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| 1 | 缺氧中和缺氧后亚低温时炎症基因表达谱的变化显示文摘目的了解缺氧中和缺氧后亚低温时炎症相关基因的变化。方法将体外培养的人脑血管内皮细胞(HCEC)分为对照组和实验组。对照组细胞常规培养,实验组细胞去掉细胞培养液,更换为无血清、低糖M199,置于缺氧箱房中,再分为2组:Ⅰ组为常温缺氧后低温恢复;Ⅱ组为低温缺氧后常温恢复。取细胞并分离总RNA后,用DNA微列阵技术观察缺氧以及缺氧中和缺氧后亚低温时HCEC炎症相关基因表达谱的变化。结果1)白介素-1受体1型(IL-1R1)、类1型白介素-1受体(IL-1RL1)、白介素-1β(IL-1β)、白介素-11(IL-11)、γ-干扰素调节因子2(IRF2)和集落刺激因子1(CSF1)分别在某些时间点上调;白介素-1受体拮抗剂(IL-1RN)、白介素-6(IL-6)、γ-干扰素受体2(IFNGR2)、集落刺激因子3受体(CSF3R)、淋巴细胞黏附因子1(SELL)、细胞间黏附因子3(ICAM3)、血小板/内皮细胞黏附因子(PECAM1)和内皮细胞黏附因子1(SELE)则在不同的时间点下调;γ-干扰素诱导蛋白30(IFI30)在某一些时间点上调,但在低温缺氧后常温恢复时下调;肿瘤坏死因子家庭成员7(TNFRSF7)则仅在低温时下调。2)缺氧4 h、32℃低温使下调基因增多。结论缺氧可以使IL-1βI、L-1RL1I、L-1R1等部分损伤性炎症基因表达上调,IL-11的上调可能为保护性反应;TNF基因表达的上调可能起双重作用。 | 崔红 张万东 Jamie Hutchison Danica Stanimirovic | 2006 | 首都医科大学学报2006，27，1： | 4 |
| 2 | Novel approaches in schizophrenia-from risk factors and hypotheses to novel drug targets显示文摘Schizophrenia is a severe psychiatric disorder characterized by emotional,behavioral and cognitive disturbances, and the treatment of schizophrenia is oftencomplicated by noncompliance and pharmacoresistance. The search for thepathophysiological mechanisms underlying schizophrenia has resulted in theproposal of several hypotheses to explain the impacts of environmental, genetic,neurodevelopmental, immune and inflammatory factors on disease onset andprogression. This review discusses the newest insights into the pathophysiologyof and risk factors for schizophrenia and notes novel approaches in antipsychotictreatment and potential diagnostic and theranostic biomarkers. The currenthypotheses focusing on neuromediators (dopamine, glutamate, and serotonin),neuroinflammation, the cannabinoid hypothesis, the gut-brain axis model, andoxidative stress are summarized. Key genetic features, including small nucleotidepolymorphisms, copy number variations, microdeletions, mutations andepigenetic changes, are highlighted. Current pharmacotherapy of schizophreniarelies mostly on dopaminergic and serotonergic antagonists/partial agonists, butnew findings in the pathophysiology of schizophrenia have allowed theexpansion of novel approaches in pharmacotherapy and the establishment ofmore reliable biomarkers. Substances with promising results in preclinical andclinical studies include lumateperone, pimavanserin, xanomeline, roluperidone,agonists of trace amine-associated receptor 1, inhibitors of glycine transporters,AMPA allosteric modulators, mGLUR2-3 agonists, D-amino acid oxidase inhibitorsand cannabidiol. The use of anti-inflammatory agents as an add-on therapy ismentioned. | MatejĽupták Danica Michaličková Zdeněk Fišar Eva Kitzlerová Jana Hroudová | 2021 | World Journal of Psychiatry2021，11，7： | 3 |
| 3 | Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation显示文摘 | Xiaolei Qiu Katharine Brown Matthew D. Hirschey Eric Verdin Danica Chen | 2010 | Cell Metabolism2010，，6： | 2 |
| 4 | Results of National Colorectal Cancer Screening Program in Croatia(2007-2011)显示文摘AIM:To study the epidemiologic indicators of uptake and characteristic colonoscopic findings in the Croatian National Colorectal Cancer Screening Program.METHODS:Colorectal cancer(CRC) was the second leading cause of cancer mortality in men(n = 1063,49.77/100 000),as well as women(n = 803,34.89/100 000) in Croatia in 2009.The Croatian National CRC Screening Program was established by the Ministry of Health and Social Welfare,and its implementation started in September,2007.The coordinators were recruited in each county institute of public health with an obligation to provide fecal occult blood testing(FOBT) to the participants,followed by colonoscopy in all positive cases.The FOBT was performed by hypersensitive guaiac-based Hemognost card test(Biognost,Zagreb).The test and short questionnaire were delivered to the home addresses of all citizens aged 50-74 years consecutively during a 3-year period.Each participant was required to complete the questionnaire and send it together with the stool specimen on three test cards back to the institute for further analysis.About 4% FOBT positive cases are expected in normal risk populations.A descriptive analysis was performed.RESULTS:A total of 1 056 694 individuals(born between 1933-1945 and 1952-1957) were invited to screening by the end of September 2011.In total,210 239(19.9%) persons returned the envelope with a completed questionnaire,and 181 102 of them returned it with a correctly placed stool specimen on FOBT cards.Until now,12 477(6.9%),FOBT-positive patients have been found,which is at the upper limit of the expected values in European Guidelines for Quality Assurance in CRC Screening and Diagnosis [European Union(EU) Guidelines].Colonoscopy was performed in 8541 cases(uptake 66%).Screening has identified CRC in 472 patients(5.5% of colonoscopied,3.8% of FOBT-positive,and 0.26% of all screened individuals).This is also in the expected range according to EU Guidelines.Polyps were found and removed in 3329(39% of colonoscopied) patients.The largest number of polyps were found in the left half of the colon:64%(19%,37% and 8% in the rectum,sigma,and descendens,respectively).The other 36% were detected in the proximal part(17% in the transverse colon and 19% in ceco-ascending colon).Small polyps in the rectum(5-10 mm in diameter),sigmoid and descending colon were histologically found to be tubular adenomas in 60% of cases,with a low degree of dysplasia,and 40% were classified as hyperplastic.Polyps of this size in the transverse or ceco-ascending colon in almost 20% had a histologically villous component,but still had a low degree of dysplasia.Polyps sized 10-20 mm in diameter were in 43% cases tubulovillous,and among them,32% had areas with a high degree of dysplasia,especially those polyps in the cecoascending or transverse part.The characteristics of the Croatian CRC Screening National Program in the first 3 years were as follows:relatively low percentage of returned FOBT,higher number of FOBT-positive persons but still in the range for population-based programs,and higher number of pathologic findings(polyps and cancers).CONCLUSION:These results suggest a need for intervention strategies that include organizational changes and educational activities to improve awareness of CRC screening usefulness and increase participation rates. | Miroslava Katii Nataa Antoljak Milan Kujundzi Valerija Stameni Dunja Skoko Poljak Danica Kramari Davor timac Marija Strnad Peikan Mirko amija Zdravko Ebling | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 5 | Visible light photoredox catalysis with transition metal complexes:applications in organic synthesis显示文摘 | Christopher K P Danica A R David W C M | 2013 | Chem Rev2013，113，： | 1 |
| 6 | Acid-base equilibria andsolubility of loratadine and desloratadine in water and micellarmedia 显示文摘 | POPOVIC G CAKAR M DANICA A | 2009 | J Pharm Biomed Anal2009，49，1： | 1 |
| 7 | Im+ provement of the stability of glucose oxidase via encapsulation in sodium alginate-ccllulose sulfate-poly (methyiene-co-guani- dine) capsules显示文摘 | Alica Vikartovskfi Marek Bfiko Danica Mislovieovfi | 2007 | Enzyme and Microbial Technology2007，41，6： | 1 |
| 8 | A detailed analysis of 16S ribosomal RNA gene segments for the diagnosis of pathogenic bacte- ria显示文摘 | Soumitesh Chakravorty Danica Helb Michele Bur- day | 2007 | J Microbiol Methods2007，69，2： | 1 |
| 9 | Rapid detection of Myco- bacterium tuberculosis and rifampin resistance by use of on - de- mand, near- patient technolggy显示文摘 | Danica H Martin J Elizabeth S | 2010 | J Clin Microbiol2010，48，1： | 1 |
| 10 | SIRT3 Reverses Aging-Associated Degeneration显示文摘 | Katharine Brown Stephanie Xie Xiaolei Qiu Mary Mohrin Jiyung Shin Yufei Liu Dan Zhang David T. Scadden Danica Chen | 2013 | Cell Reports2013，，2： | 1 |
| 11 | Hyperoxaluria is reduced and nephrocalcinosis prevented with an oxalate-degrading enzyme in mice with hyperoxaluria 显示文摘 | Danica G Eduardo C Salido Bhami C Shenoy | 2009 | Am J Nephrol2009，29，： | 1 |
| 12 | Cross Shaft Design From the Aspect of Capacity显示文摘 | LOZICA I DANICA J KATARINA Z | 2011 | Scientific Technical Review2011，61，1： | 1 |
| 13 | Multiple antiviral activities of Cyanovirin-N: blocking of Hunan Immunodeficiency Virus Type 1 gp120 interaction with CD4 and CorecePtor and inhibition of diverse enveloped viruses显示文摘 | Bama Dey Danica L L Paolo L | 2000 | American Society for Microbiology J Virol2000，74，10： | 1 |
| 14 | Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation显示文摘 | Xiaolei Qiu Katharine Brown Matthew D. Hirschey Eric Verdin Danica Chen | 2010 | Cell Metabolism2010，，6： | 1 |
| 15 | Densitometric determination of urinary 4-hydroxy-3-methoxymandelic acid (vanillylmandelic acid ) 显示文摘 | Danica A Marina S Smiya R | 1993 | Clin Chem1993，39，： | 1 |
| 16 | A detail analysis of 16s ribosomal RNA gene segments for the diagnosis of pathogenic bacteria 显示文摘 | Soumitesh Chakravorty Danica Helb Michele Burdy | 2007 | Journal of Microbiological Methods2007，69，： | 1 |
| 17 | Robust output model predictive control design:BMI approach显示文摘 | Vojtech V Danica R | | 0，，04： | 1 |
| 18 | Improvement of the stability of glucose oxidase via encapsulation in sodium alginate–cellulose sulfate–poly(methylene- co -guanidine) capsules显示文摘 | Alica Vikartovská Marek Bu?ko Danica Mislovi?ová Vladimír P?toprsty Igor Lacík Peter Gemeiner | 2007 | Enzyme and Microbial Technology2007，，6： | 1 |
| 19 | Sequential design of robust output model predictive control显示文摘 | Vojtech V Danica R | | 0，，10： | 1 |
| 20 | Tracheal temperature for monitoring body temperature during mild hypothermia in pigs显示文摘 | Danica K Moritz H Fritz S | 2010 | Resuscitation2010，81，1： | 1 |
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