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| 1 | Stress- and Pathogen-Induced Arabidopsis WRKY48 is a Transcriptional Activator that Represses Plant Basal Defense显示文摘植物 WRKY 抄写因素能作为植物的积极或否定的管理者工作基础疾病抵抗。Arabidopsis WRKY48 被机械或渗透的应力由于渗入和病原体感染导致并且因此,可以在植物防卫回答起一个作用。WRKY48 对原子核局部性,在 vitro 与一种高亲密关系认出 TTGACC W 盒子顺序并且在象强壮的 transcriptional 使活跃之物的植物房间工作。直接决定生物功能,我们孤立 loss-of-function T-DNA 插入异种并且产生了转基因的 overexpression 在 Arabidopsis 为 WRKY48 种的 gain-of-function。细菌的病原体 Pseudomonas syringae 的剧毒的紧张的生长在 wrky48 T-DNA 插入异种被减少。loss-of-function 异种的提高的抵抗与水杨酸的增加的正式就职被联系由细菌的病原体的调整酸的 PR1。由对比,转基因的 WRKY48-overexpressing 植物支持 P 的提高的生长。syringae 和提高的危险性与防卫相关的 PR 基因的减少的表示被联系。这些结果建议 WRKY48 是 PR 基因表示和基础抵抗的一个否定管理者到细菌的病原体 P。syringae。 | Deng-Hui Xing Zi-Bing Lai Zu-Yu Zheng K. M. Vinod Bao-Fang Fan Zhi-Xiang Chen | 2008 | Molecular Plant2008，1，3： | 37 |
| 2 | Effect of Land Cover Change on Soil Phosphorus Fractions in Southeastern Horqin Sandy Land, Northern China显示文摘In the past 50 years, large areas of the Horqin sandy land were afforested to prevent desertification. Although the afforestation policy appears successful, many people now doubt whether it is suitable to plant trees with high density on the poor soils in semiarid regions. Little is known about the impacts of afforestation on the sandy soil properties, although the evaluation of these impacts is fundamental to judge the rationality of afforestation policy. Soil phosphorus (P) fractions, acid phosphomonoesterase activities, and other soil chemical properties were compared among five adjoining typical ecosystems on poor sandy soils in southeastern Horqin sandy land. The ecosystems studied are natural elm savanna, degraded grassland, Mongolian pine (Pinus sylvestris var. mongolica) plantation, Chinese pine (Pinus tabulaeformis) plantation, and mixed plantation of Mongolian pine and poplar (Populus simonii). The results showed that organic P dominated soil P (47%–65%) was the principal source of available P. The degradation of elm savanna to grassland significantly reduced soil pH and resulted in an overall reduction in soil fertility, although slightly increased labile inorganic P. Grassland afforestation had no significant influence on soil pH, organic carbon, and total N but significantly reduced total P. Impacts of grassland afforestation on soil P fractions depended on tree species. Natural elm savanna had higher soil P conserving ability than artificial plantations. Therefore, with the aim of developing a sustainable ecosystem, we suggested that vegetations with low nutrient demand (particularly P) and effcient nutrient cycling would be more suitable for ecosystem restoration in the semiarid region. | ZHAO Qiong ZENG De-Hui FAN Zhi-Ping D. K. LEE | 2008 | Pedosphere2008，18，6： | 7 |
| 3 | Long-term survival after intraluminal brachytherapy for inoperable hilar cholangiocarcinoma: A case report显示文摘Surgical resection with a tumor-free margin is the onlycurative treatment for hilar cholangiocarcinoma (Klatskin tumor). However, over half of the patients present late with unresectable tumors. Radiotherapy using external beamirradiation or intraluminal brachytherapy (ILBT) has been used to treat unresectable hilar cholangiocarcinoma with satisfactory outcome. We reported a patient with unresectable hilar cholangiocarcinoma surviving more than 6 years after combined external beam irradiation and ILBT. | Siu-Yin Chan Ronnie T. Poon Kelvin K. Ng Chi-Leung Liu Raymond T. Chan Sheung-Tat Fan | 2005 | World Journal of Gastroenterology2005，11，20： | 7 |
| 4 | Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers显示文摘OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to cisplatin.METHODS The effect of garcinol and cisplatin on HNSCC was assessed by MTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse model.RESULTS We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by cisplatin.Both the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and garcinol.The pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,respectively.CONCLUSION Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers. | Feng Li Muthu K. Shanmugam Kodappully Sivaraman Siveen Fan Wang Tina H. Ong Ser Yue Loo Mahadeva M.M. Swamy Somnath Mandal Alan Prem Kumar Boon Cher Goh Tapas Kundu Kwang Seok Ahn Ling Zhi Wang Kam Man Hui Gautam Sethi | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 4 |
| 5 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 4 |
| 6 | Effects of Tidal Currents on Nonlinear Internal Solitary Waves in the South China Sea显示文摘The propagation and fission process of internal solitary waves (ISWs) with amplitudes of about 170 m are simulated in the northeast of the South China Sea (NSCS) by using the generalized Korteweg-de Vries (KdV) equation under continuous stratification. More attention is paid to the effects of the ebb and flood background currents on the fission process of ISWs. This kind of background current is provided by the composed results simulated in terms of monthly mean baroclinic circulation and barotropic tidal current. It is found that the obtained relation of the number of fission solitons to the water depth and stratification is roughly in accordance with the fission law derived by Djordjevic and Redekopp in 1978; however, there exists obvious difference between the effects of the ebb and flood background currents on the wave-lengths of fission solitons (defined as the distance between two neighboring peaks of ISWs). The difference in nonlinearity coefficient α between the ebb and flood background currents is a main cause for the different wave-lengths of fission solitons. | FAN Zhisong SHI Xingang Antony K. Liu LIU Hailong LI Peiliang | 2013 | Journal of Ocean University of China2013，12，1： | 3 |
| 7 | Continuous Improvement of Survival Outcomes of Resection of Hepatocellular Carcinoma: A 20-Year Experience显示文摘 | Sheung Tat Fan Chung Mau Lo Ronnie T. P. Poon Chun Yeung Chi Leung Liu Wai Key Yuen Chi Ming Lam Kelvin K. C. Ng See Ching Chan | 2011 | Annals of Surgery2011，，4： | 3 |
| 8 | Liver transplantation for acute-on-chronic liver failure显示文摘 | Albert C. Chan Sheung Tat Fan Chung Mau Lo Chi Leung Liu See Ching Chan Kelvin K. Ng Boon Hun Yong Alexander Chiu Banny K. Lam | 2009 | Hepatology International2009，，4： | 2 |
| 9 | Influence of rolling temperature on the microstructure and mechanical properties of Mg–Gd–Y–Zn–Zr alloy sheets显示文摘 | C. Xu M.Y. Zheng K. Wu E.D. Wang G.H. Fan S.W. Xu S. Kamado X.D. Liu G.J. Wang X.Y. Lv | 2013 | Materials Science & Engineering A2013，，： | 2 |
| 10 | Is Hepatic Resection for Large or Multinodular Hepatocellular Carcinoma Justified? Results From a Multi-Institutional Database显示文摘 | Kelvin K. Ng Jean-Nicolas Vauthey Timothy M. Pawlik Gregory Y. Lauwers Jean-Marc Regimbeau Jacques Belghiti Iwao Ikai Yoshio Yamaoka Steven A. Curley David M. Nagorney Irene O. Ng Sheung Tat Fan Ronnie T. Poon | 2005 | Annals of Surgical Oncology2005，，5： | 2 |
| 11 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 2 |
| 12 | Continuous Improvement of Survival Outcomes of Resection of Hepatocellular Carcinoma: A 20-Year Experience显示文摘 | Sheung Tat Fan Chung Mau Lo Ronnie T. P. Poon Chun Yeung Chi Leung Liu Wai Key Yuen Chi Ming Lam Kelvin K. C. Ng See Ching Chan | 2011 | Annals of Surgery2011，，4： | 2 |
| 13 | Thin sectional anatomy, three-dimensional reconstruction and visualization of the heart from the Chinese Visible Human显示文摘 | Y.-L. Guo P.-A. Heng S.-X. Zhang Z.-J. Liu L.-W. Tan Q.-Y. Li M.-G. Qiu K. Li H.-Q. Fan Y.-S. Wang Z.-S. Tang | 2005 | Surgical and Radiologic Anatomy2005，，2： | 1 |
| 14 | Sorption of tetracycline on organo-montmorillonites显示文摘 | Niu Liu Ming-xia Wang Ming-ming Liu Fan Liu Liping Weng Luuk K. Koopal Wen-feng Tan | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 15 | Meta‐analysis: effect of preoperative infliximab use on early postoperative complications in patients with ulcerative colitis undergoing abdominal surgery显示文摘 | Z. Yang Q. Wu F. Wang K. Wu D. Fan | 2012 | Aliment Pharmacol Ther2012，，10： | 1 |
| 16 | Additive Enhanced Crystallization of Solution‐Processed Perovskite for Highly Efficient Planar‐Heterojunction Solar Cells显示文摘 | Po‐Wei Liang Chien‐Yi Liao Chu‐Chen Chueh Fan Zuo Spencer T. Williams Xu‐Kai Xin Jiangjen Lin Alex K.‐Y. Jen | 2014 | Adv. Mater2014，，22： | 1 |
| 17 | Prognostic significance of osteopontin in hepatitis B virus-related hepatocellular carcinoma显示文摘 | H. Xie J. Song R. Du K. Liu J. Wang H. Tang F. Bai J. Liang T. Lin J. Liu D. Fan | 2006 | Digestive and Liver Disease2006，，2： | 1 |
| 18 | Low-dimensional SiC nanostructures: Fabrication, luminescence, and electrical properties显示文摘 | J.Y. Fan X.L. Wu Paul K. Chu | 2006 | Progress in Materials Science2006，，8： | 1 |
| 19 | Changing Paradigm in the Management of Hepatocellular Carcinoma Improves the Survival Benefit of Early Detection by Screening显示文摘 | Albert C. Y. Chan Ronnie T. P. Poon Kelvin K. C. Ng Chung Mau Lo Sheung Tat Fan John Wong | 2008 | Annals of Surgery2008，，4： | 1 |
| 20 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 1 |
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