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| 1 | Identification and differentiation of Panax ginseng,Panax quinquefolium, and Panax notoginseng by monitoring multiple diagnostic chemical markers显示文摘To differentiate traditional Chinese medicines(TCM) derived from congeneric species in TCM compound preparations is usually challenging. The roots of Panax ginseng(PG), Panax quinquefolium(PQ) and Panax notoginseng(PN) are used as popular TCM. They contain similar triterpenoid saponins(ginsenosides) as the major bioactive constituents. Thus far, only a few chemical markers have been discovered to differentiate these three species. Herein we present a multiple marker detection approach to effectively differentiate the three Panax species, and to identify them in compound preparations. Firstly, 85 batches of crude drug samples(including 32 PG, 30 PQ, and 23 PN) were analyzed by monitoring 40 major ginsenosides in the extracted ion chromatograms(EICs) using a validated LC–MS fingerprinting method. Secondly, the samples were clustered into different groups by pattern recognition chemometric approaches using PLS-DA and OPLS-DA models, and17 diagnostic chemical markers were discovered. Aside from the previously known Rf and p-F11, ginsenoside Rs1 could be a new marker to differentiate PG from PQ. Finally, the above multiple chemical markers were used to identify the Panax species in 60 batches of TCM compound preparations. | Wenzhi Yang Xue Qiao Kai Li Jingran Fan Tao Bo De-an Guo Min Ye | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 18 |
| 2 | A Topology-Matching Spike Protein-Capping Tetrahedral DNA Nanocrown for SARS-CoV-2 Neutralization显示文摘The constantly mutating severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)poses great risk of efficacy loss to the present neutralizing therapeutics.Thus,it is urgently needed to develop versatile strategies that enable rapid design and engineering of potent neutralizing therapeutics for newly emerging variants.Herein,we present an unprecedented DNA nanocrown that can topologically match and multivalently bind the S-trimer of SARS-CoV-2 and thereby inhibit its infection to host cells.A neutralizing aptamer binding the N-terminal domain(NTD)supersite of the S protein was first screened and identified.It was further elaborately engineered onto the best fitting tetrahedral DNA nanostructure to form a spike protein-capping nanocrown,which can effectively block not only wild-type(WT)SARS-CoV-2 pseudovirus,but also several important mutants including D614G,N501Y,andΔ69–70.Significantly,it can evidently diminish the RNA copies of authentic WT SARS-CoV-2 in host cells by 4.6 orders of magnitude.Therefore,utilizing the aptamer selection method and the dedicated engineering route,our topology-matching DNA framework provides a versatile platform for SARS-CoV-2 inhibition and has the potential to be facilely expanded to newly emerging variants and other fatal coronaviruses. | Jingran Chen Shuxin Xu Qing Ye Hang Chi Ying Li Mei Wu Baochao Fan Zhanchen Guo Cheng-Feng Qin Bin Li Zhen Liu | 2023 | CCS Chemistry2023，5，6： | 0 |
| 3 | Study on Cleaner Production Subsidies, Income Distribution Imbalance and Carbon Emissions Permit Reallocation Mechanism显示文摘The allocation mechanism for carbon emissions permit(CEP)is an institutional guarantee for advancing the development of China’s unified carbon trading market.The initial allocation of carbon quotas fails to solve new inequalities stemming from subsidizing cleaner production.This paper constructs a theoretical framework that describes China’s progressive decline in carbon intensity,calculates the equilibrium solution on the neoclassical saddle point path using the shooting method,and studies the income distribution imbalance caused by cleaner production subsidies and the reallocation mechanism of carbon emissions permit The main conclusion is that the incremental cleaner production subsidy policy meets the goal of maximizing welfare on the saddle point path,but it may lead to over-investment in the clean sector,thus causing the income distribution imbalance among entities.Further research suggests that the amount of carbon emissions permit acquired by the clean sector should be higher than the actual emissions in the trading market and that,as the cleaner support increases,the share of carbon emissions permit acquired by the sector should be constantly increased through reallocation mechanism.This helps achieve the Pareto improvement in all parties’economic benefi ts. | Qingquan Fan Jingran Liu Jingda Wang | 2022 | China Finance and Economic Review2022，11，4： | 0 |
| 4 | Double dividend of carbon intensity:environmental-quality improvement and sustainable economic growth显示文摘This paper established an equilibrium model including representative household,government,and eight industries,and two different environmental policy tools such as carbon intensity and carbon cap were added into the model.The paper points out that the carbon intensity policy imposed on major high-emission industries achieved double dividend of environmentalquality improvement and sustainable economic growth under the condition of proper constraint target.This result supports the environmental Porter hypothesis.This paper finds out that the double dividend is due to the fact that environmental governance policy leads to the rising price of resources and demand of labors,resulting in an effective redistribution of production factors among industries and sustainable economic growth.Furthermore,this paper estimates the marginal effect of economic structure on carbon emission and carbon intensity and provides targeted suggestions. | Qingquan Fan Xianhua Zhou Jingran Liu | 2015 | Chinese Journal of Population,Resources and Environment2015，13，3： | 0 |
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