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| 1 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 2 | Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes显示文摘 | Zeng, X. N. Sun, X. L. Gao, L. Fan, Y. Ding, J. H. Hu, G. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 20 |
| 3 | GIS-based risk analysis of debris flow:an application in Sichuan,southwest China显示文摘Debris flow is a serious geologic hazard in China.It is estimated that nationally debris flows cause up to 2 billion RMB(250 million US$) in damages and 300-600 deaths and injuries annually.To mitigate debris flow hazards,it is necessary to map,model,and identify zones of debris flow hazards and vulnerability as to inform the local people about the potential risk with a geographic information system.This research presents a regional scale case study modeling debris flow risk(hazard and vulnerability) in Sichuan Province,Southwestern China.In this area,3,290 debris flows have been identified and the spatial-temporal distribution and activity characteristics of them have been documented.Based on the available meteorological data,a Digital Elevation Model with the rate of 1:250,000 and a regional geological map,the 24-hr rainfall threshold(y) for debris flow occurrence is closely related(significant at 99% confidence level) to the index(x) defined using a geology factor(rock hardness:a) and a topographical factor(channel gradient:d) where y = 21 + 10200 / x,in which x = 2.7 × ea + 1000 × d.The discipline is constructive in developing the rainfall threshold for debris flow activity in remote mountainous areas that lack data.For a given watershed,a four-level debris flow hazard map is developed by comparing the rainfall threshold to the design rainfall intensities with 50-,20-,and 5-year average recurrence intervals,respectively.The degree of debris flow vulnerability is determined by the watershed socio-economic conditions.A four-class debris flow risk map,at the final phase of the research,is generated by combining debris flow hazards and vulnerability.With the debris flow risk assessment,the Sichuan Province is classified into the slight,moderate,severe and very severe regions,which accounts for 36%,19%,20% and 25% of total area respectively. | B. F. DI N. S. CHEN P. CUI Z. L. LI Y. P. HE Y. C. GAO | 2008 | International Journal of Sediment Research2008，23，2： | 19 |
| 4 | Late Cenozoic high-resolution magnetostratigraphy in the Kunlun Pass Basin and its implications for the uplift of the northern Tibetan Plateau显示文摘The Kunlun Pass Basin, located in the middle of the eastern Kunlun Mountains, received relatively continuous late Cenozoic sediments from the surrounding mountains, archiving great information to understand the deformation and uplift histories of the northern Tibetan Plateau. The Kunlun-Yellow River Movement, identified from the tectonomorphologic and sedimentary evolution of the Kunlun Pass Basin by Cui Zhijiu et al. (1997, 1998), is roughly coincident with many important global and Plateau climatic and environmental events, becoming a crucial time interval to understand tectonic-climatic interactions. However, the ages used to constrict the events remain great uncertainty. Here, we present the results of detailed magnetostratigraphy of the late Cenozoic sediments in the Kunlun Pass Basin, which show the basin sediments were formed between about 3.6 Ma and 0.5 Ma and the Kunlun-Yellow River Movement occurred at 1.2 to ~0.78 Ma. The lithology, sedimentary facies and lithofacies associations divide the basin into five stages of tectonosedimentary evolution, indicating the northern Tibetan Plateau having experienced five episodes of tectonic uplifts at ~3.6, 2.69-2.58, 1.77, 1.2, 0.87 and ~0.78 Ma since the Pliocene. | SONG Chunhui GAO Dongling FANG Xiaomin CUI Zhijiu LI Jijun YANG Shengi JIN Hongbo Douglas Burbank Joseph L. Kirschvink | 2005 | Chinese Science Bulletin2005，50，17： | 10 |
| 5 | Core Collection Based Backcrossing: An Eff icient Approach for Breeding, Germplasm Enhacement and Gene Discovery显示文摘Plant germplasm underpins much of crop development. Millions of germplasm accessions have been collected and conserved ex situ, and the major challenge is now how to exploit and utilize this abundant resource. | J.Z. Jia R.H. Zhou X.Y. Zhang L. Zhang Y.L. Li J. Wang X.Z. Liu L.F. Gao S.B. Liu | 2007 | 分子植物育种2007，5，2： | 8 |
| 6 | GELCASTING OF NANO-SIZE Y-TZP显示文摘GELCASTINGOFNANO-SIZEY-TZPJ.Sun;L.Gao;J.K.GuoandD.S.Yan(StateKeyLab.ofHighPerformanceCeramicsandSuperfineMicrostructure,Shang... | J.Sun L. Gao J.K. Guo and D.S. Yan (State Key Lab.of High PerformanceCeramics and Superfine Microstructure, Shanghai Institute of Ceram ics, Chinese Academy of Sciences, Shanghai 200050, China ) | 1996 | Acta Metallurgica Sinica(English Letters)1996，9，6： | 7 |
| 7 | Effects of PI3-k/Akt short hairpin RNA on proliferation, fibronectin production and synthesis of thrombospondin-1 and transforming growth factor-beta(1 ) in glomerular mesangial cells induced by sublytic C5b-9 complexes显示文摘 | Gao, L. Zhang, Y. Qiu, W. Xu, W. Feng, X. Ren, J. Jiang, X. Wang, H. Zhao, D. Wang, Y. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 5 |
| 8 | Effect of ablation of complex fractionated atrial electrogram on vagal modulation in dogs显示文摘背景临床的观察证明了复杂 fractionated atrial 电记录图(CFAE ) 在心脏的自治神经系统与 ganglionated 丛活动联系。这研究试图在 vagal 调整上调查 CFAE 脱离的影响到正厅和危险开发 atrial 纤维性颤动(AF ).Methods 十条成年杂种狗被包含。颈的 sympathovagal 箱子被分散,同情的效果被堵住。CFAE 是在 atrial 3-dimensional 图象上标注并且加 sympathovagal 箱子刺激在 S1S2 导致的 AF 期间切除了规划刺激的颜色。Atrial 有效倔强的时期(ERP ) 和 AF 的危险窗户(VW ) 在 4 个中庭地点在基线上并且在 vagal 刺激被测量。连续织物节从夺格并且控制标本收到了 hematoxylin 并且曙红染色因为显微镜的 examination.Results 大多数 CFAE 区域在正确上级是局部性的肺的象限,远侧的冠的湾穴(CSd ) 象限,和近似冠的湾穴(CSp ) 象限(21.74% ,独立) 。弄短的湾穴节奏周期长度(SCL ) 没在这些地点在脱离以后显著地减少,包括正确 atrial 附器,左 atrial 附器, CSd,和 CSp (P 0.05 ) 。显著地在 vagal 刺激期间弄短的 ERP 在脱离(P 0.01 ) 以后减少了;到 vagal 刺激的 VW 显著地在脱离(P 0.05 ) 以后减少了。在 ablation.Conclusions CFAE 以后改变的单个 ganglia 的建筑学在狗有一个自治基础。在 CFAE 脱离以后弄短到 vagal 刺激的减少的 SCL 和 ERP 证明那 CFAE 脱离稀释 vagal 调整到正厅,从而压制 AF 由提高的 vagal 调停了活动。CFAE 脱离能压制 AF 由提高的 vagal 调停了活动。 | ZHANG Shu-long DONG Ying-xue JIANG Peng GAO Lian-jun CHA Yong-mei Douglas L. Packer XIA Yun-long YIN Xiao-meng CHANG Dong YANG Yan-zong | 2010 | Chinese Medical Journal2010，，22： | 5 |
| 9 | A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma显示文摘 | Cun Wang Haojie Jin Dongmei Gao Liqin Wang Bastiaan Evers Zheng Xue Guangzhi Jin Cor Lieftink Roderick L. Beijersbergen Wenxin Qin Rene Bernards | 2018 | Cell Research2018，28，6： | 4 |
| 10 | Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest显示文摘 | Meng, Z. X. Nie, J. Ling, J. J. Sun,J. X. Zhu,Y. X. Gao,L. Lv,J. H. Zhu,D. Y. Sun,Y. J. Han,X. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 4 |
| 11 | Hepatitis B virus reactivation after radiofrequency ablation or hepatic resection for HBV-related small hepatocellular carcinoma: A retrospective study显示文摘 | J.-Q. Dan Y.-J. Zhang J.-T. Huang M.-S. Chen H.-J. Gao Z.-W. Peng L. Xu W.Y. Lau | 2013 | European Journal of Surgical Oncology2013，，8： | 4 |
| 12 | The level of oncogene H-Ras correlates with tumorigenicity and malignancy显示文摘Normal bovine adrenocortical cells and some human fibroblasts can be transformed by SV40T and H-Ras in a Ras-dependent manner. We recently reported that high levels of Ras derived from 5' LTR of retrovirrus can induce highly malignant and fast growing tumors, while lower levels of Ras derived from internal ribosome entry site(IRES) promotes slower tumor growth and loss of malignancy. Ras derived from CMV promoters resulted in much lower Ras levels and loss of tumor malignancy and growth. Further studies showed that the tumors formed in the presence of lower levels of Ras and dominant negative P53(P53DD) had fewer apoptotic cells and grew faster than the tumors formed from cells with same level Ras and SV40T. Our studies suggest that low levels of Ras are insufficient to inhibit apoptosis induced by pRb inactivation. In contrast, high levels of Ras not only allow normal cells to exit senescence and form tumors, but also protect against pRb inhibition-induced cell apoptosis. | Sun, B. C. Gao, Y. Deng, L. Li, G. Q. Cheng, F. Wang, X. H. Nanjing Med Univ, Liver Transplantat Ctr, Affiliated Hosp 1, Jiangsu 210029, Peoples R China. Nanjing Med Univ, Liver Transplantat Ctr, Ctr Canc, Jiangsu 210029, Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 3 |
| 13 | Extension/Compression-Controlled Complete Band Gaps in 2D Chiral Square-Lattice-Like Structures显示文摘Achieving tunable band gaps in a structure by external stimuli is of great importance in acoustic applications. This paper aims to investigate the tunability of band gaps in square-lattice-like elastic periodic structures that are usually not featured with notable band gaps.Endowed with chirality, the periodic structures here are able to undergo imperfection-insensitive large deformation under extension or compression. The influences of geometric parameters on band gaps are discussed via the nonlinear finite element method. It is shown that the band gaps in such structures with curved beams can be very rich and, more importantly, can be efficiently and robustly tuned by applying appropriate mechanical loadings without inducing buckling. As expected, geometry plays a more significant role than material nonlinearity does in the evolution of band gaps. The dynamic tunability of band gaps through mechanical loading is further studied. Results show that closing, opening, and shifting of band gaps can be realized by exerting real-time global extension or compression on the structure. The proposed periodic structure with well-designed chiral symmetry can be useful in the design of particular acoustic devices. | Y. L. Huang N. Gao W.Q. Chen R.H. Bao | 2018 | Acta Mechanica Solida Sinica2018，31，1： | 3 |
| 14 | Microstructure characteristics of nanophase composite synthesized by mechanical alloying of immiscible Pb-Al and Fe-Cu systems显示文摘 | M. Zhu B.L. Li Y. Gao L. Li K.C. Luo H.X. Sui Z.X. Li | 1997 | Scripta Materialia1997，，4： | 2 |
| 15 | Study on the relationship between structure and enantioselectivity of a hyperthermophilic esterase from archaeon Aeropyrum pernix K1显示文摘 | Zhang, G. R. Gao, R. J. Zheng, L. Y. Zhang, A. J. Wang, Y. H. Wang, Q. Y. Feng, Y. Cao, S. G. | 2007 | 中国生物学文摘2007，21，4： | 2 |
| 16 | Deregulated expression of Notch receptors in human hepatocellular carcinoma显示文摘 | J. Gao Z. Song Y. Chen L. Xia J. Wang R. Fan R. Du F. Zhang L. Hong J. Song X. Zou H. Xu G. Zheng J. Liu D. Fan | 2007 | Digestive and Liver Disease2007，，2： | 2 |
| 17 | Deposition and transport of functionalized carbon nanotubes in water-saturated sand columns显示文摘 | Yuan Tian Bin Gao Yu Wang Verónica L. Morales Rafael Mu?oz Carpena Qingguo Huang Liuyan Yang | 2012 | Journal of Hazardous Materials2012，，： | 2 |
| 18 | Analysis of the Complete Genome of Tembusu Virus, a Flavivirus Isolated from Ducks in China显示文摘 | Y. Tang Y. Diao X. Gao C. Yu L. Chen D. Zhang | 2011 | Transboundary and Emerging Diseases2011，，4： | 2 |
| 19 | Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: A role for Nrf2 in vascular protection in diabetes显示文摘 | M. He R.C.M. Siow D. Sugden L. Gao X. Cheng G.E. Mann | 2010 | Nutrition, Metabolism and Cardiovascular Diseases2010，，4： | 2 |
| 20 | Dietary Lycium barbarum Polysaccharide Induces Nrf2/ARE Pathway and Ameliorates Insulin Resistance Induced by High-Fat via Activation of PI3K/AKT Signaling显示文摘 | Yi Yang Wang Li Yan Li Qing Wang Ling Gao Jiajun Zhao José L. Quiles | 2014 | Oxidative Medicine and Cellular Longevity2014，，： | 2 |
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