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| 1 | Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways显示文摘Inflammatory bowel disease(IBD)refers to a group of disorders characterized by chronic inflammation of the gastrointestinal(GI)tract.The elevated levels of nitric oxide(NO)in serum and affected tissues;mainly synthesized by the inducible nitric oxide synthase(iNOS)enzyme;can exacerbate GI inflammation and is one of the major biomarkers of GI inflammation.Various natural and synthetic agents are able to ameliorate GI inflammation and decrease iNOS expression to the extent comparable with some IBD drugs.Thereby,the purpose of this study was to gather a list of natural or synthetic mediators capable of modulating IBD through the NO pathway.Electronic databases including Google Scholar and PubMed were searched from 1980 to May 2018.We found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factorκB(NF-κB)and JAK/STAT signaling pathways.Prebiotics and probiotics can also alter the GI microbiota and reduce NO expression in IBD models through a broad array of mechanisms.A number of synthetic molecules have been found to suppress NO expression either dependent on the NF-κB signaling pathway(i.e.,dexamethasone,pioglitazone,tropisetron)or independent from this pathway(i.e.,nicotine,prednisolone,celecoxib,β-adrenoceptor antagonists).Co-administration of natural and synthetic agents can affect the tissue level of NO and may improve IBD symptoms mainly by modulating the Toll like receptor-4 and NF-κB signaling pathways. | Aida Kamalian Masoud Sohrabi Asl Mahsa Dolatshahi Khashayar Afshari Shiva Shamshiri Nazanin Momeni Roudsari Saeideh Momtaz Roja Rahimi Mohammad Abdollahi Amir Hossein Abdolghaffari | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Diagnostic accuracy of CT scan in abdominal blunt trauma显示文摘 | Javad Salimi Khadyjeh Bakhtavar Mehdi Solimani Patricia Khashayar Aft Pasha Meysamie Moosa Zargar | 2009 | Chinese Journal of Traumatology2009，12，2： | 4 |
| 3 | Human NOTES Cholecystectomy: Transgastric Hybrid Technique显示文摘 | Edward D. Auyang Eric S. Hungness Khashayar Vaziri John A. Martin Nathaniel J. Soper | 2009 | Journal of Gastrointestinal Surgery2009，，6： | 2 |
| 4 | Deceased Donor Split-Liver Transplantation in Adult Recipients: Is the Learning Curve Over?显示文摘 | Ryan P. Cauley Khashayar Vakili Nora Fullington Kristina Potanos Dionne A. Graham Jonathan A. Finkelstein Heung Bae Kim | 2013 | Journal of the American College of Surgeons2013，，： | 2 |
| 5 | Fault Detection in Reaction Wheel of a Satellite Using Observer-Based Dynamic 显示文摘 | Li Zhongqi Ma Liying KHASHAYAR KHORASANI | 2005 | Neural Networks2005，，： | 1 |
| 6 | The clinical spectrum of chronic metabolic acidosis: homeostatic mechanisms produce significant morbidity 显示文摘 | Alpem RJ Khashayar S | 1997 | Am J Kidney Dis1997，29，2： | 1 |
| 7 | A Study of the Extreme Effects of Fading Correlation and the Impact of Imperfect MMSE Channel Esti- mation on the Performance of SIMO Zero - Forc- ing Receivers and on the Capacity - Maximizing Strategy in SIMO Links 显示文摘 | Khashayar Salehi Nobandegani Paeiz Azmi | 2010 | Ieee transactions on vehicular technology2010，59，3： | 1 |
| 8 | Management of infected femoral pseudoaneurysrns in intravenous drug abusers: a review of 57 cases 显示文摘 | Salimi J Shojaeefar A Khashayar P | 2008 | Arch Med Res2008，39，1： | 1 |
| 9 | Diet-specific salivary gene expression and glucose oxidase activity in Spodoptera exigua(Lepidoptera:Noctuidae)larvae显示文摘 | Khashayar A Dufresne P J Li P | 2010 | Journal of Insect Physiology2010，56，12： | 1 |
| 10 | Color manage- ment of porcelain veneers: influence of dentin and resin cement colors显示文摘 | Dozic A Tsagkari M Khashayar G | 2010 | Quintessence Int2010，41，7： | 1 |
| 11 | Laparoscopic Resection of a Retroperitoneal Cystic Lymphangioma in an Adult显示文摘 | Jason Kasza Fredrick J. Brody Fatima Khambaty Khashayar Vaziri Brian Wallace | 2010 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2010，，3： | 1 |
| 12 | Firework-Related Injuries in Tehran’s Persian Wednesday Eve Festival ( Chaharshanbe Soori )显示文摘 | Hassan Tavakoli Patricia Khashayar Hadi Ahmadi Amoli Khalil Esfandiari Hossein Ashegh Jalal Rezaii Javad Salimi | 2011 | Journal of Emergency Medicine2011，，3： | 1 |
| 13 | Influence of mixing characteristics for water encapsulation by self-assembling hydrophobic silica nanoparticles显示文摘 | Laurent F Khashayar S Isabelle p | | 0，，02： | 1 |
| 14 | Mild and moderate asthma is associated with goblet cell hyperplasia and abnormalities in mucin gene expression 显示文摘 | Ordonez CL Khashayar R Wong HH | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 15 | Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma显示文摘 | Woodruff PG Khashayar R Lazarus SC | 2001 | J Allergy Clin Immunol2001，108，： | 1 |
| 16 | Management of in-fectedfemoral pseudoaneurysms in intravenous drug abusers: areview of57 cases显示文摘 | Salimi J Shojaeefar A Khashayar P | 2008 | Ared Med Res2008，39，1： | 1 |
| 17 | Methodology for design of a vibration operated valve for abrasive viscous fluids显示文摘 | Khashayar Behdinan | 2013 | Mechatcis2013，23，8： | 1 |
| 18 | Equilibrium and kinetics studies for the adsorption of Basic Red 46 on nickel oxide nanoparticles-modied diatomite in aqueous solutions显示文摘 | Reza K S Mohammad R K N Khashayar B | 2014 | Journal of the Taiwan Institute of Chemical Engineers2014，45，： | 1 |
| 19 | Management of infected femoral pseudoaneurysms in intravenous drug abusers:a review of 57 case显示文摘 | Salimi J Shojaeefar A Khashayar P | 2008 | Arch Med Res2008，39，1： | 1 |
| 20 | Osteoar- titular tuberculosis in Teran, Iran: a 2-year study显示文摘 | Hadadi A Rasoulinejad M Khashayar P | 2010 | Clin Microbiollnfect2010，，16： | 1 |
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