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| 1 | Apatite Fission Track Evidence of Uplift Cooling in the Qiangtang Basin and Constraints on the Tibetan Plateau Uplift显示文摘The Qiangtang basin is located in the central Tibetan Plateau. This basin has an important structural position,and further study of its tectonic and thermal histories has great significance for understanding the evolution of the Tibetan Plateau and the hydrocarbon potential of marine carbonates in the basin. This study focuses on low temperature thermochronology and in particular conducted apatite fission track analysis. Under constraints provided by the geological background,the thermal history in different tectonic units is characterized by the degree of annealing of samples,and the timing of major(uplift-erosion related) cooling episodes is inferred. The cooling history in the Qiangtang basin can be divided into two distinct episodes. The first stage is mainly from the late Early Cretaceous to the Late Cretaceous(69.8 Ma to 108.7 Ma),while the second is mainly from the MiddleLate Eocene to the late Miocene(10.3 Ma to 44.4 Ma). The first cooling episode records the uplift of strata in the central Qiangtang basin caused by continued convergent extrusion after the BangongNujiang ocean closed. The second episode can be further divided into three periods,which are respectively 10.3 Ma,22.6–26.1 Ma and 30.8–44.4 Ma. The late Oligocene-early Miocene(22.6–26.1 Ma) is the main cooling period. The distribution and times of the earlier uplift-related cooling show that the effect of extrusion after the collision between Eurasian plate and India plate obviously influenced the Qiangtang basin at 44.4 Ma. The Qiangtang basin underwent compression and started to be uplifted from the middle-late Eocene to the early Oligocene(45.0–30.8 Ma). Subsequently,a large-scale and intensive uplift process occurred during the late Oligocene to early Miocene(26.1–22.6 Ma) and the basin continued to undergo compression and uplift up to the late Miocene(10.3 Ma). Thus,uplift-erosion in the Qiangtang basin was intensive from 44.5 Ma to about 10 Ma. The timing of cooling in the second episode shows that the uplift of the Qiangtang basin was caused by the strong compression after the collision of the Indian plate and Eurasian plate. On the whole,the new apatite fission-track data from the Qiangtang basin show that the Tibetan Plateau started to extrude and uplift during 45–30.8 Ma. The main period of uplift and formation of the Tibetan Plateau took place about 22.6–26.1 Ma,and uplift and extrusion continued until the late Miocene(10.3 Ma). | REN Zhanli CUI Junping LIU Chiyang LI Tiejun CHEN Gang DOU Shuang TIAN Tao LUO Yating | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 11 |
| 2 | Thermal conductivity of natural rubber nanocomposites with hybrid fillers显示文摘Natural rubber nanocomposites filled with hybrid fillers of multi-walled carbon nanotubes(CNTs) and carbon black(CB) were prepared. CNTs were ultrasonically modified in mixture of hydrogen peroxide(H2O2) and distilled water(H2O). The functional groups on the surface of CNTs, changes in nanotube structure and morphology were characterized by Fourier transform infrared spectroscopy(FT-IR), Raman Spectroscopy, and transmission electron microscopy(TEM). It shows that hydroxyl(OH·) is successfully introduced. The surface defects of modified CNTs were obviously higher than those of original CNTs, and the degree of agglomeration was greatly reduced. Thermal conductivity of the composites was tested by protection heat flow meter method. Compared with unmodified CNTs/CB filling system, the thermal conductivity of hybrid composites is improved by an average of 5.8% with 1.5 phr(phr is parts per hundred rubber) of hydroxyl CNTs and 40 phr of CB filled. A three-dimensional heat conduction network composed of hydroxyl CNTs and CB, as observed by TEM, contributes to the good properties. Thermal conductivity of the hybrid composites increases as temperature rises. The mechanical properties of hybrid composites are also good with hydroxyl CNTs filled nanocomposites;the tensile strength, 100% and 300% tensile stress are improved by 10.1%, 22.4% and 26.2% respectively. | Junping Song Xiteng Li Kaiyan Tian Lianxiang Ma Wei Li Shichune Yao | 2019 | Chinese Journal of Chemical Engineering2019，27，4： | 3 |
| 3 | Ambulatory blood pressure profile and stroke recurrence显示文摘Objectives To establish a new ambulatory blood pressure(ABP)parameter(24-hour ABP profile)and evaluated its performance on stroke outcome in ischaemic stroke(IS)or transient ischaemic attack(TIA)patients.Methods The prospective cohort consisted of 1996 IS/TIA patients enrolled for ABP monitoring and a 3-month follow-up for stroke recurrence as outcome.Profile groups of systolic blood pressure(SBP)were identified via an advanced functional clustering method,and the associations of the profile groups and conventional ABP parameters with stroke recurrence were examined in a Cox proportional hazards model.Results Three discrete profile groups(n=604,781 and 611 in profiles 1,2 and 3,respectively)in 24-hour ambulatory SBP were identified.Profile 1 resembled most to the normal diurnal blood pressure pattern;profile 2 also dropped at night,but climbed earlier and with higher morning surge;while profile 3 had sustained higher nocturnal SBP without significant nocturnal SBP decline.The incidence of stroke recurrence was 2.9%,3.9%and 5.5%in profiles 1,2 and 3,respectively.After adjustment for covariates,profile 3 was significantly associated with higher risk of stroke recurrence with profile 1 as reference(HR 1.76,95%CI:1.00 to 3.09),while no significant difference was observed between profiles 2 and 1(HR 1.22,95%CI:0.66 to 2.25).None of conventional ABP parameters showed significant associations with the outcome.Conclusions Ambulatory 24-hour SBP profile is associated with short-term stroke recurrence.Profiles of ABP may help improve identification of stroke recurrence by capturing the additive effects of individual ABP parameters. | Jie Xu Fei Jiang Anxin Wang Hui Zhi Yuan Gao Junping Tian Jinglin Mo Zimo Chen An-Ding Xu Benyan Luo Bo Hu Yuqing Zhang Xingquan Zhao Yilong Wang Hao Li Haipeng Shen Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，3： | 3 |
| 4 | Optimization of movable irrigation system and performance assessment of distribution uniformity under varying conditions显示文摘The evaluation of the performance of distribution uniformity by linearly moved irrigation system(LMIS)should consider the impacts of non uniformity of the water on crop yield.With increasing pressures to improve water use efficiency,plant productivity and farm profitability,questions continue to be raised concerning the future direction of irrigated agriculture.This study therefore aimed at evaluating water distribution under LMIS newly designed by the National Research Centre of Fluid Machinery Engineering and Technology,Jiangsu University,China.This article reports the real distribution of irrigation water under the LMIS with respect to sprinkler height above the ground surface as well as the consequence of different operating pressures.Water distribution coefficients used in the performance assessment were Christiansen’s coefficient of uniformity(CU),distribution uniformity(DU),scheduling coefficients(Sc)and the coefficient of variation(CV).The results showed that the mean CU ranged from 82.30%to 93.17%,and mean DU ranged from 70.39%to 88.44%.Also Sc values ranged from 1.13 to 1.42 with CV values ranging from 10.3%to 22.5%.The optimum method and results in this study can provide a reference to the operations for saving water and cost in the application of LMIS. | Yuan Shouqi Ransford Opoku Darko Zhu Xingye Liu Junping Tian Kun | 2017 | International Journal of Agricultural and Biological Engineering2017，10，1： | 2 |
| 5 | Isolation and expression of McF3H gene in the leaves of crabapple显示文摘 | Hongxiang Shen Jie Zhang Yuncong Yao Ji Tian Tingting Song Jian Geng Junping Gao | 2012 | Acta Physiologiae Plantarum2012，，4： | 1 |
| 6 | Detection of influenza A virus based on fluorescence resonance energy transfer from quantum dots to carbon nanotubes显示文摘 | Tian Junping Zhao Huimin Liu Meng | | 0，，： | 1 |
| 7 | Antithrombotic activities of aqueous extract from radix Ophiopogon japonicus and its two constituents 显示文摘 | Junping Kou Youqing Tian Yunkit Tang | 2006 | Biol Pharm Bull2006，29，6： | 1 |
| 8 | Involvement of rose aquaporin RhPIP1;1 in ethylene-regulated petal expansion through interaction with RhPIP2;1显示文摘 | Wen Chen Xia Yin Lei Wang Ji Tian Ruoyun Yang Daofeng Liu Zhenhao Yu Nan Ma Junping Gao | 2013 | Plant Molecular Biology2013，，3： | 1 |
| 9 | Cascade biocatalysis for production of enantiopure(S)-2-hydroxybutyric acid using recombinant Escherichia coli with a tunable multi-enzyme-coordinate expression system显示文摘Racemize 2-hydroxybutyric acid is usually synthesized by organic methods and needs additional deracemization to obtain optically pure enantiomers for industrial application.Here we present a cascade biocatalysis system in Escherichia coli BL21 which employed L-threonine deaminase(TD),NAD-dependent L-lactate dehydrogenase(LDH)and alcohol dehydrogenase(ADH)for producing optically pure(S)-2-hydroxybutyric acid((S)-2-HBA)from bulk chemical L-threonine.To solve the mismatch in the conversion rate and the consumption rate of intermediate 2-oxobutyric acid(2-OBA)formed in the multi-enzyme catalysis reaction,ribosome binding site regulation strategy was explored to control TD expression levels,achieving an eightfold alteration in the conversion rate of 2-OBA.With the optimized activity ratio of the three enzymes and using ADH for NADH regeneration,the recombinant strain ADH-r53 showed increased production of(S)-2-HBA with the highest titer of 129 g/L and molar yield of 93%within 24 h,which is approximately 1.65 times that of the highest yield reported so far.Moreover,(S)-2-HBA could easily be purified by distillation,making it have great potential for industrial application.Additionally,our results indicated that constructing a tunable multi-enzyme-coordinate expression system in single cell had great significance in biocatalysis of hydroxyl acids. | Lingzhi Tian Junping Zhou Taowei Yang Xian Zhang Meijuan Xu Zhiming Rao | 2021 | Systems Microbiology and Biomanufacturing2021，1，2： | 1 |
| 10 | Recycle-Friendly Aluminum Alloy Sheets for Automotive Applications Based on Hemming显示文摘Unavoidably,Fe impurities are mixed into Al alloys during recycling of aluminum automotive parts.High Fe content recyclefriendly aluminum alloy sheets(RASs)are discussed in terms of their applications to car body parts and closures.RASs have advantages,such as they are low cost and light weight,they require less energy to process,and they reduce emissions when used in vehicles.The hemming ability of RASs was investigated through various quenching rates and hot-rolling reduction rates.The hemming factor(HF)values of low Fe content samples(0.1 and 0.3 wt%Fe content)were 2 and 3.The hemming ability of samples with an Fe content of 0.5 wt%was unacceptable for applications to automotive outer closures(i.e.,HF values of 4 and 5).The HF values changed from 3 to 5 for even higher Fe content samples(0.8 wt%Fe),depending on the quenching and hot-rolling reduction rates.Lower quenching(air quenching)and lower hot-rolling reduction rates(6-pass hot rolling)both improved the hemming ability of the high Fe content samples.A low-cost and recycle-friendly aluminum alloy automotive sheet from end-of-life vehicles is presented,and its hemming properties are characterized. | Hongzhou Lu Junping Zhang Ni Tian Xinli Song Mingtu Ma Guimin Lu | 2018 | Automotive Innovation2018，1，1： | 1 |
| 11 | Mutation in the gene encoding 1-aminocyclopropane-1-carboxylate synthase 4 (CitACS4) led to andromonoecy in watermelon显示文摘Although it has been reported previously that ethylene plays a critical role in sex determination in cucurbit species, how the andromonoecy that carries both the male and hermaphroditic flowers is determined in watermelon is still unknown. Here we showed that the watermelon gene 1-aminocyclopropane-1-carboxylate synthase 4(Cit ACS4), expressed specifically in carpel primordia, determines the andromonoecy in watermelon. Among four single nucleotide polymorphism(SNPs) and one InDel identified in the coding region of Cit ACS4, the C364 W mutation located in the conserved box 6 was cosegregated with andromonoecy. Enzymatic analyses showed that the C364 W mutation caused a reduced activity in Cit ACS4. We believe that the reduced Cit ACS4 activity may hamper the programmed cell death in stamen primordia, leading to the formation of hermaphroditic flowers. | Gaojie Ji Jie Zhang Haiying Zhang Honghe Sun Guoyi Gong Jianting Shi Shouwei Tian Shaogui Guo Yi Ren Huolin Shen Junping Gao Yong Xu | 2016 | Journal of Integrative Plant Biology2016，58，9： | 1 |
| 12 | Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer’s disease by neurotoxin neutralization and immune recognition suppression显示文摘Immune recognition of excessive neurotoxins by microglia is a trigger for the onset of neuroinflammation in the brain,leading to neurodegeneration in Alzheimer’s disease(AD).Blocking active recognition of microglia while removing neurotoxins holds promise for fundamentally alleviating neurotoxin-induced immune responses,but is very challenging.Herein,an engineered macrophage-biomimetic versatile nanoantidote(OT-Lipo@M)is developed for inflammation-targeted therapy against AD by neurotoxin neutralization and immune recognition suppression.Coating macrophage membranes can not only endow OT-Lipo@M with anti-phagocytic and inflammation-tropism capabilities to target inflammatory lesions in AD brain,but also efficiently reduce neurotoxin levels to prevent them from activating microglia.The loaded oxytocin(OT)can be slowly released to downregulate the expression of immune recognition site Toll-like receptor 4(TLR4)on microglia,inhibiting TLR4-mediated pro-inflammatory signalling cascade.Benefiting from this two-pronged immunosuppressive strategy,OT-Lipo@M exhibits outstanding therapeutic effects on ameliorating cognitive deficits,inhibiting neuronal apoptosis,and enhancing synaptic plasticity in AD mice,accompanied by the delayed hippocampal atrophy and brain microstructural disruption by in vivo 9.4T MR imaging.This work provides new insights into potential AD therapeutics targeting microglia-mediated neuroinflammation at the source. | Meng Cheng Caihua Ye Chunxiao Tian Dongju Zhao Haonan Li Zuhao Sun Yuyang Miao Qiang Zhang Junping Wang Yan Dou | 2023 | Bioactive Materials2023，，8： | 1 |
| 13 | Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an enveloped RNA betacoronavirus,1 that has spread globally since December 2019.As of July 22,2020,more than 14,000,000 confirmed cases and 607,781 deaths from COVID-19 have been reported to the World Health Organization from 216 areas and territories.2 Patientswithmore prominent laboratory abnormalities may develop acute respiratory distress syndrome(ARDS),which potentially leads tomultiple organ failure and death.1,3 However,at present,there are no regulatory approved antiviralmedicines,vaccines,or specific clinical treatments for COVID-19. | Junping Wu Cherie S.Tan Hongzhi Yu Youwei Wang Yutao Tian Wenwei Shao Yifei Zhang Kuo Zhang Hongxia Shao Guangjian Ni Jun Shen Antonio Carlo Galoforo Qi Wu Dong Ming | 2020 | The Innovation2020，1，3： | 1 |
| 14 | The influences of composition and pore structure on the adsorption behavior of CH_(4) and CO_(2) on shale显示文摘CO_(2) enhanced shale gas recovery(CO_(2)-ESGR)has attracted extensive attention as it can improve the shale gas recovery efficiency and sequestrate CO_(2) simultaneously.In this study,the relationship between mineral composition,pore structure,CH_(4) and CO_(2) adsorption behavior as well as selective adsorption coefficient of CO_(2) over CH_(4)(αCO_(2)/CH_(4))in marine and continental shales at different temperatures was investigated.The results illustrated that shale with higher total organic carbon(TOC),higher clay minerals and lower brittle mineral contents has a larger micropores and mesopores volume and specific surface area.TOC content was positively correlated with fractal dimension Df.Both CH_(4) and CO_(2) adsorption capacity in shale have positive correlations with TOC and clay mineral content.CO_(2) adsorption capacity of the all the tested shale samples were greater than CH_(4),and theαCO_(2)/CH_(4) of shale were larger than 1.00,which indicated that using CO_(2)-ESGR technology to improve the gas recovery is feasible in these shale gas reservoirs.A higher TOC content and in shale corresponding to a lowerαCO_(2)/CH_(4) due to the organic matters show stronger affinity on CH_(4) than that on CO_(2).Shale with a higher brittle mineral content corresponding to a higherαCO_(2)/CH_(4),and no obvious correlation betweenαCO_(2)/CH_(4) and clay mineral content in shale was observed due to the complexity of the clay minerals.TheαCO_(2)/CH_(4) of shale were decreased with increasing temperature for most cases,which indicated that a lower temperature is more favorable for the application of CO_(2)-ESGR technique. | Xiangzeng WANG Junping ZHOU Xiao SUN Shifeng TIAN Jiren TANG Feng SHEN Jinqiao WU | 2021 | Frontiers of Earth Science2021，15，2： | 0 |
| 15 | Selenium-engineered bottom-up-synthesized lanthanide coordination nanoframeworks as efficiency X-ray-responsive radiosensitizers显示文摘Radiotherapy is one of the main therapeutic methods for cancers;however,nonselective killing of normal cells and tumor cells by X-ray inevitably results in toxicity and side effects.Developing low-toxicity and high-efficiency radiosensitizers to reduce the practical dose of X-ray is a promising approach to overcoming these side effects.Here,we report the use of carboxylatecontaining organic ligands to construct one-dimensional high-Z lanthanide chains for efficient response to X-ray.The onedimensional lanthanide chains are stacked through weak interactions to form coordination nanoframeworks in the presence of polyethylenimine(PEI).The morphology and activity of the synthesized nanoframeworks can be regulated through selenium atom engineering.This study presents a promising approach for effective radiotherapy through selenium-engineering stable lanthanide nanoframeworks with precise coordination structures as radiosensitizers to mitigate X-ray side effects. | Liwen Zhu Leung Chan Junping Wang Mingkai Chen Fei Cai Yuan Tian Li Ma Tianfeng Chen | 2023 | Nano Research2023，16，4： | 0 |
| 16 | Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients显示文摘Primary ciliary dyskinesia(PCD)is a highly heterogeneous recessive inherited disorder.FAP54,the homolog of CFAP54 in Chlamydomonas reinhardtii,was previously demonstrated as the C1d projection of the central microtubule apparatus of flagella.A Cfap54 knockout mouse model was then reported to have PCD-relevant phenotypes.Through whole-exome sequencing,compound heterozygous variants c.2649_2657delinC(p.E883Dfs*47)and c.7312_7313insCGCAGGCTGAATTCTTGG(p.T2438delinsTQAEFLA)in a new suspected PCD-relevant gene,CFAP54,were identified in an individual with PCD.Two missense variants,c.4112A>C(p.E1371A)and c.6559C>T(p.P2187S),in CFAP54 were detected in another unrelated patient.In this study,a minigene assay was conducted on the frameshift mutation showing a reduction in mRNA expression.In addition,a CFAP54 in-frame variant knock-in mouse model was established,which recapitulated the typical symptoms of PCD,including hydrocephalus,infertility,and mucus accumulation in nasal sinuses.Correspondingly,two missense variants were deleterious,with a dramatic reduction in mRNA abundance from bronchial tissue and sperm.The identification of PCD-causing variants of CFAP54 in two unrelated patients with PCD for the first time provides strong supportive evidence that CFAP54 is a new PCD-causing gene.This study further helps expand the disease-associated gene spectrum and improve genetic testing for PCD diagnosis in the future. | Xinyue Zhao Haijun Ge Wenshuai Xu Chongsheng Cheng Wangji Zhou Yan Xu Junping Fan Yaping Liu Xinlun Tian Kai-Feng Xu Xue Zhang | 2023 | Frontiers of Medicine2023，17，6： | 0 |
| 17 | Association between 5-HTTLPR and STin2 VNTR polymorphisms in the serotonin transporter gene and clinical response of a selective serotonin reuptake inhibitor (dapoxetine) in lifelong premature ejaculation显示文摘To the Editor:Premature ejaculation(PE)is one of the commonplace male sexual dysfunctions affecting about 30%of men worldwide.PE can either be lifelong or acquired.Genetic polymorphisms situated on the SLC6A4 of humans encoding the 5-hydroxytryptamine transporter(serotonin transporter)(5-HTT)also called the serotonin transporter(SERT),a significant controller of serotonergic neurotransmission,were related to the pathogenesis of PE.[1,2]Polymorphisms in SLC6A4 are associated with the incidence of lifelong premature ejaculation(LPR).The effects of 5-hydroxytryptamine(serotonin)transporter gene-linked polymorphic region(5-HTTLPR)and serotonin transporter gene intron 2(STin2)polymorphism on lifelong PE(LPE)are controversial.We aimed to determine possible relationships between 5-HTTLPR and STin2 polymorphisms in the SERT gene and clinical response of a selective serotonin reuptake inhibitor(dapoxetine)in LPE. | Abdullah Yang Yang Shang-Shu Ding Ping Sun Huoyong-Wei Tian Hong Junping Xing | 2022 | Chinese Medical Journal2022，，13： | 0 |
| 18 | Overproduction of nitrate and S-nitrosothiols in diabetic patients显示文摘Objective The present study was designed to investigate changes in serum or plasma concentrations of nitric oxide and its derivatives in diabetic patients.Methods Serum nitrate concentration of 84 diabetic patients was measured by using an enzyme kinetic method,and the plasma S-nitrosothiols concentration of 10 cases was measured by using HPLC technique.Results Serum nitrate concentration and plasma S-nitrosothiols concentration in the diabetics were significantly higher than in control group (P<0.01 andP<0.05,respectively).The serum nitrate concentration in diabetics also had a significant positive correlation with the serum glucose concentration (R=0.7256,P<0.05),but this correlation was not found in control group.Conclusion These data showed that NO and its derivatives are overproduced in the diabetic patients.(J Geriatr Cardiol 2008;5:25-27) | Junping Zhao Chengbin Wang Hongli Tong Yuzhen Li Chunxi Zhou Yaping Tian Shiwei Liu | 2008 | Journal of Geriatric Cardiology2008，5，1： | 0 |
| 19 | Pore structure evolution of mudstone caprock under cyclic load-unload and its influence on breakthrough pressure显示文摘The pore structure of caprock plays an important role in underground gas storage security, as it significantly influences the sealing capacity of caprock. However, the pore structure evolution of caprock with the cyclic stress perturbations triggered by the cyclic gas injection or extraction remains unclear. In this study, the pore structure changes of mudstone caprock under cyclic loading and unloading were obtained by the nuclear magnetic resonance (NMR) tests system, then the influence of the changes on the breakthrough pressure of caprock was discussed. The results indicated that the pore structure changes are depending on the stress loading-unloading path and stress level. In the first cyclic, at the loading stage, with the increase of confining stress, the NMR T2 spectrum curve moved to the left, the NMR signal amplitude of the first peak increased, while the amplitude of the second peak decreased gradually. This indicated that the larger pores of mudstone are compressed and transformed into smaller pores, then the number of macropores decreased and the number of micro- and mesopores increased. For a certain loading-unloading cycle, the porosity curve of mudstone in the loading process is not coincide with that in the unloading process, the porosity curve in the loading process was located below that in the unloading process, which indicated that the pore structure change is stress path dependent. With the increase of cycle numbers, the total porosity shown an increasing trend, indicating that the damage of mudstone occurred under the cyclic stress load-unload effects. With the increase of porosity, the breakthrough pressure of mudstone decreased with the increase of the cyclic numbers, which may increase the gas leakage risk. The results can provide significant implication for the underground gas storage security evaluation. | Junchang SUN Zhiqiang DONG Sinan ZHU Shifeng TIAN Junping ZHOU | 2023 | Frontiers of Earth Science2023，17，3： | 0 |
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