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| 1 | Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication显示文摘Hepatitis B virus(HBV)can cause chronic hepatitis B,which may lead to cirrhosis and liver cancer.Type I interferon(IFN)is an approved drug for the treatment of chronic hepatitis B.However,the fundamental mechanisms of antiviral action by type I IFN and the downstream signaling pathway are unclear.TRIM25 is an IFN-stimulated gene(ISG)that has an important role in RIG-I ubiquitination and activation.Whether TRIM25 is induced in liver cells by type I IFN to mediate anti-HBV function remains unclear.Here we report that interleukin-27(IL-27)has a critical role in IFN-induced TRIM25 upregulation.TRIM25 induction requires both STAT1 and STAT3.In TRIM25 knockout HepG2 cells,type I IFN production was consistently attenuated and HBV replication was increased,whereas overexpression of TRIM25 in HepG2 cells resulted in elevated IFN production and reduced HBV replication.More interestingly,we found that TRIM25 expression was downregulated in HBV patients and the addition of serum samples from HBV patients could inhibit TRIM25 expression in HepG2 cells,suggesting that HBV might have involved a mechanism to inhibit antiviral ISG expression and induce IFN resistance.Collectively,our results demonstrate that type I IFN-induced TRIM25 is an important factor in inhibiting HBV replication,and the IFN-IL-27-TRIM25 axis may represent a new target for treating HBV infection. | Guangyun Tan Qingfei Xiao Hongxiao Song Feng Ma Fengchao Xu Di Peng Na Li Xiaosong Wang Junqi Niu Pujun Gao F Xiao-Feng Qin Genhong Cheng | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 2 | Effects of Cr Content on the Microstructure and Properties of 26Cr–3.5Mo–2Ni and 29Cr–3.5Mo–2Ni Super Ferritic Stainless Steels显示文摘By using scanning electron microscopy,energy-dispersive spectrometry,X-ray diffraction,strength and hardness measurements,the microstructure,precipitation,mechanical properties,and corrosion resistance have been investigated for two super ferritic stainless steels,26Cr–3.5Mo–2Ni and 29Cr–3.5Mo–2Ni,with the aim to consider the effect of Cr content.The results showed that with the addition of Cr content,the recrystallization temperature was increased;the precipitation of Laves and Sigma(σ)phases was promoted and the mechanical properties of super ferritic stainless steel were modified.Furthermore,the pitting corrosion resistance and corrosion resistance to H_2SO_4 of the two super ferritic stainless steels were improved.In addition,suitable annealing processing is a key factor to maintain integrated performance by optimizing microstructure and removing detrimental precipitation phases. | Li Ma Shengsun Hu Junqi Shen Jian Han Zhixiong Zhu | 2016 | Journal of Materials Science & Technology2016，32，6： | 8 |
| 3 | Effects of Microalloying and Heat-Treatment Temperature on the Toughness of 26Cr–3.5Mo Super Ferritic Stainless Steels显示文摘The effects of Ni content and heat-treatment process on the toughness of a super ferritic stainless steel with26 wt% Cr and 3.5 wt% Mo were investigated. It was found that with the increase of Ni content, the Charpy impact toughness improved remarkably, and transformed from cleavage brittle fracture to the most ductile fracture. There were no obvious differences between the high- and low-Ni contents on the microstructure and mechanical properties since the addition of Ni did not influence crystal structure, phase composition, and precipitation of ultra pure ferritic stainless steels.Meanwhile, the heat-treatment process was a key point to maintain a high level of toughness by optimizing structure and removing detrimental precipitation, i.e., chi phase. | Li Ma Jian Han Junqi Shen Shengsun Hu | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，3： | 6 |
| 4 | Activating Flux Design for Laser Weldingof Ferritic Stainless Steel显示文摘The behaviors of YAG laser welding process of ferritic stainless steel with activating fluxes were investigatedin this study. Some conventional oxides, halides and carbonates were applied in laser welding. The resultsshowed that the effect of oxides on the penetration depth was more remarkable. Most activating fluxes improved thepenetration more effectively at low power than that at high power. The uniform design was adopted to arrange theformula of multicomponent activating fluxes, showing that the optimal formula can make the penetration depth up to2.23 times as large as that without flux, including 50% ZrO2, 12.09% CaCO3, 10.43% CaO and 27.48% MgO. Throughthe high-speed photographs of welding process, CaF2 can minimize the plasma volume but slightly improve the penetrationcapability. | Ma Li | 2014 | Transactions of Tianjin University2014，20，6： | 3 |
| 5 | Improvement in quality of life in depressed patients following verum acupuncture or electroacupuncture plus paroxetine:A randomized controlled study of 157 cases显示文摘Depressed patients with scores of 17 or more on the 17 items of the Hamilton Depression Rating Scale were treated with the antidepressant drug paroxetine. They also underwent verum acupuncture or electroacupuncture at Baihui (GV20) and Yintang (GV29). The World Health Organization Quality of Life Scale Brief Version showed a significant increase in the total scores of patients who underwent verum acupuncture and electroacupuncture for 6 weeks compared with those who were given paroxetine only; significantly increased physical domain and social relationship scores in verum acupuncture patients compared with paroxetine only; and significantly elevated psychological domain scores with electroacupuncture compared with paroxetine only. These results indicate that both verum acupuncture and electroacupuncture can improve quality of life in depressed patients undergoing paroxetine treatment. | Shenghui Ma Shanshan Qu Yong Huang Junqi Chen Renyong Lin Chongqi Wang Ganlong Li Canghuan Zhao Shenchang Guo Zhangjin Zhang | 2012 | Neural Regeneration Research2012，7，27： | 3 |
| 6 | 青海河湟谷地胃癌病理特征及其变化趋势分析(英文)显示文摘Objective: The aim of our study was to discuss changes in the clinicopathological characteristics of gastric cancer in Hehuang Valley of China in recent 10 years. Methods: A retrospective case-control study was performed on 2379 newly-diagnosed gastric cancer patients. All of them came from Hehuang Valley. The patients were divided into two groups [recent 5 years(R5Y) and late 5 years(L5Y)] from February 2003 to February 2013, and the clinicopathological data were surveyed retrospectively. Results: The constituent ratio of upper 1/3 gastric cancer in R5Y and L5Y was 33.5% and 20.7%, respectively, and it showed a significant difference between the two groups(χ2 = 21.28, P = 0.00). The constituent ratio of squamous carcinoma/adenosquamous carcinoma was 2.7% and 1.6%, respectively, and it also showed a significant difference between two groups(χ2 = 50.91, P = 0.00). The constituent ratio of moderately-poorly differentiated/poorly differentiated gastric carcinoma was 84.2% and 50.2%, respectively, and it showed statistically significant difference(χ2 = 30.28, P = 0.00). The detection rate of early gastric cancer(EGC) was 1.47%(35/2379). The constituent ratio of the types of Borrmann II and Borrmann IV of advanced gastric cancer(AGC) among 2379 cases was 47.6% and 40.8%, respectively, and that still showed statistically significant difference(χ2 = 18.80, P = 0.00). The constituent ratio of diffuse-type of gastric cancer in R5Y and L5Y was 36.2% and 30.8%, respectively, even there was a significant difference(χ2 = 7.49, P = 0.01). Furthermore, there were also significant differences in regional lymph nodes metastasis, perineural infiltration and vascular invasion(P < 0.05). The positive detection rate of HER2, ER and PR was 14.88%, 17.23% and 15.93%, respectively. The constituent ratio of HP in two groups was 43.8% and 36.2% respectively, and it also showed a significant difference(χ2 = 13.51, P = 0.00). Conclusion: The pathogenic sites in gastric cancer change to the upper stomach in Hehuang Valley in recent 10 years, and the detection rate of squamous carcinoma/adenosquamous carcinoma reveals a sharp rise. Borrmann III is still one of the main types of advanced gastric cancer, but the detection rates of Borrmann II and IV are increasing. The main type of gastric cancer is the intestinaltype, but the ratio of diffuse-type is also increasing in recent 10 years. The HP detection rate is 40.65%(967/2379), and it has a slight rise in recent 10 years. The detection rate of poorly differentiated adenocarcinoma is increasing despite the fact that the moderately/moderately-poorly differentiated adenocarcinoma is the main histologic types. High detection rates of lymph nodes metastasis, perineural infiltration and vascular invasion indicate poor prognosis in patients with gastric cancer. There is no change in HER2 positive rate, on the contrary, there are a little increase in ER and PR expression in Hehuang Valley. | Su Yan Bin Li Junqi Wu Dawei Xie Yingcai Ma Yuanzhi Xiong Xuxiang Ma Xinjian Guo Man Dai Daquan Zhang Xinyang Liu | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，2： | 2 |
| 7 | MULTI-SHOP SCHEDULING PROBLEM显示文摘A new concept of multi-shop (M ) is put forward which contains all basic shops including open shop (O), job shop (J ), flow shop (F ) and hybrid flow shop (H ) so that these basic shop can be scheduled together. Several algorithms including ant colony optimization (ACO), most work remaining (MWR), least work remaining (LWR), longest processing time (LPT) and shortest processing time (SPT) are used for scheduling the M. Numerical experiments of the M adopting data of some car and reC series benchmark instances are tested. The results show that the ACO algorithm has better performance for scheduling the M than the other algorithms, if minimizing the makespan ( C m*ax) is taken as the objective function. As a comparison, the separate shops contained in the M are also scheduled by the ACO algorithm for the same objective function, when the completing time of the jobs in the previous shop is taken as the ready time of these jobs in the following shop. The results show that the M has the advantage of shortening the makespan upon separate shops. | HU Yanhai YAN Junqi MA Dengzhe YE Feifan ZHANG Jie | 2007 | Chinese Journal of Mechanical Engineering2007，20，3： | 2 |
| 8 | Production engineering-oriented virtual factory: a planning cell-based approach to manufacturing systems design显示文摘 | ZHAI Wenbin YAN Junqi MA Dengzhe | 2006 | International Journal of Advanced Manufacturing Technology2006，28，910： | 1 |
| 9 | Th1 and Th2 Immune Response in Chronic Hepatitis B Patients during a Long-Term Treatment with Adefovir Dipivoxil显示文摘 | Yanfang Jiang Zhenhua Ma Guijie Xin Hongqing Yan Wanyu Li Huining Xu Chunhai Hao Junqi Niu Pingwei Zhao Dennis Daniel Taub | 2010 | Mediators of Inflammation2010，，： | 1 |
| 10 | Ion-triggered exfoliation of layer-by-layer assembled poly (acrylic acid)/poly(allylamine hydrochloride) films from substrates: A facile way to prepare free-standing multilayer films 显示文摘 | Ma Ying Sun Junqi Shen Jiacong | 2007 | Chemistry of Materials2007，19，21： | 1 |
| 11 | Fast-response fluorescent probe with favorable water solubility for highly sensitive imaging of endogenous tyrosinase in living cells and zebrafish model显示文摘Tyrosinase(TYR) is an important polyphenolic oxidase enzyme and usually regards as a biomarker of melano ma cancer.Highly effective tracking TYR activity in vivo will help to study the mechanism of TYR in living organisms and forecasts related diseases.In this study,we present a novel TYR-activatable fluo rescent probe(CHMC-DOPA) for tracking TYR activity in vitro and in vivo.CHMC-DOPA is constructed by incorporating dopamine(DOPA) moiety into a fluorescent chloro-hydroxyl-merocyanine(CHMC)scaffold.Upon exposure to TYR,the dopamine unit in CHMC-DOPA is oxidized to a dopaquinone derivative,and an intramolecular photo-induced electron transfer(PET) process between CHMC fluorophore and o-dopaquinone will take place,the fluorescence of CHMC-DOPA is quenched rapidly.Therefore,the evaluation of TYR activity is established in terms of the relationship between fluorescence quenching efficiency and TYR activity.In our experiments,CHMC-DOPA shows various advantages,such as fast response(8 min),low concentration of TYR activation(0.5 U/mL),good water-solubility,as well as the lowest detection limit(0.003 U/mL) compared with previously reported works.Furthermore,CHMCDO PA also exhibits excellent cell membrane permeability and low cytotoxicity,which is successfully used to monitor endogenous TYR activity in living cancer cells and zebrafish models.CHMC-DOPA performs well,and we anticipate that this newly designed novel platform will provide an alternative for high effective monitoring TYR activity in biosystems. | Zheng Li Xiaofeng Xia Yu You Cuifen Lu Guichun Yang Chao Ma Junqi Nie Qi Sun Shuilin Wu Jun Ren Feiyi Wang | 2021 | Chinese Chemical Letters2021，32，5： | 1 |
| 12 | Virtual maching based on holographic product modeling显示文摘 | YAN Junqi JIANG Zuhua MA Dengzhe | 2000 | Computer Integrated Manufacturing Systems-CIMS2000，6，5： | 1 |
| 13 | Overview of Studies on Financial Support for China's Agricultural Industrialization显示文摘Agricultural industrialization is an innovative operation mode and effective drive for transformation of traditional agriculture to modern agriculture. Benign development of agricultural industrialization depends on financial support. With increase of the function of financial support for agricultural industrialization development,academic circles have made deeper and deeper researches on agricultural industrialization. These researches mainly touch upon four aspects:( i) definition of concept of financial support for agricultural industrialization;( ii)functions of financial support for agricultural industrialization;( iii) existing problems in financial support for agricultural industrialization and problem causes;( iv) specific recommendations of promotion of financial support for agricultural industrialization development. Although existing researches are already extensive and some common understandings have been reached,there are still some research gaps and weak points,and it needs further researches. | Junyu MIAO Junqi MA Jingyao TANG | 2014 | Asian Agricultural Research2014，6，11： | 1 |
| 14 | Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody显示文摘Induction of broadly neutralizing monoclonal antibodies(bNAbs)that bind to the viral envelope glycoproteins is a major goal of hepatitis C virus(HCV)vaccine research.The study of bNAbs arising in natural infection is essential in this endeavor.We generated a human antibody,8D6,recognizing the E2 protein of HCV isolated from a chronic hepatitis C patient.This antibody shows broadly neutralizing activity,which covers a pan-genotypic panel of cell culture-derived HCV virions(HCVcc).Functional and epitope analyses demonstrated that 8D6 can block the interaction between E2 and CD81 by targeting a highly conserved epitope on E2.We describe how the 8D6 lineage evolved via somatic hypermutation to achieve broad neutralization.We found that the V(D)J recombination-generated junctional and somatic hypermutation-induced disulfide bridge(C-C)motif in the CDRH3 is critical for the broad neutralization and binding activity of 8D6.This motif is conserved among a series of broadly neutralizing HCV antibodies,indicating a common binding model.Next,the 8D6 inferred germline(iGL)was reconstructed and tested for its binding affinity and neutralization activity.Interestingly,8D6 iGL-mediated relatively strong inhibition of the 1b genotype PR79L9 strain,suggesting that PR79L9 may serve as a potential natural viral strain that provides E2 sequences that induce bNAbs.Overall,our detailed epitope mapping and genetic studies of the HCV E2-specific mAb 8D6 have allowed for further refinement of antigenic sites on E2 and reveal a new mechanism to generate a functional CDRH3,while its iGL can serve as a probe to identify potential HCV vaccine strains. | Chunyan Yi Jing Xia Lan He Zhiyang Ling Xuesong Wang Yu Yan Jiangjun Wang Xinhao Zhao Weiguo Fan Xiaoyu Sun Ronghua Zhang Sheng Ye Rongguang Zhang Yongfen Xu Liyan Ma Yaguang Zhang Honglin Zhou Zhong Huang Junqi Niu Gang Long Junxia Lu Jin Zhong Bing Sun | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
| 15 | Postoperative Radiotherapy and N2 Non-small Cell Lung Cancer Prognosis: A Retrospective Study Based on Surveillance, Epidemiology, and End Results Database显示文摘The purpose of this study is to clarify the significance of postoperative radiotherapy for N2 lung cancer.This study aimed to investigate the effect of postoperative radiotherapy on the survival and prognosis of patients with N2 lung cancer.Data from 12,000 patients with N2 lung cancer were extracted from the Surveillance,Epidemiology,and End Results database(2004-2012).Age at disease onset and 5-year survival rates were calculated.Survival curves were plotted using the Kaplan-Meier method.The univariate log-rank test was performed.Multivariate Cox regression were used to examine factors affecting survival.Patients’median age was 67 years(mean 66.46±10.03).The 5-year survival rate was 12.55%.Univariate analysis revealed age,sex,pathology,and treatment regimen as factors affecting prognosis.In multivariate analysis,when compared to postoperative chemotherapy,postoperative chemoradiotherapy was better associated with survival benefits(hazard ratio[HR]=0.85,95%confidence interval[CI]:0.813-0.898,P<0.001).Propensity score matching revealed that patients who had received postoperative chemoradiotherapy had a better prognosis than did patients who had received postoperative chemotherapy(HR=0.869,95%CI:0.817-0.925,P<0.001).Female patients and patients aged<65 years had a better prognosis than did their counterparts.Patients with adenocarcinoma had a better prognosis than did patients with squamous cell carcinoma.Moreover,prognosis worsened with increasing disease T stage.Patients who had received postoperative chemoradiotherapy had a better prognosis than did patients who had received postoperative chemotherapy.Postoperative radiotherapy was an independent prognostic factor in this patient group. | Yunbo Zhang Liping Zheng Junqi Liu Jinqiu Li Jianguang Zhang Jingjing Ma Yuxiu Song | 2021 | Journal of Oncology Research2021，3，2： | 0 |
| 16 | RESEARCH AND PRACTICE FOR MANUFACTURING ENVIRONMENT MODELLING TECHNOLOGY OF CIMS显示文摘RESEARCHANDPRACTICEFORMANUFACTURINGENVIRONMENTMODELLINGTECHNOLOGYOFCIMSRESEARCHANDPRACTICEFORMANUFACTURINGENVIRONMENTMODELLIN... | Ma Dengzhe Jin Ye Ming Xinguo Yan Junqi(Shanghai Jiaotong University) | 1994 | Chinese Journal of Mechanical Engineering1994，7，3： | 0 |
| 17 | Continuous-wave single-mode quantum cascade laser at 5.1 THz based on graded sampled grating design显示文摘We report on the terahertz(THz)quantum cascade lasers in continuous-wave(CW)operation with an emitting frequency above 5 THz.Excellent performance with a smaller leakage current and higher population inversion efficiency is obtained by one-well bridged bound-to-continuum hybrid quantum design at 5 THz.By designing and fabricating a graded metallic sampled distributed feedback grating in the waveguide,the first single-mode THz quantum cascade laser at 5.13 THz in CW operation mode is achieved.The maximum single-mode optical power of~48 mW is achieved at 15 K with a side-mode suppression ratio above 24 dB.This will draw great interest in the spectroscopy applications above the 5 THz range for THz quantum cascade lasers. | WEIJIANG LI YU MA YUNFEI XU JUNQI LIU LIJUN WANG NING ZHUO QUANYONG LU JINCHUAN ZHANG SHENQIANG ZHAI SHUMAN LIU FENGQI LIU | 2022 | Photonics Research2022，10，12： | 0 |
| 18 | Deposition of water-soluble inorganic ions in PM_(2.5) in a typical forestry system in Beijing,China显示文摘Background: Rapid economic development in China has resulted in an increase in severe air pollution in city groups such as the Beijing-Tianjin-Hebei Metropolitan Region. PM2.5(fine particles with an aerodynamic equivalent diameter of 2.5 [xm or less) is one of the most important pollutants. The deposition process is an important way of removing particles from the air. To evaluate the effect of an urban forest on atmospheric particle removal, a concentration gradient method was used to measure the deposition velocities of water-soluble inorganics in PM2.5 in two national forest parks in Beijing, China. The following eight water-soluble inorganic ions in PM2.5 were investigated: sodium, ammonium, potassium, magnesium, calcium, chloride, nitrate, and sulfate.Methods: Samples were taken from two sites in Beijing from the 7 th to the 15 th May, 2013. The concentrations of water-soluble inorganic ions were analyzed with ion chromatography. We used the concentration gradient technique to estimate the deposition flux and velocity. To determine the relationships between leaf traits and particle accumulation, typical leaf samples from each selected species were studied using scanning electron microscopy.Results: The total deposition flux and total deposition velocity during the daytime were higher than those at night.Sulfate showed the biggest deposition flux and velocity at both study sites, whereas the other ions showed different trends at each site. Result from higher proportion of coniferous to broadleaved trees, the total deposition flux of the eight ions measured in Jiufeng National Forest Park was greater than that in Olympic Forest Park.Conclusions: The deposition velocity was affected by meteorological conditions such as wind speed, temperature,and humidity. The deposition velocity was also influenced by tree species. The surface of plants is an important factor influencing particle deposition. The results of this study may help in assessing the effects of forestry systems on particle removal and provide evidence for urban air pollution control and afforestation of urban areas. | Junqi Ding Xiaoxiu Lun Weifang Ma Lu Zhao Yingying Cao Fengbin Sun Renna Li | 2018 | Forest Ecosystems2018，5，4： | 0 |
| 19 | Dual-mode distributed feedback quantum cascade laser based on stacked 3D monolithic integration for on-chip multi-channel gas sensing显示文摘To facilitate the development of on-chip integrated mid-infrared multi-channel gas sensing systems,we propose a high-power dual-mode(7.01 and 7.5μm)distributed feedback quantum cascade laser based on stacked 3D monolithic integration.Longitudinal mode control is achieved by preparing longitudinal nested bi-periodic compound one-dimensional Bragg gratings along the direction of the cavity length in the confinement layer.Additionally,transverse coherent coupling ridges perpendicular to the cavity length direction are fabricated in the upper waveguide layer to promote the fundamental transverse mode output when all ridges are in phase.Stable dual-wavelength simultaneous emission with a side-mode suppression ratio of more than 20 dB was achieved by holographic exposure and wet etching.The entire spectral tuning range covers nearly 100 nm through joint tuning of the injection current and heat-sink temperature.High peak power and beam quality are guaranteed by the parallel coherent integration of seven-element ridge arrays.The device operates in a fundamental supermode with a single-lobed far-field pattern,and its peak output power reaches 3.36 W in pulsed mode at 20℃.This dual-mode laser chip has the potential for in-situ on-chip simultaneous detection of CH4and C2H6gases in leak monitoring. | XIYU LU YANJIAO GUAN PENGCHANG YANG SHAN NIU YU MA LIJUN WANG NING ZHUO JINCHUAN ZHANG SHENQIANG ZHAI FENGMIN CHENG SHUMAN LIU FENGQI LIU JUNQI LIU | 2023 | Photonics Research2023，11，12： | 0 |
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