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| 1 | 肠道菌群衍生的短链脂肪酸促进老年小鼠的脑卒中后恢复显示文摘老年人在脑卒中后经历了严重的全身反应,这导致了更高的死亡率和更严重的长期残疾。最近的研究表明,肠道微生物群的组成可以影响脑卒中的预后。然而,在损伤后肠道微生物群对预后影响的潜在益处尚不清楚。为了确定脑卒中后年轻肠道微生物是否有助于老年受试者的康复,研究者通过年轻粪便移植灌胃(young fecal transplant gavage,young FTG)改变了实验性脑卒中后老年小鼠的肠道微生物群。 | 刘青(译) 刘莉(摘/审校) Lee J d’Aigle J Atadja L | 2020 | 中华高血压杂志2020，28，6： | 12 |
| 2 | Molecular targets in the treatment of alcoholic hepatitis显示文摘Alcohol related costs to health and society are high. One of the most serious complications of alcohol misuse to the individual is the development of alcoholic hepatitis (AH), a clinical syndrome of jaundice and progressive inflammatory liver injury in patients with a history of recent heavy alcohol use. It has a poor outcome and few existing successful therapies. The use of glucocorticoids in patients with severe AH is still controversial and there remains a group of patients with glucocorticoid-resistant disease. However, as our understanding of the pathogenesis of the condition improves there are opportunities to develop new targeted therapies with specific actions to control liver inflammation without having a detrimental effect on the immune system as a whole. In this article we review the molecular mechanisms of AH concentrating on the activation of the innate and adaptive immune response. We consider existing treatments including glucocorticoids, anti-tumor necrosis factor therapy and pentoxifylline and their limitations. Using our knowledge of the disease pathogenesis we discuss possible novel therapeutic approaches. New targets include pro-inflammatory cytokines such as interleukin (IL)-17, chemokines and their receptors (for example IL-8, CXCL9 and CXCR3) and augmentation of anti-inflam- matory molecules such as IL-10 and IL-22. And there is also future potential to consider combination therapy to selectively modulate the immune response and gain control of disease. | Ashwin D Dhanda Richard WL Lee Peter L Collins C Anne McCune | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 3 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 4 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 5 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 6 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 7 | An effective stress model for liquefaction显示文摘 | Finn W D L Lee K W Martin G R | 1977 | Journal of the Geotechnical Engineering Division ASCE1977，103，6： | 2 |
| 8 | Biotin synthase from Escherichia coli,an investigation of the low molecular weight and protein components required for activity in Vitro显示文摘 | Sanyal L Lee S L Flint D H | 1994 | J Am Chem Soc1994，116，： | 1 |
| 9 | Composition and accumulation of secondary carotenoids in Chlorococcum sp显示文摘 | LEE Y K NG M L PHANG S M | 1997 | J Appl Phycol1997，9，： | 1 |
| 10 | Characterization and distribution of metals in surficial sediments in Sontheastern Taiwan显示文摘 | Lee C L Fang M D Hsich M T | 1998 | Marine Pollution Bulletin1998，36，6： | 1 |
| 11 | Growth retardation and premature aging phenotypes in mice with disruption of the SNF2- like gene, PASC显示文摘 | SUN L Q LEE D W ZHANG Q | 2004 | Genes & Development2004，18，9： | 1 |
| 12 | Effect of heat treatment path on the cold formability of drawn dual-phase steels 显示文摘 | Park K S Park K T Lee D L | 2007 | Materials Science and Engineering : A2007，，： | 1 |
| 13 | Potential DC system support to enhance AC system performance in the Western United States显示文摘 | LEE R L MELVOID D J SZOMLAS D J | 1993 | IEEE Trans on Power Systems1993，8，1： | 1 |
| 14 | Sludge chemical composition changes under uni-directional freezing 显示文摘 | Huang W T Chang I L Lee D J | 1996 | Water Science and Technology1996，34，34： | 1 |
| 15 | Gas chromatography-mass spectrometric and nuclear magnetic resonance determination of polynuclear aromatic hydrocarbons in airborne particulates 显示文摘 | LEE M L NOVOTNY M BARTLE K D | 1976 | Anal Chem1976，48，： | 1 |
| 16 | Quay crane scheduling with noninterference constraints in port container terminals显示文摘 | Lee D H Wang H Q Miao L | 2008 | Transportation Research Part E: Logistics and Transportation Review2008，44，1： | 1 |
| 17 | Project evaluation in the presence of multiple embedded real options-evidence from the Taiwan high-speed rail project显示文摘 | Bowe M Lee D L | 2004 | Journal of Asian Economics2004，15，： | 1 |
| 18 | Quality of minimally processed apple slices from selected cultivars 显示文摘 | Kim D M Smith N L Lee C Y | 1993 | Journal of Food Science1993，58，5： | 1 |
| 19 | Development of the as-cast microstructure in magnesium?aluminium alloys 显示文摘 | DAHLE K A LEE Z C NAVE M D SCHAFFER P L JOHNSON D H | 2001 | Light Metals2001，，1： | 1 |
| 20 | Expression of versican 3'?untranslated region modulates endogenous microRNA functions 显示文摘 | Lee D Y Jeyapalan Z Fang L | 2010 | PLoS One2010，5，13： | 1 |
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