|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 2 | Object-level change detection based on full-scale image segmentation and its application to Wenchuan Earthquake显示文摘Aiming at object fragmentation and poor detection results caused by discontinuous segmentation scale in object-level change detection,a new object-level change detection method based on the full-scale object tree is presented in this paper.The core idea of this new algorithm is to establish the full-scale object tree based on convexity model theory and integrate full-scale image segmentation techniques and change detection into the whole process.Some Wenchuan Earthquake images are taken as an example to discuss the new method for earthquake damage detection and evaluation in urban area,landslide detection,and extraction of barrier lake boundary.The application shows that the new method is robust and it provides an advanced tool for the quantitative detection and evaluation of earthquake damage. | GONG JianYa,SUI HaiGang,SUN KaiMin,MA GuoRui & LIU JunYi State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan University,Wuhan 430072,China | 2008 | Science China(Technological Sciences)2008，51，S2： | 7 |
| 3 | Nickel Complexes Based on Salicylaldehyde-imine Ligands: Synthesis, Characterization and Catalytic Oligomerization of Ethylene显示文摘 | CHEN Liduo HUO Hongliang WANG Libo MA Lili JIANG Yan XIE Junyi WANG Jun | 2018 | Chemical Research in Chinese Universities2018，34，6： | 3 |
| 4 | Rapid velocity reduction and drift potential assessment of off-nozzle pesticide droplets显示文摘The droplet velocity and diameter significantly affect both the spatial drift loss and the interfacial deposition behaviors, thus determining the ultimate utilization efficiency during pesticide spraying.Investigating the spatial velocity and diameter evolutions can reveal the mechanism of drift loss and guide to design regulation strategy. Here, we explored the spatial velocity distribution of droplets after leaving the nozzle by particle image velocimetry technology and particle tracking model, considering that the effect of nozzle configuration and the air velocity. It shows that all droplets decelerate rapidly with the velocity attenuation ratio ranging from 50% to 80% within the region of 200 mm below the nozzle.The spatial velocity evolution differences between droplets in crossflow are determined by the competition of vertical drag force and net gravity, and the drag force sharply increases as the droplet diameter decreases, especially for that smaller than 150 μm. Based on the spatial evolution differences of the droplet velocity and diameter, a functional adjuvant was added to the liquid for improving the diameter distribution. And the drift loss was significantly reduced due to the reduction of the proportion of easily drifting droplets. | Shidong Xue Jingkun Han Xi Xi Junyi Zhao Zhong Lan Rongfu Wen Xuehu Ma | 2022 | Chinese Journal of Chemical Engineering2022，35，6： | 2 |
| 5 | Integrated transcriptome and metabolite profiling highlights the role of benzoxazinoids in wheat resistance against Fusarium crown rot显示文摘Fusarium crown rot(FCR), caused by Fusarium spp., is a chronic and severe plant disease worldwide. In the last years, the incidence and severity of FCR in China has increased to the point that it is now considered a threat to local wheat crops. In this study, for the first time, the metabolites and transcripts responsive to FCR infection in the partial resistant wheat cultivar 04 Zhong 36(04 z36) and susceptible cultivar Xinmai 26(XM) were investigated and compared at 20 and 25 days post inoculation(dpi). A total of 443 metabolites were detected, of which 102 were significantly changed because of pathogen colonization.Most of these 102 metabolites belonged to the flavonoid, phenolic acid, amino acid and derivative classes.Some metabolites, such as proline betaine, lauric acid, ribitol, and arabitol, were stably induced by Fusarium pseudograminearum(Fp) infection at two time points and may have important roles in FCR resistance. In line with the reduced seedling height of 04 z36 and XM plants, RNA-seq analysis revealed that FCR infection significantly affected the photosynthesis activities in two cultivars. Furthermore, 15 jasmonate ZIM-domain genes(JAZ) in the significantly enriched ‘regulation of jasmonic acid mediated signaling pathway’ in 04 z36 were down-regulated. The down-regulation of these JAZ genes in 04 z36 may cause a strong activation of the jasmonate signaling pathway. Based on combined data from gene expression and metabolite profiles, two metabolites, benzoxazolin-2-one(BOA) and 6-methoxy-benzoxazolin-2-one(MBOA), involved in the benzoxazinoid-biosynthesis pathway, were tested for their effects on FCR resistance. Both BOA and MBOA significantly reduced fungal growth in vitro and in vivo, and, thus, a higher content of BOA and MBOA in 04 z36 may contribute to FCR resistance. Above all, the current analysis extends our understanding of the molecular mechanisms of FCR resistance/susceptibility in wheat and will benefit further efforts for the genetic improvement of disease resistance. | Shuonan Duan Jingjing Jin Yutian Gao Changlin Jin Junyi Mu Wenchao Zhen Qixin Sun Chaojie Xie Jun Ma | 2022 | The Crop Journal2022，10，2： | 1 |
| 6 | Genomic insights into salt adaptation in a desert poplar显示文摘 | Ma Tao Wang Junyi Zhou Gongke | 2013 | Nature Commu- nications2013，，： | 1 |
| 7 | Agronomic cultivation measures on productivity of oilseed flax:A review显示文摘Oilseed flax is one of the most important oil crops in China.With the improvement of people's living standards and the deepening knowledge of the nutritional value of oilseed flax,the demand and economic value of oilseed flax are increasing,and the cultivated area in China is expanding.However,the grain yield of oilseed flax is lower than other oil crops.It varies significantly from year to year,combined with a lower degree of mechanization,which has greatly limited the healthy development of the flax industry.Some of the effects of agronomic measures on productivity and water use efficiency of oilseed flax are reviewed in this paper.The major agronomic strategies for the productivity of oilseed flax were presented based on fertilization,plant density,irrigation,cropping pattern and weed control.Future research should investigate the effect of silicon and potassium fertilizers on the mechanism of lodging resistance of oilseed flax,the effects of diversified cropping systems(strip intercropping and crop rotation)on high and stable productivity and efficient utilization of resources. | Zhengjun Cui Bin Yan Yuhong Gao Bing Wu Yifan Wang Haidi Wang Peng Xu Bangqing Zhao Zhi Cao Yong Zhang Yaping Xie Yapeng Hu Xingbang Ma Junyi Niu | 2022 | Oil Crop Science2022，7，1： | 1 |
| 8 | Nonlinear dynamics of Duffing system with fractional order damping 显示文摘 | CAO Junyi MA C XIE H | 2010 | Journal of Computational and Nonlinear Dynamics2010，5，04： | 1 |
| 9 | Polynomial method based design of low-order controllers for twomass systems显示文摘 | MA Chengbin CAO Junyi QIAO Yue | 2013 | IEEE Transactions on Industrial Electronics2013，60，3： | 1 |
| 10 | Experimental Study on Anatomic Reduction of Lateral Pterygoid Muscle(Simulated Manipulation Fracture Reduction)and Condylar Free Reduction for Condylar Fracture显示文摘[Objectives]To compare the fracture healing of keeping lateral pterygoid muscle anatomic reduction(simulated manipulation fracture reduction)with condylar free reduction in the treatment of condylar fractures.[Methods]Twenty-four New Zealand rabbits were randomly divided into two groups to mandibular condylar neck fracture model was established.one team keep the lateral pterygoid muscle,the other excise it.Cervical vascular perfusion was done with ink before animals executed after operation 2,4,6 and 8 weeks.Bilateral anteroposterior and mediolateral condylar diameters measured.Changes of operation side condylar proliferating layer,microvessel number and bone parameters were observed and analyzed after slices and HE staining.[Results]The mediolateral condylar diameters of operation side were significantly smaller than health side in condylar free reduction group at the 4,6,8 weeks(P<0.05),but there was no statistical difference in the anteroposterior condylar diameters at each time point(P>0.05).There were no significant differences in the anteroposterior and mediolateral condylar diameters of the anatomic reduction lateral pterygoid muscle group compared between the operation side and health side(P>0.05).The number of microvessel in condylar free reduction group were smaller than those in anatomic reduction lateral pterygoid muscle group(P<0.05).There were significant differences in BV/TV,Tb.Th,Tb.Sp between the condylar free reduction group and the anatomic reduction lateral pterygoid muscle group(all P<0.05),and the Tb.N were significantly differences between two groups at the 4,6,8 weeks(P<0.05).[Conclusions]When the condyle is fractured it should keep lateral pterygoid muscle(manipulation fracture reduction)as possible,which is important in the fracture healing and functional recovering of mandibular. | Junyi YOU Xiaofeng SHEN Qihan MA Guoqiang LIANG | 2023 | Medicinal Plant2023，14，5： | 0 |
| 11 | Spectral analysis of generalized Volterra equation显示文摘A generalized Volterra lattice with a nonzero boundary condition is considered by virtue of the inverse scattering transform.The two-sheeted Riemann surface associated with the boundary problem is transformed into the Riemann sphere by introducing a suitable variable transformation.The associated spectral properties of the lattice in single-valued variable was discussed.The constraint condition about the nonzero boundary condition and the scattering data is found. | Junyi ZHU Xinxin MA Zhijun QIAO | 2019 | Frontiers of Mathematics in China2019，14，5： | 0 |
| 12 | Boosted sustained-release with iron-based MOF-derived mesoporouscarbon-spheres as a nitroimidazole drugs carrier显示文摘Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).However,as a drug carrier,the MOF-derived PC developed thus far are generally composed of irregular powder shape due to their crystalline nature,which consequently causing the cerebral infarction,cerebral thrombosis,and other blood diseases.In this article,we propose a novel approach to constructing amorphous carbon microspheres(AcMs)by dis-torting the topological network through hydrothermal treatment precursors of MIL-101(Fe).Then,a distinctive MIL-101(Fe)-derived spherical porous carbons(MSPC)is achieved through high temperature calcination toward ACMs.Effects of the glucose initial concentration and hydrothermal treatment time on the sphericity of the as-prepared mesoporous MsPC were investigated in depth.And the loading capacities and sustained-release performances of nitroimidazole drugs over MsPC through simulation internal environment of human body at different pH values was systematically evaluated.The nitro-imidazole drugs loading rate and release time of MsPC are 10% and 17 h under preferred process.Furthermore,the MSPC exhibited very low toxicity on Hela cells and 293T cells at the concentrations tested(10-800μg mL^(-1)).This study,therefore,supports the potential of the mesoporous carbon spheres as a carrierfor nitroimidazole drug delivery. | Danping Wu Jiaying Zou Junyi Chen Yan Li Na Ma Wei Dai | 2024 | Particuology2024，86，3： | 0 |
| 13 | Mutations of Desmoglein‑2 in Sudden Unexplained Death in the Chinese Han Population显示文摘Sudden unexplained death(SUD)remains a puzzle in forensic medicine.Desmoglein‑2(DSG2)has been linked to arrhythmogenic right ventricular cardiomyopathy which may cause life‑threatening ventricular arrhythmias and sudden death.Fatal arrhythmias resulting in sudden death also occur in the absence of morphologic cardiac abnormalities at autopsy.We hypothesized that DSG2 mutations may be responsible for certain Chinese SUD cases.We sequenced all 15 exons of DSG2 in DNA extracted from postmortem heart tissues of 25 Chinese patients dying from SUD.The primers were designed using the Primer Express 3.0 software.Direct sequencing for both sense and antisense strands was performed with a BigDye Terminator DNA sequencing kit on a 3130 Xl Genetic Analyzer.Mutation damage prediction was made using Mutation Taster,PolyPhen,and SIFT software.In 2 of 25 cases of Chinese SUD samples,two DSG2 heterozygous mutations(p.P927 L and p.T1070M)were identified,and one is probably damaging.We concluded that DSG2 mutations may be related to the occurrence of part of SUD cases in the Chinese Han population. | Junyi Lin Yulei Yang Ziqin Zhao Yiwen Shen Kaijun Ma Mingchang Zhang | 2019 | Journal of Forensic Science and Medicine2019，5，2： | 0 |
| 14 | Polarity-triggered anti-Kasha system for high-contrast cell imaging and classification显示文摘Kasha’s rule,which states that all exciton emissions occur from the lowest excited state and are independent of excitation energy,makes high-energy excitons difficult to use and severely hinders the widespread applications of organic photoluminescent materials in the real world.For decades,scientists have tried to break this rule to unleash the power of high-energy excitons,but only minimal progress has been achieved,with no rational guiding principles provided,and few applications developed.So far,breaking Kasha’s rule has remained a purely academic concept.In this paper,we introduce a design principle for a purely organic anti-Kasha system and synthesise a series of compounds based on the design rule.As predicted,these compounds all display evident S_(2) emissions in dilute solutions.In addition,we introduce a highly accurate(over 90%)convolutional neural network as an assistant for the classification of cells using anti-Kasha luminogens,thereby providing a new application direction for anti-Kasha systems. | Junyi Gong Peifa Wei Junkai Liu Yuncong Chen Zheng Zhao Weijun Zhao Huilin Xie Chao Ma Jacky W.Y.Lam Kam Sing Wong Ying Li Ben Zhong Tang | 2023 | Aggregate2023，4，2： | 0 |
| 15 | Measurements of the effective mass transfer areas for the gas–liquid rotating packed bed显示文摘Rotating packed bed(RPB) is one of the most effective gas–liquid mass transfer enhancement reactors, its effective specific mass transfer area(ae) is critical to understand the mass transfer process. By using the NaOH–CO_(2) chemical absorption method, the aevalues of three RPB reactors with different rotor sizes were measured under different operation conditions. The results showed that the high gravity factor and liquid flow rate were major affecting factors, while the gas flow rate exhibited minor influence.The radius of packing is the dominant equipment factor to affect aevalue. The results indicated that the contact area depends on the dispersion of the liquid phase, thus the centrifugal force of rotating packed bed greatly influenced the aevalue. Moreover, the measured ae/ap(effective specific mass transfer area/specific surface area of packing) values were fitted with dimensionless correlation formulas. The unified correlation formula with dimensionless bed size parameter can well predict the experimental data and the prediction errors were within 15%. | Wen Tian Junyi Ji Hongjiao Li Changjun Liu Lei Song Kui Ma Siyang Tang Shan Zhong Hairong Yue Bin Liang | 2023 | Chinese Journal of Chemical Engineering2023，55，3： | 0 |
| 16 | Biomechanical properties of ready-to-harvest rapeseed plants:Measurement and analysis显示文摘A large loss occurs in the combine harvesting of rapeseeds due to the fragility of rapeseed pods,and all the more so with the vibration of the combine header and the collision between the header and plants.Seed loss is greatly affected by the biomechanical properties of ready-to-harvest rapeseed plants.To understand the mechanism of pod cracking and seed loss and to propose measures for alleviating them,it is needed to study the biomechanical properties of ready-to-harvest rapeseed plants.To this end,“Huayouza 62”,a widely planted rapeseed variety in central China,was selected to study the biomechanical properties,including pod-cracking resistance,main stem-shearing resistance and resonant frequencies,of whole plants.The results showed that the distribution of pod-cracking resistance forces was 1.333–6.100 N in the mature stage,and the pod width and thickness had a significant influence on the cracking resistance.The main influencing factor of the main stem-shearing resistance was the stem diameter.A thicker main stem resulted in a larger shearing resistance force but a smaller shear stress.The moisture contents of the main stems varied from 47.71%to 76.13%.However,the varying moisture contents did not show a significant impact on the shearing resistance.The resonant frequencies of whole rapeseed plants ready for harvest ranged from 6.5 Hz to 7.5 Hz,which was close to the excitation frequency of the cutter bar on the 4LL-1.5Y harvester.This study lays a foundation for improving the design and construction of harvesting devices for rapeseed plants to reduce seed loss. | Guangchao Zhan Wangyuan Zong Lina Ma Junyi Wei Wei Liu | 2023 | Information Processing in Agriculture2023，10，3： | 0 |
| 17 | Advances in CIGS thin film solar cells with emphasis on the alkali element post-deposition treatment显示文摘In the past tens of years,the power conversion efficiency of Cu(In,Ga)Se2(CIGS)has continuously improved and been one of the fastest growing photovoltaic technologies that can also help us achieve the goal of carbon emissions reduction.Among several key advances,the alkali element post-deposition treatment(AlK PDT)is regarded as the most important finding in the last 10 years,which has led to the improvement of CIGS solar cell efficiency from 20.4%to 23.35%.A profound understanding of the influence of alkali element on the chemical and electrical properties of the CIGS absorber along with the underlying mechanisms is of great importance.In this review,we summarize the strategies of the alkali element doping in CIGS solar cell,the problems to be noted in the PDT process,the effects on the CdS buffer layer,the effects of different alkali elements on the structure and morphology of the CIGS absorber layer,and retrospect the progress in the CIGS solar cell with emphasis on the alkali element post deposition treatment. | Chenchen Zhao Shen Yu Wei Tang Xinye Yuan Hongfei Zhou Tongqing Qi Xue Zheng De Ning Ming Ma Junyi Zhu Jie Zhang Chunlei Yang Weimin Li | 2023 | Materials Reports(Energy)2023，3，3： | 0 |
| 18 | Progress and Challenges Toward Effective Flexible Perovskite Solar Cells显示文摘The demand for building-integrated photovoltaics and portable energy systems based on flexible photovoltaic technology such as perovskite embedded with exceptional flexibility and a superior power-to-mass ratio is enormous.The photoactive layer,i.e.,the perovskite thin film,as a critical component of flexible perovskite solar cells(F-PSCs),still faces long-term stability issues when deformation occurs due to encountering temperature changes that also affect intrinsic rigidity.This literature investigation summarizes the main factors responsible for the rapid destruction of F-PSCs.We focus on long-term mechanical stability of F-PSCs together with the recent research protocols for improving this performance.Furthermore,we specify the progress in F-PSCs concerning precise design strategies of the functional layer to enhance the flexural endurance of perovskite films,such as internal stress engineering,grain boundary modification,self-healing strategy,and crystallization regulation.The existing challenges of oxygen-moisture stability and advanced encapsulation technologies of F-PSCs are also discussed.As concluding remarks,we propose our viewpoints on the large-scale commercial application of F-PSCs. | Xiongjie Li Haixuan Yu Zhirong Liu Junyi Huang Xiaoting Ma Yuping Liu Qiang Sun Letian Dai Shahzada Ahmad Yan Shen Mingkui Wang | 2023 | Nano-Micro Letters2023，15，11： | 0 |
| 19 | A non-uniform quadtree map building method including dead-end semantics extraction显示文摘To reduce the complexity of large-scene high-resolution maps while using the dead-end information distributed in the unmanned vehicle driving environment,we propose a novel non-uniform quadtree map-building method including dead-end semantic information extraction.By utilizing quadtree data structures,submaps and a positive-order tree depth organization approach,our proposed map can adapt to the large-scale high-resolution requirement and expand more easily to larger environments.To verify the practicality of our proposed map,we have successfully implemented map matching and path planning in real environments.Additionally,we effectively extract the dead-end semantic information that widely distributes in the environment,which can help unmanned vehicles avoid collisions and improve the search efficiency of the planning procedure.We evaluate our method with KITTI datasets,CARLA Simulator,and our self-collected real-world datasets.The experimental results show that our proposed method significantly reduces the complexity of large-scale high-resolution maps,effectively extracts dead-end semantic information,and has good practicality in real environments.The implementation of our method is released here:http://gffzz188fe103f8f1460as6u0qpxwn0coc6qwv.ffgz.tsg.suse.edu.cn/biter0088/Non-uniform-quadtree-map. | Xiuzhong Hu Guangming Xiong Junyi Ma Gege Cui Quanfu Yu Shihao Li Zijie Zhou | 2023 | Green Energy and Intelligent Transportation2023，2，2： | 0 |
| 20 | High-Superelasticity NiTi Shape Memory Alloy by Directed Energy Deposition-Arc and Solution Heat Treatment显示文摘Directed energy deposition-arc(DED-Arc)technology has the advantages of simple equipment,low manufacturing cost and high deposition rate,while the use of DED-Arc has problems of microstructure inhomogeneity,position dependence of macroscopic mechanical properties and anisotropy.Therefore,it is necessary to carry out a subsequent heat treatment to improve its microstructure uniformity,mechanical properties and superelasticity.In this investigation,the DED-Arc 15-layer NiTi alloy thin-walled parts with the solution treatment at different process parameters were studied to analyze the effects of solution heat treatment on microstructure,phase composition,phase transformation,microhardness,tensile and superelasticity.The temperature range of solution treatment is 800-1050℃,and the treatment time range is 1-5.5 h.The results show that after solution treatment at 800℃/1 h,the content of precipitated phase decreases,the grain is refined,the microhardness increases,and the mechanical properties in the 0°direction are improved.The strain recovery rate after 10 tensile cycles has increased from 37.13%(as-built)to 49.25%(solid solution treatment).This research provides an effective post treatment method for high-performance DED-Arc NiTi shape memory alloys. | Junyi Ma Lin Yu Qing Yang Jie Liu Lei Yang | 2024 | Acta Metallurgica Sinica(English Letters)2024，37，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员