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| 1 | Yangtze Three Gorges Reservoir, China: A holistic assessment of organic pollution, mutagenic effects of sediments and genotoxic impacts on fish显示文摘Besides obvious benefits,the Three Gorges Dam's construction resulted in new pollution scenarios with the potentials to threaten the Three Gorges Reservoir(TGR) ecosystem.In order to record organic contamination,to find links to ecotoxicological impacts and to serve as reference for ensuing monitoring,several sites in the TGR area were screened applying the triad approach with additional lines-of-evidence as a holistic assessment method.Sediments and the benthic fish species Pelteobagrus vachellii were sampled in 2011 and 2012 to determine organic pollution levels,mutagenic potentials and genotoxic impacts.Two regional hot-spots near the cities of Chongqing and Kaixian were identified and further investigated in 2013.Only polycyclic aromatic hydrocarbons(PAHs) could be detected in sediments in 2011(165–1653 ng/g),emphasizing their roles as key pollutants of the area.Their ubiquity was confirmed at Chongqing(150–433 ng/g) and Kaixian(127–590 ng/g) in2013.Concentrations were comparable to other major Chinese and German rivers.However,the immense sediment influx suggested a deposition of 216–636 kg PAH/day(0.2–0.6 mg PAH/(m2·day)),indicating an ecotoxicological risk.PAH source analysis highlighted primary impacts of combustion sources on the more industrialized upper TGR section,whereas petrogenic sources dominated the mid-low section.Furthermore,sediment extracts from several sites exhibited significant activities of frameshift promutagens in the Ames fluctuation assay.Additionally,significant genotoxic impairments in erythrocytes of P.vachellii were detected(Chongqing/Kaixian),demonstrating the relevance of genotoxicity as animportant mode of action in the TGR's fish.PAHs,their derivatives and non-target compounds are considered as main causative agents. | Tilman Floehr Bj?rn Scholz-Starke Hongxia Xiao Josef Koch Lingling Wu Junli Hou Anja Wolf Axel Bergmann Kerstin Bluhm Xingzhong Yuan Martina Ro?-Nickoll Andreas Sch?ffer Henner Hollert | 2015 | Journal of Environmental Sciences2015，27，12： | 9 |
| 2 | Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload 显示文摘 | Zoller H Koch RO Theurl I | 2001 | Gastroentorology2001，120，： | 1 |
| 3 | Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload显示文摘 | Zoller H Koch RO Theurl I | 2001 | Gastroenterology2001，120，： | 1 |
| 4 | Long-term efficacy and safety of mycophenolate mofetil in liver transplant recipients with calcineurin inhibitor-induced renal dysfunction显示文摘 | Koch RO Graziadei IW Schulz F | 2004 | Transpl Int2004，17，9： | 1 |
| 5 | DEHP metabolites in urine of children and DEHP in house dust显示文摘 | Kerstin Becker Margarete Seiwert Jürgen Angerer Wolfgang Heger Holger M. Koch Regine Nagorka Elke Ro?kamp Christoph Schlüter Bernd Seifert Detlef Ullrich | 2004 | International Journal of Hygiene and Environmental Health2004，，5： | 1 |
| 6 | A successful therapy of high-altitude pulmonary edema with a CPAP helmet on lenin peak 显示文摘 | Koch RO Hinterhuber L Faulhaber M | 2009 | Clin J Sport Med2009，19，1： | 1 |
| 7 | Distribution of High Conductance Ca^2+-activated K^+ Channels in Rat Brain: Targeting to Axons and Nerve Terminals显示文摘 | KNAUS HG SCHWARZER C KOCH RO | 1996 | J Neurosci ( S0020 - 7454 )1996，16，3： | 1 |
| 8 | Activation of caspase-3 by interferon alpha causes interleukin-16 secretion but fails to modulate activation induced cell death显示文摘 | Ludwiczek O Kaser A Koch RO | 2001 | Eur Cytokine Netw2001，12，3： | 1 |
| 9 | High-conductance Calcium-activated Potassium Channels in Rat Brain: Pharmacology, Distribution, and Subunit Composition 显示文摘 | WANNER SG KOCH RO KOSCHAK A | 1999 | Biochemistry ( S0006 -2960)1999，38，17： | 1 |
| 10 | A successful therapy of high-altitude pulmonary edema with a CPAP helmet on Lenin Peak显示文摘 | Koch RO Hinterhuber L Faulhaber M | | 0，，： | 1 |
| 11 | Acute hepatic failure and Lactate acidosis associated with antiretroviral treatment for HIV 显示文摘 | Koch RO Graziadei IW Zangerle R | 2003 | Wien Klin Wochenschr2003，115，： | 1 |
| 12 | Long-term efficacy and safety of mycophenolate mofetil in liver transplant recipients with calcineurin inhibitor-induced renal dysfunction显示文摘 | Koch RO Graziadei IW Schulz F | 2004 | Transpl Int2004，17，9： | 1 |
| 13 | Long-term efficacy and safety of mycophenolate mofetil in liver transplant recipients with calcineurin inhibitor-induced renal dysfunction显示文摘 | Koch RO Graziadei IW Schulz F | 2004 | Transpl Int2004，17，： | 1 |
| 14 | DEHP metabolites in urine of children and DEHP in house dust显示文摘 | Kerstin Becker Margarete Seiwert Jürgen Angerer Wolfgang Heger Holger M. Koch Regine Nagorka Elke Ro?kamp Christoph Schlüter Bernd Seifert Detlef Ullrich | 2004 | International Journal of Hygiene and Environmental Health2004，，5： | 1 |
| 15 | Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload显示文摘 | Zoller H Koch RO Theurl I | 2001 | Gastroenterology2001，120，： | 1 |
| 16 | Duodenal cytochromeb and hephaestin expression in patients with iron deficiency and hemochromatosis显示文摘 | Zoller H Theurl I Koch RO | 2003 | Gastroenterol2003，125，： | 1 |
| 17 | Long-term efficacy and safety of mycophenolate mofetil in liver transplant recipients with calcineurin inhibitor-induced renal dysfunction显示文摘 | Koch RO Graziadei IW Schulz F | 2004 | Transpl Int2004，17，9： | 1 |
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