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| 1 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 2 | Statistically designed two step response surface optimization of enzymatic prepress treatment to increase juice yield and lower turbidity of elderberry juice显示文摘 | Anne Katrine Landbo Karl Kaack Anne S Meyer | 2007 | Innovative Food Science and Emerging Technologies2007，8，1： | 1 |
| 3 | Carboxymethyl xylan-control of properties by synthesis 显示文摘 | Thomas H Katrin P Katrin S | 2005 | Macromol Sympo2005，232，1： | 1 |
| 4 | XX/XY Chimerism and Freemartinism in a Female Llama Co - twin to a Male显示文摘 | Katrin H Lance C Buoen B S | 1999 | Journal of the American Veterinary Medical Association1999，215，8： | 1 |
| 5 | Development of an ex vivo retention model simulating bioadhesion in the oral cavity using human saliva and physiologically relevant irrigation media显示文摘 | KATRINE D M CAMILLA S STEFANIA B | 2013 | International Journal of Pharmaceutics2013，448，2： | 1 |
| 6 | Compliant membranes im- prove resolution in full - wafer micro/nanostencil lithography 显示文摘 | Katrin S Villanueva LG Oscar VM | 2012 | Nanoseale2012，4，3： | 1 |
| 7 | Relevance of intra-and extra-cellularcyanotoxins for drinking water treatment显示文摘 | J-rg P Katrin B Wido S | 2002 | Acta HydrochimHydrobiol2002，30，1： | 1 |
| 8 | The 3D positioning of ANT2 and ANT 3 gene within female X chromosome territories correlates with gene activity显示文摘 | Steffen D Katrin S Graham L | 1999 | Experimental Cell Research1999，252，： | 1 |
| 9 | Review the multiple functions of coenzyme Q显示文摘 | Hans N Katrin S Lars G | 2001 | Bioorg Chem2001，29，1： | 1 |
| 10 | High bacterial diversity in permanently cold marine sediments显示文摘 | Katrin R Kerstin S Jakob P | 1999 | Applied and Environmental Microbiology1999，65，9： | 1 |
| 11 | Incidence, pathogens and resistance patterns of nosocomial infections at a rural hospital in Gabon显示文摘 | Micha S Katrin K Raymund EM | 2014 | BMC Infect Dis2014，11，14： | 1 |
| 12 | Lactic acid delays theinflammatory response of human monocytes显示文摘 | KATRIN P MICHAEL R KATRIN S | 2015 | Biochemical andBiophysical Research Communications2015，457，3： | 1 |
| 13 | Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model显示文摘Background:We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages(BM-M)in APP/PS1 transgenic mice.Method:BM-M were transplanted into the tail vein and the animals analysed 1 month later.Results:BM-M transplantation promoted the reduction of the amyloid beta[37-42]plaque number and size in the cortex and hippocampus of the treated mice,but no change in the more heavily modified pyroglutamate amyloid beta E3 plaques.The number of phenotypically‘small’microglia increased in the hippocampus.Astrocyte size decreased overall,indicating a reduction of activated astrocytes.Gene expression of interleukin 6 and 10,interferongamma,and prostaglandin E receptor 2 was significantly lower in the hippocampus,while interleukin 10 expression was elevated in the cortex of the treated mice.Conclusions:BM-M systemically transplanted,promote a decrease in neuroinflammation and a limited reversion of amyloid pathology.This exploratory study may support the potential of BM-M or microglia-like cell therapy and further illuminates the mechanisms of action associated with such transplants. | Luís Costa-Marques Katrin Arnold Marie-Christine Pardon Christiane Leovsky Samantha Swarbrick Claire Fabian Alexandra Stolzing | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 14 | The sulfation pattern of chondroitin sulfate from articular cartilage explants in response to mechanical loading 显示文摘 | Katrin S Anna H K P Ruth X R | 2003 | Biochimica et biophysica acta2003，1638，： | 1 |
| 15 | Ionic liquids as reaction medium in cellulose fictionalization显示文摘 | Thoma S H Katrin S Susann B | | 0，，06： | 1 |
| 16 | Chloroplast and cytosofic triosephosphate isomerases from spinach: purification, microse- quencing and cDNA cloning of the chloroplast enzyme 显示文摘 | KATRIN H CLAUS S JOSEF K | 1994 | Plant Mol Biol1994，26，： | 1 |
| 17 | Microemulsion in technical processes 显示文摘 | Katrin S | 1995 | Chem Rev1995，95，： | 1 |
| 18 | The sulfationpattem ofchondroitin sulfate from articular cartilage explantsin response tomechanical loading显示文摘 | Katrin S Anna H K P Ruth X R | 2003 | Biochimicaet biophysica acta2003，1638，： | 1 |
| 19 | Review the multiple functions of coenzyme Q显示文摘 | HANS N KATRIN S LARS G | 2001 | Bioorg Cherm2001，29，： | 1 |
| 20 | The multiple functions of coenzyme Q 显示文摘 | HANS N ANDREY V K KATRIN S | 2001 | Bioorg Chem2001，29，： | 1 |
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