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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Behavioural and neurochemical effects of post-weaning social isolation in rodents-Relevance to developmental neuropsychiatric disorders显示文摘 | Kevin C F F Veronica M P | 2008 | Neuroscience and Biobehavioral Reviews2008，，32： | 1 |
| 3 | Selective killing of vaccinia virus by LL-37: Implications for eczema vaccinatum显示文摘 | Howell M D James F Kevin O | 2004 | Immunol2004，172，3： | 1 |
| 4 | Voluntary disclosure by state-owned enterprises listed on the Stock Exchange of Hong Kong 显示文摘 | Michael J F Kevin C K Grace M L | 2002 | Journal of International Financial Management and Accounting2002，13，2： | 1 |
| 5 | The fate of nitro- gen applied to a mature Kentucky bluegrass turf显示文摘 | Kevin W F Kevin M O Crum J R | 2006 | Crop Science2006，46，： | 1 |
| 6 | The fate of nitrogen applied to a mature Kentucky bluegrass turf显示文摘 | Kevin W F Kevin M O Crum J R | 2006 | Crop Sci2006，46，： | 1 |
| 7 | Green light: a signal to show down or stop显示文摘 | Kevin M F Stefanie A M | 2007 | Journal of Experimental Botany2007，58，12： | 1 |
| 8 | Changes in Rela- tive Wages, 1963-1987 : Supply and Demand Factors 显示文摘 | Katz Lawrence F & Murphy Kevin M | 1992 | The Quarterly Journal of Economics MIT Press1992，107，1： | 1 |
| 9 | Association of ambient air pollution with respiratory hospitalization in a government designated 'area of concern': the case of Windsor, Ontario 显示文摘 | Isaac N L Karen Y F Kevin M G | 2005 | Environ Health Perspeet2005，113，3： | 1 |
| 10 | Apparent attenuation due to intrabed multiples显示文摘 | SCHOENBERGER M KEVIN F K | 1974 | Geophysics1974，39，3： | 1 |
| 11 | Herbal Remedies in Gastroenterology显示文摘 | Kevin M Comar Donald F Kirby | 2005 | Journal of Clinical Gastroenterology2005，，： | 1 |
| 12 | Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants显示文摘 | Robert B Perni Luc J Farmer Kevin M Cottrell John J Court Lawrence F Courtney David D Deininger Cynthia A Gates Scott L Harbeson Joseph L Kim Chao Lin Kai Lin Yu-Ping Luong John P Maxwell Mark A Murcko Janos Pitlik B.Govinda Rao Wayne C Schairer Roger D T | 2004 | Bioorganic & Medicinal Chemistry Letters2004，，8： | 1 |
| 13 | Speaker recognition using neural networks and conventional classifiers 显示文摘 | Kevin R F Richard J M Khaled T A | 1994 | IEEE Trans on Speech and Audion processing1994，2，1： | 1 |
| 14 | Speaker recognition using neural networks and conventional classifiers 显示文摘 | Kevin R F Richard J M Khaled T A | 1994 | IEEE Trans on Speech and Audio processing1994，2，1： | 1 |
| 15 | Life History Traits of the Tennessee Dace (Phoxinus tennesseensis) in Northeast Tennessee显示文摘 | Hamed M Kevin Alsop Fred J Laughlin Thomas F | 2008 | The American Midland Naturalist2008，，2： | 1 |
| 16 | Differential regulation of cytokine and chemokine production in lipopolysaccharide-induced tolerance and priming显示文摘 | Octavia M Peck David L Williams Kevin F Breuel John H Kalbfleisch Hongkuan Fan George E Tempel Giuseppe Teti James A Cook | 2004 | Cytokine2004，，5： | 1 |
| 17 | Chitosan nanoparticles as delivery systems for doxorubicin显示文摘 | Kevin A J Marie P F Ana M | | 0，，： | 1 |
| 18 | Food products containing free tall oil-based phytosterols and oat b-glnean lower serum total and LDL cholesterol in Hypereholesterolemic adults显示文摘 | Kevin C M Shinnick F Seeley M A | 2003 | J Nutr2003，133，： | 1 |
| 19 | Empirical Age-Earning Profiles 显示文摘 | Murphy Kevin M Welch F | 1990 | Journal of Labor Economics1990，，2： | 1 |
| 20 | The Structure of Wages 显示文摘 | Murphy Kevin M Welch F | 1992 | Quarterly Journal of Economics1992，，1： | 1 |
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