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| 1 | Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model显示文摘瞄准:Sildenafil, phosphodiesterase 5 (PDE5 ) 禁止者,被显示了在心失败施加有益的效果。这研究的目的是测试 sildenafil 是否压制了横向小管的(T 小管) 在左改变室(LV ) 失败并且从而提供治疗学的 benefits.Methods:一个压力导致超载的鼠科的心失败模型被胸的大动脉的 banding (标签) 在老鼠建立。在标签以后的一天,鼠标收到了 sildenafil (100 mg· kg −1·d−1, sc ) 或为 5 个星期盐。在处理的结束, echocardiography 被用来检验 LV 功能。然后,未经触动的心外面被把并且把房间放在 Langendorff 灌注为在 situ 从 epicardial myocytes.Results 的 T 小管超微结构的共焦的成像:标签外科导致了改变的显著 T 小管伴随的心失败。Sildenafil 处理显著地稀释了导致标签的心脏的肥大和充血的心失败,改进了 LV 可收缩的功能,并且保存了在 LV cardiomyocytes 的 T 小管正直。但是 sildenafil 处理显著地没影响房间膨胀。LV T 小管结构的完整与心脏的肥大被相关(R 2=0.74, P< 0.01 ) 并且全球 LV 功能(R 2=0.47, P< 0.01 ).Conclusion:Sildenafil 有效地改善在标签老鼠改变的 LV T 小管,揭示在心失败位于 sildenafil 的治疗学的好处下面的新奇机制。 | Chun-kai HUANG Bi-yi CHEN Ang GUO Rong CHEN Yan-qi ZHU William KUTSCH KE Jiang HONG Long-sheng SONG | 2016 | Acta Pharmacologica Sinica2016，37，4： | 2 |
| 2 | Lethal granuloma disintegration in mycobacteria-infected TNFRp55-/- mice is dependent on T cells and IL-12显示文摘 | Ehlers S Kutsch S Ehlers E M | 2000 | J Immunol2000，165，： | 1 |
| 3 | The effect of intervening conditions on the management of project risk显示文摘 | Kutsch E | 2008 | International Journal of Managing Projects in Business2008，1，4： | 1 |
| 4 | Benveniste EN tumor necrosis factor-related apoptosis-inducing ligand induces caspase-dependent interleukin-8 expression and apoptosis in human astroglioma cells显示文摘 | Choi C Kutsch O Park J | 2002 | Mol Cell Biol2002，22，3： | 1 |
| 5 | The international prognostic index for patients with chronic lymphocytic leukaemia(CLL-IPI):an international meta-analysis显示文摘 | Bahlo J Kutsch N Bergmann M | 2015 | Hematol Oncol2015，33，1： | 1 |
| 6 | Microphthalmia with linearskin defects syndrome (MLS) : a male with a mosaic paracentric in- version of Xp显示文摘 | Kutsche K Wemer W Bartsch O | 2002 | Cytogenet Genome Res2002，99，14： | 1 |
| 7 | Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response显示文摘 | Ivan Grskovic Anna Kutsch Christian Frie Gergely Groma Jacek Stermann Ursula Schl?tzer‐Schrehardt Anja Niehoff Stephen E Moss Sabrina Rosenbaum Ernst P?schl Markus Chmielewski Gunter Rappl Hinrich Abken John F Bateman Kathryn SE Cheah Mats Paulsson Bent B | 2012 | J Bone Miner Res2012，，11： | 1 |
| 8 | Abnormal renalphenotype in L1 knockout mice: a novel cause of CAKUT 显示文摘 | Debiec H Kutsche M Schachner M | 2002 | Nephrol Dial Transplant2002，17，9： | 1 |
| 9 | Expression patterns of Wnt genes in mouse gut development 显示文摘 | Liekert H Kispert A Kutsch S Kemler R | 2001 | Mech Dev2001，105，12： | 1 |
| 10 | Fatal granuloma necrosis without exacerbated mycobacterial growth in tumor necrosis factor receptor p55gene-deficient mice intravenously infected with Mycobacterium avium显示文摘 | Ehlers S J Benini S Kutsch R | 2000 | Infect Immun2000，68，7： | 1 |
| 11 | New directions in the etiology of dental caries disease显示文摘 | Kutsch VK Young DA | 2011 | J Calif Dent Assoc2011，39，10： | 1 |
| 12 | Response of mycorrhizal,rhizosphere and soil basal respiration to temperature and photosynthesis in a barley field显示文摘 | Moyano F E Kutsch W L Schulze E D | 2007 | Soil Biology and Biochemistry2007，39，4： | 1 |
| 13 | Nef- mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV- 1显示文摘 | SCHINDLER M MUNCH J KUTSCH O | 2006 | Cell2006，125，6： | 1 |
| 14 | Microdentistry:A New Standard of Care显示文摘 | Kutsch VK | 1999 | J Mass Dent Soc1999，47，4： | 1 |
| 15 | Leaf litter nitrogen concentration as related to climatic factors in Eurasian forests显示文摘 | LIU C BERG B KUTSCH W | 2006 | Global Ecology and Biogeography2006，15，： | 1 |
| 16 | Federated information systems:concepts,terminology and architectures显示文摘 | Susanne Busse Ralf-Detlef Kutsche Ulf Leser | 1999 | Forschunsberichte des Fachbereichs Informatik Bericht1999，99，9： | 1 |
| 17 | Field measurements of root respiration and total soil respiration in an alder forest显示文摘 | Kutsch W L Staack A Wtzel J | 2001 | New Phytologist2001，150，： | 1 |
| 18 | Response of mycorrhizal, rhizosphere and soil basal respiration to temperature and photosynthesis in a barley field 显示文摘 | Moyano F E Kutsch W L Schulze E D | 2007 | Soil Biology and Biochemistry2007，39，4： | 1 |
| 19 | A function for AAMP in Nod2-mediated NF-kappaB activation显示文摘 | Bielig H Zurek B Kutsch A | 2009 | Mol Immunol2009，46，13： | 1 |
| 20 | SAXS and TEM investigations on thermoplastic nanocomposites containing functionalized silica nanoparticles显示文摘 | Becker C Kutsch B Krug H | 1998 | J Sol-Gel Sci Techn1998，13，： | 1 |
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