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| 1 | Sporadic fundic gland polyps are not associated with proton pump inhibitors therapy but negatively correlate with Helicobacter pylori infection in China显示文摘 | Cao Hailong Qu Rui Zhang Zhihua Kong Xinyue Wang Shan Jiang Kui Wang Bangmao | 2014 | Chinese Medical Journal2014，，7： | 29 |
| 2 | Inhibition of survivin expression and mechanisms of reversing drug-resistance of human lung adenocarcinoma cells by siRNA显示文摘背景 Survivin, apoptosis 的禁止者的一个成员蛋白质(国际机场) 家庭,在肿瘤房间并且不的 overexpresses 在严重地区分的成年纸巾表示。试图在 vitro 并且在 vivo 在房间增长, apoptosis 和 chemosensitivity 上调查 survivin 特定的 siRNA 的效果到 cisplatin 并且在颠倒癌症房间抵抗到化学疗法的 drug.Methods 关于 survivin 的减少的表示探索机制的这研究 Survivin 特定的 siRNA 是进 A549/DDP 房间的 transfected。抵抗相关的蛋白质( LRP ) mRNA 铺平的 survivin 和肺的表示被 RT-PCR 决定,到 cisplatin 的 A549/DDP ( cisplatin )房间的 chemosensitivity 被 MTT 试金决定,并且 apoptosis 和房间骑车被流动 cytometry ( FCM )决定 survivin 的 .The 蛋白质表示层次, LRP , cyclin-D1 , caspase-3 和 bcl-2 被西方的弄污的分析决定。肿瘤生长上的 survivin siRNA 抑制的效果在 vivo.Results 在 athymic 裸体人老鼠被学习 Survivin 特定的 siRNA 高效地下面调整的 survivin 表示。房间周期在 G2/M 阶段被逮捕,并且 apoptosis 显然被发现。survivin 表示的抑制能让 IC50 和 cisplatin 的药抵抗的索引减少,并且提高癌症房间敏感到 cisplatin。在由 survivin 特定的 siRNA 的 transfection 以后, LRP 和 cyclin-D1 的表示是 downregulated, caspase-3 表示是 upregulated,有的 bcl-2 表示没有明显的变化。survivin 击倒的证实的动物实验能禁止肿瘤 growth.Conclusions Survivin 特定的 siRNA 罐头高效地压制 survivin 的表示,增加 apoptosis,禁止细胞增长并且提高到在 vitro 并且在 vivo 的 cisplatin 的 chemosensitivity。survivin 表示帮助颠倒药抵抗的抑制可以与 LRP 的 downregulation 有关系, caspase-3.Anti-tumor 策略的 upregulation 可能在指向肺腺癌基于 survivin 的抑制是有用的。 | LIU Jing-lei WANG Yan JIANG Ji KONG Rui YANG Yan-mei JI Hong-fei SHI Yu-zhi | 2010 | Chinese Medical Journal2010，，20： | 22 |
| 3 | Transurethral seminal vesiculoscopy for recurrent hemospermia: experience from 419 cases显示文摘 | Rui Chen Lei Wang Xia Sheng Shu-Guang Piao Xin-Wen Nian Xin Cheng Tie Zhou Hui-Zhen Li Ya-Wei Liu Guang-Hua Chen Chun-Lei Zhang De-Pei Kong Guang-An Xiao Xin Lu Zhen-Yu Jia Zhi-Yong Liu Ying-Hao Sun | 2018 | Asian Journal of Andrology2018，20，5： | 18 |
| 4 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 5 | Shenfu injection attenuates lipopolysaccharide-induced myocardial inflammation and apoptosis in rats显示文摘Shenfu injection(SFI), a Chinese medicinal product, shows potent efficacy in treating sepsis. The aim of the present study was to clarify the protective effects of SFI against lipopolysaccharide(LPS)-induced myocardial inflammation and apoptosis.Experiments were carried out in Sprague-Dawley(SD) rats treated with LPS or LPS + SFI, and in H9 C2 cardiomyocytes. The sepsisassociated myocardial inflammation and apoptosis was induced by the intraperitoneal injection of LPS(20 mg·kg–1). SFI attenuated the increased expression of tumor necrosis factor(TNF)-α and interleukin(IL)-1β induced by LPS both in serum and heart. In LPS group,cell viability was reduced, and reversed after SFI administration. LPS treatment increased the expression levels of cleaved-caspase 3 and Bax, and those of Bcl2 and Bcl2/Bax. These two trends were reversed by SFI administration. The expression levels of phosphorylated mitogen-activated protein kinase kinase(p-MEK) and phosphorylated extracellular regulated protein kinases(p-ERK) were increased by LPS, and reversed by SFI. MEK inhibitor U0126 attenuated the apoptosis induced by LPS. These results indicate that SFI could treat LPS-induced cardiac dysfunction. In conclusion, SFI attenuates the inflammation and apoptosis induced by LPS via downregulating the MEK and ERK signaling pathways. | CHEN Rui-Juan RUI Qing-Lin WANG Qiong TIAN Fang WU Jian KONG Xiang-Qing | 2020 | Chinese Journal of Natural Medicines2020，18，3： | 12 |
| 6 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 7 | Characteristics and tectonic setting of volcanic rocks in Early Cretaceous Baiyingaolao Formation of Keyouzhongqi area,Inner Mongolia显示文摘The authors studied zircon LA-ICP-MS U-Pb dating,the zircon Hf isotope and geochemistry of acidic volcanic rocks in Baiyingaolao Formation of Keyouzhongqi area,Inner Mongolia,and discussed the chronology,source region and tectonic setting of the volcanic rocks in the studied area. The clear oscillatory zoning of zircons indicates a typical magmatic origin,and the results of dating show that the volcanic rocks of Baiyingaolao Formation were formed in Early Cretaceous( 121. 5 ± 1. 0 Ma). The features of major and trace elements show that the rocks are alkali-rich,poor in calcium and magnesium with enrichment in LILEs like Th,U,K and Gd and depletion in HFSEs,e. g. Nb,Ta,Sr and Ti. The fact implies that they were the products of partial melting of the crust. εHf( t) =( +6.30--+9.06) and TDM2= 600--835 Ma,suggest the magma originated from partial melting of the young crust. Combined with the evolution of regional tectonic structure,the authors conclude that the acidic volcanic rocks of Baiyingaolao Formation may be formed under the extensional environment related to the subduction of Paleo-Pacific Plate. | KONG Yuanming MA Rui HE Zhonghua YANG Deming WU Qing WANG Yang | 2014 | Global Geology2014，17，2： | 8 |
| 8 | Outcomes of simple saline-coupled bipolar electrocautery for hepatic resection显示文摘AIM:To evaluate the application of bipolar coagulation(BIP)in hepatectomy by comparing the efficacy of BIP alone,cavitron ultrasonic surgical aspirator(CUSA)+BIP and conventional clamp crushing(CLAMP).METHODS:Based on our database of patient records,a total of 380 consecutive patients who underwent hepatectomy at our hospital were retrospectively studied for the efficacy of BIP alone,CUSA+BIP and CLAMP.Of all the patients,75 received saline-coupled BIP(Group A),53 received CUSA+BIP(Group B),and252 received CLAMP(Group C).The pre-,mid-,and postoperative clinical manifestations were compared,and the effects of those maneuvers were evaluated.RESULTS:There was no obvious difference among the preoperative indexes between the different groups.The operative time was longer in Groups A and B than in Group C(P<0.001 for both).The amount of bleeding and the rate of transfusion during the operation were significantly higher in Group C than in Groups A and B(P<0.001 for all).The incidence of postoperative complications in Group C(46.43%)was higher than that in Groups A(30.67%,P=0.015)and B(28.30%,P=0.016).The patients’liver function recovery and postoperative hospital stay were not significantly different.BIP could decrease intraoperative hemorrhage and postoperative complications compared to CLAMP.CONCLUSION:Simple saline-coupled BIP should be considered a safe and reliable technique for liver resection to decrease intraoperative hemorrhage and postoperative complications. | Jian-Yang Guo De-Wei Li Rui Liao Ping Huang Xian-Bing Kong Ji-Ming Wang Hong-Lin Wang Shi-Qiao Luo Xiong Yan Cheng-You Du | 2014 | World Journal of Gastroenterology2014，20，26： | 7 |
| 9 | Seismic performance assessment of high CFRDs based on fragility analysis显示文摘Due to a large number of high concrete face rockfill dams(CFRDs) being constructed, the seismic safety is crucially important and seismic performance assessment must be performed for such dams. Fragility analysis is a method of great vitality for seismic performance assessment; it can intuitively forecast the structural effects of different ground motion intensities and provide an effective path for structure safety assessment. However, this method is rarely applied in the field of high earth dam risk analysis.This paper introduces fragility analysis into the field of high CFRD safety assessment and establishes seismic performance assessment methods. PGA, Sa(T1, 5%), PGV and PGD are exploited as the earthquake intensity measure(IMs). Relative settlement ratio of dam crest, cumulative sliding displacement of dam slope stability and a new face-slab destroying index(based on DCR and COD) are regarded as the dam damage measures(DMs). The dividing standards of failure grades of high CFRDs are suggested based on each DM. Fragility function is estimated according to incremental dynamic analysis(IDA) and multiple stripes analysis(MSA) methods respectively from a large number of finite element calculations of a certain CFRD, and seismic fragility curves are determined for each DM. Finally, this study analyzes the failure probabilities of the dam under different earthquake intensities and can provide references and bases for the seismic performance design and safety risk assessment of high CFRDs. | PANG Rui XU Bin ZOU DeGao KONG XianJing | 2019 | Science China(Technological Sciences)2019，62，4： | 6 |
| 10 | Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese显示文摘Alzheimer's disease is the most common neurodegenerative disease,and has a high level of genetic heritability and population heterogeneity.In this study,we performed the whole-exome sequencing of Han Chinese patients with familial and/or early-onset Alzheimer's disease,followed by independent validation,imaging analysis and function characterization.We identified an exome-wide significant rare missense variant rs3792646(p.K420Q)in the C7 gene in the discovery stage(P=1.09×10^(-6),odds ratio=7.853)and confirmed the association in different cohorts and a combined sample(1615 cases and 2832 controls,P_(combined)=2.99×10^(-7),odds ratio=1.930).The risk allele was associated with decreased hippocampal volume and poorer working memory performance in early adulthood,thus resulting in an earlier age of disease onset.Overexpression of the mutant p.K420Q disturbed cell viability,immune activation and β-amyloid processing.Electrophysiological analyses showed that the mutant p.K420Q impairs the inhibitory effect of wild type C7 on the excitatory synaptic transmission in pyramidal neurons.These findings suggested that C7 is a novel risk gene for Alzheimer’s disease in Han Chinese. | Deng-Feng Zhang Yu Fan Min Xu Guihong Wang Dong Wang Jin Li Li-Li Kong Hejiang Zhou Rongcan Luo Rui Bi Yong Wu Guo-Dong Li Ming Li Xiong-Jian Luo Hong-Yan Jiang Liwen Tan Chunjiu Zhong Yiru Fang Chen Zhang Nengyin Sheng Tianzi Jiang Yong-Gang Yao | 2019 | National Science Review2019，6，2： | 6 |
| 11 | D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP显示文摘 | Fengjing Jia Jiayi Wang Jinxiu Peng Ping Zhao Ziqing Kong Kairong Wang Wenjin Yan Rui Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，10： | 5 |
| 12 | Subtype Identification of Avian Influenza Virus on DNA Microarray显示文摘We have developed a rapid microarray-based assay for the reliable detection of H5, H7 and H9 subtypes of avian influenza virus (AIV). The strains used in the experiment were A/Goose/Guangdong/1/96 (H5N1), A/African starling/983/79 (H7N1) and A/Turkey/Wiscosin/1/66 (H9N2). The capture DNAs clones which encoding approximate 500-bp avian influenza virus gene fragments obtained by RT-PCR, were spotted on a slide-bound microarray. Cy5-labeled fluorescent cDNAs, which generated from virus RNA during reverse transcription were hybridized to these capture DNAs. These capture DNAs contained multiple fragments of the hemagglutinin and matrix protein genes of AIV respectively, for subtyping and typing AIV. The arrays were scanned to determine the probe binding sites. The hybridization pattern agreed approximately with the known grid location of each target. The results show that DNA microarray technology provides a useful diagnostic method for AIV. | WANG Xiu-rong YU Kang-zhen DENG Guo-hua SHI Rui LIU Li-ling QIAO Chuan-ling BAO Hong-mei KONG Xian-gang CHEN Hua-lan | 2005 | Agricultural Sciences in China2005，4，9： | 5 |
| 13 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 14 | A Femur-Implant Model for the Prediction of Bone Remodeling Behavior Induced by Cementless Stem显示文摘 | He Gong Lingyan Kong Rui Zhang Juan Fang Meisheng Zhao | 2013 | Journal of Bionic Engineering2013，10，3： | 4 |
| 15 | Digital Light Processing 3D-Printed Ceramic Metamaterials for Electromagnetic Wave Absorption显示文摘Combining 3D printing with precursor-derived ceramic for fabricating electromagnetic(EM) wave-absorbing metamaterials has attracted great attention. This study presents a novel ultraviolet-curable polysiloxane precursor for digital light processing(DLP) 3D printing to fabricate ceramic parts with complex geometry, no cracks and linear shrinkage. Guiding with the principles of impedance matching, attenuation, and effective-medium theory, we design a crosshelix-array metamaterial model based on the complex permittivity constant of precursor-derived ceramics. The corresponding ceramic metamaterials can be successfully prepared by DLP printing and subsequent pyrolysis process, achieving a low reflection coefficient and a wide effective absorption bandwidth in the X-band even under high temperature. This is a general method that can be extended to other bands, which can be realized by merely adjusting the unit structure of meta-materials. This strategy provides a novel and effective avenue to achieve “target-design-fabricating” ceramic metamaterials, and it exposes the downstream applications of highly efficient and broad EM wave-absorbing materials and structures with great potential applications. | Rui Zhou Yansong Wang Ziyu Liu Yongqiang Pang Jianxin Chen Jie Kong | 2022 | Nano-Micro Letters2022，14，7： | 4 |
| 16 | Epstein-Barr Virus EA-IgA, VCA-IgA, and EBVNA-IgG Antibodies in a Population of Wuhan, China显示文摘The study investigated the distribution of Epstein-Barr virus(EBV)EA-IgA,VCAIgA,and EBVNA-IgG antibodies in a local population of Wuhan,China.Chemiluminescence immunoassay(CL1A)was used to detect EBV EA-IgA,VCA-IgA,and EBVNA-IgG antibodies in 972 subjects undergoing physical examination in Wuhan,and the results were analyzed.The detection rate of EBV was positively correlated with age.In the 972 cases,there was significant difference between different genders in the positive rate of VCA-IgA and EBVNA-IgG.Moreover,the positive rate of VCA-IgA and EBVNA-IgG was higher in men>60 years old than in those<60 but no significant differences were found in three antibodies among various age groups.Our results suggested that the EBV infection should be intensively monitored in elderly people in Wuhan. | Zhen-gang TANG Hui-hui LI Yun-cheng LI Mei-xia LV Xin XU Jun-chao ZENG Wei-jia KONG Rui YANG | 2020 | Current Medical Science2020，40，1： | 4 |
| 17 | Prevalence and clinical application of TMPRSS2-ERG fusion in Asian prostate cancer patients: a large-sample study in Chinese people and a systematic review显示文摘Fusion between the transmembrane protease serine 2 and v-ets erythroblastosis virus E26 oncogene homolog(TMPRSS2-ERG fusion)is a common genetic alteration in prostate cancer among Western populations and has been suggested as playing a role in tumorigenesis and progression of prostate cancer.However,the prevalence of TMPRSS2-ERG fusion differs among different ethnic groups,and contradictory results have been reported in Asian patients.We aim to evaluate the prevalence and significance of TMPRSS2-ERG fusion as a molecular subtyping and prognosis indicator of prostate cancer in Asians.We identified the fusion status in 669 samples from prostate biopsy and radical prostatectomy by fluorescence in situ hybridization and/or immunohistochemistry in China.We examined the association of TMPRSS2-ERG fusion with clinicopathological characteristics and biochemical recurrence by Chi-square test and Kaplan–Meier analysis.Finally,a systematic review was performed to investigate the positive rate of the fusion in Asian prostate cancer patients.McNemar’s test was employed to compare the positive rates of TMPRSS2-ERG fusion detected using different methods.The positive rates of TMPRSS2-ERG fusion were 16%in our samples and 27%in Asian patients.In our samples,9.4%and 19.3%of cases were recognized as fusion positive by fluorescence in situ hybridization and immunohistochemistry,respectively.No significant association between the fusion and clinical parameters was observed.TMPRSS2-ERG fusion is not a frequent genomic alteration among Asian prostate cancer patients and has limited significance in clinical practices in China.Besides ethnic difference,detection methods potentially influence the results showing a positive rate of TMPRSS2-ERG fusion. | De-Pei Kong Rui Chen Chun-Lei Zhang Wei Zhang Guang-An Xiao Fu-Bo Wang Na Ta Xu Gao Ying-Hao Sun | 2020 | Asian Journal of Andrology2020，22，2： | 4 |
| 18 | Adiponectin attenuates lipopolysaccharide-induced cell injury of H9c2 cells by regulating AMPK pathway显示文摘Adiponectin,an adipokine synthesized and secreted majorly by adipose tissue,is reported to exert cardioprotective properties via anti-inflammation and antiapoptosis.Lipopolysaccharide(LPS)is a common inflammation and apoptosis inducer of cardiomyocytes.However,few studies have reported the roles of adiponectin on LPS-induced inflammation as well as apoptosis of H9c2 cells,and the possible mechanisms of these effects.In the present study,we found that adiponectin significantly relieved LPS-induced cytotoxicity including decreased viability and elevated LDH release,inhibited LPS-triggered inflammation,which is evidenced by increases in release of TNF-α,IL-1β as well as IL-6,and attenuated the enhanced rates of apoptotic cells as well as increased caspase-3 activity caused by LPS in H9c2 cells.In addition,our data demonstrated that adiponectin upregulated AMP-activated protein kinase(AMPK)activation of H9c2 cells with or without LPS administration.Moreover,we found that blocking AMPK pathway by compound c attenuated the protective effects of adiponectin against the cytotoxicity,inflammatory response,and apoptosis of H9c2 cells resulted from LPS.Our observations bring novel insights for understanding the mediatory role of AMPK pathway implicated in the protective effects of adiponectin against LPS-induced cardiotoxicity. | Rui Hao Guoying Su Xiaolin Sun Xiangran Kong Cuiying Zhu Guohai Su | 2019 | Acta Biochimica et Biophysica Sinica2019，51，2： | 4 |
| 19 | Excavation-induced deep hard rock fracturing:Methodology and applications显示文摘To analyze and predict the mechanical behaviors of deep hard rocks,some key issues concerning rock fracturing mechanics for deep hard rock excavations are discussed.First,a series of apparatuses and methods have been developed to test the mechanical properties and fracturing behaviors of hard rocks under high true triaxial stress paths.Evolution mechanisms of stress-induced disasters in deep hard rock excavations,such as spalling,deep cracking,massive roof collapse,large deformation and rockbursts,have been recognized.The analytical theory for the fracturing process of hard rock masses,including the three-dimensional failure criterion,stress-induced mechanical model,fracturing degree index,energy release index and numerical method,has been established.The cracking-restraint method is developed for mitigating or controlling rock spalling,deep cracking and massive collapse of deep hard rocks.An energy-controlled method is also proposed for the prevention of rockbursts.Finally,two typical cases are used to illustrate the application of the proposed methodology in the Baihetan caverns and Bayu tunnels of China. | Xia-Ting Feng Cheng-Xiang Yang Rui Kong Jun Zhao Yangyi Zhou Zhibin Yao Lei Hu | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，1： | 4 |
| 20 | The Value of Subjective Visual Vertical in Diagnosis of Vestibular Migraine显示文摘Objective To study the value of the subjective visual vertical(SVV)in the diagnosis of vestibular migraine(VM).Methods This study recruited 128 VM patients and 64 age-matched normal subjects.We detected the SVV during the interval between attacks in both groups,in sitting upright,and the head tilted at 45°to the left or right.We then examined the correlation between the SVV results with the vestibular evoked myogenic potential(VEMP)and canal paresis(CP).Results It was found there was a significant difference in SVV at the upright position between VM patients and normal controls(P=0.006)and no significant difference was found at the tilts of 45°to the left or right between the two groups.The SVV results at the upright position were significantly correlated with cervical VEMP(P=0.042)whereas not significantly correlated with CP and VEMP.There existed no significant difference in the conformity to the Müller effect(M effect)between the two groups.ROC analysis exhibited that the sensitivity,specificity of SVVs at the upright were 67.200%and 62.500%respectively.The diagnostic value of SVV at the upright position was significantly higher than that at tilts of 45°to the left and right(P=0.006).Nonetheless the diagnostic accuracy was relatively low.Conclusion Abnormality in SVV possibly stems from the lasting functional disorder of cerebellar or high-level cortical centers in VM patients or is linked to the vestibular compensation.The SVV is of low diagnostic value for VM and the value of SVV in VM warrants further study. | Fei LI Jin XU Gen-ru LI Rui GAO Chen-yong SHANG E TIAN Wei-jia KONG Jian-hua ZHUANG Su-lin ZHANG | 2021 | Current Medical Science2021，41，4： | 3 |
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