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| 1 | GRADE指南:Ⅶ.证据质量评价--不一致性显示文摘本文针对二分类变量结局指标相对(而非绝对)治疗效果的不一致性。证据本身不会因不同研究结果具有一致性而升级,但可能因不一致而降低质量级别。衡量一致性的标准包括点估计值的相似性、可信区间的重叠程度以及统计学判定标准包括异质性检验和I2。系统评价作者应提出并检验少数几个与患者、干预措施、结局指标以及方法学相关的先验假设以探寻异质性来源。当不一致性很大且无法解释时,因不一致性而降低质量级别是恰当的,特别当某些研究显示有显著益处而其他显示无益甚至有害时(而非仅是疗效大与疗效小的比较)。明显的亚组效应可能不可靠。如果亚组效应满足以下条件,其可信度将会增加:基于少数几个有具体方向的先验假设、亚组比较来自研究内而非研究间、交互检验的P值小、结果有生物学意义。 | Gordon H.Guyatt Andrew D.Oxman Regina Kunz James Woodcock Jan Brozek Mark Helfand Pablo Alonso-Coello Paul Glasziou Roman Jaeschke Elie A.Akl Susan Norris Gunn Vist Philipp Dahm Vijay K.Shukla Julian Higgins Yngve Falck-Ytter Holger J.Schünemann 代表GRADE小组 李幼平 杨晓妍 王莉 蔡羽嘉 陈群飞 | 2011 | 中国循证医学杂志2011，11，12： | 33 |
| 2 | An integrated theoretical and experimental investigation of insensitive munition compounds adsorption on cellulose,cellulose triacetate, chitin and chitosan surfaces显示文摘This manuscript reports results of combined computational chemistry and batch adsorption investigation of insensitive munition compounds, 2,4-dinitroanisole(DNAN), triaminotrinitrobenzene(TATB), 1,1-diamino-2,2-dinitroethene(FOX-7) and nitroguanidine(NQ), and traditional munition compound 2,4,6-trinitrotoluene(TNT) on the surfaces of cellulose, cellulose triacetate, chitin and chitosan biopolymers. Cellulose,cellulose triacetate, chitin and chitosan were modeled as trimeric form of the linear chain of4 C1 chair conformation of β-D-glucopyranos, its triacetate form, β-N-acetylglucosamine and D-glucosamine, respectively, in the 1 ? 4 linkage. Geometries were optimized at the M062 X functional level of the density functional theory(DFT) using the 6-31 G(d,p) basis set in the gas phase and in the bulk water solution using the conductor-like polarizable continuum model(CPCM) approach. The nature of potential energy surfaces of the optimized geometries were ascertained through the harmonic vibrational frequency analysis. The basis set superposition error(BSSE) corrected interaction energies were obtained using the 6-311 G(d,p)basis set at the same theoretical level. The computed BSSE in the gas phase was used to correct interaction energy in the bulk water solution. Computed and experimental results regarding the ability of considered surfaces in adsorbing the insensitive munitions compounds are discussed. | Luke A.Gurtowski Chris S.Griggs Veera G.Gude Manoj K.Shukla | 2018 | Journal of Environmental Sciences2018，30，2： | 1 |
| 3 | Mycotic keratitis: an overview of diagnosis and therapy显示文摘 | P. K.Shukla M.Kumar G. B. S.Keshava | 2008 | Mycoses2008，，3： | 1 |
| 4 | Mycotic keratitis: an overview of diagnosis and therapy显示文摘 | P. K.Shukla M.Kumar G. B. S.Keshava | 2008 | Mycoses2008，，3： | 1 |
| 5 | Neuroproteetive effect of curcumin in arsenic-induced neurotoxicity in rats显示文摘 | Rajesh S.Yadav Rajendra K.Shukla Madhu Lata Sankhwar | | 0，，05： | 1 |
| 6 | CH ARACTERIZATION OF LA YERED Na_(2-x-y)LixKyTi_(3)O_(7) CERAMICS BY DIELECTRIC-SPECTROSCOPIC INV ESTIG ATIONS显示文摘In this paper,we present detailed investigations on the dielectric properties of Lithium(x=0.10)and Potassium(y=0.01,0.02,0.04,0.05)mixed Sodium trititanate,Na_(2-x-y)LixKyTi_(3)O_(7) poly-crystalline ma terials synthesized by solid-state reaction.The characteristics of the pelletized samples have been studied in the temperature range from 350 to 725 K and on the frequency in the range from 10kHz to 1 MHz.The studies reveal that the chain structured Na_(2-x-y)LixKyTi_(3)O_(7) layered compound posses electronic,ionic,dipolar,and space charge polarization mechanisms over the respective temperature regions in the entire temperature range of study. | SHRIPAL RAKESH SINGH GEETIKA RAVI K.SHUKLA K.K.RAINA | 2011 | Journal of Advanced Dielectrics2011，1，4： | 0 |
| 7 | Microbial and size characterization of airborne particulate matter collected on sticky tapes along US–Mexico border显示文摘Particulate matter(PM) emissions from various sources can affect significantly human health and environmental quality especially in the Chihuahuan Desert region along US–Mexico border. The objective of this study was to use the low-cost sticky tape method to collect airborne PM for size characterization and identification of fungal spores. Sticky tape samplers were placed at 1.0 and 2.0 m above the ground surface at experimental sites in Ciudad Juárez, Mexico and at 0.6, 1.2 and 1.8 m at New Mexico sites, USA. Soil samples were collected in both countries to determine fungal diversity, texture and moisture content Dust particles collected from all of the experimental sites had a dominant texture of clay(< 0.002 mm). The dominant textures identified from soil samples collected from the US and Mexican sites were loam and sandy clay loam, respectively. Alternaria, Penicillium and Fusarium were frequently found funguses in the US sites while Alternaria and Aspergillus were commonly observed in the Mexican sites. The sticky tapes also showed a similar diversity of fungal microorganisms present in the airborne PM at both Mexico and US sites Alternaria, Penicillium and Aspergillus were the three groups of airborne fungal microorganisms consistently present in the US and Mexican sites. The low-cost sticky tape method has the potential to be used for characterizing different airborne microorganisms and dust particles. | Amir Gonzalez-Delgado Manoj K.Shukla David W.DuBois Juan P.Flores-Mdrgez Joel A.Hernandez Escamilla Evangelina Olivas | 2017 | Journal of Environmental Sciences2017，29，3： | 0 |
| 8 | Effect of application rate and irrigation on the movement and dissipation of indaziflam显示文摘Indaziflam is a new preemergence herbicide for the control of annual grass and broadleaf weeds in various cropping systems including pecan orchards.The objectives of this study were to(1) determine the mobility and dissipation of indaziflam and(2) evaluate herbicide efficacy in a flood-irrigated pecan orchard in southern New Mexico,USA.Indaziflam was applied at 0,35.5,and 73.1 g/ha in areas with(impacted) and without(unimpacted) tree injury symptoms.Soil samples were collected at 0-15,15-30,and 30-46 cm depths 25,63,90,and 125 days after the first herbicide application.Additional soil samples were collected 4,30,and 55 days after the second application.Indaziflam was detected in soil samples collected at each depth,suggesting movement with irrigation water.Indaziflam concentrations decreased with increasing soil depth and time.Indaziflam mass recoveries were greater in the unimpacted area than in the impacted area after the first and second applications.Dissipation half-lives of indaziflam in the soil ranged from 30 to 85 days for total indaziflam recovered from the entire soil profile after the first and second applications in both areas.The percent weed control was similar in the impacted and unimpacted areas for both rates of indaziflam on 25 and 53 days after application;however,on 90 days after the application,percent weed control was lower in the impacted than unimpacted area. | Amir M.Gonzalez-Delgado Manoj K.Shukla Jamshid Ashigh Russ Perkins | 2017 | Journal of Environmental Sciences2017，29，1： | 0 |
| 9 | Effect of indaziflam on microbial activity and nitrogen cycling processes in an orchard soil显示文摘Indaziflam is a preemergent herbicide widely used for the control of weeds in pecan(Carya illinoinensis)orchards in the southwestern region of the United States.Given the paucity of data regarding the effect of indaziflam on the biochemical properties of soils supporting pecan production,this study was conducted to evaluate the effects of different application rates of indaziflam on soil microbial activity,diversity,and biochemical processes related to nitrogen(N)cycling.During two consecutive growing seasons(2015 and 2016),soil samples were obtained from experimental mesocosms consisting of soil-filled pots where pecan saplings were grown and treated with indaziflam applied at two different rates(25 and 50 g active ingredient(ai)ha^(-1),with the higher rate being slightly lower than the recommended field application rate of 73.1 g ai ha^(-1)).Soil samples were collected approximately one week before and one week after herbicide application for determination of soil microbial biomass and diversity,N mineralization,andβ-glucosaminidase activity.Soil samples collected from the control mesocosms without herbicide application were treated in the laboratory with two rates of indaziflam(75 and 150 g ai ha^(-1))to determine the immediate effect on microbial activity.No significant effect of herbicide treatment on soil respiration and microbial biomass was detected.The results showed a slight to moderate decrease in microbial diversity(7%in 2015 and 44%in 2016).However,decreasedβ-glucosaminidase activity with herbicide treatment was observed in soils from the mesocosms(33%)and soils treated with indaziflam in the laboratory(45%).The mineral N pool was generally dominated by ammonium after indaziflam application,which was consistent with the drastic decrease(75%)in nitrification activity measured in the laboratory experiment.The results of this study indicate that indaziflam,even when applied at higher than recommended rates,has limited effects on soil microbial activity,but may affect N cycling processes. | Amir M.GONZÁLEZ-DELGADO Pierre-AndréJACINTHE Manoj K.SHUKLA | 2022 | Pedosphere2022，32，6： | 0 |
| 10 | In vitro and in vivo anticancer potential and molecular targets of the new colchicine analog ⅢM-067显示文摘Objective: The current study evaluated various new colchicine analogs for their anticancer activity and to study the primary mechanism of apoptosis and in vivo antitumor activity of the analogs with selective anticancer properties and minimal toxicity to normal cells.Methods: Sulforhodamine B(SRB) assay was used to screen various colchicine analogs for their in vitro cytotoxicity. The effect of N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(pyrrolidine-1-yl)5,6,7,9-tetrahydrobenzo[a] heptalene-7-yl] acetamide(ⅢM-067) on clonogenicity, apoptotic induction, and invasiveness of A549 cells was determined using a clonogenic assay, scratch assay, and staining with 4’,6-diamidino-2-phenylindole(DAPI) and annexin V/propidium iodide. Mitochondrial membrane potential(MMP) and reactive oxygen species(ROS) levels were observed using fluorescence microscopy. Western blot analysis was used to quantify expression of proteins involved in apoptosis, cell cycle, and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR) signaling. Pharmacokinetic and in vivo efficacy studies against Ehrlich ascites carcinoma(EAC) and Ehrlich solid tumor models were conducted using Swiss albino mice.Results: ⅢM-067 showed potent cytotoxicity and better selectivity than all other colchicine analogs screened in this study. The selective activity of ⅢM-067 toward A549 cells was higher among other cancer cell lines,with a selectivity index(SI) value of 2.28. ⅢM-067 demonstrated concentration-and time-dependent cytotoxicity against A549 cells with half-maximal inhibitory concentration values of 0.207, 0.150 and0.106 μmol/L at 24, 48 and 72 h, respectively. It also had reduced toxicity to normal cells(SI > 1) than the parent compound colchicine(SI = 1). ⅢM-067 reduced the clonogenic ability of A549 cells in a dose-dependent manner. ⅢM-067 enhanced ROS production from 24.6% at 0.05 μmol/L to 82.1% at 0.4 μmol/L and substantially decreased the MMP(100% in control to 5.6% at 0.4 μmol/L). The annexin V-FITC assay demonstrated78% apoptosis at 0.4 μmol/L. ⅢM-067 significantly(P < 0.5) induced the expression of various intrinsic apoptotic pathway proteins, and it differentially regulated the PI3K/AKT/mTOR signaling pathway. Furthermore,ⅢM-067 exhibited remarkable in vivo anticancer activity against the murine EAC model, with tumor growth inhibition(TGI) of 67.0% at a dose of 6 mg/kg(i.p.) and a reduced mortality compared to colchicine. ⅢM-067also effectively inhibited the tumor growth in the murine solid tumor model with TGI rates of 48.10%, 55.68%and 44.00% at doses of 5 mg/kg(i.p.), 6 mg/kg(i.p.) and 7 mg/kg(p.o.), respectively.Conclusion: ⅢM-067 exhibited significant anticancer activity with reduced toxicity both in vitro and in vivo and is a promising anticancer candidate. However, further studies are required in clinical settings to fully understand its potential. | Sumera Malik Mubashir J.Mintoo Chilakala Nagarjuna Reddy Rajesh Kumar Pankul Kotwal Sandip BBharate Utpal Nandi Dilip M.Mondhe Sanket K.Shukla | 2023 | Journal of Integrative Medicine2023，21，1： | 0 |
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