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| 1 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 2 | Feeding of Riptortus pedestris on soybean plants, the primary cause of soybean staygreen syndrome in the Huang-Huai-Hai river basin显示文摘Staygreen syndrome or Zhengqing in soybean has recently become a major issue for Chinese growers in the Huang-Huai-Hai river basin.Although previous studies revealed that staygreen can be induced when pods/seeds are damaged, it is unknown whether virus infection or insect infestation causes staygreen.To determine whether viral infection causes staygreen, a survey of soybean staygreen incidence in the Huang-Huai-Hai river basin was conducted in 2016 and 2017.Diseased samples were collected and analyzed using DAS-ELISA for Soybean mosaic virus, Watermelon mosaic virus, Bean pod mottle virus, Cucumber mosaic virus, and Bean common mosaic virus.The survey showed that the severity of soybean staygreen syndrome was most prevalent in Beijing, Henan, Shaanxi, and some parts of Shandong provinces, with yield losses from 0 to nearly 100%, but only a small fraction of samples were positive for the tested viruses.A field cage experiment and an insecticide treatment field trial were conducted to determine the contribution of the bean bug, Riptortus pedestris, to staygreen incidence.The field cage experiment showed that R.pedestris treatment resulted in shorter plants, more empty pods, increased numbers of abnormal seeds, and decreased yields.The field experiment showed that there were fewer R.pedestris and less soybean staygreen incidence in fields treated with insecticide than in untreated control fields.Together, these results suggest that R.pedestris infestation rather than virus infection induces staygreen syndrome and that growers in this region can mitigate staygreen syndrome via bean bug control. | Kai Li Xinxin Zhang Jianqiu Guo Hannah Penn Tingting Wu Lin Li Hong Jiang Lidan Chang Cunxiang Wu Tianfu Han | 2019 | The Crop Journal2019，7，3： | 30 |
| 3 | Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery显示文摘AIM: To investigate the effect of compound Danshen injection on lipopolysaccharide (LPS)-induced rat mesenteric microcirculatory dysfunctions and the underlying possible mechanism by an inverted intravital microscope and high-speed video camera system. METHODS: LPS was continuously infused through the jugular artery of male Wistar rats at the dose of 2 mg/kg per hour. Changes in mesenteric microcirculation,such as diameters of arterioles and venules,velocity of RBCs in venules,leukocyte rolling,adhesion and emigration,free radicals released from post-capillary venules,FITC- albumin leakage and mast cell degranulation,were observed through an inverted intravital microscope assisted with CCD camera and SIT camera. Meanwhile,the expression of adhesion molecules CD11b/CD18 and the production of free radical in neutrophils,and the expression of intercellular adhesion molecule 1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) were quantified by flow cytometry (FACS) in vitro. RESULTS: The continuous infusion with LPS resulted in a number of responses in microcirculation,including a significant increase in the positive region of venulestained with Monastral blue B,rolling and adhesion of leukocytes,production of oxygen radical in venular wall,albumin efflux and enhanced mast cell degranulation in vivo,all of which,except for the leukocyte rolling,were attenuated by the treatment with compound Danshen injection. Experiments performed in vitro further revealed that the expression of CD11b/CD18 and the production of oxygen free radical in neutrophils,and the expression of ICAM-1 in HUVECs were increased by exposure to LPS,and they were attenuated by compound Danshen injection. CONCLUSION: These results suggest that compound Danshen injection is an efficient drug with multi-targeting potential for improving the microcirculatory disturbance. | Jing-Yan Han Yoshinori Horie Soichiro Miura, Yasutada Akiba Jun Guo Dan Li Jing-Yu Fan Yu-Ying Liu Bai-He Hu Li-Hua An Xin Chang Man Xu De-An Guo Kai Sun Ji-Ying Yang Shu-Ping Fang Ming-Ji Xian Masahiro Kizaki Hiroshi Nagata Toshifumi Hibi | 2007 | World Journal of Gastroenterology2007，13，26： | 26 |
| 4 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 5 | Sexual and reproductive health service needs of university/ college students: updates from a survey in Shanghai, China显示文摘瞄准:由在上海探索大学学生的态度和感觉支持为年轻人的繁殖健康服务的预备,中国,向繁殖健康。方法:从 2004 年 7 月到 2006 年 5 月,在上海的 14 所大学的 5 243 个学生参加了我们的调查。话题在性健康上并且性用性,到色情材料的暴露,和知识盖住繁殖保健服务,对的态度和经验的要求播送感染(STI )/AIDS。结果:提供了有效答案表的 5 067 个学生, 50.05% 是女性, 49.95% 是男性的, 14.86% 是医学院的学生,并且 85.14% 有非医学的背景。38.4% 回答者的一个总数以前收到了繁殖卫生教育。学生的多数支持了基于学校的繁殖卫生教育,并且也从书,同学,和因特网主要关于性获得了信息。婚前的性行为被 17.7% 调查参加者反对,并且 37.5% 能识别在问询表列出的 STI 的所有三种类型。尽管 83.7% 知道了 HIV 怎么被播送,仅仅, 55.7% 知道了什么时候使用避孕套, 57.8% 知道避孕套的使用能减少 HIV 感染的风险。结论:繁殖健康服务正在落后于大学学生的当前的态度和要求。尽管学生对性事的态度是开明的,他们繁殖健康和 STIs/AIDS 的知识仍然是有限的。提供有效、机密的繁殖健康服务给年轻人因此是必要的。 | Bin Chen Yong-Ning Lu Hong-Xiang Wang Qing-Liang Ma Xiao-Ming Zhao Jian-Hua Guo Kai Hu Yi-Xin Wang Yi-Ran Huang Pei Chen | 2008 | Asian Journal of Andrology2008，10，4： | 20 |
| 6 | Inheritance and Gene Mapping of Resistance to Soybean Mosaic Virus Strain SC14 in Soybean显示文摘大豆马赛克病毒(SMV ) 是世界范围的最广泛地分布式的疾病之一。它在大豆(甘氨酸最大(L.) Merr ) 引起严重收获损失和种子质量缺乏。从山西省孤立的 SMV 紧张 SC14,中国,是最新识别的剧毒的紧张并且能感染 Kefeng 号码 1,有宽光谱抵抗的来源。在现在的学习,大豆就职, PI96983, Qihuang 号码 1 和 Qihuang 号码 22 被识别是抵抗(R) andNannong 1138-2, Pixianchadou 易受影响的(S) 到 SC14。PI96983 x Nannong1138-2 的分离分析显示了那单个显性基因(指定了为 RSC14 ) 控制了抵抗到 SC14at V2 和 R1 发育阶段。一样的结果为 QihuangNo 的十字被获得。在 PI96983 x ,在 V2stage ,但是在 R1 的 Nannong 1138-2 上演的 1 个 x Nannong 1138-2 和 Qihuang 号码 22 x Nannong 1138-2 , F1 作为坏死(除马赛克以外的易受影响的症状)表现了,在 1R:2N:1S 的比率的 F2segregated ,并且坏死的(N) F2 个人的子孙在 R , N 和 S 也分离了。它显示了那单个基因(指定了为 RSC14Q,与那 ofPI96983 不同) 控制了抵抗到 SC14,它的优势与在 PI96983 x Nannong1138-2 一样(没有症状) 在 V2,在 R1 的舞台和并非一样上演。紧连接的 co-dominantsimple 顺序重复(SSR ) 标记 Satt334 显示所有异质接合的乐队完全相应于坏死的 F2 个人,否则所有坏死的 F2 个人是异质接合体。坏死力量由于在 SMV 紧张,抵抗基因,抵抗基因的遗传背景,和植物发展舞台之中的相互作用,这被推断。而且, SSR 标记的 bulked segregant 分析(BSA ) 被进行印射抵抗基因。在 PI96983 x Nannong 1138-2 的 F2,五个 SSR 标记, Sat_297, Sat_234, Sat_154, Sct_033 andSat_120,被发现仔细连接了到 RSC14 与 14.5 厘米, 11.3 厘米, 4.3 厘米, 3.2cM 和 6 厘米的遗传距离,分别地。在 Qihuang 号码 1 x Nannong 1138-2,三个 SSR 标记, Sat_234, Satt334 和 Sct_033 的 F2,紧分别地与 7.2 厘米, 1.4 厘米和 2.8 厘米的遗传距离连接了到 RSC14Q。由 Cregan 等基于综合联合地图。(1999 ) , RSC14 和 RSC14Q 与大豆的组 F 在 Sat_234 和 Sct_033 之间位于连接,分别地与他们在一样的方面的距离 fromSct_033 是 3.2 厘米和 2.8 厘米。因此, RSC14 和 RSC14Q 可能在一个一样的地点上。获得的信息在引起抵抗基因的节目并且好印射并且基于地图的克隆的大豆为抵抗基因的帮助标记的选择提供基本知识…… | Hai-Chao Li Hai-Jian Zhi Jun-Yi Gai Dong-Quan Guo Yan-Wei Wang Kai Li Li Bai Hua Yang | 2006 | Journal of Integrative Plant Biology2006，48，12： | 19 |
| 7 | Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs.3 doses in young women显示文摘A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women.A randomized,immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in China.Girls aged 9–14 years were randomized to receive 2 doses at months 0 and 6(n=301)or 3 doses at months 0,1 and 6(n=304).Girls aged 15–17 years(n=149)and women aged 18–26 years(n=225)received 3 doses.The objectives included noninferiority analysis of the IgG geometric mean concentration(GMC)ratio(95%CI,lower bound>0.5)to HPV-16 and HPV-18 at month 7 in girls compared with women.In the per-protocol set,the GMC ratio of IgG was noninferior for girls aged 9–17 years receiving 3 doses compared with women(1.76(95%CI,1.56,1.99)for HPV-16 and 1.93(95%CI,1.69,2.21)for HPV-18)and noninferior for girls aged 9–14 years receiving 2 doses compared with women(1.45(95%CI,1.25,1.62)for HPV-16 and 1.17(95%CI,1.02,1.33)for HPV-18).Noninferiority was also demonstrated for neutralizing antibodies.The immunogenicity of the HPV vaccine in girls receiving 3 or 2 doses was noninferior compared with that in young adult women. | Yue-Mei Hu Meng Guo Chang-Gui Li Kai Chu Wen-Gang He Jing Zhang Jian-Xiang Gu Juan Li Hui Zhao Xiang-Hong Wu Bi-Zhen Lin Zhi-Jie Lin Xing-Mei Yao Ya-Fei Li Fei-Xue Wei Yue Huang Ying-Ying Su Feng-Cai Zhu Shou-Jie Huang Hui-Rong Pan Ting Wu Jun Zhang Ning-Shao Xia | 2020 | Science China(Life Sciences)2020，63，4： | 19 |
| 8 | YAP promotes osteogenesis and suppresses adipogenic differentiation by regulatingβ-catenin signaling显示文摘YAP(yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo pathway, a conserved pathway for the development and size control of multiple organs. The exact function of YAP in bone homeostasis remains controversial. Here we provide evidence for YAP's function in promoting osteogenesis, suppressing adipogenesis, and thus maintaining bone homeostasis.YAP is selectively expressed in osteoblast(OB)-lineage cells. Conditionally knocking out Yap in the OB lineage in mice reduces cell proliferation and OB differentiation and increases adipocyte formation, resulting in a trabecular bone loss. Mechanistically, YAP interacts with β-catenin and is necessary for maintenance of nuclear β-catenin level and Wnt/β-catenin signaling. Expression of β-catenin in YAP-deficient BMSCs(bone marrow stromal cells) diminishes the osteogenesis deficit. These results thus identify YAP-β-catenin as an important pathway for osteogenesis during adult bone remodeling and uncover a mechanism underlying YAP regulation of bone homeostasis. | Jin-Xiu Pan Lei Xiong Kai Zhao Peng Zeng Bo Wang Fu-Lei Tang Dong Sun Hao-han Guo Xiao Yang Shun Cui Wen-Fang Xia Lin Mei Wen-Cheng Xiong | 2018 | Bone Research2018，6，2： | 19 |
| 9 | Identification and differentiation of Panax ginseng,Panax quinquefolium, and Panax notoginseng by monitoring multiple diagnostic chemical markers显示文摘To differentiate traditional Chinese medicines(TCM) derived from congeneric species in TCM compound preparations is usually challenging. The roots of Panax ginseng(PG), Panax quinquefolium(PQ) and Panax notoginseng(PN) are used as popular TCM. They contain similar triterpenoid saponins(ginsenosides) as the major bioactive constituents. Thus far, only a few chemical markers have been discovered to differentiate these three species. Herein we present a multiple marker detection approach to effectively differentiate the three Panax species, and to identify them in compound preparations. Firstly, 85 batches of crude drug samples(including 32 PG, 30 PQ, and 23 PN) were analyzed by monitoring 40 major ginsenosides in the extracted ion chromatograms(EICs) using a validated LC–MS fingerprinting method. Secondly, the samples were clustered into different groups by pattern recognition chemometric approaches using PLS-DA and OPLS-DA models, and17 diagnostic chemical markers were discovered. Aside from the previously known Rf and p-F11, ginsenoside Rs1 could be a new marker to differentiate PG from PQ. Finally, the above multiple chemical markers were used to identify the Panax species in 60 batches of TCM compound preparations. | Wenzhi Yang Xue Qiao Kai Li Jingran Fan Tao Bo De-an Guo Min Ye | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 18 |
| 10 | Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model显示文摘目的: 调查胡椒碱,在 Piper nigrum 在场的主要的刺鼻的碱和 Piper longum 的效果,在肿瘤生长和老鼠 4T1 的转移上在 vitro 并且在 vivo 的乳房的癌,并且阐明内在的机制。 | Li-hua LAI Qi-hong FU Yang LIU Kai JIANG Qing-ming GUO Qing-yun CHEN Bin YAN Qing-qing WANG Jian-gen SHEN | 2012 | Acta Pharmacologica Sinica2012，33，4： | 16 |
| 11 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 12 | Establishment and preliminery use of hepatitis Bvirus preS1/2 antigen assay显示文摘 | CHEN Kun, HAN Bao Guang, MA Xian Kai, ZHANG He Qiu, MENG Li, WANG Guo Hua, XIA Fang, SONG Xiao Guo and LING Shi Gan | 1999 | World Journal of Gastroenterology1999，5，6： | 14 |
| 13 | Optimal planning of stand-alone microgrids incorporating reliability显示文摘This paper proposes a new method for the planning of stand-alone microgrids.By means of clustering techniques,possible operating scenarios are obtained considering the daily patterns of wind and load profiles.Then,an approximate analytical model for reliability evaluation of battery energy storage system is developed in terms of the diverse scenarios,along with multistate models for wind energy system and diesel generating system.An optimal planning model is further illustrated based on the scenarios and the reliability models,with the objective of minimizing the present values of the costs occurring within the project lifetime,and with the constraints of system operation and reliability.Finally,a typical stand-alone microgrid is studied to verify the efficiency of the proposed method. | Chengshan WANG Bingqi JIAO Li GUO Kai YUAN Bing SUN | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，3： | 13 |
| 14 | Genome-Wide Expression Pattern Analyses of the Arabidopsis Leucine-Rich Repeat Receptor-Like Kinases显示文摘像受体的蛋白质 kinases (RLK ) 是在房间房间和房间环境通讯起关键作用的 transmembrane 蛋白质的一个大组。基于细胞外的领域结构, RLK 被分类进超过 21 个亚科,充满白氨酸的重复 RLK (LRR-RLKs ) 在象 Arabidopsis 和米饭那样的植物在之中属于最大的亚科。在 Arabidopsis,有近似 223LRR-RLKs,但是哪个中的仅仅大约 60 个机能上地迄今为止被描述了。为了系统地在调整调查 LRR-RLKs 的 theroles,种生长,开发,和压力改编,我们产生了 promoter::GUS 为在 Arabidopsis 的所有 223 LRR-RLK 基因的转基因的植物并且在各种各样的发展舞台分析了他们的详细表达式模式。Theresults 提供 forfunctionally 阐明的珍贵资源这个大、必要的发信号的蛋白质亚科。 | Yunzhe Wu Qingqing Xun Yi Guo Jinghua Zhang Kaili Cheng Tao Shi Kai He Suiwen Hou Xiaoping Gou Jia Li | 2016 | Molecular Plant2016，9，2： | 13 |
| 15 | Resveratrol protects rabbit ventricular myocytes against oxidative stress-induced arrhythmogenic activity and Ca2+ overload显示文摘 | Wei Li Yue-peng Wang Ling Gao Peng-pai Zhang Qing Zhou Quan-fu Xu Zhi-wen Zhou Kai Guo Ren-hua Chen Huang-tian Yang Yi-gang Li | 2013 | Acta Pharmacologica Sinica2013，34，9： | 12 |
| 16 | Late-Quaternary Slip Rate and Seismic Activity of the Xianshuihe Fault Zone in Southwest China显示文摘The Xianshuihe fault zone is a seismo-genetic fault zone of left-lateral slip in Southwest China. Since 1725, a total of 59 Ms ≥ 5.0 earthquakes have occurred along this fault zone, including 18 Ms 6.0–6.9 and eight Ms ≥ 7.0 earthquakes. The seismic risk of the Xianshuihe fault zone is a large and realistic threat to the western Sichuan economic corridor. Based on previous studies, we carried out field geological survey and remote sensing interpretation in the fault zone. In addition, geophysical surveys, trenching and age-dating were conducted in the key parts to better understand the geometry, spatial distribution and activity of the fault zone. We infer to divide the fault zone into two parts: the northwest part and the southeast part, with total eight segments. Their Late Quaternary slip rates vary in a range of 11.5 mm/a –(3±1) mm/a. The seismic activities of the Xianshuihe fault zone are frequent and strong, periodical, and reoccurred. Combining the spatial and temporal distribution of the historical earthquakes, the seismic hazard of the Xianshuihe fault zone has been predicted by using the relationship between magnitude and frequency of earthquakes caused by different fault segments. The prediction results show that the segment between Daofu and Qianning has a possibility of Ms ≥ 7.0 earthquakes, while the segment between Shimian and Luding is likely to have earthquakes of about Ms 7.0. It is suggested to establish a GPS or In SAR-based real-time monitoring network of surface displacement to cover the Xianshuihe fault zone, and an early warning system of earthquakes and post seismic geohazards to cover the major residential areas. | ZHANG Yongshuang YAO Xin YU Kai DU Guoliang GUO Changbao | 2016 | Acta Geologica Sinica(English Edition)2016，90，2： | 12 |
| 17 | Primary hepatic neuroendocrine tumor with multiple liver metastases:A case report with review of the literature显示文摘We herein present a case involving a 41-year-old woman in whom ultrasound examination revealed multiple liver hemangiomas more than 3 years ago.Follow-up ultrasound examination revealed that the masses had significantly increased;the largest was located in the right lobe(about 8.2 cm×7.4 cm×6.0cm).Abdominal multidetector computed tomographyrevealed multiple well-circumscribed,heterogeneous,hypodense masses(largest,6.4 cm×6.3 cm×5.0cm)with significant contrast enhancement during the arterial and portal phases and with contrast washout and peripheral enhancement during the delayed phases.Magnetic resonance images demonstrated multiple well-circumscribed,heterogeneous,hypointense hepatic masses with significant contrast enhancement(largest,6.4 cm×6.5 cm×5.1 cm);multiple enlarged porta lymph nodes;and multiple s l i g h t l y e n l a rg e d re t ro p e r i t o n e a l l y m p h n o d e s.Histological and immunohistochemical examination of the right mass biopsy specimen suggested a malignant neoplasm that had originated from a neuroendocrine cell type(grade 2 well-differentiated neuroendocrine carcinoma).After performing a systemic examination to exclude metastasis from an extrahepatic primary site,we considered that the masses had arisen from a primary hepatic neuroendocrine tumor with multiple liver metastases.The patient underwent transcatheter arterial chemoembolization using a combination of oxaliplatin(150 mg)mixed with one bottle of gelatin sponge particles(560-710μm)and lipiodol(6 m L).Primary neuroendocrine tumors of the liver are extremely rare.This case is interesting because of the rarity of this neoplasm and previous misdiagnosis as multiple liver hemangiomas.Previously reported cases in the literature are also reviewed. | Kai Yang Ying-Sheng Cheng Ji-Jin Yang Xu Jiang Ji-Xiang Guo | 2015 | World Journal of Gastroenterology2015，21，10： | 11 |
| 18 | 高脂饮食联合低剂量链脲佐菌素造大鼠二型糖尿病模型稳定性的研究(英文)显示文摘目的:探讨高脂饮食联合低剂量链脲佐菌素(STZ)造大鼠二型糖尿病模型在不同饮食背景下的稳定性。创新点:首次探讨在正常饮食和高脂饮食的背景下,该常见的大鼠二型糖尿病模型的稳定性。可为造模后期干预阶段的饲料选择提供依据。方法:饲喂Wistar大鼠高脂饮食8周后,注射25或35 mg/kg STZ来诱导二型糖尿病。之后每组分别饲喂正常饲料和高脂饲料4周,检测血液生化指标的稳定性。结论:不管在何种饮食下,糖尿病大鼠都出现了空腹血糖显著恢复,血脂紊乱加剧的现象。其中35 mg/kg STZ注射组大鼠的特征更接近一型糖尿病,而25 mg/kg STZ注射组大鼠表现出二型糖尿病的特征。相比高脂饮食,正常饮食更容易导致空腹血糖和胰岛结构的恢复。因此,在正常饮食下该模型稳定性欠佳,在后期的药理学实验中推荐使用高脂饮食。 | Xiao-xuan GUO Yong WANG Kai WANG Bao-ping JI Feng ZHOU | 2018 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2018，19，7： | 11 |
| 19 | Non-Darcy flow in oil accumulation (oil displacing water) and relative permeability and oil saturation characteristics of low-permeability sandstones显示文摘Hydrocarbon resources in low-permeability sandstones are very abundant and are extensively distributed. Low-permeability reservoirs show several unique characteristics,including lack of a defi nite trap boundary or caprock,limited buoyancy effect,complex oil-gas-water distribution,without obvious oil-gas-water interfaces,and relatively low oil(gas) saturation. Based on the simulation experiments of oil accumulation in low-permeability sandstone(oil displacing water) ,we study the migration and accumulation characteristics of non-Darcy oil flow,and discuss the values and influencing factors of relative permeability which is a key parameter characterizing oil migration and accumulation in low-permeability sandstone. The results indicate that:1) Oil migration(oil displacing water) in lowpermeability sandstone shows non-Darcy percolation characteristics,and there is a threshold pressure gradient during oil migration and accumulation,which has a good negative correlation with permeability and apparent fluidity;2) With decrease of permeability and apparent fluidity and increase of fluid viscosity,the percolation curve is closer to the pressure gradient axis and the threshold pressure gradient increases. When the apparent fluidity is more than 1.0,the percolation curve shows modifi ed Darcy flow characteristics,while when the apparent fluidity is less than 1.0,the percolation curve is a 'concaveup' non-Darcy percolation curve;3) Oil-water two-phase relative permeability is affected by core permeability,fluid viscosity,apparent fluidity,and injection drive force;4) The oil saturation of lowpermeability sandstone reservoirs is mostly within 35%-60%,and the oil saturation also has a good positive correlation with the permeability and apparent fluidity. | Zeng Jianhui Cheng Shiwei Kong Xu Guo Kai Wang Hongyu | 2010 | Petroleum Science2010，7，1： | 11 |
| 20 | TaqMan Real-time RT-PCR Assay for Detecting and Differentiating Japanese Encephalitis Virus显示文摘Objective To detect Japanese encephalitis virus(JEV) rapidly and distinguish its genotypes, a TaqMan-based reverse transcriptase quantitative polymerase chain reaction(RT-PCR) detection system was developed.Methods By aligning the full-length sequences of JEV(G1-G5), six sets of highly specific TaqMan real-time RT-PCR primers and probes were designed based on the highly conserved NS1, NS2, and M genes of JEV, which included one set for non-specific JEV detection and five sets for the detection of specific JEV genotypes. Twenty batches of mosquito samples were used to evaluate our quantitative PCR assay.Results With the specific assay, no other flavivirus were detected. The lower limits of detection of the system were 1 pfu/mL for JEV titers and 100 RNA copies/μL. The coefficients of variation of this real-time RT-PCR were all < 2.8%. The amplification efficiency of this method was between 90% and 103%.Conclusion A TaqMan real-time RT-PCR detection system was successfully established to detect and differentiate all five JEV genotypes. | SHAO Nan LI Fan NIE Kai FU Shi Hong ZHANG Wei Jia HE Ying LEI Wen Wen WANG Qian Ying LIANG Guo Dong CAO Yu Xi WANG Huan Yu | 2018 | Biomedical and Environmental Sciences2018，31，3： | 10 |
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