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| 1 | Controlling schistosomiasis with praziquantel:How much longer without a viable alternative?显示文摘The current approach of morbidity control of schistosomiasis,a helminth disease of poverty with considerable public health and socioeconomic impact,is based on preventive chemotherapy with praziquantel.There is a pressing need for new drugs against this disease whose control entirely depends on this single drug that has been widely used over the past 40 years.We argue that a broader anthelminthic approach supplementing praziquantel with new antischistosomals targeting different parasite development stages would not only increase efficacy but also reduce the risk for drug resistance.Repositioning drugs already approved for other diseases provides a shortcut to clinical trials,as it is expected that such drugs rapidly pass the regulatory authorities.The antischistosomal properties of antimalarial drugs(e.g.,semisynthetic artemisinins,synthetic trioxolanes,trioxaquines and mefloquine)and of drugs being developed or registered for other purposes(e.g.,moxidectin and miltefosin),administered alone or in combination with praziquantel,have been tested in the laboratory and clinical trials.Another avenue to follow is the continued search for new antischistosomal properties in plants.Here,we summarise recent progress made in schistosomiasis chemotherapy,placing particular emphasis on repositioning of existing drugs against schistosomiasis. | Robert Bergquist Jürg Utzinger Jennifer Keiser | 2017 | Infectious Diseases of Poverty2017，6，1： | 7 |
| 2 | Nonlinear terahertz devices utilizing semiconducting plasmonic metamaterials显示文摘The development of responsive metamaterials has enabled the realization of compact tunable photonic devices capable of manipulating the amplitude,polarization,wave vector and frequency of light.Integration of semiconductors into the active regions of metallic resonators is a proven approach for creating nonlinear metamaterials through optoelectronic control of the semiconductor carrier density.Metal-free subwavelength resonant semiconductor structures offer an alternative approach to create dynamic metamaterials.We present InAs plasmonic disk arrays as a viable resonant metamaterial at terahertz frequencies.Importantly,InAs plasmonic disks exhibit a strong nonlinear response arising from electric field-induced intervalley scattering,resulting in a reduced carrier mobility thereby damping the plasmonic response.We demonstrate nonlinear perfect absorbers configured as either optical limiters or saturable absorbers,including flexible nonlinear absorbers achieved by transferring the disks to polyimide films.Nonlinear plasmonic metamaterials show potential for use in ultrafast terahertz(THz)optics and for passive protection of sensitive electromagnetic devices. | Huseyin R Seren Jingdi Zhang George R Keiser Scott J Maddox Xiaoguang Zhao Kebin Fan Seth R Bank Xin Zhang Richard D Averitt | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 3 | The Drugs We Have and the Drugs We Need Against Major Helminth Infections显示文摘 | Jennifer Keiser Jürg Utzinger | 2010 | Advances in Parasitology2010，，： | 2 |
| 4 | Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk显示文摘 | Peter Steinmann Jennifer Keiser Robert Bos Marcel Tanner Jürg Utzinger | 2006 | The Lancet Infectious Diseases2006，，7： | 2 |
| 5 | Past,present,and future of Japanese encephalitis显示文摘 | Erlanger TE Weiss S Keiser J | 2009 | Emerg Infect Dis2009，15，1： | 1 |
| 6 | Past, present and future of Japanese encephalitis 显示文摘 | Erlanger TE Weiss S Keiser J | 2009 | Emerg Infect Dis2009，15，1： | 1 |
| 7 | Schistosomiasis and water re sources development:systematic review,meta analysis,and esti mates of people at risk显示文摘 | Steinmann P Keiser J Bos R | 2006 | Lancet Infect Dis2006，6，7： | 1 |
| 8 | Schistosomiasis and water resources development, systematic review, meta-analysis, and es- timates of people at risk显示文摘 | Steinmann P Keiser J Bos R | 2006 | Lancet Infect Dis2006，6，7： | 1 |
| 9 | Past,present,and future of Japanese encephalitis显示文摘 | Erlanger T E Weiss S Keiser J | 2009 | Emerg Infect Dis2009，15，1： | 1 |
| 10 | Effect of single-dose oral artemether and tribendimidine on the tegument of adult Clonorehis sinensis in rats显示文摘 | Xiao SH Keiser J Xue J | 2009 | Parasitol Res2009，104，3： | 1 |
| 11 | Schistosomiasis and water re- sources development: systematic review, meta - analysis, and esti- mates of people at risk 显示文摘 | Steinmann P Keiser J Bos R | 2006 | Lancet Infect Dis2006，6，7： | 1 |
| 12 | Antimalarials in the treatment of schistoso- miasis显示文摘 | Keiser J Utzinger J | 2012 | Curr Pharm Des2012，18，24： | 1 |
| 13 | Schistosomiasis and water re- sources development: systematic review, meta-analysis, and esti- mates of people at risk 显示文摘 | Steinmann P Keiser J Bos R | 2006 | Lancet Infect Dis2006，6，7： | 1 |
| 14 | Schistosomiasis and water re- sources development: systematic review, meta- analysis, and esti- mates of people at risk显示文摘 | Steinmann P Keiser J Bos R | 2006 | Lancet Infect Dis2006，6，7： | 1 |
| 15 | Global burden of human food-borne trematodiasis: a systematic review and meta-analysis显示文摘 | Thomas Fürst Jennifer Keiser Jürg Utzinger | 2012 | The Lancet Infectious Diseases2012，，3： | 1 |
| 16 | Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk显示文摘 | Steinmann P Keiser J Bos R | 2006 | Lancet Infect Dis2006，6，7： | 1 |
| 17 | Schistosomiasis and wa- ter resources development: systematic review, meta- analy- sis, and esti-mates of people at risk 显示文摘 | Steinmann P Keiser J Bos R | 2006 | Lancet Infect Dis2006，6，7： | 1 |
| 18 | Urbanization in sub-saharan Africa and implication for malaria control显示文摘 | Keiser J | 2004 | Am J Trop Med Hyg2004，71，2： | 1 |
| 19 | Relating protein pharmacology by ligand chemistry 显示文摘 | Keiser M J Roth B L Armbruster B N | 2007 | Nat Biotechnol2007，25，2： | 1 |
| 20 | Past, present, and future of Japanese encephalitis显示文摘 | Erlanger TE Weiss S Keiser J Utzinger J Wiedenmayer K | 2009 | Emerg Infect Dis2009，15，1： | 1 |
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