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| 1 | Heterotrimeric G protein α subunit is involved in rice brassinosteroid response显示文摘Heterotrimeric G proteins are known to function as messengers in numerous signal transduction pathways.The nullmutation of RGA(rice heterotrimeric G protein α subunit),which encodes the α subunit of heterotrimeric G proteinin rice,causes severe dwarfism and reduced responsiveness to gibberellic acid in rice.However,less is known aboutheterotrimeric G protein in brassinosteroid(BR)signaling,one of the well-understood phytohormone pathways.In thepresent study,we used root elongation inhibition assay,lamina inclination assay and coleoptile elongation analysis todemonstrated reduced sensitivity of dl mutant plants(caused by the null mutation of RGA)to 24-epibrassinolide(24-epiBL),which belongs to brassinosteroids and plays a wide variety of roles in plant growth and development.Moreover,RGA transcript level was decreased in 24-epiBL-treated seedlings in a dose-dependent manner.Our results show thatRGA is involved in rice brassinosteroid response,which may be beneficial to elucidate the molecular mechanisms of Gprotein signaling and provide a novel perspective to understand BR signaling in higher plants. | Lei Wang Yun-Yuan Xu Qi-Bin Ma Dan Li Zhi-Hong Xu Kang Chong | 2006 | Cell Research2006，16，12： | 29 |
| 2 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 3 | Circadian Evening Complex Represses Jasmonate-lnduced Leaf Senescence in Arabidopsis显示文摘 | Yuanyuan Zhang Yan Wang Hua Wei Na Li Wenwen Tian Kang Chong Lei Wang | 2018 | Molecular Plant2018，11，2： | 12 |
| 4 | Ferroptosis in cancer and cancer immunotherapy显示文摘The hallmark of tumorigenesis is the successful circumvention of cell death regulation for achieving unlimited replication and immortality.Ferroptosis is a newly identified type of cell death dependent on lipid peroxidation which differs from classical programmed cell death in terms of morphology,physiology and biochemistry.The broad spectrum of injury and tumor tolerance are the main reasons for radiotherapy and chemotherapy failure.The effective rate of tumor immunotherapy as a new treatment method is less than 30%.Ferroptosis can be seen in radiotherapy,chemotherapy,and tumor immunotherapy;therefore,fer-roptosis activation may be a potential strategy to overcome the drug resistance mechanism of traditional cancer treatments.In this review,the characteristics and causes of cell death by lipid peroxidation in ferroptosis are briefly described.In addition,the three metabolic regulations of ferroptosis and its crosstalk with classical signaling pathways are summarized.Collectively,these findings sug-gest the vital role of ferroptosis in immunotherapy based on the interaction of ferroptosis with tumor immunotherapy,chemotherapy and radiotherapy,thus,indicating the remarkable potential of ferroptosis in cancer treatment. | Lei Zhao Xiaoxue Zhou Feng Xie Lei Zhang Haiyan Yan Jun Huang Chong Zhang Fangfang Zhou Jun Chen Long Zhang | 2022 | Cancer Communications2022，42，2： | 10 |
| 5 | Lamivudine prophylaxis of liver allograft HBV reinfection in HBV related cirrhotic patients after liver transplantation显示文摘BACKGROUND: Liver allograft hepatitis B virus (HBV) reinfection and hepatitis B (HB) recurrence jeopardize the long-term survival of recipient and liver allograft. Lamivu- dine has been referred as a novel antiviral agent against HBV in HBV cirrhotic patients even in liver transplantation setting. We assessed the prophylatic effect of lamivudine on liver allograft HBV reinfection and clarified the dynamic changes of HBV markers in HBV related decompensated liver cirrhosis after liver transplantation. METHODS: Twenty-five recipients were divided into three groups: HBV active replication group (15 recipients), HBV inactive replication group (7), and control group (3). 100 mg/d lamivudine was administered preoperatively except in the control group. The HBV markers of serial sera and liver biopsy samples of the 25 recipients were evaluated re- gularly with enzyme-linked radioimmunoassay, HBV DNA fluorecent quantitative assay, immunohistochemical stain- ing , labelled streptavidin biotin ( LSAB) and digoxin la- belled HBV DNA hybridization in situ. The dynamic alter- nation of HBV markers under lamivudine prophylaxis was observed. RESULTS: In the HBV active replication group who had received lamivudine 2 weeks before liver transplantation, serum HBV DNA positive converted to negative by 80%. HBsAg of all recipients disappeared after liver transplanta- tion , but corresponding antibodies of HBV appeared within one week after the operation. HBsAb 9/15, HBcAb 13/15 and HBeAb 11/15 appeared and subsided gradually within 24 weeks. HBV DNA in sera was kept negative; HBsAg, HBcAg and HBV DNA hybridization in situ of liver biopsy samples remained negative after use of lamivudine. Ten of the 15 recipients showed clearance of HBV, and per se HBV markers were undetectable both in serum and liver bi- opsy samples between 12 to 44 weeks (24 weeks on ave- rage). The 1-, 2-year survival rates were 83% in this group. Two of the 15 recipients developed HBV allograft reinfection or recurrence of hepatitis 2 years after lamivudi- ne monoprophylaxis (2/15, 13.3%). In the HBV inactive replication group, the outcome was similar to that of the HBV active group. The HBV antibody frequency was HBs- Ab 4/7, HBcAb 6/7, and HBeAb 2/7. Three of 7 recipients showed HBV clearance both in sera and liver biopsy sam- ples , whereas in the control group all 3 recipients developed HBV allograft reinfection and recurrent hepatitis 8, 10, 12 months postoperatively; one of them died of fibrosing cho- lestatic hepatitis, and the remaining 2 recovered after addi- tional lamivudine therapy. The overall allograft reinfection rate was 9.1% (2/22) and the overall 1-, 2-year survival rates were 87%) in the lamivudine prophylaxis group. CONCLUSIONS: Lamivudine prophylaxis can prevent ef- fectively liver allograft from HBV reinfection in patients with HBV-related decompensated liver cirrhosis even in HBV active replication recipient after liver transplantation. Its long-term outcome remains to be studied. | Shi-Chun Lu, Lu-Nan Yan, Bo Li, Tian-Fu Wen, Ji-Chun Zhao, Nan-Sheng Cheng, Chong Liu, Jun Liu, Xiao-Bo Wang, Xiao-Dong Li, Shan Qin, Lian-Shan Zhao, Bin-Jun Lei and Xiu-Hui Zhang Chengdu, China Department of Surgery Viral Hepa- titis Research Center Department of Pathology , West China Hospital, Sichuan University, Cheng- du 610041 , China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，1： | 9 |
| 6 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，4： | 8 |
| 7 | Salmeterol attenuates the inflammatory response in asthma and decreases the pro-inflammatory cytokine secretion of dendritic cells显示文摘Salmeterol 是长行动的 β激活 adenylate cyclase 的 2 收缩筋,引起长持续的 bronchodilation 并且被用于许多年到控制气喘。然而,很少信息都不关于 salmeterol 的 immunoregulatory 效果是可得到的。我们发现 salmeterol 减少在表示了肿瘤坏死 factor-alpha, interleukin-1 和 interleukin-6 的质问变应原的老鼠的一个模型的支持 inflammatory cytokines 的生产。树枝状的房间(DC ) 是介绍抗原的房间并且在航线充当哨兵。我们发现了那 salmeterol (10 −5 mol/l ) 减少了 lipopolysaccharide 引起的发炎(0.1 µ g/ml ) 在激活的鼠科的骨头导出髓的 DC。而且,西方的污点证明这保护的效果被禁止通过原子 factor-kappa B 发信号部分调停(NF-κ B ) ,激活 mitogen 的蛋白质 kinase (MAPK ) 小径和津贴的戏剧性地减少的层次。我们建议 salmeterol 由 modulating DC 调整导致变应原的气喘的发炎。在结论,我们提供 DC 是为对气喘的 salmeterol 的行动负责的目标免疫者房间的证据。 | Zhenli Hu Ruohua Chen Zhijian Cai Lei Yu Yang Fei Lixia Weng Jinghan Wang Xiahui Ge Tianyi Zhu Jianli Wang Chong Bai | 2012 | Cellular & Molecular Immunology2012，9，3： | 8 |
| 8 | Expression of Recombinant Human Lysozyme-tachyplesin I(hLYZ-TP I)in Pichia Pastoris and Analysis of Antibacterial Activity显示文摘Antimicrobial peptides(AMPs)are making headlines in science because they demonstrate superior microbicidal characteristics compared to synthetic and semi-synthetic antibiotics [1].Importantly,AMPs kill pathogens via a different mechanism compared to antibiotics [2].Therefore, | GAO Yu ZHAO Hong Lei FENG Xin ZHAI Rui Dong ZHU Seng DU Chong Tao SUN Chang Jiang LEI Lian Cheng | 2013 | Biomedical and Environmental Sciences2013，26，4： | 7 |
| 9 | A new tripodal rhodamine B derivative as a highly selective and sensitive fluorescence chemosensor for copper(Ⅱ)显示文摘A new tripodal rhodamine B derivative 2 was designed and synthesized by tripodal trialdehyde and rhodamine B hydrazide for the first time. This derivative could be used as a fluorescent chemosensor for the selective and sensitive determination of copper(II) in Tris-HCl buffer and ethanol aqueous mixed media. Under the optimum conditions described herein,fluorescence enhancement at 557/577 nm was linearly related to the concentration of copper(II) in the range of 0.10 to 10.00×10-5 mol·L-1,with a corre-lation coefficient of R2=0.9964 (n=15) and a detection limit of 1.129×10-7 mol·L-1 (the relative standard deviation for five repeated measurements at 4.00×10-5 mol·L-1 Cu(II) was 2.2%). The absorbance meas-urements at 557 nm were linearly related to the concentration of Cu(II) in the range of 0.50 to 25.00×10-5 mol·L-1,with a correlation coefficient of R2=0.9948 (n=13) and a detection limit of 3.338×10-7mol·L-1. | ZENG Xi,WU Chong,DONG Lei,MU Lan,XUE SaiFeng & TAO Zhu College of Chemistry and Chemical Engineering ,Guizhou University,Guiyang 550003,China Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province,Guizhou University,Guiyang 550025,China | 2009 | Science China Chemistry2009，52，4： | 7 |
| 10 | The brassinosteroid signal transduction pathway显示文摘类固醇作为在动物和植物表明分子工作。当动物类固醇荷尔蒙被抄写因素的原子受体家庭察觉时,在植物的 brassinosteroids (BR ) 被房间表面受体 kinase 察觉, BRI1。最近的研究证明了到 BRI1 的细胞外的域的那 BR 绑定与另一受体 kinase 导致 kinase 激活和 dimerization, BAK1。激活的 BRI1 或 BAK1 然后调整,可能间接地, BIN2 kinase 的活动或 BSU1 磷酸酶,它直接调整 phosphorylation 地位和二个相应抄写因素, BZR1 和 BES1 的原子累积。BZR1 和 BES1 直接绑在 BR 应答的基因的倡导者调整他们的表示。表明小径的 BR 为在一般来说由房间表面受体发信号的植物和类固醇发信号的两受体 kinase 成为了一个范例。 | Zhi-Yong Wang Qiaomei Wang Kang Chong Fengru Wang Lei Wang Mingyi Bai Chengguo Jia | 2006 | Cell Research2006，16，5： | 7 |
| 11 | Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells显示文摘 | Chong Li Song Wu Zhao Yang Xiaolong Zhang Qi Zheng Ling Lin Zexiong Niu Ruiqiang Li Zhiming Cai Lei Li | 2017 | Cell Research2017，27，4： | 7 |
| 12 | Shenfu injection attenuates neurotoxicity of bupivacaine in cultured mouse spinal cord neurons显示文摘背景我们的以前的在里面在老鼠的 vivo 学习表明那 Shenfu 注射,从中国植物的临床上使用的摘录准备,稀释 bupivacaine 的静脉内的注入导致的神经、心脏的毒性,局部麻醉。这研究被设计调查 bupivacaine 是否能在主要有教养的老鼠导致有毒的效果针的绳索神经原并且如果那么, Shenfu 注射是否在房间模型有类似的 neuroprotective 效果。方法从 11- 的针的绳索到 14-day-old 胎儿的老鼠被切碎并且孵化。Cytarabine 被增加进媒介禁止 non-neuronal 房间的增长。导管素染色的 immunocytochemical 被用来决定有教养的房间的身份。有教养的神经原随机分别地被分配进与 bupivacaine, Shenfu 和 bupivacaine+Shenfu 的各种各样的剂量对待的三个集合,为 48 个小时。在每个组的房间生存能力被甲基 thiazoleterazolium (MTT ) 分析试金。有教养的神经原的生存能力在 0.01% , 0.02% , 0.04% 和 0.08% 的集中与 bupivacaine 对待的结果以一种剂量依赖者方式被减少。尽管在从 1/50 到 1/12.5 (V/V ) 的集中的 Shenfu 注射没在有教养的神经原(P0.05 对控制) 的生存能力上有重要影响,注射显著地与 0.03% bupivacaine (P0.05 ) 增加了有教养的神经原 pretreated 的细胞的生存能力。结论尽管 Shenfu 注射本身没在针的神经原上有效果,它能减少 bupivacaine 在 vitro 的导致的 neurotoxicity。 | XIONG Li-ze WANG Qiang LIU Mu-yun PENG Ye LI Qing-bo LU Zhi-hong LEI Chong | 2007 | Chinese Medical Journal2007，，22： | 7 |
| 13 | The influence of formation temperature on the solid electrolyte interphase of graphite in lithium ion batteries显示文摘Lithium-ion battery has greatly changed our lifestyle and the solid electrolyte interphase(SEI)covered on the graphite anode determines the service life of a battery.The formation method and the formation temperature at initial cycle of a battery determine the feature of the SEI.Herein,we investigate the gap of formation behavior in both a half cell(graphite matches with lithium anode)and a full cell(graphite matches with NCM,short for LiNixCoyMn1-x-yO2)at different temperatures.We conclude that high temperature causes severe side reactions and low temperature will result in low ionic conductive SEI layer,the interface formed at room temperature owns the best ionic conductivity and stability. | Chong Yan Yu-Xing Yao Wen-Long Cai Lei Xu Stefan Kaskel Ho Seok Park Jia-Qi Huang | 2020 | Journal of Energy Chemistry2020，29，10： | 6 |
| 14 | Crystal Structure of the MH2 domain of Drosophila Mad显示文摘The decapentaplegic(Dpp),a member of the TGF-β superfamily,plays a pivotal role in the control of proliferation,global patterning and induction of specific cell fates during Drosophila development.Mother against Dpp(Mad) is the founding member of the conserved Smad protein family which spe-cifically transduces the intracellular TGF-β signaling cascade.Here we report the 2.80 structure of the MH2 domain of Mad(Mad-MH2) that was readily superposed to the mammal Smad-MH2 structures.This unphosphorylated Mad-MH2 forms a symmetric homotrimer in crystals,consistent with the result of the size-exclusion chromatography that Mad-MH2 exhibited a propensity for concentration-dependent oligomerization prior to phosphorylation.Structural analysis revealed that the formation of homotrimeric Mad-MH2 is mainly mediated by contacts involving the extreme C-terminal SSVS motif,and is strengthened by phosphorylation of the last two Ser residues which was confirmed by the gel filtration analysis of the pseudophosphorylated Mad-MH2(DVD).Intriguingly,the homotrimer within an asymmetric unit only possesses two ordered C-terminal tails,reminiscent of the arrangement of the R-Smad/Smad4 complexes,indicating that the subunit with a flexible SSXS motif would be readily replaced by Co-Smad to form a functional heterotrimer. | WANG Chong,CHEN Lei,WANG Le & WU JiaWei MOE Key Laboratory of Bioinformatics,Department of Biological Sciences and Biotechnology,Tsinghua University,Beijing 100084,China | 2009 | Science China(Life Sciences)2009，52，6： | 5 |
| 15 | miRNA deregulation in multiple myeloma显示文摘多重骨髓瘤(公里) 是医不好的血浆房间恶意并且是第二很普通的 hematological 癌症。它被建筑群描绘,周期性基因并且 epigenetic 畸形。最近的出版物连接了 miRNAs,到包括公里的癌症的基因管理者的一个新奇的班。miRNAs 是大约 20 核苷酸,单个海滨,镇压的非编码的 RNA 由 mRNA 的基因表示降级或翻译压抑。异常 miRNA 表示侧面在公里被描述了,并且他们在公里致病的功能的角色逐渐地正在被认出。这评论在公里管理在未来研究和 miRNAs 的利用上在公里和提议观点在 miRNAs 的角色上总结当前的文学。 | BI Chong Lei CHNG Wee Joo | 2011 | Chinese Medical Journal2011，，19： | 5 |
| 16 | Position tracking and attitude control for quadrotors via active disturbance rejection control method显示文摘In this paper, a trigonometric-saturation-function-based position controller is designed for the quadrotor system with internal and external disturbances. Furthermore, in the attitude control problem, a dual closed-loop structure is put forward. Specifically, a nonlinear extended-state-observer(ESO) is employed to provide an estimate for the so-called total disturbance. Then, based on the estimate provided by the ESO,a nonlinear composite control strategy is designed for the purpose of angular tracking. Some sufficient conditions are established to guarantee that the position and attitude subsystems are stable. The contributions are mainly as follows.(1) A trigonometric-saturation-function is used in the position control which could guarantee that the studied system is fully-actuated.(2) The nonlinear ESO is implemented in the attitude control-loop which could enhance the anti-disturbance property. Finally, some numerical simulations and practical experiments are provided to verify the applicability of the proposed methodology. | Yuan YUAN Lei CHENG Zidong WANG Chong SUN | 2019 | Science China(Information Sciences)2019，62，1： | 5 |
| 17 | One Step Quick Detection of Cancer Cell Surface Marker by Integrated NiFe-based Magnetic Biosensing Cell Cultural Chip显示文摘RGD peptides has been used to detect cell surface integrin and direct clinical effective therapeutic drug selection. Herein we report that a quick one step detection of cell surface marker that was realized by a specially designed NiF e-based magnetic biosensing cell chip combined with functionalized magnetic nanoparticles. Magnetic nanoparticles with 20-30 nm in diameter were prepared by coprecipitation and modified with RGD-4C, and the resultant RGD-functionalized magnetic nanoparticles were used for targeting cancer cells cultured on the NiF e-based magnetic biosensing chip and distinguish the amount of cell surface receptor-integrin.Cell lines such as Calu3, Hela, A549, CaF br, HEK293 and HUVEC exhibiting different integrin expression were chosen as test samples. Calu3, Hela, HEK293 and HUVEC cells were successfully identified. This approach has advantages in the qualitative screening test. Compared with traditional method, it is fast, sensitive, low cost,easy-operative, and needs very little human intervention. The novel method has great potential in applications such as fast clinical cell surface marker detection, and diagnosis of early cancer, and can be easily extended to other biomedical applications based on molecular recognition. | Chenchen Bao Lei Chen Tao Wang Chong Lei Furong Tian Daxiang Cui Yong Zhou | 2013 | Nano-Micro Letters2013，5，3： | 5 |
| 18 | In-situ determination of onset lithium plating for safe Li-ion batteries显示文摘Lithium plating in working batteries has attracted wide attention in the exploration of safe energy storage. Establishing an effective and rapid early-warning method is strongly considered but quite challenging since lithium plating behavior is determined by diverse factors. In this contribution, we present a non-destructive electrochemical detection method based on transient state analysis and threeelectrode cell configuration. Through dividing the iR drop value by the current density, the as-obtained impedance quantity(R_(i)) can serve as a descriptor to describe the change of electrochemical reaction impedance on the graphite anode. The onset of lithium plating can be identified from the sharp drop of R_(i). Once the dendritic plated lithium occurs, the extra electrochemical reactions at the lithium interfaces leads to growing active area and reduced surface resistance of the anode. We proposed a protocol to operate the batteries under the limited capacity, which renders the cell with 98.2% capacity retention after 1000 cycles without lithium plating. The early-warning method has also been validated in in-situ optical microscopy batteries and practical pouch cells, providing a general but effective method for online lithium plating detection towards safe batteries. | Lei Xu Yi Yang Ye Xiao Wen-Long Cai Yu-Xing Yao Xiao-Ru Chen Chong Yan Hong Yuan Jia-Qi Huang | 2022 | Journal of Energy Chemistry2022，31，4： | 4 |
| 19 | Green Tea Polyphenols Alleviate Autophagy Inhibition Induced by High Glucose in Endothelial Cells显示文摘Bovine aortic endothelial cells(BAECs)were cultured with high glucose(33 mmol/L),4 mg/L green tea polyphenols(GTPs)or 4 mg/L GTPs co-treatment with high glucose for 24 h in the presence or absence of Bafilomycin-A1(BAF).We observed that high glucose increased the accumulation of LC3-II.Treatment with BAF did not further increase the accumulation of LC3-II.Results also showed an increased level of p62 | ZHANG Pi Wei TIAN Chong XU Fang Yi CHEN Zhuo Raynard BURNSIDE YI Wei Jie XIANG Si Yun XIE Xiao WU Nan Nan YANG Hui ZHAO Na Na YE Xiao Lei YING Chen Jiang | 2016 | Biomedical and Environmental Sciences2016，29，7： | 3 |
| 20 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
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