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| 1 | Molecular classifications of gastric cancers: Novel insights and possible future applications显示文摘Despite some notable advances in the systemic management of gastric cancer(GC), the prognosis of patients with advanced disease remains overall poor and their chance of cure is anecdotic. In a molecularly selected population, a median overall survival of 13.8 mo has been reached with the use of human epidermal growth factor 2(HER2) inhibitors in combination with chemotherapy, which has soon after become the standard of care for patients with HER2-overexpressing GC. Moreover, oncologists have recognized the clinical utility of conceiving cancers as a collection of different molecularlydriven entities rather than a single disease. Several molecular drivers have been identified as having crucial roles in other tumors and new molecular classifications have been recently proposed for gastric cancer as well. Not only these classifications allow the identification of different tumor subtypes with unique features, but also they serve as springboard for the development of different therapeutic strategies. Hopefully, the application of standard systemic chemotherapy, specifictargeted agents, immunotherapy or even surgery in specific cancer subgroups will help maximizing treatment outcomes and will avoid treating patients with minimal chance to respond, therefore diluting the average benefit. In this review, we aim at elucidating the aspects of GC molecular subtypes, and the possible future applications of such molecular analyses. | Silvio Ken Garattini Debora Basile Monica Cattaneo Valentina Fanotto Elena Ongaro Marta Bonotto Francesca V Negri Rosa Berenato Paola Ermacora Giovanni Gerardo Cardellino Mariella Giovannoni Nicoletta Pella Mario Scartozzi Lorenzo Antonuzzo Nicola Silvestris Gianpiero Fasola Giuseppe Aprile | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 5 |
| 2 | The somatotropic axis in a short children born small for gestational age: Relation to insulin resistance显示文摘 | Kale A Maria V Ken KL | 2002 | Pediatric Research2002，51，： | 1 |
| 3 | Individual Characterization of Broadband Sampling Oscilloscopes with a 'Nose-to-Nose' Calibration Procedure显示文摘 | Jan V Ken R | 1994 | IEEE Transaction on Instrumentation and Measurement1994，43，2： | 1 |
| 4 | Cytokine and C-reactive protein profiles induced by porcine circovirus type 2 experimental infection in 3- week-old piglets显示文摘 | Leanne S S Ken M C Isabelle V | 2006 | Viral humunology2006，19，2： | 1 |
| 5 | Unusual origin of free subarachnoid fat drops: a ruptured spinal dermoid tumour显示文摘 | P. Barsi J. Kenéz G. Várallyay L. Gergely | 1992 | Neuroradiology1992，，4： | 1 |
| 6 | Dynamic tensile -compres-sive behavior of concrete显示文摘 | PAUL F M KEN P V ROBERT A C | 1985 | ACI Journal1985，82，4： | 1 |
| 7 | On the effect of particles on carri- er phase turbulence in gas-particle flows显示文摘 | KENNING V M CROWE C T | 1997 | International Journal of Multiphase Flow1997，23，2： | 1 |
| 8 | Familial circadian rhythm disorder in the diurnal primate, Macaca mulatta 显示文摘 | Zhdanova I V Ken M Bozhokin S V | 2012 | PLoS One2012，7，33： | 1 |
| 9 | Methano land dimethyl sulfide removal by pulsed corona part I:experiment显示文摘 | LOCK E H SAYELIEY A V KENNED L A | 2006 | Plasma Chem Plasma Process2006，26，： | 1 |
| 10 | Subcooled flow boiling at high heat flux显示文摘 | Valle D V H Kenning D B R | 1985 | International [J]ournal of Heat and Mass Transfer1985，28，： | 1 |
| 11 | Short-Term Effects of a Course of Manual Therapy and Exercise in People with Moderate Chronic Obstructive Pulmonary Disease:a Preliminary Clinical Trial 显示文摘 | Roger M E Subramanyam R V Ken B | 2013 | Journal of Manipulative and Physiological Therapeutics2013，36，8： | 1 |
| 12 | Behavior and climate change: Consumer perceptions of responsibility 显示文摘 | Wels V K Ponting C A Ken P | 2011 | Journal of Marketing Management2011，27，78： | 1 |
| 13 | Subtraction helical CT angiography of intra-and extracranial vessels:technical considerations and preliminary experience显示文摘 | White PM Ait ken D | 2003 | AJNR2003，24，7： | 1 |
| 14 | Preparation of separate astroglial and oligodendro-glial ceu cultures from rat cerebral tissue显示文摘 | Jean D V | 1980 | J Cell Biol1980，85，8： | 1 |
| 15 | Fibrinogen that appears in Bowman' s space of proteinuric kidneys in vivo activates podo: cyte Toll - Like receptors 2 and 4 in vitro显示文摘 | Motojima M Matsusaka T Ken V | 2010 | Nephron Exp Neph- rol2010，114，2： | 1 |
| 16 | Kinetics of oxytetra-cycline reaction with a hydrous manganese oxide显示文摘 | Kenned Y F Rubert I V Pedersen A | 2006 | En-viron Sci Technol2006，40，： | 1 |
| 17 | Reduction of noise of loaded and unloaded misaligned gear drives显示文摘 | Litvin F L Daniele V Ken Y | 2006 | Computer Methods Apply Mechanical Engineering2006，195，414243： | 1 |
| 18 | Ontological informatics infrastructure for pharmaceutical product development and manufacturing 显示文摘 | Venkatasubramanian Venkat Zhao Chunhua Joglekar Girish Jain Ankur Hailemariam Leaelaf Suresh Pradeep AkkisettyPavankumar Morris Ken ReklaitisG V | 2006 | Computers and Chemical Engineering2006，30，： | 1 |
| 19 | Building organizational and scientific platforms in the pharmaceutical industry:A process perspective on the development of dynamic capabilities显示文摘 | V K NARAYANAN KEN COLWELL FRANK L DOUGLAS | | 0，，20： | 1 |
| 20 | Cruise missile mission planning:a heuristic algorithm for automatic generation显示文摘 | Kenning J L Lewis K R | 2001 | Journal of Heuristics2001，7，： | 1 |
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