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| 1 | Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells显示文摘尽管有非酒精的脂肪肝疾病是良性的混乱的起始的信仰,纤维变性前进发生在病人的一个重要数字,这现在被认出。而且,肝的脂肪变性在大量其它为肝的纤维变性的前进作为一个风险因素被识别了肝疾病。这里,我们建立了一在里面在肝的星形的房间(HSC ) 上学习肝的类脂化合物累积的效果的 vitro 模型,肝 fibrogenesis 的中央调停人。主要人的 hepatocytes 与浸透的丰满的酸 palmitate 被孵化导致细胞内部的类脂化合物累积。随后,人的 HSC 从 steatotic 或控制 hepatocytes 与调节媒介(厘米) 被孵化。在 hepatocytes 的类脂化合物累积导致了加速了 HSC 的激活和增长的因素的版本,并且提高了他们的抵抗到 apoptosis,大部分经由 PI-3-kinase 小径的激活调停了。而且,从 steatotic hepatocytes 的厘米导致了 profibrogenic 基因 TGF- 尾, metallo-proteinase-1 (TIMP-1 ) 的织物禁止者, TIMP-2 和 matrix-metallo-proteinase-2 的表示,以及在 HSC 的原子因素的魏 B 依赖者 MCP-1 表示。在摘要,我们的在里面 vitro 数据在 vivo 为在肝的脂肪变性和 fibrogenesis 之间的 pathophysiological 连接显示潜在的机制。附此,这研究提供一在 vitro 吸引人学习导致脂肪变性的 fibrogenesis 的分子的机制,并且识别并且测试小说的模型在脂肪肝为 antifibrotic 指向治疗疾病。 | Hella Wobser Christoph Dora Thomas S Weiss Thomas Amann Cornelius Bollheimer Roland Btittner Juergen Schoelmerich Claus Helterbrand | 2009 | Cell Research2009，19，8： | 16 |
| 2 | Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis. | Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 3 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 4 | Towards new understanding of the heart structure and function 显示文摘 | Langeland S Wouters PF Claus P | 2005 | Eur J Cardiol Thorac Surg2005，27，2： | 1 |
| 5 | Prevalenoe of BRCA1 and BRCA2 mutations in women diagnosed with ductal carcinoma in situ显示文摘 | Claus EB Petruzella S Matloff E | 2005 | JAMA2005，294，5： | 1 |
| 6 | Experimental assessm- ent of a new research tool for the estimation of two-dimensional myocardial strain显示文摘 | Langeland S Wouters PF Claus P | 2006 | Ultrasound Med Biol2006，32，： | 1 |
| 7 | Escitalopram: a unique mechanism of action显示文摘 | Claus B Connie S | 2004 | International Journal of Psychiatry in Clinical Practice2004，8，： | 1 |
| 8 | Escitalopram:a unique mechanism of action显示文摘 | Claus B Connie S | 2004 | International Journal of Psychiatry in Clinical Practice2004，8，1： | 1 |
| 9 | Structural Control: past, present, and future显示文摘 | Housner G Bergman L Gaughey T Chassiakos A Claus R Masri S Skellton R Soong T Spencer B Yao J | 1997 | Journal of Engineering Mechanics (ASCE)1997，123，： | 1 |
| 10 | Capsule null locus meningococci:Typing of antigens used in an investigational multicomponent meningococcus serogroup B vaccine显示文摘 | CLAUS H JORDENS M S KRIZ P | 2012 | Vaccine2012，30，2： | 1 |
| 11 | Efficacy and safety of dutasteride in the four-year treatment of men with benign prostatic hyperplasia显示文摘 | Roehrborn Claus G Marks Leonard S Fenter Tom | 2004 | Urology2004，63，4： | 1 |
| 12 | Novel insight into structure and function of MRP8 and MRP14显示文摘 | Claus K Martin K Clemens S | 1998 | Biochim Biophy Acta1998，1448，： | 1 |
| 13 | Elliptical-core two mode optical-fiber sensor implementation methods显示文摘 | K A Murphy M S Miller A M Vengsarkar R O Claus | | 0，，： | 1 |
| 14 | Hemorrhagic transformation in cardioembolic cerebral infarction 显示文摘 | Claus H Thomas B Carmen S | 1993 | Stroke1993，24，2： | 1 |
| 15 | A pervasive role of ubiquitin conjugation in activation and termination of IkB kinase pathways显示文摘 | Daniel K Claus S | 2005 | EMBO Reports2005，6，4： | 1 |
| 16 | Escitalopram:a unique mechanism of action显示文摘 | Claus B Connie S | | 0，，1： | 1 |
| 17 | Low-fat,high - moisture frankfurters :Effects of temperature and water during extended mixing 显示文摘 | SYLVIA S F CLAUS J R MARRIOTT N G | 1994 | Journal of Food Science1994，59，5： | 1 |
| 18 | Structural Control: Past, Present, and Future显示文摘 | HOUSNER G W BERGMAN L A CAUGHEY T K CHASSIAKOS A G CLAUS R O MASRI S F SKELTON R E SOONG T T SPENCER B F YAO J T P | 1997 | Journal of Engineering Mechanics1997，123，9： | 1 |
| 19 | Hemorrhagic transformation in cardioembolic cerebral infarction显示文摘 | Thomas B Carmen S | 1993 | Stroke1993，24，： | 1 |
| 20 | Experimental assessment of a new research tool for the estimation of two-dimensional myocardial strain显示文摘 | Langeland S Wouters PF Claus P | 2006 | Ultrasound Med Biol2006，32，10： | 1 |
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