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| 1 | Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3inflammasome activation in LPS-induced vascular injury显示文摘The loss of endothelial connective integrity and endothelial barrier dysfunction can lead to increased vascular injury, which is related to the activation of endothelial inflammasomes. There are evidences that low concentrations of aspirin can effectively prevent cardiovascular diseases. We hypothesized that low-dose aspirin could ameliorate endothelial injury by inhibiting the activation of NLRP3 inflammasomes and ultimately prevent cardiovascular diseases. Microvascular endothelial cells were stimulated by lipopolysaccharide(2 μg/mL) and administrated by 0.1–2 mmol/L aspirin. The wild type mice were stimulated with LPS(100 μg/kg/day), and 1 h later treated with aspirin(12.5, 62.5, or125 mg/kg/day) and dexamethasone(0.0182 mg/kg/day) for 7 days. Plasma and heart were harvested for measurement of ELISA and immunofluorescence analyses. We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway. We also found that low-concentration aspirin could inhibit the formation and activation of NLRP3 inflammasome and restore the expression of theendothelial tight junction protein zonula occludens-1/2(ZO1/2). We assume that aspirin can ameliorate the endothelial layer dysfunction by suppressing the activation of NLRP3 inflammasome. | Xing Zhou Yanjiao Wu Lifeng Ye Yunting Wang Kaimin Zhang Lingjun Wang Yi Huang Lei Wang Shaoxiang Xian Yang Zhang Yang Chen | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 13 |
| 2 | Analysis of the element content in poplar tree leaves by femtosecond laser-induced breakdown spectroscopy显示文摘Femtosecond laser-induced breakdown spectroscopy (fs-LIBS) is employed to analyze the element content in poplar tree leaves from four representative locations in Changchun City (Jingyue National Forest Park,JYP),Changchun University of Science and Technology (CUST),Casting Factory (CF) and Forging Factory (FF) of First Automobile Works (FAW) under identical experimental conditions.Those elements of N,P,K,Ca,Fe,Ti,Mn and Na are identified in the poplar tree leaves from the recorded spectrogram and the elemental content in the leaves is further obtained by applying free calibration method to the spectrogram.Our results show that the elements Ca and Fe in the poplar tree leaves from the CF area have the highest concentration in the four locations,which is a factor of 2.05 and 1.66 respectively to those of JYP.This experiment demon-strates that fs-LIBS can be utilized to analyze element content in a sample and find new applications in the environmental detection. | MA Shuang GAO Xun GUO KaiMin KAHSAY Medhanie LIN JingQuan | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 8 |
| 3 | Object-level change detection based on full-scale image segmentation and its application to Wenchuan Earthquake显示文摘Aiming at object fragmentation and poor detection results caused by discontinuous segmentation scale in object-level change detection,a new object-level change detection method based on the full-scale object tree is presented in this paper.The core idea of this new algorithm is to establish the full-scale object tree based on convexity model theory and integrate full-scale image segmentation techniques and change detection into the whole process.Some Wenchuan Earthquake images are taken as an example to discuss the new method for earthquake damage detection and evaluation in urban area,landslide detection,and extraction of barrier lake boundary.The application shows that the new method is robust and it provides an advanced tool for the quantitative detection and evaluation of earthquake damage. | GONG JianYa,SUI HaiGang,SUN KaiMin,MA GuoRui & LIU JunYi State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan University,Wuhan 430072,China | 2008 | Science China(Technological Sciences)2008，51，S2： | 7 |
| 4 | Temporal variation of suspended sediment load in the Pearl River due to human activities显示文摘在到 2006 的从 1950 年代的三个 hydrologic 车站的沉积流动上的数据被利用在从珍珠河送到海洋的推迟的沉积负担学习十、年度、每月的变化。结果证明包括西方河,北方河和东方河,在来自三条主要支流的沉积流动的变化是空间地不一致的。因为将近 90% 推迟的沉积负担来自西方河,它的变化在全部珀尔河里统治了沉积流动的全面趋势。尽管一个重要减少趋势在全部的沉积流动的年度变化存在,十的变化能被划分成一个增加的阶段和一个减少的阶段,与在在 1980 年代末的二个阶段之间的转弯的点。从 1950 年代到 1980 年代,平均的年度河沉积流动增加了 30.43% 。然而,自从 1990 年代,沉积流动显著地减少了,与是的平均沉积流动在 2000 年代的 38.60% 更少比那在 1950 年代。当前的沉积流动也是 52.93% 不到它在 1980 年代的山峰。到海的推迟的沉积负担运输的每月的变化模式更有趣。为西方河,所有月显示出一个减少的趋势,并且为大多数月,减小价值是重要的。然而,为东方河,沉积负担在湿季节在旱季和一个增加趋势显示出一个减少趋势。回归分析的方法被用来在沉积流动上在变化学习降水的影响。气候变化不是在在推迟的沉积负担的变化后面的主要驱动力,这被发现。在 1990 年代前,集中的陆地使用破坏了上面的珀尔河的脆弱的生态系统,并且加快了岩石 desertification 的过程。因而,加重了侵蚀在推迟的沉积负担引起了增加的土壤。然而,在水库以内的沉积保留开始了在 1990 以后在大水坝的巨大的构造以后起一个主导的作用,并且在送到海洋的推迟的沉积负担导致减少。 | Wei ZHANG Shousheng MU Yanjing ZHANG Kaimin CHEN | 2011 | International Journal of Sediment Research2011，26，4： | 6 |
| 5 | A novel approach to design microwave medium of negative refractive index and simulation verification显示文摘In this paper, a novel approach is presented to synthesize microwave medium of negative refractive index by incorporating metallic wire array with negative effective permittivity into the host media such as ferrimagnet-YIG (yttrium iron garnet) applied by external magnetic field whose permeability is negative. We have designed the composite medium having negative refractive index in C/X band frequencies, analyzed and simulated its electromagnetic (EM) properties by use of EM EDA package based on time-domain finite integration method. The simulation results show that: ① the effective permittivity of the designed metallic wire array is negative in the frequency range from 7.02 GHz to 9.80 GHz; ② the permeability of YIG substrate immersed into an external magnetic field is negative in the frequency range from 5.22 GHz to 8.14 GHz; ③ EM wave can pass through the composite medium synthesized by the above designed metallic wire array and YIG substrate, and ④ the negative refraction behavior occurs on the interface between the composite medium and the normal material with positive refractive index in 7.51―8.13 GHz frequency range, in which the effective permittivity of the metallic wire array and the permeability of YIG substrate are negative simultaneously. The full wave simulation has demonstrated that the effective refractive index of the designed composite medium is indeed negative and ascertained that the proposed approach to design microwave medium with negative refractive index is viable. | CAO YunJian WEN GuangJun WU KaiMin XU XinHe | 2007 | Chinese Science Bulletin2007，52，4： | 6 |
| 6 | Nanocomposites based on lanthanide-doped upconversion nanoparticles:diverse designs and applications显示文摘Lanthanide-doped upconversion nanoparticles(UCNPs)have aroused extraordinary interest due to the unique physical and chemical properties.Combining UCNPs with other functional materials to construct nanocomposites and achieve synergistic effect abound recently,and the resulting nanocomposites have shown great potentials in various fields based on the specific design and components.This review presents a summary of diverse designs and synthesis strategies of UCNPs-based nanocomposites,including self-assembly,in-situ growth and epitaxial growth,as well as the emerging applications in bioimaging,cancer treatments,anti-counterfeiting,and photocatalytic fields.We then discuss the challenges,opportunities,and development tendency for developing UCNPs-based nanocomposites. | Kaimin Du Jing Feng Xuan Gao Hongjie Zhang | 2022 | Light(Science & Applications)2022，11，8： | 4 |
| 7 | The addition of microbes for treating textile wastewater显示文摘Some strains and culture of bacteria which are able to decolorize dyes and degrade polyvinyl alcohol(PVA) were isolated and selected. A pilot scale facultative anaerobic-aerobic biological process was applied for treatment of textile wastewater containing dyes and PVA. Activated carbon adsorption was used as a tertiary treatment stage, and residual sludge from clarifier returned to the anaerobic reactor again. The pilot test were carried out with two systems. One was inoculated by acclimated sludge, and the another was adding the mixed culture of dye-decoloring and PVA-degrading bacteria for forming biological films, the latter was observed to be more effective than the former. The test has run normally for ten months with a COD loading of 2.13 kg/m3/day, a BOD5 loading of 0.34 kg/m3/day in anaerobic reactor; a COD loading of 1.71 kg/m3/day, a BOD5 loading 0.44 kg/m3/day in aerobic reactor. The pollutants removal efficiency by adding microbes was about 20% higher than that by acclimated sludge. The | Yang Huifang, Wang Kaimin, Jia Shengfen Qu Angui and Xian HaijunInstitute of Microbiology,Academia Sinica,Beijing 100080,ChinaDesiging Institute of the Ministry of Textile,Beijing,China | 1991 | Journal of Environmental Sciences1991，3，1： | 4 |
| 8 | Effect of Methylene Blue (MB)-value of Manufactured Sand on the Durability of Concretes显示文摘The relation between the methylene blue (MB) value of MS and its limestone powder content and clay content was investigated. The effects of MB values ranging from 0.35 to 2.5 on the workability of fresh concrete, the mechanical properties, the resistance to freezing as well as the resistance to chlorine ion permeation of the hardened concrete were all investigated. The experimental results showed that the MB value had no correlation with the limestone powder content of MS, while it was directly related to the clay content. With an increase of MB value, concrete workability decreased, as did the flexural and 7-day compressive strengths, however, the 28-day compressive strength was not affected. Furthermore, influence of MB value on concretes of different strength levels was different. For low-strength concretes, an increase of MB value could improve its impermeability, but this was not the case for high-strength concretes. Instead, their resistance to chloride ion permeability decreased slightly. However, even a slight increase in MB value remarkably accelerated freeze-thaw damage of MS concrete. It was thus concluded that the critical MB value of 1.4 would not cause significant deterioration in the performance of MS concretes. | 王稷良 NIU Kaimin TIAN Bo SUN liqun | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，6： | 4 |
| 9 | Review of Coded Modulation Free Space Optical Communication System显示文摘This paper presents a constructive discussion and inclusive review on advancements in the coded modulation free-space optical(FSO) communication system and corresponding techniques. These techniques mainly include channel model,forward error correction(FEC) and modulation schemes. Firstly,a complete view of FSO system is presented which contains the description,the current research situation along with the advantages over the traditional radio frequency(RF) wireless communication and fiber optical communications. Then,the channel model,FEC,modulation schemes and complete system of coded modulation FSO are analyzed successively. At last,the review work of coded modulation FSO system is summarized and further improvements are prospected. | WANG Kaimin LIU Bo ZHANG Lijia ZHANG Qi TIAN Qinghua XIN Xiangjun | 2015 | China Communications2015，12，11： | 3 |
| 10 | Effect of lentiviral vector-mediated KSR1 gene silencing on the proliferation of renal tubular epithelial cells and expression of inflammatory factors in a rat model of ischemia/reperfusion injury显示文摘 | Yang Bai Guanghong Han Kaimin Guo Lili Yu Xiadong Du Ying Xu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 3 |
| 11 | IGFBP7 regulates sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling显示文摘The epithelial-mesenchymal transition(EMT)process results in fibrosis of renal tubular epithelial cells and is of great importance in the development of acute kidney injury(AKI).Urinary IGF-binding protein-7(IGFBP7)was obviously increased in AKI and is considered to be a biomarker for AKI.However,whether it has an effect on the inhibition of lipopolysaccharide(LPS)-induced EMT in human HK2 cells and on that of cecal ligation and puncture(CLP)-induced EMT in human HK2 cells and in mice remains to be elucidated.Western blot analysis was performed to examine the phosphorylation of ERK1/2 level and expressions of IGFBP7,ERK1/2,EMT markers,such as E-cadherin,α-SMA,and vimentin,and EMT regulatory factors,such as Snail,transforming growth factor-β1(TGF-β1),and connective tissue growth factor(CTGF).The levels of IGFBP7,TGF-β1,and CTGF were detected by enzyme linked immunosorbent assay(ELISA).Concentrations of creatinine(Cr),blood urea nitrogen(BUN),and albumin(ALB)were measured by biochemical analysis.Here,we found that LPS promoted EMT and ERK1/2 activation in HK2 cells,which were inhibited by silencing of IGFBP7.Furthermore,IGFBP7 overexpression significantly increased EMT and ERK1/2 activation in HK2 cells,which were inhibited by ERK1/2 signaling inhibitor PD98059.IGFBP7 knockdown effectively attenuated renal fibrosis,concentrations of Cr,BUN and ALB,and activation of ERK1/2 signaling in CLP-induced mice.These results suggest that inhibiting IGFBP7 can effectively protect the renal tubular epithelial cells from EMT induced by LPS or CLP both in vitro and in vivo,which may be associated with inactivation of ERK1/2 signaling. | Xiaolin Wang Yan Li Zhenzhen Zhao Yan Meng Jinjun Bian Rui Bao Kaimin Zhu Tao Yang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 3 |
| 12 | Surface‑Enhanced Raman Scattering Fiber Probe Based on Silver Nanocubes显示文摘Surface-enhanced Raman scattering(SERS)provides a novel method for low concentration molecular detection.The performances were highly dependent on the sizes,geometries and distributions of metal nanostructures.Here,highly sensitive SERS fber probe based on silver nanocubes(Ag NCs)was fabricated,by assembled nanostructures on planar and tapered fber tips.Ag NCs were synthesized by polyol method,and controlled by reductant content,reaction temperatures and crystal growth durations.Tapered fbers with diferent cone angles were prepared by chemical etching.The electromagnetic distribution simulation indicated that nanocubes had stronger electric feld between two cubes and vertex corners than nanosphere,under 532 nm laser excitation.The intensity could reach 53.52 V/m,for cubes with 70 nm edge length.The SERS performance of probes was characterized using crystal violet analyte.The detectable lowest concentration could reach 10^(-9) and 10^(-10) M for planar and tapered fber probes,respectively.The corresponding enhancement factor could be 9.02×10^(7) and 6.22×10^(8).The relationship between SERS peak intensities and analyte concentrations showed well linear,which indicated both fber probes could be applied for both qualitative and quantitative analysis.Furthermore,optimal cone angle of tapered fber SERS probe was 8.3°.The tapered fber SERS probes have highly sensitive activity and great potential in substance detection. | Miao Yu Qihang Tian Guangyuan He Kaimin Cui Jihong Zhang | 2021 | Advanced Fiber Materials2021，3，6： | 3 |
| 13 | Cancer classification with data augmentation based on generative adversarial networks显示文摘Accurate diagnosis is a significant step in cancer treatment.Machine learning can support doctors in prognosis decision-making,and its performance is always weakened by the high dimension and small quantity of genetic data.Fortunately,deep learning can effectively process the high dimensional data with growing.However,the problem of inadequate data remains unsolved and has lowered the performance of deep learning.To end it,we propose a generative adversarial model that uses non target cancer data to help target generator training.We use the reconstruction loss to further stabilize model training and improve the quality of generated samples.We also present a cancer classification model to optimize classification performance.Experimental results prove that mean absolute error of cancer gene made by our model is 19.3%lower than DC-GAN,and the classification accuracy rate of our produced data is higher than the data created by GAN.As for the classification model,the classification accuracy of our model reaches 92.6%,which is 7.6%higher than the model without any generated data. | Kaimin WEI Tianqi LI Feiran HUANG Jinpeng CHEN Zefan HE | 2022 | Frontiers of Computer Science2022，16，2： | 2 |
| 14 | Compound Danshen Dripping Pill inhibits hypercholesterolemia/atherosclerosis-induced heart failure in ApoE and LDLR dual deficient mice via multiple mechanisms显示文摘Heart failure is the leading cause of death worldwide.Compound Danshen Dripping Pill(CDDP)or CDDP combined with simvastatin has been widely used to treat patients with myocardial infarction and other cardiovascular diseases in China.However,the effect of CDDP on hypercholesterolemia/atherosclerosis-induced heart failure is unknown.We constructed a new model of heart failure induced by hypercholesterolemia/atherosclerosis in apolipoprotein E(ApoE)and LDL receptor(LDLR)dual deficient(ApoE^(–/–)LDLR^(–/–))mice and investigated the effect of CDDP or CDDP plus a low dose of simvastatin on the heart failure.CDDP or CDDP plus a low dose of simvastatin inhibited heart injury by multiple actions including anti-myocardial dysfunction and anti-fibrosis.Mechanistically,both Wnt and lysine-specific demethylase 4A(KDM4A)pathways were significantly activated in mice with heart injury.Conversely,CDDP or CDDP plus a low dose of simvastatin inhibited Wnt pathway by markedly up-regulating expression of Wnt inhibitors.While the anti-inflammation and anti-oxidative stress by CDDP were achieved by inhibiting KDM4A expression and activity.In addition,CDDP attenuated simvastatin-induced myolysis in skeletal muscle.Taken together,our study suggests that CDDP or CDDP plus a low dose of simvastatin can be an effective therapy to reduce hypercholesterolemia/atherosclerosis-induced heart failure. | Yanfang Yang Ke Feng Liying Yuan Yuxin Liu Mengying Zhang Kaimin Guo Zequn Yin Wenjia Wang Shuiping Zhou He Sun Kaijing Yan Xijun Yan Xuerui Wang Yajun Duan Yunhui Hu Jihong Han | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
| 15 | Quantum-enhanced stochastic phase estimation with the Su(1,1)interferometer显示文摘Quantum stochastic phase estimation has many applications in the precise measurement of various physical parameters.Similar to the estimation of a constant phase,there is a standard quantum limit for stochastic phase estimation,which can be obtained with the Mach-Zehnder interferometer and coherent input state.Recently,it has been shown that the stochastic standard quantum limit can be surpassed with nonclassical resources such as squcezed light.However,practical methods to achieve quantum enhancement in the stochastic phase estimation remain largely unexplored.Here we propose a method utilizing the SU(1,1)interferometer and coherent input states to cstimate a stochastic optical phase.As an example,we investigate the Ornstcin-Uhlenback stochastic phase.We analyze the performance of this method for three key estimation problems:prediction,tracking,and smoothing.The results show significant reduction of the mean square error compared with the Mach-Zehnder interferometer under the same photon number flux inside the interferometers.In particular,we show that the method with the SU(1,1)interferometer can achieve fundamental quantum scaling,achieve stochastic Heisenberg scalinga and surpass the precision of the canonical measurement. | KAIMIN ZHENG MINGHAO MI BEN WANG LANG XU LIYUN HU SHENGSHUAI LIU YANBO LOU JETAI JING LIJIAN ZHANG | 2020 | Photonics Research2020，8，10： | 2 |
| 16 | Binding BetweenProteins and Cationic Spherical Polyelectrolyte Brushes:Effect of pH, Ionic Strength, and Stoichiometry显示文摘 | Wang Siyi Chen Kaimin Li Li | 2013 | Biomacromolecules2013，14，3： | 1 |
| 17 | Spherical polyelectrolyte brushes as a nanoreactor for synthesis of ultra fine magnetic nanoparticles显示文摘 | Zhu Yan Chen Kaimin Wang Xiang | 2012 | Nanotechnology2012，23，26： | 1 |
| 18 | Synthesis charac- terization and electrical response of phosphazene polyelec- trolytes显示文摘 | Ganapathiappan S Kaimin C Shriver D F | 1989 | Journal of the American Chemical Society1989，111，： | 1 |
| 19 | Palladium-Indium Catalyzed Reduction of N-Nitrosodimethylamine: Indium as a Promoter Metal显示文摘 | Matthew G Davie Kaimin Shih Federico A Pacheco | 2006 | Environmental Science &Technology2006，42，8： | 1 |
| 20 | Copper stabilization in beneficial use of waterworks sludge and copper-laden electroplating sludge for ceramic materials显示文摘 | Yuanyuan Tang Siu-Wai Chan Kaimin Shih | 2013 | Waste Management2013，，1： | 1 |
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