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| 1 | Yangtze Three Gorges Reservoir, China: A holistic assessment of organic pollution, mutagenic effects of sediments and genotoxic impacts on fish显示文摘Besides obvious benefits,the Three Gorges Dam's construction resulted in new pollution scenarios with the potentials to threaten the Three Gorges Reservoir(TGR) ecosystem.In order to record organic contamination,to find links to ecotoxicological impacts and to serve as reference for ensuing monitoring,several sites in the TGR area were screened applying the triad approach with additional lines-of-evidence as a holistic assessment method.Sediments and the benthic fish species Pelteobagrus vachellii were sampled in 2011 and 2012 to determine organic pollution levels,mutagenic potentials and genotoxic impacts.Two regional hot-spots near the cities of Chongqing and Kaixian were identified and further investigated in 2013.Only polycyclic aromatic hydrocarbons(PAHs) could be detected in sediments in 2011(165–1653 ng/g),emphasizing their roles as key pollutants of the area.Their ubiquity was confirmed at Chongqing(150–433 ng/g) and Kaixian(127–590 ng/g) in2013.Concentrations were comparable to other major Chinese and German rivers.However,the immense sediment influx suggested a deposition of 216–636 kg PAH/day(0.2–0.6 mg PAH/(m2·day)),indicating an ecotoxicological risk.PAH source analysis highlighted primary impacts of combustion sources on the more industrialized upper TGR section,whereas petrogenic sources dominated the mid-low section.Furthermore,sediment extracts from several sites exhibited significant activities of frameshift promutagens in the Ames fluctuation assay.Additionally,significant genotoxic impairments in erythrocytes of P.vachellii were detected(Chongqing/Kaixian),demonstrating the relevance of genotoxicity as animportant mode of action in the TGR's fish.PAHs,their derivatives and non-target compounds are considered as main causative agents. | Tilman Floehr Bj?rn Scholz-Starke Hongxia Xiao Josef Koch Lingling Wu Junli Hou Anja Wolf Axel Bergmann Kerstin Bluhm Xingzhong Yuan Martina Ro?-Nickoll Andreas Sch?ffer Henner Hollert | 2015 | Journal of Environmental Sciences2015，27，12： | 9 |
| 2 | U. S. Householder survey of functional gastrointestinal disorders显示文摘 | Douglas A. Drossman Zhiming Li Eileen Andruzzi Robert D. Temple Nicholas J. Talley W. Grant Thompson William E. Whitehead Josef Janssens Peter Funch-Jensen Enrico Corazziari Joel E. Richter Gary G. Koch | 1993 | Digestive Diseases and Sciences1993，，9： | 4 |
| 3 | Evaluation of environmental and management effects on Fusarium head blight infection and deoxynivalenol concentration in the grain of winter wheat 显示文摘 | Heinz - Josef Koch Christodulos Pringas Bemward Maerlaender | 2006 | European Journal of Agron- omy2006，24，： | 1 |
| 4 | U. S. Householder survey of functional gastrointestinal disorders显示文摘 | Dr Douglas A. Drossman MD Zhiming Li MD Eileen Andruzzi Robert D. Temple PhD Nicholas J. Talley MD W. Grant Thompson MD William E. Whitehead PhD Josef Janssens MD Peter Funch-Jensen MD Enrico Corazziari MD Joel E. Richter MD Gary G. Koch PhD | 1993 | Digestive Diseases and Sciences1993，，9： | 1 |
| 5 | U. S. Householder survey of functional gastrointestinal disorders显示文摘 | Dr Douglas A. Drossman MD Zhiming Li MD Eileen Andruzzi Robert D. Temple PhD Nicholas J. Talley MD W. Grant Thompson MD William E. Whitehead PhD Josef Janssens MD Peter Funch-Jensen MD Enrico Corazziari MD Joel E. Richter MD Gary G. Koch PhD | 1993 | Digestive Diseases and Sciences1993，，9： | 1 |
| 6 | U. S. Householder survey of functional gastrointestinal disorders显示文摘 | Dr Douglas A. Drossman MD Zhiming Li MD Eileen Andruzzi Robert D. Temple PhD Nicholas J. Talley MD W. Grant Thompson MD William E. Whitehead PhD Josef Janssens MD Peter Funch-Jensen MD Enrico Corazziari MD Joel E. Richter MD Gary G. Koch PhD | 1993 | Digestive Diseases and Sciences1993，，9： | 1 |
| 7 | PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca 2+ ] i increases in renal mesangial cells显示文摘 | Alexander Koch Anja V?lzke Bianca Puff Kira Blankenbach Dagmar Meyer zu Heringdorf Andrea Huwiler Josef Pfeilschifter | 2013 | BBA - Molecular and Cell Biology of Lipids2013，，： | 1 |
| 8 | Yielddecrease in sugar beet caused by reduced tillage and direct drilling显示文摘 | Heinz Josef Koch Jan Dieckmann Andreas Buchse | 2009 | European Journal of Agronomy2009，30，： | 1 |
| 9 | U. S. Householder survey of functional gastrointestinal disorders显示文摘 | Dr Douglas A. Drossman MD Zhiming Li MD Eileen Andruzzi Robert D. Temple PhD Nicholas J. Talley MD W. Grant Thompson MD William E. Whitehead PhD Josef Janssens MD Peter Funch-Jensen MD Enrico Corazziari MD Joel E. Richter MD Gary G. Koch PhD | 1993 | Digestive Diseases and Sciences1993，，9： | 1 |
| 10 | U. S. Householder survey of functional gastrointestinal disorders显示文摘 | Dr Douglas A. Drossman MD Zhiming Li MD Eileen Andruzzi Robert D. Temple PhD Nicholas J. Talley MD W. Grant Thompson MD William E. Whitehead PhD Josef Janssens MD Peter Funch-Jensen MD Enrico Corazziari MD Joel E. Richter MD Gary G. Koch PhD | 1993 | Digestive Diseases and Sciences1993，，9： | 1 |
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