 | First light of the 1.8-m solar telescope–CLST显示文摘Large-aperture solar telescopes play an important role in solar observations and research,and require high temporal and spatial resolution[1].To solve some fundamental problems such as the solar dynamo,coronal heating,and the triggering of major solar eruptions,the spatial resolution for solar-atmosphere observation should reach at least 0.1 arcsec[2]. | ChangHui Rao NaiTing Gu XueJun Rao Cheng Li LanQiang Zhang JinLong Huang Lin Kong Ming Zhang YunTao Cheng Yi Pu Hua Bao YouMing Guo YangYi Liu JinSheng Yang LiBo Zhong ChangJun Wang Kai Fang XiaoJun Zhang DongHong Chen Cheng Wang XinLong Fan ZhiWu Yan KeLe Chen XiYa Wei Lei Zhu Hong Liu YongJian Wan Hao Xian WenLi Ma | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 6 |
| 2 | Adaptive optics based on machine learning: a review显示文摘Adaptive optics techniques have been developed over the past half century and routinely used in large ground-based telescopes for more than 30 years.Although this technique has already been used in various applications,the basic setup and methods have not changed over the past 40 years.In recent years,with the rapid development of artificial in-telligence,adaptive optics will be boosted dramatically.In this paper,the recent advances on almost all aspects of adapt-ive optics based on machine learning are summarized.The state-of-the-art performance of intelligent adaptive optics are reviewed.The potential advantages and deficiencies of intelligent adaptive optics are also discussed. | Youming Guo Libo Zhong Lei Min Jiaying Wang Yu Wu Kele Chen Kai Wei Changhui Rao | 2022 | Opto-Electronic Advances2022，5，7： | 6 |
| 3 | Electrical activities of neural systems exposed to sinusoidal induced electric field with random phase显示文摘The brain neural system is often disturbed by electromagnetic and noise environments, and research on dynamic response of its interaction has received extensive attention. This paper investigates electrical activity of Morris-Lecar neural systems exposed to sinusoidal induced electric field(IEF) with random phase generated by electromagnetic effect. By introducing a membrane depolarization model under the effect of random IEF, transition state of firing patterns, including mixed-mode oscillations(MMOs) with layered inter-spike intervals(ISI) and intermittency with a power law distribution in probability density function of ISI, is obtained in a single neuron. Considering the synergistic effects of frequency and noise, coherence resonance is performed by phase noise of IEF under certain parameter conditions. For the neural network without any internal coupling, we demonstrate that synchronous oscillations can be induced by IEF coupling, and suppression of synchronous spiking is achieved effectively by phase noise of IEF. Results of the study enrich the dynamical response to electromagnetic induction and provide insights into mechanisms of noise affecting information coding and transmission in neural systems. | DU Lin CAO ZiLu LEI YouMing DENG ZiChen | 2019 | Science China(Technological Sciences)2019，62，7： | 5 |
| 4 | DeST 3.0:A new-generation building performance simulation platform显示文摘Buildings contribute to almost 30%of total energy consumption worldwide.Developing building energy modeling programs is of great significance for lifecycle building performance assessment and optimization.Advances in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and platforms.To meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and released.The structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing iterations.DeST 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation architecture.DeST 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study calibration.DeST 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and education.The new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization. | Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong Dong Lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong Wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng | 2022 | Building Simulation2022，15，11： | 5 |
| 5 | Serum proteomic analysis revealed diagnostic value of hemoglobin for nonalcoholic fatty liver disease显示文摘 | Chaohui Yu Chengfu Xu Lei Xu Jiekai Yu Min Miao Youming Li | 2011 | Journal of Hepatology2011，，1： | 3 |
| 6 | First light of solar multi-conjugate adaptive optics at the 1-m new vacuum solar telescope显示文摘Observations play a leading role in any branches of astronomy,including solar physics.In order to solve fundamental problems,such as solar dynamo[1],coronal heating[2]and the triggering of major solar eruptions[3],solar observations with spatial resolution better than 0.1 arcsec are required.Such a goal cannot be achieved without the help of adaptive optics(AO),which eliminates the wavefront distortion caused by atmosphere turbulence[4,5].However,solar observations are performed over an extended field of | ChangHui Rao LanQiang Zhang Lin Kong YouMing Guo XueJun Rao Hua Bao Lei Zhu LiBo Zhong | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，8： | 2 |
| 7 | Fractal properties of interpolatory subdivision schemes and their application in fractal generation显示文摘 | Zheng Hongchan Ye Zhenglin Lei Youming | 2007 | Chaos Solitons & Fractals2007，32，1： | 1 |
| 8 | Stochastic chaos in a Duffing oscillator and its control显示文摘 | Wu Cunli Lei Youming Fang Tong | 2006 | Chaos Solitons and Fractals2006，27，2： | 1 |
| 9 | Study on surface modification and flame retardants properties of ammonium polyphosphate for polypropylene 显示文摘 | LEI Zhouqiao CAO Youming XIE Fei | 2012 | J Appl Polym Sci2012，124，： | 1 |
| 10 | Synchronization in a fractional-order dynamic network with uncertain parameters using an adaptive control strategy显示文摘This paper studies synchronization of all nodes in a fractional-order complex dynamic network. An adaptive control strategy for synchronizing a dynamic network is proposed. Based on the Lyapunov stability theory, this paper shows that tracking errors of all nodes in a fractional-order complex network converge to zero. This simple yet practical scheme can be used in many networks such as small-world networks and scale-free networks. Unlike the existing methods which assume the coupling configuration among the nodes of the network with diffusivity, symmetry, balance, or irreducibility, in this case,these assumptions are unnecessary, and the proposed adaptive strategy is more feasible.Two examples are presented to illustrate effectiveness of the proposed method. | Lin DU Yong YANG Youming LEI | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，3： | 1 |
| 11 | Stochastic chaos in a Duffing oscillator and its control显示文摘 | Cunli Wu Youming Lei Tong Fang | 2005 | Chaos, Solitons and Fractals2005，，2： | 1 |
| 12 | TLR9 and BAFF: Their expression in patients with IgA nephropathy显示文摘 | Weiwei Li Xiaofei Peng Yuyuan Liu Hong Liu Fuyou Liu Liyu He Yang Liu Fan Zhang Chunyan Guo Guochun Chen Lei Zhang Zheng Dong Youming Peng | 2014 | Molecular Medicine Reports2014，，3： | 1 |
| 13 | Association of serum uric acid level with non-alcoholic fatty liver disease: A cross-sectional study显示文摘 | Youming Li Chengfu Xu Chaohui Yu Lei Xu Min Miao | 2008 | Journal of Hepatology2008，，5： | 1 |
| 14 | Stochastic chaos in a Duffing oscillator and its control 显示文摘 | Wu Cunli Lei Youming Fang Tong | 2006 | Chaos Solitons & Fractals2006，27，2： | 1 |
| 15 | Maximal Lyapunov Exponent and Almost-Sure Stability for Sto-chastic Mathieu-Duffing Systems显示文摘 | Jiaorui Li Wei Xu Zhengzheng Ren Youming Lei | 2005 | Journal of Sound and Vibration2005，，12： | 1 |
| 16 | Identification of tumor-suppressor genes in lung squamous cell carcinoma through integrated bioinformatics analyses显示文摘Lung cancer is a prevalent malignancy,and fatalities of the disease exceed 400,000 cases worldwide.Lung squamous cell carcinoma(LUSC)has been recognized as the most common pathological form of lung cancer.The comprehensive understanding of molecular features related to LUSC progression has great significance in LUSC prognosis assessment and clinical management.In this study,we aim to identify a panel of signature genes closely associated with LUSC,which can provide novel insights into the progression of LUSC.Gene expression profiles were retrieved from public resources including gene expression omnibus(GEO)and the cancer genome atlas(TCGA)database.Differentially expressed genes(DEGs)between LUSC specimens and normal lung tissues were identified by bioinformatics analyses.A total of 66 DEGs were identified based on two cohorts of data.CytoHubba plugin of Cytoscape software was utilized for the further analyses of the top 10 candidate hub genes including OGN,ABI3BP,MAMDC2,FGF7,FAM107A,SPARCL1,DCN,COL14A1,and MFAP4 and CHRDL1,which showed significant downregulation in LUSC.Two LUSC cell lines were used to validate the functions of CHRDL1 and FAM107A through overexpression experiment.Together,our data revealed novel candidate tumor-suppressor genes in LUSC,suggesting previously unappreciated mechanisms in the progression of LUSC. | HENG LI YOUMING LEI GAOFENG LI YUNCHAO HUANG | 2024 | Oncology Research2024，32，1： | 0 |
| 17 | 'Third eye' of colonoscopists: a preclinical comparative study of artificial intelligence-assisted polyp detection显示文摘To the Editor: In China, colorectal cancer (CRC) ranks third in cancer incidence and fifth in cancer-related deaths.[1] Most CRCs arise from adenomatous polyps. Colonoscopy can detect and remove polyps early to prevent CRC. However, the polyp miss rate in conventional colonoscopy may be more than 40%.[2] New endoscopic devices for detecting polyps have made some progress over the past few decades,[3] but are still operator-dependent and require additional costs. Therefore, artificial intelligence (AI)-assisted polyp detection systems have emerged in recent years. This study aimed to evaluate the effectiveness of our newly developed AI-assisted polyp detection system for colonoscopy in a preclinical manner. | Xinjue He Lei Xu Chengfu Xu Jie Zhang Meng Li Weihong Wang Xiaoyun Ding Youming Li Xuequn Zhang | 2022 | Chinese Medical Journal2022，135，22： | 0 |
| 18 | miR-34b-3p Inhibition of eIF4E Causes Post-stroke Depression in Adult Mice显示文摘Post-stroke depression(PSD)is a serious and common complication of stroke,which seriously afects the rehabilitation of stroke patients.To date,the pathogenesis of PSD is unclear and efective treatments remain unavailable.Here,we established a mouse model of PSD through photothrombosis-induced focal ischemia.By using a combination of brain imaging,transcriptome sequencing,and bioinformatics analysis,we found that the hippocampus of PSD mice had a signifcantly lower metabolic level than other brain regions.RNA sequencing revealed a signifcant reduction of miR34b-3p,which was expressed in hippocampal neurons and inhibited the translation of eukaryotic translation initiation factor 4E(eIF4E).Furthermore,silencing eIF4E inactivated microglia,inhibited neuroinfammation,and abolished the depression-like behaviors in PSD mice.Together,our data demonstrated that insufcient miR34b-3p after stroke cannot inhibit eIF4E translation,which causes PSD by the activation of microglia in the hippocampus.Therefore,miR34b-3p and eIF4E may serve as potential therapeutic targets for the treatment of PSD. | Xiao Ke Manfei Deng Zhuoze Wu Hongyan Yu Dian Yu Hao Li Youming Lu Kai Shu Lei Pei | 2023 | Neuroscience Bulletin2023，39，2： | 0 |
| 19 | DAPK1(death associated protein kinase 1)mediates mTORC1 activation and antiviral activities in CD8^(+)T cells显示文摘Mechanistic target of rapamycin complex 1(mTORCt)regulates CD8^(+)T-cell differentiation and function.Despite the links between PI3K-AKT and mTORCI activation in CD8^(+)T cells,the molecular mechanism underlying mTORCI activation remains undear.Here,we show that both the kinase activity and the death domain of DAPK1 are required for maximal mTOR activation and CD8^(+)T-cell function.We found that TCR-induced activation of calcineurin activates DAPK1,which subsequently interacts with TSC2 via its death domain and phosphorylates TSC2 to mediate mTORCI activation.Furthermore,both the kinase domain and death domain of DAPK1 are required for CD8^(+)T-cell antiviral responses in an LCMV infection model.Together,our data reveal a novel mechanism of mTORCI activation that mediates optimal CD8^(+)T-cell function and antiviral activity. | Zhengping Wei Pingfei Li Ran He Huicheng Liu Na Liu Yu Xia Guoyu Bi Qiuyang Du Minghui Xia Lei Pei Jing Wang Guihua Wang Zhao-Hui Tang Xiang Cheng Huabin Li Zhuoya Li Lilin Ye Arian Laurence Youming Lu Xiang-Ping Yang | 2021 | Cellular & Molecular Immunology2021，18，1： | 0 |
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