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| 1 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014,6,4: | 2 |
| 2 | Developmental outcome and psychosocial adjustment in children after surgery for congenital heart disease during infancy 显示文摘 | Katja H Karl - Otto D Herman K | 2007 | SRIP2007,25,2: | 1 |
| 3 | Cephalometric characteristics of Class 2 division 2 malocclusion : A comparative study in children 显示文摘 | Pancherz D Katja Z Britta H | 2007 | An- gle Orthod2007,67,2: | 1 |
| 4 | Pathogenesis of the toxic shock syndrome: T cell mediated lethal shock caused by the superantigen TSST-1 显示文摘 | THOMAS M KATJA D CLAUDIA W | 1993 | European Journal of Immunology1993,23,7: | 1 |
| 5 | Hawthorn extract for treating chronic heartfailure:meta-analysis of randomized trials显示文摘 | MaxH P M D Katja S | 2003 | The American Journal of Medicine2003,14,1: | 1 |
| 6 | Advances in amino acid analysis显示文摘 | Hannelore K Katja D Wolfram G | 2009 | Anal Biochem2009,393,2: | 1 |
| 7 | Elevated diurnal salivary cortisol in nurses is associated with burnout but not with vital exhaustion 显示文摘 | Katja W Michael S Annika D | 2009 | Psychoneuroendocrinology2009,34,: | 1 |
| 8 | Glanzmann thrombasthenia Frankfurt I is associated with a point mutation Thr176I1e in the N-terminal region of αⅡb subunit integrin 显示文摘 | Westrup D Santoso S Katja F H | 2004 | Thromb Haemost2004,92,5: | 1 |
| 9 | Misocyclone characteristics along Florida gust fronts during CAPE显示文摘 | Katja F Kingsmill D E Young C R | | 0,,11: | 1 |
| 10 | α-synuclein and its Molecular Pathophysiological Role in Neurodegenerative Disease显示文摘 | Katja Hofele Samuel Barbieri | 2003 | Neuropharmacology2003,45,: | 1 |
| 11 | Cephalometric characteristics of Class Ⅱ division 2 malocclusion:A comparative study in children显示文摘 | Pancherz D Katja Z Britta H | 1997 | Angle Orthod1997,67,2: | 1 |
| 12 | Rectal Cancer: Mucinous Carcinoma on Magnetic Resonance Imaging Indicates Poor Response to Neoadjuvant Chemoradiation显示文摘 | Katja Oberholzer Matthias Menig Andreas Kreft Astrid Schneider Theodor Junginger Achim Heintz Karl-Friedrich Kreitner Andreas M. H?tker Torsten Hansen Christoph Düber Heinz Schmidberger | 2012 | International Journal of Radiation Oncology Biology Physics2012,,2: | 1 |
| 13 | Improved Meth- ods for Urinary Atrazine Mercapturate Analysis-assessment of an Enzyme-linked Immunosorbent Assay (ELISA) and a Novel Liquid Chromatography-mass Spectrometry (LC-MS) Method Utilizing Online Solid Phase Extraction(SPE)显示文摘 | MARJA E KOIVUNEN A A KATJA D | 2006 | Analytica Chimica Acta2006,572,: | 1 |
| 14 | Characterization and three-dimensional structures of two dis?tinct bacterial xyloglucanases from families GH5 and GH12显示文摘 | TRACEY M G FARID M I KATHERINE M JENS M E SHIRLEY R JOHAN P T MADS E B PER L J STEFFEN D KATJA S J TORBEN V B KEITH S W HARRY B GIDEON J D | 2007 | Journal of Biological Chemistry2007,282,19: | 1 |
| 15 | ot - synuclein and its Molecular Pathophysiological Role in Neurodegenemtive Disease显示文摘 | Kumlesh K D Katja Hofele Samuel Barbieri | 2003 | Nettropharmacology2003,45,: | 1 |
| 16 | Hawthorn extract for treating chronic heartfailure : metar - analysis of randomizes trials 显示文摘 | Max H P M D Katja S | 2003 | The American Journal of Medicine2003,14,1: | 1 |
| 17 | Cephalometric characteristics of Class II division 1 and Class II division 2 malocclusion:A comparative study in children显示文摘 | Pancherz D Katja Z Britta H | 2009 | Angle Orthod2009,67,2: | 1 |
| 18 | Cephalometric characteristics of Class II devision 1 and Class II division 2 malocclusion: a comparative study in children显示文摘 | Pancherz D Katja Z Britta H | 1997 | Angle Orthod1997,67,2: | 1 |
| 19 | Toward the recognition of structure-function relationships in galactomannans显示文摘 | PIET J H D KATJA G TON V V | 2002 | J Agric Food Chem2002,50,15: | 1 |
| 20 | Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy,field-flow fractionation and transmission electron microscopy显示文摘 | Katja J Wolfgang M Markus D | 2004 | J Controlled Release2004,95,2: | 1 |