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| 1 | Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer显示文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers. | Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 6 |
| 2 | Risk factors of electrocoagulation syndrome after esophageal endoscopic submucosal dissection显示文摘AIM To investigate post endoscopic submucosal dissection electrocoagulation syndrome(PEECS) of the esophagus.METHODS We analyzed 55 consecutive cases with esophageal endoscopic submucosal dissection for superficial esophageal squamous neoplasms at a tertiary referral hospital in South Korea. Esophageal PEECS was defined as 'mild' meeting one of the following criteria without any obvious perforation: fever(≥ 37.8 ℃), leukocytosis(> 10800 cells/μl), or regional chest pain more than 5/10 points as rated on a numeric pain intensity scale. The grade of PEECS was determined as 'severe' when meet two or more of above criteria.RESULTS We included 51 cases without obvious complications in the analysis. The incidence of mild and severe esophageal PEECS was 47.1% and 17.6%, respectively. Risk factor analysis revealed that resected area, procedure time, and muscle layer exposure were significantly associated with PEECS. In multivariate analysis, a resected area larger than 6.0 cm^2(OR = 4.995, 95%CI: 1.110-22.489, P = 0.036) and muscle layer exposure(OR = 5.661, 95%CI: 1.422-22.534, P = 0.014) were independent predictors of esophageal PEECS. All patients with PEECS had favorable outcomes with conservative management approaches, such as intravenous hydration or antibiotics.CONCLUSION Clinicians should consider the possibility of esophageal PEECS when the resected area exceeds 6.0 cm^2 or when the muscle layer exposure is noted. | Dae Won Ma Young Hoon Youn Da Hyun Jung Jae Jun Park Jie-Hyun Kim Hyojin Park | 2018 | World Journal of Gastroenterology2018，24，10： | 3 |
| 3 | Stereotactic body radiation therapy for inoperable hepatocellular carcinoma as a local salvage treatment after incomplete transarterial chemoembolization显示文摘 | Jin‐Kyu Kang Mi‐Sook Kim Chul Koo Cho Kwang Mo Yang Hyung Jun Yoo Jin Ho Kim Sun Hyun Bae Da Hoon Jung Kum Bae Kim Dong Han Lee Chul Ju Han Jin Kim Su Cheol Park Young Han Kim | 2012 | Cancer2012，，21： | 3 |
| 4 | Effect of esmolol and lidocaine on agitation in awake phase of anesthesia among children:a double-blind,randomized clinical study显示文摘Background:Sevoflurane is widely used to anesthetize children because of its rapid action with minimal irritation of the airways.However,there is a high risk of agitation after emergence from anesthesia.Strabismus surgery,in particular,can trigger agitation because patients have their eyes covered in the postoperative period.The aim of this study was to determine whether or not esmolol and lidocaine could decrease emergence agitation in children.Methods:Eighty-four patients aged 3 to 9 years undergoing strabismus surgery were randomly assigned to a control group(saline only),a group that received intravenous lidocaine 1.5 mg/kg,and a group that received intravenous esmolol 0.5 mg/kg and lidocaine 1.5 mg/kg.Agitation was measured using the objective pain score,Cole 5-point score,and Richmond Agitation Sedation Scale score at the end of surgery,on arrival in the recovery room,and 10 and 30 min after arrival.Results:The group that received the combination of esmolol and lidocaine showed lower OPS and RASS scores than the other two groups when patients awoke from anesthesia(OPS=0(0-4),RASS=-4[(-5)-1])and were transferred to the recovery room(OPS=0(0-8),RASS=-1[(-5)-3])(P<0.05).There was no significant difference in the severity of agitation among the three groups at other time points(P>0.05).Conclusions:When pediatric strabismus surgery is accompanied by sevoflurane anesthesia,an intravenous injection of esmolol and lidocaine could alleviate agitation until arrival in the recovery room. | Jae Young Ji Jin Soo Park Ji Eun Kim Da Hyung Kim Jin Hun Chung Hea Rim Chun Ho Soon Jung Sie Hyeon Yoo | 2019 | Chinese Medical Journal2019，，7： | 3 |
| 5 | Secondary endoscopic submucosal dissection for locally recurrent or incompletely resected gastric neoplasms显示文摘AIM To investigate the feasibility and safety of secondary endoscopic submucosal dissection(ESD) for residual or locally recurrent gastric tumors. METHODS Between 2010 and 2017, 1623 consecutive patients underwent ESD for gastric neoplasms at a single tertiary referral center. Among these, 28 patients underwent secondary ESD for a residual or locally recurrent tumor. Our analysis compared clinicopathologic factors between primary ESD and secondary ESD groups. RESULTS The en bloc resection and curative rate of resection of secondary ESD were 92.9% and 89.3%, respectively. The average procedure time of secondary ESD was significantly longer than primary ESD(78.2 min vs 55.1 min, P = 0.004), and the adverse events rate was not significantly different but trended slightly higher in the secondary ESD group compared to the primary ESD group(10.7% vs 3.8%, P = 0.095). Patients who received secondary ESD had favorable outcomes without severe adverse events. During a mean follow-up period, no local recurrence occurred in patients who received secondary ESD. CONCLUSION Secondary ESD of residual or locally recurrent gastric tumors appears to be a feasible and curative treatment though it requires greater technical efficiency and longer procedure time. | Da Hyun Jung Young Hoon Youn Jie-Hyun Kim Jae Jun Park Hyojin Park | 2018 | World Journal of Gastroenterology2018，24，33： | 3 |
| 6 | In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma显示文摘 | Seetharaman Rajasekar Da Jung Park Cheol Park Sejin Park Young Hoon Park Sun Tae Kim Yung Hyun Choi Young Whan Choi | 2012 | Journal of Ethnopharmacology2012，，2： | 2 |
| 7 | Low cross-talk, deep subwavelength plasmonic metal/insulator/metal waveguide intersections with broadband tunability显示文摘We suggest a low cross-talk plasmonic cross-connector based on a metal/insulator/metal cavity and waveguides.We separately investigate the isolated cavity mode, the waveguide mode, and the combination of cavity and waveguide modes using a finite-different time-domain method. Due to resonant tunneling and the cutoff frequency of the odd waveguide mode, our proposed structure achieves a high throughput transmission ratio and eliminates cross-talk. Furthermore, the proposed structure has a broadband tunability of 587 nm, which can be achieved by modulating the cavity air gap thickness. This structure enables the miniaturization of photonic integrated circuits and sensing applications. | Tae-Woo Lee Da Eun Lee Young Jin Lee Soon-Hong Kwon | 2016 | Photonics Research2016，4，6： | 2 |
| 8 | Tissue engineered regeneration of completely transected spinal cord using human mesenchymal stem cells显示文摘 | Kkot Nim Kang Da Yeon Kim So Mi Yoon Ju Young Lee Bit Na Lee Jin Seon Kwon Hyo Won Seo Il Woo Lee Ha Cheol Shin Young Man Kim Hyun Soo Kim Jae Ho Kim Byoung Hyun Min Hai Bang Lee Moon Suk Kim | 2012 | Biomaterials2012，，19： | 1 |
| 9 | Blockade of the interleukin- 21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthiritis 显示文摘 | Young DA Hegen M Ma HL | 2007 | Arthritis Aheum2007，56，4： | 1 |
| 10 | Bonded Repair of Composite Aircraft Structures:A Review of Scientific Challenges And Opportunities显示文摘 | Katnam K B Da Silva L Young T M | 2013 | Progress in Aerospace Sciences2013，，61： | 1 |
| 11 | The mouse ear inflammatory response to topical arachidonic acid显示文摘 | Young JM Spires DA Bedord CJ | 1984 | J Invest Dermatol1984，82，： | 1 |
| 12 | Lineage choice and differentiation in mouse embryos and embryonic stem cells显示文摘 | Loebel DA Watson CM de Young RA | 2003 | Dev Biol2003，264，1： | 1 |
| 13 | DNA content and proliferative activity in ovarian small cell carcinomas of the hypercalcemic type: implications for diagnosis, prognosis and histogenesis 显示文摘 | Eichhorn JH Bell DA Young RH | 1992 | Am J Clin Pathol1992，98，： | 1 |
| 14 | A laser-powered hydrokinetic system for caries removal and cavity preparation显示文摘 | Hardley J Young DA Eversole LR | 2000 | J Am Dent Assoc2000，131，6： | 1 |
| 15 | Measuring Sustainable Income from Mineral Extraction in Brazil显示文摘 | Young C E F Ser6a da Motta R | 1995 | Resources Policy1995，21，2： | 1 |
| 16 | Abnomal platelet and lymphocyte calcium handling in prehypertensive rats显示文摘 | Oshima T Young EW McCarron DA | 1991 | Hypertension1991，18，： | 1 |
| 17 | Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes:the DIAD study:a randomized controlled trial显示文摘 | Young LH Wackers FJ Chyun DA | 2009 | JAMA2009，30，15： | 1 |
| 18 | The mouse ear inflammatory response to topical arachidonic acid 显示文摘 | Young JM Spires DA Bedord C J | 1984 | J Invest Dennatol1984，，82： | 1 |
| 19 | Activation of glucose transport in muscle by exercise显示文摘 | Holloszy J O Constable SH Young DA | 1986 | Diabetes Metab Rev1986，1，4： | 1 |
| 20 | A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25 显示文摘 | Hysi PG Young TL Mackey DA | 2010 | Nat Genet2010，42，： | 1 |
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